{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:30:32Z","timestamp":1791354632439,"version":"4.3.1"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"United States Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biomedical Laboratory Research"},{"name":"Development Service"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1-MH090067"],"award-info":[{"award-number":["RO1-MH090067"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Symptoms of psychosis are often observed in patients with post-traumatic stress disorder (PTSD) and are driven by aberrant regulation of the mesolimbic dopamine system. We have previously shown that targeting upstream brain regions that regulate dopamine neuron activity, the ventral hippocampus (vHipp), and paraventricular nucleus of the thalamus (PVT) maybe a novel approach to restore dopamine system function. The vHipp and PVT work in concert to regulate ventral tegmental area (VTA) dopamine neuron activity through a multisynaptic circuit that begins with inputs to the nucleus accumbens (NAc). Therefore, we hypothesized that inhibition of projections from either the vHipp or PVT to the NAc would reverse stress-induced alterations in dopamine system function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we induced stress-related pathophysiology in rats using a 2-day inescapable foot shock procedure. We then examined if foot shock stress altered the firing patterns and coordinated neuronal activity within vHipp and PVT circuits. Finally, we examined if chemogenetic inhibition of NAc afferents could reverse stress-induced alterations in dopamine system function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed a significant increase in coherence between the PVT and NAc up to 48 hours after foot shock stress. In addition, stress increased VTA dopamine neuron population activity, which was reversed following chemogenetic inhibition of either vHipp-NAc or PVT-NAc projections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Taken together, these results suggest that increased coherence between the PVT and NAc, following stress, may contribute to psychosis-like symptoms but targeting either the PVT or vHipp may be viable options for the treatment of comorbid psychosis related to PTSD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ijnp\/pyaf034","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T09:06:27Z","timestamp":1747818387000},"source":"Crossref","is-referenced-by-count":6,"title":["Inhibition of hippocampal or thalamic inputs to the nucleus accumbens reverses stress-induced alterations in dopamine system function"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6106-4011","authenticated-orcid":false,"given":"Hannah B","family":"Reiley","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Center for Biomedical Neuroscience, University of Texas Health Science Center , San Antonio, TX ,","place":["United States"]},{"name":"Department of Pharmacology, Vanderbilt University , Nashville, TN ,","place":["United States"]},{"name":"Vanderbilt Center for Addiction Research, Vanderbilt University , Nashville, TN ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra M","family":"McCoy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Center for Biomedical Neuroscience, University of Texas Health Science Center , San Antonio, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M","family":"Boley","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Center for Biomedical Neuroscience, University of Texas Health Science Center , San Antonio, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia J","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Center for Biomedical Neuroscience, University of Texas Health Science Center , San Antonio, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie I","family":"Belle","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Wooster , Wooster, OH ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J","family":"Lodge","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Center for Biomedical Neuroscience, University of Texas Health Science Center , San Antonio, TX ,","place":["United States"]},{"name":"South Texas Veterans Health Care System, Audie L. Murphy Division , San Antonio, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"2026071302114426600_CIT0001","doi-asserted-by":"publisher","first-page":"2470547017710916","DOI":"10.1177\/2470547017710916","article-title":"Neurobiology of chronic stress-related psychiatric disorders: evidence from molecular imaging studies","volume":"1","author":"Davis","year":"2017","journal-title":"Chronic Stress."},{"key":"2026071302114426600_CIT0002","doi-asserted-by":"publisher","first-page":"20142516","DOI":"10.1098\/rspb.2014.2516","article-title":"Regulation of dopamine system responsivity and its adaptive and pathological response to stress","volume":"282","author":"Belujon","year":"2015","journal-title":"Proc Biol Sci."},{"key":"2026071302114426600_CIT0003","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s12640-010-9154-6","article-title":"Dopamine system dysregulation by the ventral subiculum as the common pathophysiological basis for schizophrenia psychosis, psychostimulant abuse, and stress","volume":"18","author":"Grace","year":"2010","journal-title":"Neurotox Res."},{"key":"2026071302114426600_CIT0004","doi-asserted-by":"publisher","first-page":"4280","DOI":"10.1523\/JNEUROSCI.5310-10.2011","article-title":"Aversive stimuli alter ventral tegmental area dopamine neuron activity via a common action in the ventral hippocampus","volume":"31","author":"Valenti","year":"2011","journal-title":"J Neurosci."},{"key":"2026071302114426600_CIT0005","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/0006-8993(95)00013-g","article-title":"Selective activation of dopamine transmission in the shell of the nucleus accumbens by stress","volume":"675","author":"Kalivas","year":"1995","journal-title":"Brain Res."},{"key":"2026071302114426600_CIT0006","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1111\/j.1471-4159.1989.tb09224.x","article-title":"Differential effect of stress on in vivo dopamine release in striatum, nucleus accumbens, and medial frontal cortex","volume":"52","author":"Abercrombie","year":"1989","journal-title":"J Neurochem."},{"key":"2026071302114426600_CIT0007","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/S0893-133X(00)00188-3","article-title":"Chronic cold stress reduces the spontaneous activity of ventral tegmental dopamine neurons","volume":"24","author":"Moore","year":"2001","journal-title":"Neuropsychopharmacology."},{"key":"2026071302114426600_CIT0008","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1016\/j.euroneuro.2019.09.009","article-title":"alpha7 nicotinic receptor full agonist reverse basolateral amygdala hyperactivity and attenuation of dopaminergic neuron activity in rats exposed to chronic mild stress","volume":"29","author":"Neves","year":"2019","journal-title":"Eur Neuropsychopharmacol."},{"key":"2026071302114426600_CIT0009","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.biopsych.2013.09.020","article-title":"Amygdala-ventral pallidum pathway decreases dopamine activity after chronic mild stress in rats","volume":"76","author":"Chang","year":"2014","journal-title":"Biol Psychiatry."},{"key":"2026071302114426600_CIT0010","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/s41398-021-01235-8","article-title":"Orexin receptor antagonists reverse aberrant dopamine neuron activity and related behaviors in a rodent model of stress-induced psychosis","volume":"11","author":"Reiley","year":"2021","journal-title":"Transl Psychiatry."},{"key":"2026071302114426600_CIT0011","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1093\/ijnp\/pyac035","article-title":"Positive allosteric modulation of alpha5-GABAA receptors reverses stress-induced alterations in dopamine system function and prepulse inhibition of startle","volume":"25","author":"McCoy","year":"2022","journal-title":"Int J Neuropsychopharmacol."},{"key":"2026071302114426600_CIT0012","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1001\/archgenpsychiatry.2008.514","article-title":"Elevated striatal dopamine function linked to prodromal signs of schizophrenia","volume":"66","author":"Howes","year":"2009","journal-title":"Arch Gen Psychiatry."},{"key":"2026071302114426600_CIT0013","doi-asserted-by":"publisher","first-page":"2849","DOI":"10.1017\/S003329171500080X","article-title":"Psychotic experiences and PTSD: exploring associations in a population survey","volume":"45","author":"Alsawy","year":"2015","journal-title":"Psychol Med."},{"key":"2026071302114426600_CIT0014","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.pnpbp.2018.08.001","article-title":"Posttraumatic stress disorder with secondary psychotic features (PTSD-SP): Diagnostic and treatment challenges","volume":"88","author":"Compean","year":"2019","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"key":"2026071302114426600_CIT0015","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1016\/s0006-3223(98)00301-1","article-title":"Psychotic features and illness severity in combat veterans with chronic posttraumatic stress disorder","volume":"45","author":"Hamner","year":"1999","journal-title":"Biol Psychiatry."},{"key":"2026071302114426600_CIT0016","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1023\/A:1024794232175","article-title":"PTSD and comorbid psychotic disorder: comparison with veterans diagnosed with PTSD or psychotic disorder","volume":"12","author":"Sautter","year":"1999","journal-title":"J Trauma Stress."},{"key":"2026071302114426600_CIT0017","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1097\/01.nmd.0000092177.97317.26","article-title":"Linking posttraumatic stress disorder and psychosis: a look at epidemiology, phenomenology, and treatment","volume":"191","author":"Seedat","year":"2003","journal-title":"J Nerv Ment Dis."},{"key":"2026071302114426600_CIT0018","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/j.1600-0447.2008.01252.x","article-title":"Validity of \u2018post-traumatic stress disorder with secondary psychotic features\u2019: a review of the evidence","volume":"119","author":"Braakman","year":"2009","journal-title":"Acta Psychiatr Scand."},{"key":"2026071302114426600_CIT0019","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1177\/026988119901300405","article-title":"Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies","volume":"13","author":"Laruelle","year":"1999","journal-title":"J Psychopharmacol."},{"key":"2026071302114426600_CIT0020","doi-asserted-by":"publisher","first-page":"11424","DOI":"10.1523\/JNEUROSCI.2847-07.2007","article-title":"Aberrant hippocampal activity underlies the dopamine dysregulation in an animal model of schizophrenia","volume":"27","author":"Lodge","year":"2007","journal-title":"J Neurosci."},{"key":"2026071302114426600_CIT0021","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.tips.2011.05.001","article-title":"Hippocampal dysregulation of dopamine system function and the pathophysiology of schizophrenia","volume":"32","author":"Lodge","year":"2011","journal-title":"Trends Pharmacol Sci."},{"key":"2026071302114426600_CIT0022","doi-asserted-by":"publisher","first-page":"10607","DOI":"10.1523\/JNEUROSCI.2629-16.2018","article-title":"Convergent inputs from the hippocampus and thalamus to the nucleus accumbens regulate dopamine neuron activity","volume":"38","author":"Perez","year":"2018","journal-title":"J Neurosci."},{"key":"2026071302114426600_CIT0023","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.neuron.2013.02.011","article-title":"Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver","volume":"78","author":"Schobel","year":"2013","journal-title":"Neuron."},{"key":"2026071302114426600_CIT0024","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1001\/archgenpsychiatry.2009.115","article-title":"Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disorders","volume":"66","author":"Schobel","year":"2009","journal-title":"Arch Gen Psychiatry."},{"key":"2026071302114426600_CIT0025","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.neuron.2016.09.039","article-title":"Context processing and the neurobiology of post-traumatic stress disorder","volume":"92","author":"Liberzon","year":"2016","journal-title":"Neuron."},{"key":"2026071302114426600_CIT0026","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1093\/schbul\/13.4.589","article-title":"Elevated thalamic dopamine: possible link to sensory dysfunctions in schizophrenia","volume":"13","author":"Oke","year":"1987","journal-title":"Schizophr Bull."},{"key":"2026071302114426600_CIT0027","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.schres.2003.09.017","article-title":"Thalamic dysfunction in schizophrenia: neurochemical, neuropathological, and in vivo imaging abnormalities","volume":"69","author":"Clinton","year":"2004","journal-title":"Schizophr Res."},{"key":"2026071302114426600_CIT0028","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.pnpbp.2010.06.016","article-title":"Hippocampal volume deficits associated with exposure to psychological trauma and posttraumatic stress disorder in adults: a meta-analysis","volume":"34","author":"Woon","year":"2010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"key":"2026071302114426600_CIT0029","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.pscychresns.2006.08.005","article-title":"Smaller right hippocampus in war veterans with posttraumatic stress disorder","volume":"154","author":"Pavic","year":"2007","journal-title":"Psychiatry Res."},{"key":"2026071302114426600_CIT0030","doi-asserted-by":"publisher","first-page":"e13357","DOI":"10.1111\/psyp.13357","article-title":"A review of hippocampal activation in post-traumatic stress disorder","volume":"57","author":"Joshi","year":"2020","journal-title":"Psychophysiology."},{"key":"2026071302114426600_CIT0031","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/0306-4522(94)00355-9","article-title":"Pattern and time course of immediate early gene expression in rat brain following acute stress","volume":"64","author":"Cullinan","year":"1995","journal-title":"Neuroscience."},{"key":"2026071302114426600_CIT0032","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/s0166-4328(00)00362-4","article-title":"Sleep deprivation-induced c-fos and junB expression in the rat brain: effects of duration and timing","volume":"120","author":"Semba","year":"2001","journal-title":"Behav Brain Res."},{"key":"2026071302114426600_CIT0033","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.physbeh.2011.08.001","article-title":"Fos expression following regimens of predator stress versus footshock that differentially affect prepulse inhibition in rats","volume":"104","author":"Baisley","year":"2011","journal-title":"Physiol Behav."},{"key":"2026071302114426600_CIT0034","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/(SICI)1098-2396(199904)32:1&lt;13::AID-SYN2&gt;3.0.CO;2-R","article-title":"Stress induces Fos expression in neurons of the thalamic paraventricular nucleus that innervate limbic forebrain sites","volume":"32","author":"Bubser","year":"1999","journal-title":"Synapse."},{"key":"2026071302114426600_CIT0035","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/s0031-9384(96)00524-0","article-title":"Tail pinch induces fos immunoreactivity within several regions of the male rat brain: effects of age","volume":"61","author":"Smith","year":"1997","journal-title":"Physiol Behav."},{"key":"2026071302114426600_CIT0036","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/s0361-9230(96)00332-2","article-title":"Central c-fos expression following 20kHz\/ultrasound induced defence behaviour in the rat","volume":"42","author":"Beckett","year":"1997","journal-title":"Brain Res Bull."},{"key":"2026071302114426600_CIT0037","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/s0306-4522(97)00577-0","article-title":"Neuroanatomical basis for facilitation of hypothalamic-pituitary-adrenal responses to a novel stressor after chronic stress","volume":"84","author":"Bhatnagar","year":"1998","journal-title":"Neuroscience."},{"key":"2026071302114426600_CIT0038","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1002\/cne.902970410","article-title":"Thalamic midline cell populations projecting to the nucleus accumbens, amygdala, and hippocampus in the rat","volume":"297","author":"Su","year":"1990","journal-title":"J Comp Neurol."},{"key":"2026071302114426600_CIT0039","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/s0006-8993(97)01373-5","article-title":"Thalamic paraventricular nucleus neurons collateralize to innervate the prefrontal cortex and nucleus accumbens","volume":"787","author":"Bubser","year":"1998","journal-title":"Brain Res."},{"key":"2026071302114426600_CIT0040","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1002\/cne.10596","article-title":"Projections from the paraventricular nucleus of the thalamus to the rat prefrontal cortex and nucleus accumbens shell: ultrastructural characteristics and spatial relationships with dopamine afferents","volume":"459","author":"Pinto","year":"2003","journal-title":"J Comp Neurol."},{"key":"2026071302114426600_CIT0041","doi-asserted-by":"publisher","first-page":"3927","DOI":"10.1007\/s00429-017-1445-8","article-title":"Collateralization of projections from the paraventricular nucleus of the thalamus to the nucleus accumbens, bed nucleus of the stria terminalis, and central nucleus of the amygdala","volume":"222","author":"Dong","year":"2017","journal-title":"Brain Struct Funct."},{"key":"2026071302114426600_CIT0042","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.bpsgos.2021.12.010","article-title":"Hippocampal alpha5-GABA(A) receptors modulate dopamine neuron activity in the rat ventral tegmental area","volume":"3","author":"Perez","year":"2023","journal-title":"Biol Psychiatry Glob Open Sci."},{"key":"2026071302114426600_CIT0043","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1093\/ijnp\/pyaa080","article-title":"Orexin modulation of VTA dopamine neuron activity: relevance to schizophrenia","volume":"24","author":"Perez","year":"2021","journal-title":"Int J Neuropsychopharmacol."},{"key":"2026071302114426600_CIT0044","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.neubiorev.2015.08.005","article-title":"Placing the paraventricular nucleus of the thalamus within the brain circuits that control behavior","volume":"56","author":"Kirouac","year":"2015","journal-title":"Neurosci Biobehav Rev."},{"key":"2026071302114426600_CIT0045","doi-asserted-by":"publisher","first-page":"662293","DOI":"10.3389\/fnint.2021.662293","article-title":"Functional connectivity of the human paraventricular thalamic nucleus: insights from high field functional MRI","volume":"15","author":"Kark","year":"2021","journal-title":"Front Integr Neurosci."},{"key":"2026071302114426600_CIT0046","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/cne.21502","article-title":"Projections from the paraventricular nucleus of the thalamus to the forebrain, with special emphasis on the extended amygdala","volume":"506","author":"Li","year":"2008","journal-title":"J Comp Neurol."},{"key":"2026071302114426600_CIT0047","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1152\/jn.1993.69.4.1292","article-title":"Spontaneous burst firing in cat primary auditory cortex: age and depth dependence and its effect on neural interaction measures","volume":"69","author":"Eggermont","year":"1993","journal-title":"J Neurophysiol."},{"key":"2026071302114426600_CIT0048","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.schres.2014.05.005","article-title":"A fundamental role for hippocampal parvalbumin in the dopamine hyperfunction associated with schizophrenia","volume":"157","author":"Boley","year":"2014","journal-title":"Schizophr Res."},{"key":"2026071302114426600_CIT0049","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1038\/mp.2013.111","article-title":"Hippocampal interneuron transplants reverse aberrant dopamine system function and behavior in a rodent model of schizophrenia","volume":"18","author":"Perez","year":"2013","journal-title":"Mol Psychiatry."},{"key":"2026071302114426600_CIT0050","doi-asserted-by":"publisher","first-page":"e215","DOI":"10.1038\/tp.2012.145","article-title":"A loss of hippocampal perineuronal nets produces deficits in dopamine system function: relevance to the positive symptoms of schizophrenia","volume":"3","author":"Shah","year":"2013","journal-title":"Transl Psychiatry."},{"key":"2026071302114426600_CIT0051","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.tins.2012.02.003","article-title":"Are you or aren\u2019t you? Challenges associated with physiologically identifying dopamine neurons","volume":"35","author":"Ungless","year":"2012","journal-title":"Trends Neurosci."},{"key":"2026071302114426600_CIT0052","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/0306-4522(83)90135-5","article-title":"Intracellular and extracellular electrophysiology of nigral dopaminergic neurons\u20141. Identification and characterization","volume":"10","author":"Grace","year":"1983","journal-title":"Neuroscience."},{"key":"2026071302114426600_CIT0053","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1152\/jn.00307.2013","article-title":"The lateral mesopontine tegmentum regulates both tonic and phasic activity of VTA dopamine neurons","volume":"110","author":"Chen","year":"2013","journal-title":"J Neurophysiol."},{"key":"2026071302114426600_CIT0054","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.bbr.2019.01.031","article-title":"Effect of estrous cycle on schizophrenia-like behaviors in MAM exposed rats","volume":"362","author":"Perez","year":"2019","journal-title":"Behav Brain Res."},{"key":"2026071302114426600_CIT0055","first-page":"279","article-title":"Temporal characterization of subcortical nuclei in mnemonic processes: results of tetrodotoxin reversible inactivation studies in the rat","volume":"136","author":"Ambrogi Lorenzini","year":"1998","journal-title":"Arch Ital Biol."},{"key":"2026071302114426600_CIT0056","doi-asserted-by":"publisher","first-page":"9261","DOI":"10.1523\/JNEUROSCI.0588-14.2014","article-title":"Vagal nerve stimulation reverses aberrant dopamine system function in the methylazoxymethanol acetate rodent model of schizophrenia","volume":"34","author":"Perez","year":"2014","journal-title":"J Neurosci."},{"key":"2026071302114426600_CIT0057","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1038\/nrn3599","article-title":"Modelling and analysis of local field potentials for studying the function of cortical circuits","volume":"14","author":"Einevoll","year":"2013","journal-title":"Nat Rev Neurosci."},{"key":"2026071302114426600_CIT0058","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuron.2008.12.019","article-title":"Uncovering the mysterious origins of local field potentials","volume":"61","author":"Pesaran","year":"2009","journal-title":"Neuron."},{"key":"2026071302114426600_CIT0059","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nrn1650","article-title":"Normal and pathological oscillatory communication in the brain","volume":"6","author":"Schnitzler","year":"2005","journal-title":"Nat Rev Neurosci."},{"key":"2026071302114426600_CIT0060","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1017\/S1461145704004110","article-title":"Do we still believe in the dopamine hypothesis? New data bring new evidence","volume":"7","author":"Abi-Dargham","year":"2004","journal-title":"Int J Neuropsychopharmacol."},{"key":"2026071302114426600_CIT0061","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1017\/S1461145712001344","article-title":"Hippocampal deep brain stimulation reverses physiological and behavioural deficits in a rodent model of schizophrenia","volume":"16","author":"Perez","year":"2013","journal-title":"Int J Neuropsychopharmacol."},{"key":"2026071302114426600_CIT0062","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/BF03033801","article-title":"Hippocampal dysfunction and disruption of dopamine system regulation in an animal model of schizophrenia","volume":"14","author":"Lodge","year":"2008","journal-title":"Neurotox Res."},{"key":"2026071302114426600_CIT0063","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/s41593-019-0572-3","article-title":"Two genetically, anatomically and functionally distinct cell types segregate across anteroposterior axis of paraventricular thalamus","volume":"23","author":"Gao","year":"2020","journal-title":"Nat Neurosci."},{"key":"2026071302114426600_CIT0064","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.neuron.2017.03.036","article-title":"Thalamic regulation of sucrose seeking during unexpected reward omission","volume":"94","author":"Do-Monte","year":"2017","journal-title":"Neuron."},{"key":"2026071302114426600_CIT0065","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.neuron.2019.05.018","article-title":"Paraventricular thalamus projection neurons integrate cortical and hypothalamic signals for cue-reward processing","volume":"103","author":"Otis","year":"2019","journal-title":"Neuron."},{"key":"2026071302114426600_CIT0066","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1038\/nn.4331","article-title":"Glucose-responsive neurons of the paraventricular thalamus control sucrose-seeking behavior","volume":"19","author":"Labouebe","year":"2016","journal-title":"Nat Neurosci."},{"key":"2026071302114426600_CIT0067","doi-asserted-by":"publisher","first-page":"16235","DOI":"10.1038\/srep16235","article-title":"Chronic stress alters spatial representation and bursting patterns of place cells in behaving mice","volume":"5","author":"Park","year":"2015","journal-title":"Sci Rep."},{"key":"2026071302114426600_CIT0068","doi-asserted-by":"publisher","first-page":"4394","DOI":"10.1038\/s41380-022-01700-w","article-title":"Alterations in TRN-anterodorsal thalamocortical circuits affect sleep architecture and homeostatic processes in oxidative stress vulnerable Gclm(-\/-) mice","volume":"27","author":"Czekus","year":"2022","journal-title":"Mol Psychiatry."},{"key":"2026071302114426600_CIT0069","doi-asserted-by":"publisher","first-page":"e5062","DOI":"10.1371\/journal.pone.0005062","article-title":"The nucleus accumbens: a switchboard for goal-directed behaviors","volume":"4","author":"Gruber","year":"2009","journal-title":"PLoS One."},{"key":"2026071302114426600_CIT0070","doi-asserted-by":"publisher","first-page":"5354","DOI":"10.1523\/JNEUROSCI.0131-09.2009","article-title":"Nucleus accumbens deep brain stimulation produces region-specific alterations in local field potential oscillations and evoked responses in vivo","volume":"29","author":"McCracken","year":"2009","journal-title":"J Neurosci."},{"key":"2026071302114426600_CIT0071","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.neuron.2015.09.034","article-title":"Rhythms for cognition: communication through coherence","volume":"88","author":"Fries","year":"2015","journal-title":"Neuron."},{"key":"2026071302114426600_CIT0072","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/nature14030","article-title":"A temporal shift in the circuits mediating retrieval of fear memory","volume":"519","author":"Do-Monte","year":"2015","journal-title":"Nature."},{"key":"2026071302114426600_CIT0073","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1126\/science.aat2512","article-title":"The paraventricular thalamus is a critical thalamic area for wakefulness","volume":"362","author":"Ren","year":"2018","journal-title":"Science."},{"key":"2026071302114426600_CIT0074","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1097\/j.pain.0000000000000318","article-title":"Roles of prefrontal cortex and paraventricular thalamus in affective and mechanical components of visceral nociception","volume":"156","author":"Jurik","year":"2015","journal-title":"Pain."},{"key":"2026071302114426600_CIT0075","doi-asserted-by":"publisher","first-page":"16506","DOI":"10.1038\/s41598-019-52984-y","article-title":"Presynaptic dysregulation of the paraventricular thalamic nucleus causes depression-like behavior","volume":"9","author":"Kato","year":"2019","journal-title":"Sci Rep."},{"key":"2026071302114426600_CIT0076","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1038\/npp.2011.7","article-title":"The medial prefrontal and orbitofrontal cortices differentially regulate dopamine system function","volume":"36","author":"Lodge","year":"2011","journal-title":"Neuropsychopharmacology."},{"key":"2026071302114426600_CIT0077","doi-asserted-by":"publisher","first-page":"2819","DOI":"10.1038\/s41467-019-10800-1","article-title":"Modulation of extrasynaptic GABAA alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner","volume":"10","author":"Donegan","year":"2019","journal-title":"Nat Commun."}],"container-title":["International Journal of Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ijnp\/advance-article-pdf\/doi\/10.1093\/ijnp\/pyaf034\/63313052\/pyaf034.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ijnp\/article-pdf\/28\/6\/pyaf034\/63313052\/pyaf034.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ijnp\/article-pdf\/28\/6\/pyaf034\/63313052\/pyaf034.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T06:11:48Z","timestamp":1783923108000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijnp\/article\/doi\/10.1093\/ijnp\/pyaf034\/8142563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,23]]},"references-count":77,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,6]]}},"URL":"https:\/\/doi.org\/10.1093\/ijnp\/pyaf034","relation":{},"ISSN":["1461-1457","1469-5111"],"issn-type":[{"value":"1461-1457","type":"print"},{"value":"1469-5111","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,5,23]]},"article-number":"pyaf034"}}