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However, preclinical studies identifying targets of chronic electroconvulsive seizure (ECS) are predominantly focused on animal models in young adulthood. Given that putative transcriptional, neurogenic, and neuroplastic mechanisms implicated in the behavioral effects of chronic ECS themselves exhibit age-dependent modulation, it remains unknown whether the molecular and cellular targets of chronic ECS vary with age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We subjected young adult (2\u20133 months) and middle-aged (12\u201313 months), male Sprague Dawley rats to sham or chronic ECS and assessed for despair-like behavior, hippocampal gene expression, hippocampal neurogenesis, and neuroplastic changes in the extracellular matrix, reelin, and perineuronal net numbers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chronic ECS reduced despair-like behavior at both ages, accompanied by overlapping and unique changes in activity-dependent and trophic factor gene expression. Although chronic ECS had a similar impact on quiescent neural progenitor numbers at both ages, the eventual increase in hippocampal progenitor proliferation was substantially higher in young adulthood. We noted a decline in reelin\u207a cell numbers following chronic ECS only in young adulthood. In contrast, an age-invariant, robust dissolution of perineuronal net numbers that encapsulate parvalbumin\u207a neurons in the hippocampus were observed following chronic ECS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that age is a key variable in determining the nature of chronic ECS-evoked molecular and cellular changes in the hippocampus. This raises the intriguing possibility that chronic ECS may recruit distinct, as well as overlapping, mechanisms to drive antidepressant-like behavioral changes in an age-dependent manner.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ijnp\/pyad008","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T05:07:20Z","timestamp":1678165640000},"page":"294-306","source":"Crossref","is-referenced-by-count":2,"title":["Influence of Chronic Electroconvulsive Seizures on Plasticity-Associated Gene Expression and Perineuronal Nets Within the Hippocampi of Young Adult and Middle-Aged Sprague-Dawley Rats"],"prefix":"10.1093","volume":"26","author":[{"given":"Minal","family":"Jaggar","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Tata Institute of Fundamental Research , Mumbai , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreya","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of 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