{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:14:30Z","timestamp":1791310470617,"version":"4.3.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T00:00:00Z","timestamp":1731196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Psych-STRATA"},{"name":"European Union\u2019s Horizon Europe","award":["101057454"],"award-info":[{"award-number":["101057454"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anhedonic features within major depressive disorder (MDD) have been associated with worse course and outcome and may predict nonresponse to treatment. However, a detailed clinical profile of anhedonia in MDD is still lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>One thousand two hundred ninety-four patients with MDD were selected from the cross-sectional European multicenter Group for the Study of Resistant Depression study. Anhedonia was assessed through the Montgomery\u2013\u00c5sberg Depression Rating Scale anhedonia item \u201cinability to feel.\u201d Clinical and demographic features were then analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The presence of anhedonia related to a distinct demographical (living alone) and clinical profile (thyroid diseases, diabetes, suicide risk, high number of previous depressive episodes, more severe MDD, and more frequent inpatient status). Furthermore, anhedonia was associated with nonresponse to treatment and treatment resistance, even after adjusting for confounding variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings support the role of anhedonia as a modulating feature of MDD, being associated with a more severe depression profile. Moreover, anhedonic features are independent predictors of poor treatment response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ijnp\/pyae055","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T23:25:39Z","timestamp":1730935539000},"source":"Crossref","is-referenced-by-count":42,"title":["Anhedonia is associated with a specific depression profile and poor antidepressant response"],"prefix":"10.1093","volume":"27","author":[{"given":"Antonina","family":"Luca","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery, Kore University of Enna , Enna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Luca","sequence":"additional","affiliation":[{"name":"Centre for Addiction , Adrano-Bronte 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,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Souery","sequence":"additional","affiliation":[{"name":"Psy Pluriel \u2013 Epsylon Caring for Mental Health Brussels and Laboratoire de Psychologie M\u00e9dicale Universit\u00e9 libre de Bruxelles , Bruxelles ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Imperial College School of Medicine , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Ferentinos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Athens University Medical School , Athens ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Rujescu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical University Vienna , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Messina","sequence":"additional","affiliation":[{"name":"Psychiatry Unit, Department of Mental Health, ASP Enna , Enna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Zanardi","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Vita-Salute San Raffaele University , Milan ,","place":["Italy"]},{"name":"Mood Disorder Unit, IRCCS San Raffaele Hospital , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6937-3065","authenticated-orcid":false,"given":"Raffaele","family":"Ferri","sequence":"additional","affiliation":[{"name":"Oasi Research Institute-IRCCS , Troina 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