{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T15:24:17Z","timestamp":1774538657945,"version":"3.50.1"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA050908"],"award-info":[{"award-number":["DA050908"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA056804"],"award-info":[{"award-number":["DA056804"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007859","name":"University of Kansas","doi-asserted-by":"publisher","award":["2302023"],"award-info":[{"award-number":["2302023"]}],"id":[{"id":"10.13039\/100007859","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Opioid use disorder (OUD) is a chronic relapsing psychiatric disorder with an enormous socioeconomic burden. Opioid overdose deaths have reached an epidemic level, especially for fentanyl. One of the biggest challenges to treat OUD is the relapse to drug seeking after prolonged abstinence. Abnormalities in insulin-like growth factor-1 (IGF-1) have been reported in various neurological and psychiatric disorders, including OUD. However, whether IGF-1 and its downstream signaling pathways are associated with relapse to fentanyl seeking remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Mice were subjected to daily 2-hour fentanyl (10 \u03bcg\/mL, 27 \u03bcL\/infusion) oral self-administration training for 14 days, followed by 14-day fentanyl cessation. Expression levels of IGF-1\/IGF-1 receptor and downstream signaling pathways in the dorsomedial prefrontal cortex (dmPFC) were detected. Then, IGF-1 was bilaterally microinjected into the dmPFC from fentanyl cessation day 9 to day 13. Fentanyl-seeking behavior and excitatory synaptic transmission of pyramidal neurons in PFC were evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found that 14-day cessation from fentanyl oral self-administration caused significant downregulation of IGF-1 and IGF-1 receptor phosphorylation in the dmPFC. These changes were accompanied by inhibition of the downstream Akt and S6 signaling pathway. In addition, local administration of IGF-1 in the dmPFC attenuated context-induced fentanyl-seeking behavior. Furthermore, electrophysiology and immunohistochemistry analyses showed that IGF-1 blocked fentanyl-induced reduction of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and N-methyl-D-aspartate receptors-mediated excitatory synaptic transmission as well as synaptic expression of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor and N-methyl-D-aspartate receptor subunits.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These results suggest that IGF-1 in the PFC plays a pivotal role in regulating fentanyl seeking after prolonged cessation from fentanyl oral self-administration.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ijnp\/pyad013","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T15:37:35Z","timestamp":1679585855000},"page":"359-371","source":"Crossref","is-referenced-by-count":11,"title":["IGF-1 Microinjection in the Prefrontal Cortex Attenuates Fentanyl-Seeking Behavior in Mice"],"prefix":"10.1093","volume":"26","author":[{"given":"Guohui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas , Lawrence , Kansas , USA"},{"name":"Department of Anesthesiology and Surgical Intensive Care Unit, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine , Shanghai , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuwen","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas , Lawrence , Kansas , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunwanbin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas , Lawrence , Kansas , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archana","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas , Lawrence , Kansas , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas , Lawrence , Kansas , USA"},{"name":"The University of Kansas Cofrin Logan Center for Addiction Research and Treatment , Lawrence , Kansas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"2023053104505222300_CIT0001","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1523\/JNEUROSCI.1657-17.2017","article-title":"Overexpression of the histone dimethyltransferase g9a in nucleus accumbens shell increases cocaine self-administration, stress-induced reinstatement, and anxiety","volume":"38","author":"Anderson","year":"2018","journal-title":"J Neurosci"},{"key":"2023053104505222300_CIT0002","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1038\/s41386-021-01028-z","article-title":"Remifentanil self-administration in mice promotes sex-specific prefrontal cortex dysfunction underlying deficits in cognitive flexibility","volume":"46","author":"Anderson","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"2023053104505222300_CIT0003","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1749-6632.1993.tb26223.x","article-title":"Chronic morphine decreases insulin-like growth factor-I levels in the ventral tegmental area of the rat brain","volume":"692","author":"Beitner-Johnson","year":"1993","journal-title":"Ann N Y Acad Sci"},{"key":"2023053104505222300_CIT0004","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1749-6632.1993.tb26203.x","article-title":"Patterns of insulin-like growth factor and IGF receptor gene expression in the brain. Functional implications","volume":"692","author":"Bondy","year":"1993","journal-title":"Ann N Y Acad Sci"},{"key":"2023053104505222300_CIT0005","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nn.2758","article-title":"Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin","volume":"14","author":"Bossert","year":"2011","journal-title":"Nat Neurosci"},{"key":"2023053104505222300_CIT0006","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1523\/JNEUROSCI.0005-12.2012","article-title":"Role of projections from ventral medial prefrontal cortex to nucleus accumbens shell in context-induced reinstatement of heroin seeking","volume":"32","author":"Bossert","year":"2012","journal-title":"J Neurosci"},{"key":"2023053104505222300_CIT0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pbb.2018.01.007","article-title":"Chronic administration of morphine using mini-osmotic pumps affects spatial memory in the male rat","volume":"167","author":"Brolin","year":"2018","journal-title":"Pharmacol Biochem Behav"},{"key":"2023053104505222300_CIT0008","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1126\/science.aan8868","article-title":"What constitutes the prefrontal cortex?","volume":"358","author":"Carl\u00e9n","year":"2017","journal-title":"Science"},{"key":"2023053104505222300_CIT0009","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1523\/JNEUROSCI.20-10-03864.2000","article-title":"Projections from the rat prefrontal cortex to the ventral tegmental area: target specificity in the synaptic associations with mesoaccumbens and mesocortical neurons","volume":"20","author":"Carr","year":"2000","journal-title":"J Neurosci"},{"key":"2023053104505222300_CIT0010","author":"CDC","year":"2022"},{"key":"2023053104505222300_CIT0011","author":"CDC","year":"2022"},{"key":"2023053104505222300_CIT0012","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1158\/1078-0432.CCR-07-4879","article-title":"The type 1 insulin-like growth factor receptor pathway","volume":"14","author":"Chitnis","year":"2008","journal-title":"Clin Cancer Res"},{"key":"2023053104505222300_CIT0013","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0898-6568(02)00139-0","article-title":"Mechanisms of regulating the Raf kinase family","volume":"15","author":"Chong","year":"2003","journal-title":"Cell Signal"},{"key":"2023053104505222300_CIT0014","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1615\/CritRevNeurobiol.v18.i1-2.190","article-title":"Translational control of long-term synaptic plasticity and memory storage by eIF2alpha","volume":"18","author":"Costa-Mattioli","year":"2006","journal-title":"Crit Rev Neurobiol"},{"key":"2023053104505222300_CIT0015","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00406-018-0900-8","article-title":"NMDA receptor subunits change in the prefrontal cortex of pure-opioid and multi-drug abusers: a post-mortem study","volume":"269","author":"Daneshparvar","year":"2019","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"2023053104505222300_CIT0016","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1177\/0091270006297749","article-title":"Absolute and relative bioavailability of fentanyl buccal tablet and oral transmucosal fentanyl citrate.","volume":"47","author":"Darwish","year":"2007","journal-title":"J Clin Pharmacol"},{"key":"2023053104505222300_CIT0017","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/00000542-200009000-00009","article-title":"Pharmacokinetics and pharmacodynamics of inhaled versus intravenous morphine in healthy volunteers","volume":"93","author":"Dershwitz","year":"2000","journal-title":"Anesthesiology"},{"key":"2023053104505222300_CIT0018","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.yfrne.2018.12.002","article-title":"The insulin-like growth factor-1 system in the adult mammalian brain and its implications in central maternal adaptation","volume":"52","author":"Dobolyi","year":"2019","journal-title":"Front Neuroendocrinol"},{"key":"2023053104505222300_CIT0019","doi-asserted-by":"crossref","first-page":"8208","DOI":"10.1523\/JNEUROSCI.1295-20.2020","article-title":"A Piriform-orbitofrontal cortex pathway drives relapse to fentanyl-seeking after voluntary abstinence","volume":"40","author":"Everett","year":"2020","journal-title":"J Neurosci"},{"key":"2023053104505222300_CIT0020","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.bbi.2020.03.003","article-title":"Fentanyl self-administration impacts brain immune responses in male Sprague-Dawley rats","volume":"87","author":"Ezeomah","year":"2020","journal-title":"Brain Behav Immun"},{"key":"2023053104505222300_CIT0021","author":"FDA","year":"2011"},{"key":"2023053104505222300_CIT0022","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1523\/JNEUROSCI.3216-18.2021","article-title":"Insulin bidirectionally alters NAc glutamatergic transmission: interactions between insulin receptor activation, endogenous opioids, and glutamate release","volume":"41","author":"Fetterly","year":"2021","journal-title":"J Neurosci"},{"key":"2023053104505222300_CIT0023","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/j.1552-4604.1967.tb00029.x","article-title":"Clinical investigation of the analgesic potency and respiratory depressant activity of fentanyl, a new narcotic analgesic","volume":"7","author":"Finch","year":"1967","journal-title":"J Clin Pharmacol J New Drugs"},{"key":"2023053104505222300_CIT0024","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ddmod.2009.03.001","article-title":"Relapse to drug seeking following prolonged abstinence: the role of environmental stimuli","volume":"5","author":"Fuchs","year":"2008","journal-title":"Drug Discov Today Dis Models"},{"key":"2023053104505222300_CIT0025","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nn.4036","article-title":"Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity","volume":"18","author":"Gancarz","year":"2015","journal-title":"Nat Neurosci"},{"key":"2023053104505222300_CIT0026","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/00325481.2016.1120642","article-title":"Routes of abuse of prescription opioid analgesics: a review and assessment of the potential impact of abuse-deterrent formulations","volume":"128","author":"Gasior","year":"2016","journal-title":"Postgrad Med"},{"key":"2023053104505222300_CIT0027","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.neuron.2015.12.034","article-title":"IGF-1 receptor differentially regulates spontaneous and evoked transmission via mitochondria at hippocampal synapses","volume":"89","author":"Gazit","year":"2016","journal-title":"Neuron"},{"key":"2023053104505222300_CIT0028","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/0306-4522(95)00409-2","article-title":"Systemic morphine and local opioid effects on neuronal activity in the medial prefrontal cortex","volume":"70","author":"Giacchino","year":"1996","journal-title":"Neuroscience"},{"key":"2023053104505222300_CIT0029","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nrn3119","article-title":"Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications","volume":"12","author":"Goldstein","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"2023053104505222300_CIT0030","first-page":"4","article-title":"Addiction and cognition","volume":"5","author":"Gould","year":"2010","journal-title":"Addict Sci Clin Pract"},{"key":"2023053104505222300_CIT0031","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/jnc.12323","article-title":"Cellular distribution of AMPA receptor subunits and mGlu5 following acute and repeated administration of morphine or methamphetamine","volume":"126","author":"Herrold","year":"2013","journal-title":"J Neurochem"},{"key":"2023053104505222300_CIT0032","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.tins.2009.11.003","article-title":"mTOR signaling: at the crossroads of plasticity, memory and disease","volume":"33","author":"Hoeffer","year":"2010","journal-title":"Trends Neurosci"},{"key":"2023053104505222300_CIT0033","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"James","year":"2018","journal-title":"Lancet"},{"key":"2023053104505222300_CIT0034","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrn2515","article-title":"The glutamate homeostasis hypothesis of addiction","volume":"10","author":"Kalivas","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"2023053104505222300_CIT0035","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1037\/1064-1297.5.2.99","article-title":"Sex differences in effects of predictable and unpredictable footshock on fentanyl self-administration in rats","volume":"5","author":"Klein","year":"1997","journal-title":"Exp Clin Psychopharmacol"},{"key":"2023053104505222300_CIT0036","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41467-018-08162-1","article-title":"Phosphorylation-deficient G-protein-biased mu-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects","volume":"10","author":"Kliewer","year":"2019","journal-title":"Nat Commun"},{"key":"2023053104505222300_CIT0037","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1146\/annurev-publhealth-031914-122957","article-title":"The prescription opioid and heroin crisis: a public health approach to an epidemic of addiction","volume":"36","author":"Kolodny","year":"2015","journal-title":"Annu Rev Public Health"},{"key":"2023053104505222300_CIT0038","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S2215-0366(16)00104-8","article-title":"Neurobiology of addiction: a neurocircuitry analysis","volume":"3","author":"Koob","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"2023053104505222300_CIT0039","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1017\/S1461145712001563","article-title":"Low dose risperidone attenuates cue-induced but not heroin-induced reinstatement of heroin seeking in an animal model of relapse","volume":"16","author":"Lai","year":"2013","journal-title":"Int J Neuropsychopharmacol"},{"key":"2023053104505222300_CIT0040","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/s41419-020-03051-2","article-title":"Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB\/Akt\/Fyn-mediated phosphorylation of NMDA receptors","volume":"11","author":"Ma","year":"2020","journal-title":"Cell Death Dis"},{"key":"2023053104505222300_CIT0041","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.neuron.2011.10.012","article-title":"Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons","volume":"72","author":"Mazei-Robison","year":"2011","journal-title":"Neuron"},{"key":"2023053104505222300_CIT0042","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1460-9568.2010.07502.x","article-title":"Repeated exposure to morphine alters surface expression of AMPA receptors in the rat medial prefrontal cortex","volume":"33","author":"Mickiewicz","year":"2011","journal-title":"Eur J Neurosci"},{"key":"2023053104505222300_CIT0043","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s00213-020-05722-6","article-title":"Aversion-resistant fentanyl self-administration in mice","volume":"238","author":"Monroe","year":"2021","journal-title":"Psychopharmacology"},{"key":"2023053104505222300_CIT0044","author":"NIDA","year":"2022"},{"key":"2023053104505222300_CIT0045","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1016\/j.jpainsymman.2011.07.006","article-title":"Emerging opioid abuse in terminal cancer patients taking oral transmucosal fentanyl citrate for breakthrough pain","volume":"42","author":"Nunez-Olarte","year":"2011","journal-title":"J Pain Symptom Manage"},{"key":"2023053104505222300_CIT0046","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jpainsymman.2010.03.012","article-title":"Aberrant drug-related behavior observed during clinical studies involving patients taking chronic opioid therapy for persistent pain and fentanyl buccal tablet for breakthrough pain","volume":"41","author":"Passik","year":"2011","journal-title":"J Pain Symptom Manage"},{"key":"2023053104505222300_CIT0047","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/2049463712438493","article-title":"Basic opioid pharmacology: an update","volume":"6","author":"Pathan","year":"2012","journal-title":"Br J Pain"},{"key":"2023053104505222300_CIT0048","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s10571-015-0267-6","article-title":"Expression of BDNF and TrkB phosphorylation in the rat frontal cortex during morphine withdrawal are NO dependent","volume":"36","author":"Peregud","year":"2016","journal-title":"Cell Mol Neurobiol"},{"key":"2023053104505222300_CIT0049","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1073\/pnas.1806820116","article-title":"Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and exploration","volume":"116","author":"Prister\u00e0","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023053104505222300_CIT0050","first-page":"18","article-title":"Elevated IGF1 in clinical opiate dependence","volume":"34","author":"Reece","year":"2013","journal-title":"Neuro Endocrinol Lett"},{"key":"2023053104505222300_CIT0051","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1021\/acschemneuro.1c00340","article-title":"Novologue therapy requires heat shock protein 70 and thioredoxin-interacting protein to improve mitochondrial bioenergetics and decrease mitophagy in diabetic sensory neurons","volume":"12","author":"Rodriguez","year":"2021","journal-title":"ACS Chem Neurosci"},{"key":"2023053104505222300_CIT0052","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.neuroscience.2007.10.012","article-title":"The neural circuitry underlying reinstatement of heroin-seeking behavior in an animal model of relapse","volume":"151","author":"Rogers","year":"2008","journal-title":"Neuroscience"},{"key":"2023053104505222300_CIT0053","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","article-title":"Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"Roth","year":"2018","journal-title":"Lancet"},{"key":"2023053104505222300_CIT0054","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1073\/pnas.85.1.265","article-title":"Differential expression of insulin-like growth factor genes in rat central nervous system","volume":"85","author":"Rotwein","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023053104505222300_CIT0055","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nn1812","article-title":"IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates","volume":"10","author":"Russo","year":"2007","journal-title":"Nat Neurosci"},{"key":"2023053104505222300_CIT0056","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1111\/j.1460-9568.2005.04435.x","article-title":"Differential involvement of the prelimbic cortex and striatum in conditioned heroin and sucrose seeking following long-term extinction","volume":"22","author":"Schmidt","year":"2005","journal-title":"Eur J Neurosci"},{"key":"2023053104505222300_CIT0057","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0091-3057(93)90359-2","article-title":"Effect of stress on oral fentanyl consumption in rats in an operant self-administration paradigm","volume":"46","author":"Shaham","year":"1993","journal-title":"Pharmacol Biochem Behav"},{"key":"2023053104505222300_CIT0058","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.54.1.1","article-title":"Neurobiology of relapse to heroin and cocaine seeking: a review","volume":"54","author":"Shalev","year":"2002","journal-title":"Pharmacol Rev"},{"key":"2023053104505222300_CIT0059","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1017\/S1461145712001071","article-title":"Reduced LTP and LTD in prefrontal cortex synapses in the nucleus accumbens after heroin self-administration","volume":"16","author":"Shen","year":"2013","journal-title":"Int J Neuropsychopharmacol"},{"key":"2023053104505222300_CIT0060","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-201X.2004.01382.x","article-title":"Mechanisms regulating phosphoinositide 3-kinase signaling in insulin-sensitive tissues","volume":"183","author":"Shepherd","year":"2005","journal-title":"Acta Physiol Scand"},{"key":"2023053104505222300_CIT0061","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s00213-021-06024-1","article-title":"Early social isolation stress increases addiction vulnerability to heroin and alters c-Fos expression in the mesocorticolimbic system","volume":"239","author":"Singh","year":"2022","journal-title":"Psychopharmacology"},{"key":"2023053104505222300_CIT0062","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nrn1346","article-title":"MAPK cascade signaling and synaptic plasticity","volume":"5","author":"Thomas","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"2023053104505222300_CIT0063","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1007\/s00213-022-06144-2","article-title":"Effects of heroin self-administration and forced withdrawal on the expression of genes related to the mTOR network in the basolateral complex of the amygdala of male Lewis rats","volume":"239","author":"Ucha","year":"2022","journal-title":"Psychopharmacology"},{"key":"2023053104505222300_CIT0064","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/pme.12661","article-title":"Chronic spinal and oral morphine-induced neuroendocrine and metabolic changes in noncancer pain patients","volume":"16","author":"Valverde-Filho","year":"2015","journal-title":"Pain Med"},{"key":"2023053104505222300_CIT0065","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/nn.2165","article-title":"Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking","volume":"11","author":"Van den Oever","year":"2008","journal-title":"Nat Neurosci"},{"key":"2023053104505222300_CIT0066","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejphar.2008.04.007","article-title":"Supraspinally-administered agmatine attenuates the development of oral fentanyl self-administration","volume":"587","author":"Wade","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"2023053104505222300_CIT0067","doi-asserted-by":"crossref","first-page":"9442","DOI":"10.1038\/srep09442","article-title":"Glucocorticoid receptors in the locus coeruleus mediate sleep disorders caused by repeated corticosterone treatment","volume":"5","author":"Wang","year":"2015","journal-title":"Sci Rep"},{"key":"2023053104505222300_CIT0068","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.biopsych.2016.04.020","article-title":"BRG1 in the nucleus accumbens regulates cocaine-seeking behavior","volume":"80","author":"Wang","year":"2016","journal-title":"Biol Psychiatry"},{"key":"2023053104505222300_CIT0069","doi-asserted-by":"crossref","first-page":"43658","DOI":"10.1038\/srep43658","article-title":"Activin A is increased in the nucleus accumbens following a cocaine binge","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep"},{"key":"2023053104505222300_CIT0070","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1038\/s41380-019-0351-2","article-title":"Amelioration of autism-like social deficits by targeting histone methyltransferases EHMT1\/2 in Shank3-deficient mice","volume":"25","author":"Wang","year":"2020","journal-title":"Mol Psychiatry"},{"key":"2023053104505222300_CIT0071","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/s41386-021-01029-y","article-title":"Autism risk gene KMT5B deficiency in prefrontal cortex induces synaptic dysfunction and social deficits via alterations of DNA repair and gene transcription","volume":"46","author":"Wang","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"2023053104505222300_CIT0072","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1038\/s41380-022-01574-y","article-title":"Molecular and cellular mechanisms for differential effects of chronic social isolation stress in males and females","volume":"27","author":"Wang","year":"2022","journal-title":"Mol Psychiatry"},{"key":"2023053104505222300_CIT0073","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0301-0082(97)00090-7","article-title":"The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants","volume":"54","author":"Wolf","year":"1998","journal-title":"Prog Neurobiol"},{"key":"2023053104505222300_CIT0074","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neubiorev.2010.01.013","article-title":"AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine","volume":"35","author":"Wolf","year":"2010","journal-title":"Neurosci Biobehav Rev"},{"key":"2023053104505222300_CIT0075","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1556-4029.2007.00597.x","article-title":"Oral abuse of fentanyl patches (Duragesic): seven case reports","volume":"53","author":"Woodall","year":"2008","journal-title":"J Forensic Sci"},{"key":"2023053104505222300_CIT0076","doi-asserted-by":"crossref","first-page":"109204","DOI":"10.1016\/j.neuropharm.2022.109204","article-title":"Insulin-like growth factor 1 regulates excitatory synaptic transmission in pyramidal neurons from adult prefrontal cortex","volume":"217","author":"Yue","year":"2022","journal-title":"Neuropharmacology"},{"key":"2023053104505222300_CIT0077","doi-asserted-by":"crossref","first-page":"6622","DOI":"10.1096\/fj.201802351R","article-title":"M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt","volume":"33","author":"Zhao","year":"2019","journal-title":"FASEB J"},{"key":"2023053104505222300_CIT0078","doi-asserted-by":"crossref","first-page":"e13013","DOI":"10.1111\/adb.13013","article-title":"Akt and its phosphorylation in nucleus accumbens mediate heroin-seeking behavior induced by cues in rats","volume":"26","author":"Zhu","year":"2021","journal-title":"Addict Biol"},{"key":"2023053104505222300_CIT0079","doi-asserted-by":"crossref","first-page":"134819","DOI":"10.1016\/j.neulet.2020.134819","article-title":"Heroin exposure and withdrawal differentially influence expression of NMDA receptor NR2 subunits in the prelimbic region of rat medial prefrontal cortex","volume":"721","author":"Zhu","year":"2020","journal-title":"Neurosci Lett"}],"container-title":["International Journal of Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ijnp\/advance-article-pdf\/doi\/10.1093\/ijnp\/pyad013\/49913127\/pyad013.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ijnp\/article-pdf\/26\/5\/359\/50492617\/pyad013.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ijnp\/article-pdf\/26\/5\/359\/50492617\/pyad013.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T05:19:51Z","timestamp":1685510391000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijnp\/article\/26\/5\/359\/7084803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,23]]},"references-count":79,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3,23]]},"published-print":{"date-parts":[[2023,5,31]]}},"URL":"https:\/\/doi.org\/10.1093\/ijnp\/pyad013","relation":{},"ISSN":["1461-1457","1469-5111"],"issn-type":[{"value":"1461-1457","type":"print"},{"value":"1469-5111","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5,1]]},"published":{"date-parts":[[2023,3,23]]}}}