{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:21:59Z","timestamp":1789734119073,"version":"4.0.1"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","award":["TRA\/2007\/5"],"award-info":[{"award-number":["TRA\/2007\/5"]}],"id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","award":["HPF\/2010\/17"],"award-info":[{"award-number":["HPF\/2010\/17"]}],"id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Oxidative stress and oxidation-induced DNA damage may contribute to the pathophysiology of depression. Two key mediators of base excision repair (BER) in response to oxidative damage of DNA are OGG1 and PARP1. Few studies have examined changes in OGG1 or PARP1 mRNA in patients with depression or following antidepressant treatment. We examined PARP1 and OGG1 mRNA levels in patients with depression at baseline\/pre-electroconvulsive therapy (baseline\/pre-ECT) vs in healthy controls and in patients following a course of ECT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>PARP1 and OGG1 were examined in whole blood samples from medicated patients with depression and controls using quantitative real-time polymerase chain reaction. Exploratory subgroup correlational analyses were performed to determine associations between PARP1 and OGG1 and mood (Hamilton Depression Rating Scale 24-item version) scores as well as with vitamin B3, SIRT1, PGC1\u03b1, and tumor necrosis factor alpha levels, as previously reported on in this cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>PARP1 levels were reduced in samples from patients with depression vs controls (P\u2009=\u2009.03), though no difference was noted in OGG1. ECT had no effect on PARP1 or OGG1. Higher baseline PARP1 weakly correlated with greater mood improvement post ECT (P\u2009=\u2009.008). Moreover, PARP1 positively correlated with SIRT1 at baseline and post ECT, and positive correlations were noted between change in PARP1 and change in OGG1 with change in tumor necrosis factor alpha post ECT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>To our knowledge, this is the first study to examine the effect of ECT on BER enzymes. A better understanding of BER enzymes and DNA repair in depression could unearth new mechanisms relevant to the pathophysiology of this condition and novel antidepressant treatments.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ijnp\/pyac078","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T05:45:25Z","timestamp":1670391925000},"page":"107-115","source":"Crossref","is-referenced-by-count":5,"title":["<i>PARP1<\/i> and <i>OGG1<\/i> in Medicated Patients With Depression and the Response to ECT"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9264-8757","authenticated-orcid":false,"given":"Karen M","family":"Ryan","sequence":"first","affiliation":[{"name":"Trinity College Institute of Neuroscience, Trinity College Dublin , Dublin , Ireland"},{"name":"Department of Psychiatry, Trinity College Dublin, St. Patrick\u2019s University Hospital , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan M","family":"McLoughlin","sequence":"additional","affiliation":[{"name":"Trinity College Institute of Neuroscience, Trinity College Dublin , Dublin , Ireland"},{"name":"Department of Psychiatry, Trinity College Dublin, St. Patrick\u2019s University Hospital , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"2023021407511580700_CIT0001","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1177\/0269881119874461","article-title":"Effects of selective serotonin reuptake inhibitors on DNA damage in patients with depression","volume":"33","author":"Ahmadimanesh","year":"2019","journal-title":"J Psychopharmacol"},{"key":"2023021407511580700_CIT0002","doi-asserted-by":"crossref","first-page":"812","DOI":"10.3389\/fpsyt.2019.00812","article-title":"Abnormal distribution and function of circulating monocytes and enhanced bacterial translocation in major depressive disorder","volume":"10","author":"Alvarez-Mon","year":"2019","journal-title":"Front Psychiatry"},{"key":"2023021407511580700_CIT0003","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.3390\/ijms19061801","article-title":"Role of human macrophage polarization in inflammation during infectious diseases","volume":"19","author":"Atri","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2023021407511580700_CIT0004","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.redox.2017.11.008","article-title":"8-Oxoguanine DNA glycosylase 1: beyond repair of the oxidatively modified base lesions.","volume":"14","author":"Ba","year":"2018","journal-title":"Redox Biol"},{"key":"2023021407511580700_CIT0005","volume-title":"Hamilton rating scale for depression, ECDEU version used in the treatment of depression collaborative research program","author":"Beckham","year":"1985"},{"key":"2023021407511580700_CIT0006","doi-asserted-by":"crossref","first-page":"104600","DOI":"10.1016\/j.psyneuen.2020.104600","article-title":"Alterations in levels of 8-oxo-2\u2019-deoxyguanosine and 8-oxoguanine DNA glycosylase 1 during a current episode and after remission in unipolar and bipolar depression","volume":"114","author":"Ceylan","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"2023021407511580700_CIT0007","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1478-811X-8-31","article-title":"PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration","volume":"8","author":"Chaitanya","year":"2010","journal-title":"Cell Commun Signal"},{"key":"2023021407511580700_CIT0008","first-page":"8563","article-title":"A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites","volume":"47","author":"Chen","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2023021407511580700_CIT0009","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1089\/rej.2006.0514","article-title":"Oxidative DNA damage repair and parp 1 and parp 2 expression in Epstein-Barr virus-immortalized B lymphocyte cells from young subjects, old subjects, and centenarians.","volume":"10","author":"Chevanne","year":"2007","journal-title":"Rejuvenation Res"},{"key":"2023021407511580700_CIT0010","first-page":"2043","article-title":"Repurposing antidepressant sertraline as a pharmacological drug to target prostate cancer stem cells: dual activation of apoptosis and autophagy signaling by deregulating redox balance.","volume":"10","author":"Chinnapaka","year":"2020","journal-title":"Am J Cancer Res"},{"key":"2023021407511580700_CIT0011","doi-asserted-by":"crossref","first-page":"112616","DOI":"10.1016\/j.psychres.2019.112616","article-title":"Investigation of mitochondrial DNA copy number in patients with major depressive disorder","volume":"282","author":"Chung","year":"2019","journal-title":"Psychiatry Res"},{"key":"2023021407511580700_CIT0012","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1126\/science.1096775","article-title":"Long-term memory requires polyADP-ribosylation","volume":"304","author":"Cohen-Armon","year":"2004","journal-title":"Science"},{"key":"2023021407511580700_CIT0013","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.bbamcr.2017.11.003","article-title":"Inhibition of poly(ADP-ribose) polymerase-1 alters expression of mitochondria-related genes in PC12 cells: relevance to mitochondrial homeostasis in neurodegenerative disorders.","volume":"1865","author":"Czapski","year":"2018","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"2023021407511580700_CIT0014","doi-asserted-by":"crossref","first-page":"412","DOI":"10.12659\/MSM.892317","article-title":"Elevated level of DNA damage and impaired repair of oxidative DNA damage in patients with recurrent depressive disorder.","volume":"21","author":"Czarny","year":"2015","journal-title":"Med Sci Monit"},{"key":"2023021407511580700_CIT0015","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jad.2015.05.044","article-title":"Association between single nucleotide polymorphisms of MUTYH, hOGG1 and NEIL1 genes, and depression.","volume":"184","author":"Czarny","year":"2015","journal-title":"J Affect Disord"},{"key":"2023021407511580700_CIT0016","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1007\/s12035-016-9971-6","article-title":"Impact of single nucleotide polymorphisms of base excision repair genes on DNA damage and efficiency of DNA repair in recurrent depression disorder.","volume":"54","author":"Czarny","year":"2017","journal-title":"Mol Neurobiol"},{"key":"2023021407511580700_CIT0017","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.pnpbp.2017.06.036","article-title":"The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression.","volume":"80","author":"Czarny","year":"2018","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2023021407511580700_CIT0018","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1001\/archpsyc.1997.01830190015002","article-title":"A molecular and cellular theory of depression","volume":"54","author":"Duman","year":"1997","journal-title":"Arch Gen Psychiatry"},{"key":"2023021407511580700_CIT0019","doi-asserted-by":"crossref","first-page":"e1617","DOI":"10.1002\/wrna.1617","article-title":"The multifaceted role of PARP1 in RNA biogenesis","volume":"12","author":"Eleazer","year":"2021","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"2023021407511580700_CIT0020","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41398-021-01723-x","article-title":"Blood-based mitochondrial respiratory chain function in major depression","volume":"11","author":"Fernstrom","year":"2021","journal-title":"Transl Psychiatry"},{"key":"2023021407511580700_CIT0021","doi-asserted-by":"crossref","first-page":"1178646918776658","DOI":"10.1177\/1178646918776658","article-title":"The influence of nicotinamide on health and disease in the central nervous system","volume":"11","author":"Fricker","year":"2018","journal-title":"Int J Tryptophan Res"},{"key":"2023021407511580700_CIT0022","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1471-4159.2009.06296.x","article-title":"PolyADP-ribosylation is required for long-term memory formation in mammals.","volume":"111","author":"Goldberg","year":"2009","journal-title":"J Neurochem"},{"key":"2023021407511580700_CIT0023","doi-asserted-by":"crossref","first-page":"7427","DOI":"10.1096\/fj.201902243R","article-title":"Enzymatically inactive OGG1 binds to DNA and steers base excision repair toward gene transcription.","volume":"34","author":"Hao","year":"2020","journal-title":"FASEB J"},{"key":"2023021407511580700_CIT0024","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1083\/jcb.201701154","article-title":"MEIS homeodomain proteins facilitate PARP1\/ARTD1-mediated eviction of histone H1","volume":"216","author":"Hau","year":"2017","journal-title":"J Cell Biol"},{"key":"2023021407511580700_CIT0025","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1083\/jcb.150.2.293","article-title":"A fast signal-induced activation of poly (ADP-ribose) polymerase: a novel downstream target of phospholipase c.","volume":"150","author":"Homburg","year":"2000","journal-title":"J Cell Biol"},{"key":"2023021407511580700_CIT0026","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/s41419-019-2174-0","article-title":"Defective neurogenesis and schizophrenia-like behavior in PARP-1-deficient mice","volume":"10","author":"Hong","year":"2019","journal-title":"Cell Death Dis"},{"key":"2023021407511580700_CIT0027","doi-asserted-by":"crossref","first-page":"129669","DOI":"10.1016\/j.bbagen.2020.129669","article-title":"Role of PARP-1 in mitochondrial homeostasis","volume":"1864","author":"Kadam","year":"2020","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"2023021407511580700_CIT0028","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.neuint.2006.11.010","article-title":"Multiple roles for poly(ADP-ribose)polymerase-1 in neurological disease.","volume":"50","author":"Kauppinen","year":"2007","journal-title":"Neurochem Int"},{"key":"2023021407511580700_CIT0029","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.4049\/jimmunol.174.4.2288","article-title":"Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death.","volume":"174","author":"Kauppinen","year":"2005","journal-title":"J Immunol"},{"key":"2023021407511580700_CIT0030","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.3390\/cells8091047","article-title":"The role of PARPs in inflammation-and metabolic-related diseases: molecular mechanisms and beyond","volume":"8","author":"Ke","year":"2019","journal-title":"Cells"},{"key":"2023021407511580700_CIT0031","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1001\/archpsyc.1993.01820130038007","article-title":"Smoking and major depression. A causal analysis.","volume":"50","author":"Kendler","year":"1993","journal-title":"Arch Gen Psychiatry"},{"key":"2023021407511580700_CIT0032","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1007\/s11064-019-02729-0","article-title":"Multi-targeted effect of nicotinamide mononucleotide on brain bioenergetic metabolism.","volume":"44","author":"Klimova","year":"2019","journal-title":"Neurochem Res"},{"key":"2023021407511580700_CIT0033","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.chembiol.2015.03.007","article-title":"Extracellular poly(ADP-ribose) is a pro-inflammatory signal for macrophages.","volume":"22","author":"Krukenberg","year":"2015","journal-title":"Chem Biol"},{"key":"2023021407511580700_CIT0034","doi-asserted-by":"crossref","first-page":"e52585","DOI":"10.1371\/journal.pone.0052585","article-title":"Monocytes from depressed patients display an altered pattern of response to endotoxin challenge","volume":"8","author":"Lisi","year":"2013","journal-title":"PLoS One"},{"key":"2023021407511580700_CIT0035","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2023021407511580700_CIT0036","doi-asserted-by":"crossref","first-page":"107755","DOI":"10.1016\/j.neuropharm.2019.107755","article-title":"Poly(ADP-ribose) polymerase-1 inhibits mitochondrial respiration by suppressing PGC-1alpha activity in neurons","volume":"160","author":"Lu","year":"2019","journal-title":"Neuropharmacology"},{"key":"2023021407511580700_CIT0037","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/2041-9414-4-6","article-title":"SIRT1\/PARP1 crosstalk: connecting DNA damage and metabolism","volume":"4","author":"Luna","year":"2013","journal-title":"Genome Integr"},{"key":"2023021407511580700_CIT0038","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1101\/gad.183509.111","article-title":"On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1.","volume":"26","author":"Luo","year":"2012","journal-title":"Genes Dev"},{"key":"2023021407511580700_CIT0039","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ajpath.2015.09.021","article-title":"Poly(ADP-Ribose) polymerases: new players in the pathogenesis of exocrine pancreatic diseases.","volume":"186","author":"Martinez-Bosch","year":"2016","journal-title":"Am J Pathol"},{"key":"2023021407511580700_CIT0040","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mad.2015.04.001","article-title":"PARP-1 involvement in neurodegeneration: a focus on Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"146\u2013148","author":"Martire","year":"2015","journal-title":"Mech Ageing Dev"},{"key":"2023021407511580700_CIT0041","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.euroneuro.2018.06.007","article-title":"Peripheral blood SIRT1 mRNA levels in depression and treatment with electroconvulsive therapy","volume":"28","author":"McGrory","year":"2018","journal-title":"Eur Neuropsychopharmacol"},{"key":"2023021407511580700_CIT0042","doi-asserted-by":"crossref","first-page":"108415","DOI":"10.1016\/j.intimp.2021.108415","article-title":"Metformin and fluoxetine improve depressive-like behavior in a murine model of Parkinsons disease through the modulation of neuroinflammation, neurogenesis and neuroplasticity","volume":"102","author":"Mendonca","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"2023021407511580700_CIT0043","first-page":"994","article-title":"Antidepressant-like actions of inhibitors of poly(ADP-Ribose) polymerase in rodent models","volume":"20","author":"Ordway","year":"2017","journal-title":"Int J Neuropsychopharmacol"},{"key":"2023021407511580700_CIT0044","doi-asserted-by":"crossref","first-page":"43297","DOI":"10.1038\/srep43297","article-title":"OGG1-DNA interactions facilitate NF-kappaB binding to DNA targets","volume":"7","author":"Pan","year":"2017","journal-title":"Sci Rep"},{"key":"2023021407511580700_CIT0045","first-page":"1","article-title":"BDNF blood levels after electroconvulsive therapy in patients with mood disorders: An updated systematic review and meta-analysis","author":"Pelosof","year":"2022","journal-title":"World J Biol Psychiatry"},{"key":"2023021407511580700_CIT0046","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1017\/S0033291718002556","article-title":"Peroxisome proliferator activated receptor gamma co-activator-1 alpha in depression and the response to electroconvulsive therapy.","volume":"49","author":"Ryan","year":"2018","journal-title":"Psychol Med"},{"key":"2023021407511580700_CIT0047","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.brs.2018.05.011","article-title":"BDNF plasma levels and genotype in depression and the response to electroconvulsive therapy","volume":"11","author":"Ryan","year":"2018","journal-title":"Brain Stimul"},{"key":"2023021407511580700_CIT0048","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/YCT.0000000000000633","article-title":"Low circulating levels of GR, FKBP5, and SGK1 in medicated patients with depression are not altered by electroconvulsive therapy.","volume":"36","author":"Ryan","year":"2019","journal-title":"J ECT"},{"key":"2023021407511580700_CIT0049","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbi.2019.10.005","article-title":"Tryptophan metabolite concentrations in depressed patients before and after electroconvulsive therapy","volume":"83","author":"Ryan","year":"2020","journal-title":"Brain Behav Immun"},{"key":"2023021407511580700_CIT0050","doi-asserted-by":"crossref","first-page":"100063","DOI":"10.1016\/j.bbih.2020.100063","article-title":"Blood plasma B vitamins in depression and the therapeutic response to electroconvulsive therapy","volume":"4","author":"Ryan","year":"2020","journal-title":"Brain Behav Immun Health"},{"key":"2023021407511580700_CIT0051","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3389\/fnagi.2020.00255","article-title":"Nicotinamide, a poly [ADP-Ribose] polymerase 1 (PARP-1) inhibitor, as an adjunctive therapy for the treatment of Alzheimer\u2019s disease","volume":"12","author":"Salech","year":"2020","journal-title":"Front Aging Neurosci"},{"key":"2023021407511580700_CIT0052","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1176\/appi.ajp.2015.15030372","article-title":"Bitemporal versus high-dose unilateral twice-weekly electroconvulsive therapy for depression (EFFECT-Dep): a pragmatic, randomized, non-inferiority trial","volume":"173","author":"Semkovska","year":"2016","journal-title":"Am J Psychiatry"},{"key":"2023021407511580700_CIT0053","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1001\/archpsyc.63.7.824","article-title":"Association between obesity and psychiatric disorders in the US adult population.","volume":"63","author":"Simon","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"2023021407511580700_CIT0054","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.3390\/cells9092040","article-title":"The role of PARP1 in monocyte and macrophage commitment and specification: future perspectives and limitations for the treatment of monocyte and macrophage relevant diseases with PARP inhibitors","volume":"9","author":"Sobczak","year":"2020","journal-title":"Cells"},{"key":"2023021407511580700_CIT0055","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11306-019-1604-4","article-title":"Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide","volume":"15","author":"Song","year":"2019","journal-title":"Metabolomics"},{"key":"2023021407511580700_CIT0056","doi-asserted-by":"crossref","first-page":"13161","DOI":"10.1093\/nar\/gku1089","article-title":"Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function.","volume":"42","author":"Szczesny","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2023021407511580700_CIT0057","first-page":"363","article-title":"Elevated DNA oxidation and DNA repair enzyme expression in brain white matter in major depressive disorder","volume":"20","author":"Szebeni","year":"2017","journal-title":"Int J Neuropsychopharmacol"},{"key":"2023021407511580700_CIT0058","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.psychres.2010.07.030","article-title":"Expression of oxidative stress-response genes is not activated in the prefrontal cortex of patients with depressive disorder.","volume":"186","author":"Teyssier","year":"2011","journal-title":"Psychiatry Res"},{"key":"2023021407511580700_CIT0059","doi-asserted-by":"crossref","first-page":"e49677","DOI":"10.1371\/journal.pone.0049677","article-title":"Up-regulation of leucocytes genes implicated in telomere dysfunction and cellular senescence correlates with depression and anxiety severity scores","volume":"7","author":"Teyssier","year":"2012","journal-title":"PLoS One"},{"key":"2023021407511580700_CIT0060","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1124\/pr.54.3.375","article-title":"The therapeutic potential of poly(ADP-ribose) polymerase inhibitors.","volume":"54","author":"Virag","year":"2002","journal-title":"Pharmacol Rev"},{"key":"2023021407511580700_CIT0061","doi-asserted-by":"crossref","first-page":"7420","DOI":"10.1523\/JNEUROSCI.0333-05.2005","article-title":"PolyADP-ribosylation is involved in neurotrophic activity","volume":"25","author":"Visochek","year":"2005","journal-title":"J Neurosci"},{"key":"2023021407511580700_CIT0062","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12974-015-0448-8","article-title":"NF-kappaB transcriptional activation by TNFalpha requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1","volume":"12","author":"Vuong","year":"2015","journal-title":"J Neuroinflammation"},{"key":"2023021407511580700_CIT0063","doi-asserted-by":"crossref","first-page":"6197","DOI":"10.1007\/s12035-019-1524-3","article-title":"The ERK pathway: molecular mechanisms and treatment of depression.","volume":"56","author":"Wang","year":"2019","journal-title":"Mol Neurobiol"},{"key":"2023021407511580700_CIT0064","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects","volume":"310","author":"World Medical Association","year":"2013","journal-title":"JAMA"},{"key":"2023021407511580700_CIT0065","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.tins.2015.08.001","article-title":"Depression as a microglial disease","volume":"38","author":"Yirmiya","year":"2015","journal-title":"Trends Neurosci"},{"key":"2023021407511580700_CIT0066","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.brs.2017.10.013","article-title":"Electroconvulsive therapy, depression, the immune system and inflammation: a systematic review","volume":"11","author":"Yrondi","year":"2018","journal-title":"Brain Stimul"},{"key":"2023021407511580700_CIT0067","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1042\/BJ20101723","article-title":"Poly(ADP-ribose) polymerase-1 (PARP-1) pharmacogenetics, activity and expression analysis in cancer patients and healthy volunteers","volume":"436","author":"Zaremba","year":"2011","journal-title":"Biochem J"}],"container-title":["International Journal of Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ijnp\/advance-article-pdf\/doi\/10.1093\/ijnp\/pyac078\/48522285\/pyac078.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ijnp\/article-pdf\/26\/2\/107\/49174459\/pyac078.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ijnp\/article-pdf\/26\/2\/107\/49174459\/pyac078.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T11:02:11Z","timestamp":1676372531000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijnp\/article\/26\/2\/107\/6874837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,6]]},"references-count":67,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,12,6]]},"published-print":{"date-parts":[[2023,2,14]]}},"URL":"https:\/\/doi.org\/10.1093\/ijnp\/pyac078","relation":{},"ISSN":["1461-1457","1469-5111"],"issn-type":[{"value":"1461-1457","type":"print"},{"value":"1469-5111","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,2,1]]},"published":{"date-parts":[[2022,12,6]]}}}