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Because SERT availability is considered to be negatively associated with extracellular serotonin levels, we hypothesized that current smokers would exhibit greater SERT availability than ex-smokers and non-smokers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There was a significant main effect of group on SERT binding (DASB BPND) values in the bilateral and left hippocampus, and a trend toward such in the right hippocampus. Post hoc ANOVAs revealed that current smokers exhibited greater hippocampal DASB BPND than both non-smokers and ex-smokers, while the latter 2 groups did not differ. There were no group effects on DASB BPND within the midbrain or global neocortex. Finally, there was no significant group effect on plasma tryptophan load.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study provides the first in vivo evidence that current smoking may be associated with elevated hippocampal SERT binding\u2014possibly reflecting lower synaptic serotonin concentrations, and that this change may normalize following smoking cessation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ijnp\/pyaf026","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T18:24:17Z","timestamp":1745259857000},"source":"Crossref","is-referenced-by-count":0,"title":["Cigarette smoking is associated with levels of the serotonin transporter in the brain: a [11C]DASB PET 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