{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:31:04Z","timestamp":1788406264658,"version":"build-2803163510"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Depression is a neuropsychiatric disease with a high disability rate and mainly caused by the chronic stress or genetic factors. There is increasing evidence that microRNAs (miRNAs) play a critical role in the pathogenesis of depression. However, the underlying molecular mechanism for the pathophysiology of depression of miRNA remains entirely unclear so far.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We first established a chronic social defeat stress (CSDS) mice model of depression, and depression-like behaviors of mice were evaluated by a series of behavioral tests. Next, we detected several abundantly expressive miRNAs suggested in previous reports to be involved in depression and found miR-182-5p was selected as a candidate for analysis in the hippocampus. Then western blotting and immunofluorescence were used together to examine whether adeno-associated virus (AAV)-siR-182-5p treatment alleviated chronic stress\u2013induced decrease in hippocampal Akt\/GSK3\u03b2\/cAMP-response element binding protein (CREB) signaling pathway and increase in neurogenesis impairment and neuroinflammation. Furthermore, CREB inhibitor was adopted to examine if blockade of Akt\/GSK3\u03b2\/CREB signaling pathway abolished the antidepressant actions of AAV-siR-182-5p in mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Knockdown of miR-182-5p alleviated depression-like behaviors and impaired neurogenesis of CSDS-induced mice. Intriguingly, the usage of agomiR-182-5p produced significant increases in immobility times and aggravated neuronal neurogenesis damage of mice. More importantly, it suggested that 666-15 blocked the reversal effects of AAV-siR-182-5p on the CSDS-induced depressive-like behaviors in behavioral testing and neuronal neurogenesis within hippocampus of mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These findings indicated that hippocampal miR-182-5p\/Akt\/GSK3\u03b2\/CREB signaling pathway participated in the pathogenesis of depression, and it might give more opportunities for new drug developments based on the miRNA target in the clinic.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ijnp\/pyad064","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T13:14:27Z","timestamp":1701436467000},"source":"Crossref","is-referenced-by-count":11,"title":["MiR-182-5p: A Novel Biomarker in the Treatment of Depression in CSDS-Induced Mice"],"prefix":"10.1093","volume":"27","author":[{"given":"Ya-Bin","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Neurology, The second Hospital of Nanjing, Nanjing University of Chinese Medicine , Nanjing, Jiangsu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ming","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Trauma Center, Affiliated Hospital of Nantong University , Nantong, Jiangsu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second People\u2019s Hospital of Nantong , Nantong, Jiangsu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Pharmacy College, Nantong University , Nantong, Jiangsu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"key":"2024012101432383900_CIT0001","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nrn.2017.45","article-title":"Adult hippocampal neurogenesis and cognitive flexibility - linking memory and mood","volume":"18","author":"Anacker","year":"2017","journal-title":"Nat Rev Neurosci"},{"key":"2024012101432383900_CIT0002","doi-asserted-by":"crossref","first-page":"108588","DOI":"10.1016\/j.yebeh.2022.108588","article-title":"Probiotic supplementation alleviates absence seizures and anxiety- and depression-like behavior in WAG\/Rij rat by increasing neurotrophic factors and decreasing proinflammatory cytokines","volume":"128","author":"Aygun","year":"2022","journal-title":"Epilepsy Behav"},{"key":"2024012101432383900_CIT0003","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s00737-021-01123-6","article-title":"Depression and 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