{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:54:43Z","timestamp":1773071683270,"version":"3.50.1"},"reference-count":92,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The proliferation of novel psychoactive substances (NPS) in the drug market raises concerns about uncertainty on their pharmacological profile and the health hazard linked to their use. Within the category of synthetic stimulant NPS, the phenethylamine 2-Cl-4,5-methylenedioxymethamphetamine (2-Cl-4,5-MDMA) has been linked to severe intoxication requiring hospitalization. Thereby, the characterization of its pharmacological profile is urgently warranted.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>By in vivo brain microdialysis in adolescent and adult male rats we investigated the effects of 2-Cl-4,5-MDMA on dopamine (DA) and serotonin (5-HT) neurotransmission in two\u00a0brain areas critical for the motivational and rewarding properties of drugs, the nucleus accumbens (NAc) shell and the medial prefrontal cortex (mPFC). Moreover, we evaluated the locomotor and stereotyped activity induced by 2-Cl-4,5-MDMA and the emission of 50-kHz ultrasonic vocalizations (USVs) to characterize its affective properties.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>2-Cl-4,5-MDMA increased dialysate DA and 5-HT in a dose-, brain area-, and age-dependent manner. Notably, 2-Cl-4,5-MDMA more markedly increased dialysate DA in the NAc shell and mPFC of adult than adolescent rats, while the opposite was observed on dialysate 5-HT in the NAc shell, with adolescent rats being more responsive. Furthermore, 2-Cl-4,5-MDMA stimulated locomotion and stereotyped activity in both adolescent and adult rats, although to a greater extent in adolescents. Finally, 2-Cl-4,5-MDMA did not stimulate the emission of\u00a050-kHz USVs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This is the first pharmacological characterization of 2-Cl-4,5-MDMA demonstrating that its neurochemical and behavioral effects may differ between adolescence and adulthood. These preclinical data could help understanding the central effects of 2-Cl-4,5-MDMA by increasing awareness on possible health damage in users.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ijnp\/pyae016","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T14:55:46Z","timestamp":1711637746000},"source":"Crossref","is-referenced-by-count":3,"title":["Characterization of the Neurochemical and Behavioral Effects of the Phenethylamine 2-Cl-4,5-MDMA in Adolescent and Adult Male Rats"],"prefix":"10.1093","volume":"27","author":[{"given":"Gessica","family":"Piras","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Cagliari , Cagliari , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3495-4043","authenticated-orcid":false,"given":"Cristina","family":"Cadoni","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, National Research Council of Italy , Cagliari , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Caria","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Cagliari , Cagliari , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3247-1870","authenticated-orcid":false,"given":"Nicholas","family":"Pintori","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Cagliari , Cagliari , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrica","family":"Spano","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Cagliari , Cagliari , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maksims","family":"Vanejevs","sequence":"additional","affiliation":[{"name":"Latvian Institute of Organic Synthesis , Riga , Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasija","family":"Ture","sequence":"additional","affiliation":[{"name":"Latvian Institute of Organic Synthesis , Riga , Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graziella","family":"Tocco","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, University of Cagliari , Cagliari , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7296-3197","authenticated-orcid":false,"given":"Nicola","family":"Simola","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Cagliari , Cagliari , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2647-4859","authenticated-orcid":false,"given":"Maria Antonietta","family":"De Luca","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Cagliari , Cagliari , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"2024052411462072400_CIT0001","doi-asserted-by":"crossref","first-page":"102672","DOI":"10.1016\/j.drugpo.2020.102672","article-title":"Effect of the UK Psychoactive Substances Act 2016 on episodes of toxicity related to new psychoactive substances as reported to the National Poisons Information Service. 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