{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T18:12:58Z","timestamp":1773425578103,"version":"3.50.1"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T00:00:00Z","timestamp":1697846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["1R15DA057501"],"award-info":[{"award-number":["1R15DA057501"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1SC3GM130430-03"],"award-info":[{"award-number":["1SC3GM130430-03"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>There is a strong link between chronic stress and vulnerability to drug abuse and addiction. Corticotropin releasing factor (CRF) is central to the stress response that contributes to continuation and relapse to heroin abuse. Chronic heroin exposure can exacerbate CRF production, leading to dysregulation of the midbrain CRF-dopamine-glutamate interaction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Here we investigated the role of midbrain CRF1 receptors in heroin self-administration and assessed neuroplasticity in CRF1 receptor expression in key opioid addiction brain regions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Infusions of antalarmin (a CRF1 receptor antagonist) into the ventral tegmental area (VTA) dose dependently reduced heroin self-administration in rats but had no impact on food reinforcement or locomotor activity in rats. Using RNAscope in situ hybridization, we found that heroin, but not saline, self-administration upregulated CRF1 receptor mRNA in the VTA, particularly on dopamine neurons. AMPA GluR1 and dopamine reuptake transporter mRNA in VTA neurons were not affected by heroin. The western-blot assay showed that CRF1 receptors were upregulated in the VTA and nucleus accumbens. No significant changes in CRF1 protein expression were detected in the prefrontal cortex, insula, dorsal hippocampus, and substantia nigra. In addition, we found that 15 days of environmental enrichment implemented after heroin self-administration does not reverse upregulation of VTA CRF1 receptor mRNA but it downregulates dopamine transporter mRNA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Overall, these data suggest that heroin self-administration requires stimulation of VTA CRF1 receptors and upregulates their expression in brain regions involved in reinforcement. Such long-lasting neuroadaptations may contribute to continuation of drug use and relapse due to stress exposure and are not easily reversed by EE exposure.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ijnp\/pyad060","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T21:27:09Z","timestamp":1697923629000},"page":"828-839","source":"Crossref","is-referenced-by-count":14,"title":["The Impact of Heroin Self-Administration and Environmental Enrichment on Ventral Tegmental CRF1 Receptor Expression"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7180-4378","authenticated-orcid":false,"given":"Ewa","family":"Galaj","sequence":"first","affiliation":[{"name":"Department of Psychological and Brain Sciences, Colgate University , Hamilton, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eddy D","family":"Barrera","sequence":"additional","affiliation":[{"name":"The Graduate Center of the City University of New York , New York, NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirk","family":"Persaud","sequence":"additional","affiliation":[{"name":"Department of Psychology, Queens College of the City University of New York , Flushing, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Nisanov","sequence":"additional","affiliation":[{"name":"The Graduate Center of the City University of New York , New York, NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apoorva","family":"Vashisht","sequence":"additional","affiliation":[{"name":"The Graduate Center of the City University of New York , New York, NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hindy","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Psychology, Queens College of the City University of New York , Flushing, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nima","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Psychology, Queens College of the City University of New York , Flushing, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayley","family":"Lenhard","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences, Colgate University , Hamilton, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Bing","family":"You","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program , Baltimore, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliot L","family":"Gardner","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program , Baltimore, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6663-1169","authenticated-orcid":false,"given":"Robert","family":"Ranaldi","sequence":"additional","affiliation":[{"name":"The Graduate Center of the City University of New York , New York, NY USA"},{"name":"Department of Psychology, Queens College of the City University of New York , Flushing, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,10,21]]},"reference":[{"key":"2023121811244214600_CIT0001","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1007\/s00213-019-05208-0","article-title":"Mechanisms underlying the efficacy of exercise as an intervention for cocaine relapse: a focus on mGlu5 in the dorsal medial prefrontal cortex","volume":"236","author":"Abel","year":"2019","journal-title":"Psychopharmacology (Berl)"},{"key":"2023121811244214600_CIT0067","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1111\/acer.12825","article-title":"Corticotropin-releasing factor binding protein and CRF2 receptors in the ventral tegmental area: Modulation of ethanol binge drinking in C57BL\/6J mice","volume":"39","author":"Albrechet-Souza","year":"2015","journal-title":"Alcohol Clin Exp Res"},{"key":"2023121811244214600_CIT0002","doi-asserted-by":"crossref","first-page":"109018","DOI":"10.1016\/j.neuropharm.2022.109018","article-title":"Inhibition of noradrenergic and corticotrophin-releasing factor systems: effects on enhancement of memory consolidation by unconditioned and conditioned heroin withdrawal","volume":"209","author":"Baidoo","year":"2022","journal-title":"Neuropharmacology"},{"key":"2023121811244214600_CIT0003","doi-asserted-by":"crossref","first-page":"108852","DOI":"10.1016\/j.drugalcdep.2021.108852","article-title":"Environmental enrichment reduces heroin seeking following incubation of craving in both male and female rats","volume":"226","author":"Barrera","year":"2021","journal-title":"Drug Alcohol Depend"},{"key":"2023121811244214600_CIT0004","doi-asserted-by":"crossref","first-page":"109799","DOI":"10.1016\/j.drugalcdep.2023.109799","article-title":"Environmental enrichment facilitates electric barrier induced heroin abstinence after incubation of craving in male and female rats","volume":"244","author":"Barrera","year":"2023","journal-title":"Drug Alcohol Depend"},{"key":"2023121811244214600_CIT0005","doi-asserted-by":"crossref","first-page":"e0267345","DOI":"10.1371\/journal.pone.0267345","article-title":"Corticotropin releasing factor (CRF) systems: Promoting cocaine pursuit without distress via incentive motivation","volume":"17","author":"Baumgartner","year":"2022","journal-title":"PLoS One"},{"key":"2023121811244214600_CIT0006","doi-asserted-by":"crossref","first-page":"11396","DOI":"10.1523\/JNEUROSCI.1393-11.2011","article-title":"Augmented cocaine seeking in response to stress or CRF delivered into the ventral tegmental area following long-access self-administration is mediated by CRF receptor type 1 but not CRF receptor type 2","volume":"31","author":"Blacktop","year":"2011","journal-title":"J Neurosci"},{"key":"2023121811244214600_CIT0007","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1523\/JNEUROSCI.2049-22.2023","article-title":"Effect of selective lesions of nucleus accumbens \u00b5-opioid receptor-expressing cells on heroin self-administration in male and female rats: a study with Novel Oprm1-Cre knock-in rats","volume":"43","author":"Bossert","year":"2023","journal-title":"J Neurosci"},{"key":"2023121811244214600_CIT0008","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00213-011-2266-8","article-title":"Prevention of social stress-escalated cocaine self-administration by CRF-R1 antagonist in the rat VTA","volume":"218","author":"Boyson","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"key":"2023121811244214600_CIT0009","doi-asserted-by":"crossref","first-page":"6659","DOI":"10.1523\/JNEUROSCI.3942-13.2014","article-title":"Social stress and CRF-dopamine interactions in the VTA: role in long-term escalation of cocaine self-administration","volume":"34","author":"Boyson","year":"2014","journal-title":"J Neurosci"},{"key":"2023121811244214600_CIT0010","doi-asserted-by":"crossref","first-page":"R100","DOI":"10.1186\/gb-2006-7-10-r100","article-title":"CellProfiler: image analysis software for identifying and quantifying cell phenotypes","volume":"7","author":"Carpenter","year":"2006","journal-title":"Genome Biol"},{"key":"2023121811244214600_CIT0011","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0006-8993(97)00012-7","article-title":"Neuronal responses in prefrontal cortex and nucleus accumbens during heroin self-administration in freely moving rats","volume":"754","author":"Chang","year":"1997","journal-title":"Brain Res"},{"key":"2023121811244214600_CIT0012","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1038\/npp.2009.127","article-title":"Environmental enrichment reduces cocaine seeking and reinstatement induced by cues and stress but not by cocaine","volume":"34","author":"Chauvet","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"2023121811244214600_CIT0013","doi-asserted-by":"crossref","first-page":"11560","DOI":"10.1523\/JNEUROSCI.4763-12.2014","article-title":"Knockdown of CRF1 receptors in the ventral tegmental area attenuates cue- and acute food deprivation stress-induced cocaine seeking in mice","volume":"34","author":"Chen","year":"2014","journal-title":"J Neurosci"},{"key":"2023121811244214600_CIT0014","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1111\/adb.12435","article-title":"Dissociative role for dorsal hippocampus in mediating heroin self-administration and relapse through CDK5 and RhoB signaling revealed by proteomic analysis","volume":"22","author":"Chen","year":"2017","journal-title":"Addict Biol"},{"key":"2023121811244214600_CIT0015","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/ijnp\/pyz067","article-title":"Regulation of CRF mRNA in the extended amygdala following chronic cocaine: sex differences and effects of delta opioid receptor agonism","volume":"23","author":"Connelly","year":"2020","journal-title":"Int J Neuropsychopharmacol"},{"key":"2023121811244214600_CIT0016","doi-asserted-by":"crossref","first-page":"18649","DOI":"10.1073\/pnas.0506999102","article-title":"The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal","volume":"102","author":"Contarino","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023121811244214600_CIT0017","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1523\/JNEUROSCI.19-10-03982.1999","article-title":"Differential regulation of the expression of corticotropin-releasing factor receptor type 2 (CRF2) in hypothalamus and amygdala of the immature rat by sensory input and food intake","volume":"19","author":"Eghbal-Ahmadi","year":"1999","journal-title":"J Neurosci"},{"key":"2023121811244214600_CIT0018","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1002\/cpns.63","article-title":"Detection and quantification of multiple RNA sequences using emerging ultrasensitive fluorescent in situ hybridization techniques","volume":"87","author":"Erben","year":"2019","journal-title":"Curr Protoc Neurosci"},{"key":"2023121811244214600_CIT0019","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pbb.2018.01.006","article-title":"Environmental enrichment facilitates cocaine abstinence in an animal conflict model","volume":"166","author":"Ewing","year":"2018","journal-title":"Pharmacol Biochem Behav"},{"key":"2023121811244214600_CIT0020","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neures.2021.04.007","article-title":"Environmental enrichment modulates HPA axis reprogramming in adult male rats exposed to early adolescent stress","volume":"172","author":"Fan","year":"2021","journal-title":"Neurosci Res"},{"key":"2023121811244214600_CIT0021","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1523\/JNEUROSCI.16-01-00274.1996","article-title":"Drugs of abuse and stress increase the expression of GluR1 and NMDAR1 glutamate receptor subunits in the rat ventral tegmental area: common adaptations among cross-sensitizing agents","volume":"16","author":"Fitzgerald","year":"1996","journal-title":"J Neurosci"},{"key":"2023121811244214600_CIT0022","doi-asserted-by":"crossref","first-page":"7840","DOI":"10.1523\/JNEUROSCI.22-18-07840.2002","article-title":"Environmental enrichment reverses the effects of maternal separation on stress reactivity","volume":"22","author":"Francis","year":"2002","journal-title":"J Neurosci"},{"key":"2023121811244214600_CIT0023","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.drugalcdep.2016.04.016","article-title":"Environmental enrichment as a potential intervention for heroin seeking","volume":"163","author":"Galaj","year":"2016","journal-title":"Drug Alcohol Depend"},{"key":"2023121811244214600_CIT0024","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pbb.2017.04.005","article-title":"No evidence that environmental enrichment during rearing protects against cocaine behavioral effects but as an intervention reduces an already established cocaine conditioned place preference","volume":"156","author":"Galaj","year":"2017","journal-title":"Pharmacol Biochem Behav"},{"key":"2023121811244214600_CIT0025","doi-asserted-by":"crossref","first-page":"172829","DOI":"10.1016\/j.pbb.2019.172829","article-title":"Therapeutic efficacy of environmental enrichment for substance use disorders","volume":"188","author":"Galaj","year":"2020","journal-title":"Pharmacol Biochem Behav"},{"key":"2023121811244214600_CIT0026","doi-asserted-by":"crossref","first-page":"8853","DOI":"10.1523\/JNEUROSCI.0988-20.2020","article-title":"Dissecting the Role of GABA Neurons in the VTA versus SNr in Opioid Reward","volume":"40","author":"Galaj","year":"2020","journal-title":"J Neurosci"},{"key":"2023121811244214600_CIT0027","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1369-1600.2008.00142.x","article-title":"Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats","volume":"14","author":"Greenwell","year":"2009","journal-title":"Addict Biol"},{"key":"2023121811244214600_CIT0028","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fnmol.2012.00091","article-title":"Stress and addiction: contribution of the corticotropin releasing factor (CRF) system in neuroplasticity","volume":"5","author":"Haass-Koffler","year":"2012","journal-title":"Front Mol Neurosci"},{"key":"2023121811244214600_CIT0029","doi-asserted-by":"crossref","first-page":"6535","DOI":"10.1523\/JNEUROSCI.4773-08.2009","article-title":"Chronic cocaine enhances corticotropin-releasing factor-dependent potentiation of excitatory transmission in ventral tegmental area dopamine neurons","volume":"29","author":"Hahn","year":"2009","journal-title":"J Neurosci"},{"key":"2023121811244214600_CIT0030","doi-asserted-by":"crossref","first-page":"eabo1440","DOI":"10.1126\/sciadv.abo1440","article-title":"A red nucleus-VTA glutamate pathway underlies exercise reward and the therapeutic effect of exercise on cocaine use","volume":"8","author":"He","year":"2022","journal-title":"Sci Adv"},{"key":"2023121811244214600_CIT0031","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.neuropharm.2012.05.028","article-title":"Re-exposure and environmental enrichment reveal NPY-Y1 as a possible target for post-traumatic stress disorder","volume":"63","author":"Hendriksen","year":"2012","journal-title":"Neuropharmacology"},{"key":"2023121811244214600_CIT0032","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1111\/ejn.14889","article-title":"The anterior insular cortex in the rat exerts an inhibitory influence over the loss of control of heroin intake and subsequent propensity to relapse","volume":"52","author":"Joshi","year":"2020","journal-title":"Eur J Neurosci"},{"key":"2023121811244214600_CIT0033","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.brainres.2009.11.008","article-title":"The role of CRF and CRF-related peptides in the dark side of addiction","volume":"1314","author":"Koob","year":"2010","journal-title":"Brain Res"},{"key":"2023121811244214600_CIT0034","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.brainres.2005.12.034","article-title":"Distribution and expression of CRF receptor 1 and 2 mRNAs in the CRF over-expressing mouse brain","volume":"1072","author":"Korosi","year":"2006","journal-title":"Brain Res"},{"key":"2023121811244214600_CIT0035","doi-asserted-by":"crossref","first-page":"9670","DOI":"10.1523\/JNEUROSCI.2151-08.2008","article-title":"Region-specific changes in the subcellular distribution of AMPA receptor GluR1 subunit in the rat ventral tegmental area after acute or chronic morphine administration","volume":"28","author":"Lane","year":"2008","journal-title":"J Neurosci"},{"key":"2023121811244214600_CIT0036","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neulet.2015.05.035","article-title":"Environmental enrichment blocks reinstatement of ethanol-induced conditioned place preference in mice","volume":"599","author":"Li","year":"2015","journal-title":"Neurosci Lett"},{"key":"2023121811244214600_CIT0037","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.biopsych.2010.06.022","article-title":"Aerobic exercise attenuates reinstatement of cocaine-seeking behavior and associated neuroadaptations in the prefrontal cortex","volume":"68","author":"Lynch","year":"2010","journal-title":"Biol Psychiatry"},{"key":"2023121811244214600_CIT0038","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1002\/jnr.24990","article-title":"Aerobic exercise as a promising nonpharmacological therapy for the treatment of substance use disorders","volume":"100","author":"Marrero-Cristobal","year":"2022","journal-title":"J Neurosci Res"},{"key":"2023121811244214600_CIT0039","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1523\/JNEUROSCI.4177-03.2004","article-title":"Limbic and motor circuitry underlying footshock-induced reinstatement of cocaine-seeking behavior","volume":"24","author":"McFarland","year":"2004","journal-title":"J Neurosci"},{"key":"2023121811244214600_CIT0040","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0306-4522(02)00105-7","article-title":"Role of corticotropin-releasing hormone in the amygdala and bed nucleus of the stria terminalis in the behavioral, pain modulatory, and endocrine consequences of opiate withdrawal","volume":"112","author":"McNally","year":"2002","journal-title":"Neuroscience"},{"key":"2023121811244214600_CIT0041","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.devbrainres.2004.09.001","article-title":"Effects of environmental enrichment on behavior and dopamine transporter function in medial prefrontal cortex in adult rats prenatally treated with cocaine","volume":"153","author":"Neugebauer","year":"2004","journal-title":"Brain Res Dev Brain Res"},{"key":"2023121811244214600_CIT0042","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/adb.12120","article-title":"Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia","volume":"20","author":"Park","year":"2015","journal-title":"Addict Biol"},{"key":"2023121811244214600_CIT0043","volume-title":"The Rat brain in stereotaxic coordinates","author":"Paxinos","year":"2013","edition":"7"},{"key":"2023121811244214600_CIT0044","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pbb.2015.09.009","article-title":"Environmental enrichment induces early heroin abstinence in an animal conflict model","volume":"138","author":"Peck","year":"2015","journal-title":"Pharmacol Biochem Behav"},{"key":"2023121811244214600_CIT0045","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.alcohol.2018.01.007","article-title":"CRF modulation of central monoaminergic function: Implications for sex differences in alcohol drinking and anxiety","volume":"72","author":"Pleil","year":"2018","journal-title":"Alcohol"},{"key":"2023121811244214600_CIT0046","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/FBP.0b013e3283487365","article-title":"Environmental enrichment, administered after establishment of cocaine self-administration, reduces lever pressing in extinction and during a cocaine context renewal test","volume":"22","author":"Ranaldi","year":"2011","journal-title":"Behav Pharmacol"},{"key":"2023121811244214600_CIT0047","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/bs.irn.2017.06.004","article-title":"Corticotropin-Releasing Factor (CRF) and addictive behaviors","volume":"136","author":"Roberto","year":"2017","journal-title":"Int Rev Neurobiol"},{"key":"2023121811244214600_CIT0048","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0896-6273(03)00021-7","article-title":"Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons","volume":"37","author":"Saal","year":"2003","journal-title":"Neuron"},{"key":"2023121811244214600_CIT0049","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s002130050608","article-title":"CP-154,526, a selective, non-peptide antagonist of the corticotropin-releasing factor1 receptor attenuates stress-induced relapse to drug seeking in cocaine- and heroin-trained rats","volume":"137","author":"Shaham","year":"1998","journal-title":"Psychopharmacology (Berl)"},{"key":"2023121811244214600_CIT0050","doi-asserted-by":"crossref","first-page":"146850","DOI":"10.1016\/j.brainres.2020.146850","article-title":"Role of corticotropin-releasing factor in alcohol and nicotine addiction","volume":"1740","author":"Simpson","year":"2020","journal-title":"Brain Res"},{"key":"2023121811244214600_CIT0051","doi-asserted-by":"crossref","first-page":"17145","DOI":"10.1073\/pnas.0806889105","article-title":"Reversal of cocaine addiction by environmental enrichment","volume":"105","author":"Solinas","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023121811244214600_CIT0052","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.pneurobio.2010.08.002","article-title":"Prevention and treatment of drug addiction by environmental enrichment","volume":"92","author":"Solinas","year":"2010","journal-title":"Prog Neurobiol"},{"key":"2023121811244214600_CIT0053","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/mp.2009.151","article-title":"The anxiolytic effect of environmental enrichment is mediated via amygdalar CRF receptor type 1","volume":"15","author":"Sztainberg","year":"2010","journal-title":"Mol Psychiatry"},{"key":"2023121811244214600_CIT0054","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.neuroscience.2010.10.001","article-title":"Environmental living conditions introduced during forced abstinence alter cocaine-seeking behavior and Fos protein expression","volume":"171","author":"Thiel","year":"2010","journal-title":"Neuroscience"},{"key":"2023121811244214600_CIT0055","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/ntr\/ntu278","article-title":"Nicotine withdrawal increases stress-associated genes in the nucleus accumbens of female rats in a hormone-dependent manner","volume":"17","author":"Torres","year":"2015","journal-title":"Nicotine Tob Res"},{"key":"2023121811244214600_CIT0056","doi-asserted-by":"crossref","first-page":"8780","DOI":"10.1523\/JNEUROSCI.1815-16.2016","article-title":"Social stress-induced alterations in CRF signaling in the VTA facilitate the emergence of addiction-like behavior","volume":"36","author":"Tunstall","year":"2016","journal-title":"J Neurosci"},{"key":"2023121811244214600_CIT0057","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF00431681","article-title":"Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat","volume":"86","author":"Vaccarino","year":"1985","journal-title":"Psychopharmacology (Berl)"},{"key":"2023121811244214600_CIT0058","doi-asserted-by":"crossref","first-page":"10657","DOI":"10.1523\/JNEUROSCI.2080-18.2018","article-title":"Enhanced CRFR1-dependent regulation of a ventral tegmental area to prelimbic cortex projection establishes susceptibility to stress-induced cocaine seeking","volume":"38","author":"Vranjkovic","year":"2018","journal-title":"J Neurosci"},{"key":"2023121811244214600_CIT0059","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1113\/jphysiol.2007.150078","article-title":"Corticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of Ih","volume":"586","author":"Wanat","year":"2008","journal-title":"J Physiol"},{"key":"2023121811244214600_CIT0060","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.1523\/JNEUROSCI.0955-05.2005","article-title":"Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: a role in stress-induced relapse to drug seeking","volume":"25","author":"Wang","year":"2005","journal-title":"J Neurosci"},{"key":"2023121811244214600_CIT0061","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00213-007-0782-3","article-title":"Stress-induced relapse to cocaine seeking: role of CRF(2) receptors and CRF binding protein in the ventral tegmental area of the rat","volume":"193","author":"Wang","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"2023121811244214600_CIT0062","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/npp.2017.279","article-title":"Role of glutamatergic projections from the ventral CA1 to infralimbic cortex in context-induced reinstatement of heroin seeking","volume":"43","author":"Wang","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"2023121811244214600_CIT0063","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.brainres.2009.09.101","article-title":"A ventral tegmental CRF-glutamate-dopamine interaction in addiction","volume":"1314","author":"Wise","year":"2010","journal-title":"Brain Res"},{"key":"2023121811244214600_CIT0064","doi-asserted-by":"crossref","first-page":"5437092","DOI":"10.1155\/2018\/5437092","article-title":"Long-lasting alterations in gene expression of postsynaptic density 95 and inotropic glutamatergic receptor subunit in the mesocorticolimbic system of rat offspring born to morphine-addicted mothers","volume":"2018","author":"Wu","year":"2018","journal-title":"Biomed Res Int"},{"key":"2023121811244214600_CIT0065","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1111\/j.1471-4159.2005.03130.x","article-title":"Environmental enrichment decreases cell surface expression of the dopamine transporter in rat medial prefrontal cortex","volume":"93","author":"Zhu","year":"2005","journal-title":"J Neurochem"},{"key":"2023121811244214600_CIT0066","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.yfrne.2014.01.001","article-title":"Corticotropin releasing factor: a key role in the neurobiology of addiction","volume":"35","author":"Zorrilla","year":"2014","journal-title":"Front Neuroendocrinol"}],"container-title":["International Journal of Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ijnp\/advance-article-pdf\/doi\/10.1093\/ijnp\/pyad060\/54256223\/pyad060.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ijnp\/article-pdf\/26\/12\/828\/54566100\/pyad060.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ijnp\/article-pdf\/26\/12\/828\/54566100\/pyad060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T11:25:26Z","timestamp":1702898726000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijnp\/article\/26\/12\/828\/7326733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,21]]},"references-count":67,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,10,21]]},"published-print":{"date-parts":[[2023,12,18]]}},"URL":"https:\/\/doi.org\/10.1093\/ijnp\/pyad060","relation":{},"ISSN":["1461-1457","1469-5111"],"issn-type":[{"value":"1461-1457","type":"print"},{"value":"1469-5111","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12,1]]},"published":{"date-parts":[[2023,10,21]]}}}