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However, the distinct or interactive effects of major affective disorders and suicidal symptom severity on inhibitory control function and proinflammatory cytokines remain unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study included 287 patients with bipolar disorder, 344 with major depressive disorder, and 169 healthy controls. We categorized the participants into 3 groups based on Montgomery\u2013\u00c5sberg Depression Rating Scale (MADRS) item 10 (suicidal symptoms) score: 0, 2 or 3, and \u22654. The participants completed the go\/no-go task and the measurements for C-reactive protein (CRP) and tumor necrosis factor-\u03b1 (TNF-\u03b1) levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Errors in the go\/no-go task were associated with suicidality (P\u2009=\u2009.040), regardless of the severity of suicidal symptoms and diagnosis. An elevated CRP level was especially associated with a Montgomery\u2013\u00c5sberg Depression Rating Scale item 10 score \u22654 (P\u2009=\u2009.001). An increased TNF-\u03b1 level could distinguish bipolar disorder from major depressive disorder (P\u2009&amp;lt;\u2009.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Our study indicated the distinct effects of major affective disorder diagnosis and suicide symptom severity on inhibitory control function and CRP and TNF-\u03b1 levels. Importantly, individuals with the poorest inhibitory control function and highest CRP levels had more severe suicidal symptoms.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ijnp\/pyae043","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T17:37:38Z","timestamp":1726508258000},"source":"Crossref","is-referenced-by-count":4,"title":["Distinct Effects of Major Affective Disorder Diagnoses and Suicidal Symptom Severity on Inhibitory Control Function and Proinflammatory Cytokines: Single-Site Analysis of 800 Adolescents and Adults"],"prefix":"10.1093","volume":"27","author":[{"given":"Ya-Mei","family":"Bai","sequence":"first","affiliation":[{"name":"Institute of Brain Science, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]},{"name":"Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]},{"name":"Department of Psychiatry, Taipei Veterans General Hospital , 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,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiang-Hsuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]},{"name":"Department of Psychiatry, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Shyun","family":"Jeng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]},{"name":"Department of Psychiatry, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Jen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Institute of Brain Science, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]},{"name":"Department 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