{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:22:23Z","timestamp":1769505743031,"version":"3.49.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ZIA-DA000635"],"award-info":[{"award-number":["ZIA-DA000635"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ZIA-AA000218"],"award-info":[{"award-number":["ZIA-AA000218"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000118","name":"Office of Behavioral and Social Sciences Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000118","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Division of Intramural Clinical and Biological Research"},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030692","name":"Intramural Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Oxytocin is being evaluated as a potential treatment for psychostimulant use disorders. It is unknown what effect oxytocin has on dopamine signaling in response to psychostimulants in brain regions such as the striatum where oxytocin and dopamine interact to process natural rewards. We investigated the effect of oxytocin on striatal dopamine release stimulated by methylphenidate whose mechanism of action is analogous to that of cocaine.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted an [11C] raclopride positron emission tomography study to assess striatal dopamine release in male rhesus macaques treated with oxytocin (80 IU) (administered via the intranasal [N\u2005=\u20055] and intravenous [N\u2005=\u20056] routes) followed by methylphenidate\/[11C] raclopride.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Oxytocin delivered by both routes significantly reduced methylphenidate-stimulated dopamine release in the dorsal striatum (caudate\/putamen). These effects were, in part, evidenced by a reduction in dorsal striatal [11C] raclopride binding potential (increased dopamine release) following oxytocin administration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The results provide translational and mechanistic evidence for the potential role of oxytocin as a treatment for psychostimulant use disorders.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ijnp\/pyae056","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T18:54:15Z","timestamp":1733252055000},"source":"Crossref","is-referenced-by-count":2,"title":["Oxytocin Reduces Methylphenidate-Induced Dorsal Striatal Dopamine Release in Male Rhesus Macaques"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2235-0816","authenticated-orcid":false,"given":"Mary R","family":"Lee","sequence":"first","affiliation":[{"name":"Psychiatric Neuromodulation Service, Veterans Affairs Medical Center , Washington, District of Columbia ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehsan","family":"Shokri Kojori","sequence":"additional","affiliation":[{"name":"National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Bethesda, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Dieckmann","sequence":"additional","affiliation":[{"name":"Positron Emission Tomography Department, National Institutes of Health Clinical Center , Bethesda, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erick","family":"Singley","sequence":"additional","affiliation":[{"name":"National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Bethesda, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A","family":"Mattison","sequence":"additional","affiliation":[{"name":"Translational Gerontology Branch, National Institute on Aging, NIH Animal Center , Dickerson, Maryland,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Herscovitch","sequence":"additional","affiliation":[{"name":"Positron Emission Tomography Department, National Institutes of Health Clinical Center , Bethesda, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Leggio","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Georgetown University Medical Center , Washington, District of Columbia,","place":["USA"]},{"name":"Division of Addiction Medicine, Department of Medicine, School of Medicine, Johns Hopkins University , Baltimore, Maryland,","place":["USA"]},{"name":"Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, School of Public Health, Brown University , Providence, Rhode Island,","place":["USA"]},{"name":"Medication Development Program, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health , Baltimore, Maryland,","place":["USA"]},{"name":"Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Baltimore and Bethesda, Maryland,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"2024122812052243900_CIT0001","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1177\/0269881118756059","article-title":"Reward motivation in humans and its relationship to dopamine D2\/3 receptor availability: a pilot study with dual [11C]-raclopride and [11C]-(+)-PHNO imaging","volume":"32","author":"Caravaggio","year":"2018","journal-title":"J Psychopharmacol"},{"key":"2024122812052243900_CIT0002","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/cbmr.1996.0014","article-title":"AFNI: software for analysis and visualization of functional magnetic resonance neuroimages","volume":"29","author":"Cox","year":"1996","journal-title":"Comput Biomed Res"},{"key":"2024122812052243900_CIT0003","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature12518","article-title":"Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin","volume":"501","author":"Dolen","year":"2013","journal-title":"Nature"},{"key":"2024122812052243900_CIT0004","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/0091-3057(86)90168-1","article-title":"Dopamine neurotransmission in the nucleus accumbens may be involved in oxytocin-enhanced grooming behavior of the rat","volume":"24","author":"Drago","year":"1986","journal-title":"Pharmacol Biochem Behav"},{"key":"2024122812052243900_CIT0005","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12382","article-title":"Comparative perspectives on oxytocin and vasopressin receptor research in rodents and primates: translational implications","volume":"28","author":"Freeman","year":"2016","journal-title":"J Neuroendocrinol"},{"key":"2024122812052243900_CIT0006","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/hbm.460030303","article-title":"Spatial registration and normalization of images","volume":"3","author":"Friston","year":"1995","journal-title":"Hum Brain Mapp"},{"key":"2024122812052243900_CIT0007","volume-title":"Drugs of abuse: biochemical surrogates of specific aspects of natural reward?","author":"G. Di Chiara","year":"1993"},{"key":"2024122812052243900_CIT0008","volume-title":"Homologies and differences in the action of drugs of abuse and a conventional reinforcer (food) on dopamine transmission: an interpretative framework of the mechanism of drug dependence","author":"G. Di Chiara","year":"1998"},{"key":"2024122812052243900_CIT0009","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0306-4530(92)90073-G","article-title":"Oxytocin\u2014a neuropeptide for affiliation: evidence from behavioral, receptor autoradiographic, and comparative studies","volume":"17","author":"Insel","year":"1992","journal-title":"Psychoneuroendocrinology"},{"key":"2024122812052243900_CIT0010","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0031-9384(03)00148-3","article-title":"Is social attachment an addictive disorder","volume":"79","author":"Insel","year":"2003","journal-title":"Physiol Behav"},{"key":"2024122812052243900_CIT0011","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"Fsl","volume":"62","author":"Jenkinson","year":"2012","journal-title":"Neuroimage"},{"key":"2024122812052243900_CIT0012","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1006\/nimg.1996.0066","article-title":"Simplified reference tissue model for PET receptor studies","volume":"4","author":"Lammertsma","year":"1996","journal-title":"Neuroimage"},{"key":"2024122812052243900_CIT0013","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/FBP.0000000000000258","article-title":"Oxytocin for the treatment of drug and alcohol use disorders","volume":"27","author":"Lee","year":"2016","journal-title":"Behav Pharmacol"},{"key":"2024122812052243900_CIT0014","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.euroneuro.2014.06.005","article-title":"Complexity of oxytocin\u2032 s effects in a chronic cocaine dependent population","volume":"24","author":"Lee","year":"2014","journal-title":"Eur Neuropsychopharmacol"},{"key":"2024122812052243900_CIT0015","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s40263-016-0313-z","article-title":"Targeting the oxytocin system to treat addictive disorders: rationale and progress to date","volume":"30","author":"Lee","year":"2016","journal-title":"CNS Drugs"},{"key":"2024122812052243900_CIT0016","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/mp.2017.27","article-title":"Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: determination using a novel oxytocin assay","volume":"23","author":"Lee","year":"2018","journal-title":"Mol Psychiatry"},{"key":"2024122812052243900_CIT0017","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/nyas.14101","article-title":"Effect of systemically administered oxytocin on dose response for methylphenidate self-administration and mesolimbic dopamine levels","volume":"1455","author":"Lee","year":"2019","journal-title":"Ann N Y Acad Sci"},{"key":"2024122812052243900_CIT0018","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/nyas.14101","article-title":"Effect of systemically administered oxytocin on dose response for methylphenidate self-administration and mesolimbic dopamine levels","volume":"1455","author":"Lee","year":"2019","journal-title":"Ann N Y Acad Sci"},{"key":"2024122812052243900_CIT0019","first-page":"1","article-title":"Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques","volume":"11","author":"Lee","year":"2020","journal-title":"Nat Commun"},{"key":"2024122812052243900_CIT0020","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0306-4522(03)00555-4","article-title":"Nucleus accumbens oxytocin and dopamine interact to regulate pair bond formation in female prairie voles","volume":"121","author":"Liu","year":"2003","journal-title":"Neuroscience"},{"key":"2024122812052243900_CIT0021","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nrn1845","article-title":"Dendritic peptide release and peptide-dependent behaviours","volume":"7","author":"Ludwig","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"2024122812052243900_CIT0022","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/j.1460-9568.2007.05721.x","article-title":"Oxytocin injected into the ventral tegmental area induces penile erection and increases extracellular dopamine in the nucleus accumbens and paraventricular nucleus of the hypothalamus of male rats","volume":"26","author":"Melis","year":"2007","journal-title":"Eur J Neurosci"},{"key":"2024122812052243900_CIT0023","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nrn3044","article-title":"Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine","volume":"12","author":"Meyer-Lindenberg","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"2024122812052243900_CIT0024","doi-asserted-by":"crossref","first-page":"6661","DOI":"10.1073\/pnas.76.12.6661","article-title":"Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin","volume":"76","author":"Pedersen","year":"1979","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024122812052243900_CIT0025","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1126\/science.7071605","article-title":"Oxytocin induces maternal behavior in virgin female rats","volume":"216","author":"Pedersen","year":"1982","journal-title":"Science"},{"key":"2024122812052243900_CIT0026","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41467-019-08503-8","article-title":"Oxytocin pathway gene networks in the human brain","volume":"10","author":"Quintana","year":"2019","journal-title":"Nat Commun"},{"key":"2024122812052243900_CIT0027","doi-asserted-by":"crossref","first-page":"100016","DOI":"10.1016\/j.dadr.2021.100016","article-title":"Intranasal oxytocin may improve odds of abstinence in cocaine-dependent patients: results from a preliminary study","volume":"2","author":"Raby","year":"2022","journal-title":"Drug Alcohol Depend Rep"},{"key":"2024122812052243900_CIT0028","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fninf.2012.00027","article-title":"The INIA19 template and neuromaps atlas for primate brain image parcellation and spatial normalization","volume":"6","author":"Rohlfing","year":"2012","journal-title":"Front Neuroinform"},{"key":"2024122812052243900_CIT0029","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.coph.2021.03.002","article-title":"The potential role of oxytocin in addiction: what is the target process","volume":"58","author":"Sanna","year":"2021","journal-title":"Curr Opin Pharmacol"},{"key":"2024122812052243900_CIT0030","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1002\/hbm.25733","article-title":"Brain opioid segments and striatal patterns of dopamine release induced by naloxone and morphine","volume":"43","author":"Shokri-Kojori","year":"2022","journal-title":"Hum Brain Mapp"},{"key":"2024122812052243900_CIT0031","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.biopsych.2019.03.965","article-title":"Striatal dopamine release in response to morphine: a [11C] raclopride positron emission tomography study in healthy men","volume":"86","author":"Spagnolo","year":"2019","journal-title":"Biol Psychiatry"},{"key":"2024122812052243900_CIT0032","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3109\/16066359.2016.1173682","article-title":"A two-week pilot study of intranasal oxytocin for cocaine-dependent individuals receiving methadone maintenance treatment for opioid use disorder","volume":"24","author":"Stauffer","year":"2016","journal-title":"Addict Res Theory"},{"key":"2024122812052243900_CIT0033","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.psyneuen.2013.09.026","article-title":"Oxytocin enhances attractiveness of unfamiliar female faces independent of the dopamine reward system","volume":"39","author":"Striepens","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"2024122812052243900_CIT0034","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.psyneuen.2013.09.026","article-title":"Oxytocin enhances attractiveness of unfamiliar female faces independent of the dopamine reward system","volume":"39","author":"Striepens","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"2024122812052243900_CIT0035","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.3390\/ijms22052405","article-title":"Oxytocin and addiction: potential glutamatergic mechanisms","volume":"22","author":"Sundar","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2024122812052243900_CIT0036","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1046\/j.1460-9568.1998.00135.x","article-title":"A dopamine-\u03bc1 opioid link in the rat ventral tegmentum shared by palatable food (Fonzies) and non-psychostimulant drugs of abuse","volume":"10","author":"Tanda","year":"1998","journal-title":"Eur J Neurosci"},{"key":"2024122812052243900_CIT0037","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1001\/archpsyc.1995.03950180042006","article-title":"Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in the human brain","volume":"52","author":"Volkow","year":"1995","journal-title":"Arch Gen Psychiatry"},{"key":"2024122812052243900_CIT0038","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/386830a0","article-title":"Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects","volume":"386","author":"Volkow","year":"1997","journal-title":"Nature"},{"key":"2024122812052243900_CIT0039","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/386827a0","article-title":"Relationship between subjective effects of cocaine and dopamine transporter occupancy","volume":"386","author":"Volkow","year":"1997","journal-title":"Nature"},{"key":"2024122812052243900_CIT0040","first-page":"409","article-title":"Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D2receptors","volume":"291","author":"Volkow","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"2024122812052243900_CIT0041","doi-asserted-by":"crossref","first-page":"6711","DOI":"10.1523\/JNEUROSCI.0045-12.2012","article-title":"Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain","volume":"32","author":"Volkow","year":"2012","journal-title":"J Neurosci"},{"key":"2024122812052243900_CIT0042","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.neuron.2017.06.003","article-title":"Biased oxytocinergic modulation of midbrain dopamine systems","volume":"95","author":"Xiao","year":"2017","journal-title":"Neuron"},{"key":"2024122812052243900_CIT0043","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.neuron.2017.06.003","article-title":"Biased oxytocinergic modulation of midbrain dopamine systems","volume":"95","author":"Xiao","year":"2017","journal-title":"Neuron"}],"container-title":["International Journal of Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ijnp\/advance-article-pdf\/doi\/10.1093\/ijnp\/pyae056\/60913166\/pyae056.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ijnp\/article-pdf\/28\/1\/pyae056\/60913166\/pyae056.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ijnp\/article-pdf\/28\/1\/pyae056\/60913166\/pyae056.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T12:05:45Z","timestamp":1735387545000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijnp\/article\/doi\/10.1093\/ijnp\/pyae056\/7913697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,29]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12,28]]}},"URL":"https:\/\/doi.org\/10.1093\/ijnp\/pyae056","relation":{},"ISSN":["1461-1457","1469-5111"],"issn-type":[{"value":"1461-1457","type":"print"},{"value":"1469-5111","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,1]]},"published":{"date-parts":[[2024,11,29]]},"article-number":"pyae056"}}