{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:06:33Z","timestamp":1788977193347,"version":"build-2803163510"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP25wm0625-121"],"award-info":[{"award-number":["JP25wm0625-121"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP24wm0425001"],"award-info":[{"award-number":["JP24wm0425001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["25zf0127010"],"award-info":[{"award-number":["25zf0127010"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["25zf0127012"],"award-info":[{"award-number":["25zf0127012"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["25wm062-5324"],"award-info":[{"award-number":["25wm062-5324"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JST Moonshot R&D","award":["JPMJMS239F"],"award-info":[{"award-number":["JPMJMS239F"]}]},{"name":"Transformative Research Areas","award":["23H04234"],"award-info":[{"award-number":["23H04234"]}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology in Japan","doi-asserted-by":"crossref","award":["21H04812"],"award-info":[{"award-number":["21H04812"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology in Japan","doi-asserted-by":"crossref","award":["24K22086"],"award-info":[{"award-number":["24K22086"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology in Japan","doi-asserted-by":"crossref","award":["20K07288"],"award-info":[{"award-number":["20K07288"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology in Japan","doi-asserted-by":"crossref","award":["23K06358"],"award-info":[{"award-number":["23K06358"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Japan Society for the Promotion of Science in Japan"},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008695","name":"Japan Foundation for Applied Enzymology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008880","name":"KANAE foundation for the promotion of medical science","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008880","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008667","name":"SENSHIN Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008882","name":"Meiji Yasuda Life Foundation of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008882","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006680","name":"Takeda Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006680","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005927","name":"Daiichi Sankyo Foundation of Life Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005927","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kazato Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Stress-related mental illnesses, including depression, are associated with altered glucose metabolism. However, it is unclear how chronic stress alters glucose metabolism along with depression-related behaviors, and how antidiabetic drugs normalize these alterations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using a mouse model of social defeat stress, we compared stress-induced glycemic responses among strains that differ in stress susceptibility (C57BL\/6N, C57BL\/6J, and BALB\/c). Blood glucose was measured before stress and after the last stress exposure of acute and chronic stress. Circulating metabolic hormones and inflammatory cytokines were quantified, and depression-related behaviors (social avoidance, anhedonia-like behavior and cognitive deficits) were assessed. In C57BL\/6N mice, the antidiabetic drug glyburide or liraglutide was administered 30\u00a0min before each of the 10 stress exposures, and their effects on glycemic responses and behavioral outcomes were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Acute stress elevates blood glucose in the relatively stress-resilient C57BL\/6N and C57BL\/6J strains, but not in the more stress-susceptible BALB\/c strain. After chronic stress, this stress-induced hyperglycemic response was abolished in C57BL\/6N and C57BL\/6J mice, whereas BALB\/c mice showed stress-induced hypoglycemia. Chronic stress also produced largely coordinated changes in circulating metabolic hormones and inflammatory cytokines, with strain-dependent differences in a subset of these molecules. In C57BL\/6N mice, treatment with glyburide or liraglutide, antidiabetic drugs with distinct primary mechanisms of action, before each stress exposure reduced the development of anhedonia-like behavior and cognitive deficits without affecting social avoidance, while restoring stress-induced hyperglycemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results demonstrate that chronic stress drives a hypoglycemic shift accompanied by depression-related behaviors, and that the development of both metabolic and behavioral alterations can be prevented by antidiabetic drugs with distinct primary mechanisms administered during the stress period. Thus, this study supports metabolically targeted interventions as a potential preventive strategy for stress-related mental illnesses, whereas their efficacy against an already established phenotype remains to be tested.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ijnp\/pyag046","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:48:22Z","timestamp":1787312902000},"source":"Crossref","is-referenced-by-count":0,"title":["Chronic social defeat stress induces a hypoglycemic shift and depression-related behaviors, both prevented by antidiabetic drugs"],"prefix":"10.1093","volume":"29","author":[{"given":"Wenran","family":"Qiu","sequence":"first","affiliation":[{"name":"Division of Pharmacology, Graduate School of Medicine, Kobe University , Kobe 650-0017 ,","place":["Japan"]},{"name":"Department of Anatomy, Division of Histology and Cell Biology, School of Medicine, Jichi Medical University , Shimotsuke 329-0498 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0983-8670","authenticated-orcid":false,"given":"Hirotaka","family":"Nagai","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Graduate School of Medicine, Kobe University , Kobe 650-0017 ,","place":["Japan"]},{"name":"Department of Anatomy, Division of Histology and Cell Biology, School of Medicine, Jichi Medical University , Shimotsuke 329-0498 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Ota","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Graduate School of Medicine, Kobe University , Kobe 650-0017 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Nagai","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Graduate School of Medicine, Kobe University , Kobe 650-0017 ,","place":["Japan"]},{"name":"Department of Anatomy, Division of Histology and Cell Biology, School of Medicine, Jichi Medical University , Shimotsuke 329-0498 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8089-8399","authenticated-orcid":false,"given":"Tomoyuki","family":"Furuyashiki","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Graduate School of Medicine, Kobe University , Kobe 650-0017 ,","place":["Japan"]},{"name":"Department of Pharmacology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo , Tokyo 113-8510 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"2026090913171633100_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104758","article-title":"Insulin resistance in depression: a large meta-analysis of metabolic parameters and variation","volume":"139","author":"Fernandes","year":"2022","journal-title":"Neurosci Biobehav Rev"},{"key":"2026090913171633100_ref2","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1001\/archinternmed.2010.356","article-title":"Bidirectional association between depression and type 2 diabetes mellitus in women","volume":"170","author":"Pan","year":"2010","journal-title":"Arch Intern Med"},{"key":"2026090913171633100_ref3","doi-asserted-by":"publisher","first-page":"5013","DOI":"10.1038\/s41380-025-03083-0","article-title":"Evidence of bidirectional relationship between type 2 diabetes and depression; a Mendelian randomization study","volume":"30","author":"Bala","year":"2025","journal-title":"Mol Psychiatry"},{"key":"2026090913171633100_ref4","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1186\/s12974-016-0728-y","article-title":"The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPAR\u03b3-mediated alteration of microglial activation phenotypes","volume":"13","author":"Zhao","year":"2016","journal-title":"J Neuroinflammation"},{"key":"2026090913171633100_ref5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jad.2022.12.089","article-title":"Effects of liraglutide on depressive behavior in a mouse depression model and cognition in the probe trial of Morris water maze test","volume":"324","author":"Seo","year":"2023","journal-title":"J Affect Disord"},{"key":"2026090913171633100_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121546","article-title":"Dulaglutide impedes depressive-like behavior persuaded by chronic social defeat stress model in male C57BL\/6 mice: implications on GLP-1R and cAMP\/PKA signaling pathway in the hippocampus","volume":"320","author":"Darwish","year":"2023","journal-title":"Life Sci"},{"key":"2026090913171633100_ref7","doi-asserted-by":"publisher","first-page":"e3448","DOI":"10.1002\/brb3.3448","article-title":"Dulaglutide treatment reverses depression-like behavior and hippocampal metabolomic homeostasis in mice exposed to chronic mild stress","volume":"14","author":"Jin","year":"2024","journal-title":"Brain Behav"},{"key":"2026090913171633100_ref8","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1001\/jamainternmed.2024.4346","article-title":"Psychiatric safety of semaglutide for weight management in people without known major psychopathology: post hoc analysis of the STEP 1, 2, 3, and 5 trials","volume":"184","author":"Wadden","year":"2024","journal-title":"JAMA Intern Med"},{"key":"2026090913171633100_ref9","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1001\/jamapsychiatry.2025.0679","article-title":"Glucagon-like peptide 1 receptor agonists and mental health: a systematic review and meta-analysis","volume":"82","author":"Pierret","year":"2025","journal-title":"JAMA Psychiatry"},{"key":"2026090913171633100_ref10","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.jagp.2023.08.010","article-title":"The antidepressant effects of GLP-1 receptor agonists: a systematic review and meta-analysis","volume":"32","author":"Chen","year":"2024","journal-title":"Am J Geriatr Psychiatry"},{"key":"2026090913171633100_ref11","doi-asserted-by":"publisher","first-page":"16","DOI":"10.4183\/aeb.2018.16","article-title":"Chronic unpredictable mild stress progressively disturbs glucose metabolism and appetite hormones in rats","volume":"14","author":"L\u00f3pez L\u00f3pez","year":"2018","journal-title":"Acta Endocrinol (Buchar)"},{"key":"2026090913171633100_ref12","doi-asserted-by":"publisher","first-page":"983","DOI":"10.3389\/fnins.2018.00983","article-title":"Hyperglycemia induced by chronic restraint stress in mice is associated with nucleus tractus solitarius injury and not just the direct effect of glucocorticoids","volume":"12","author":"Zheng","year":"2018","journal-title":"Front Neurosci"},{"key":"2026090913171633100_ref13","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.molmet.2015.07.008","article-title":"Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain","volume":"4","author":"Cork","year":"2015","journal-title":"Mol Metab"},{"key":"2026090913171633100_ref14","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1046\/j.1471-4159.1996.66030920.x","article-title":"Expression of the glucagon-like peptide-1 receptor gene in rat brain","volume":"66","author":"Alvarez","year":"1996","journal-title":"J Neurochem"},{"key":"2026090913171633100_ref15","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nn1038","article-title":"Epigenetic sources of behavioral differences in mice","volume":"6","author":"Francis","year":"2003","journal-title":"Nat Neurosci"},{"key":"2026090913171633100_ref16","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s12974-017-0985-4","article-title":"Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance","volume":"14","author":"Su","year":"2017","journal-title":"J Neuroinflammation"},{"key":"2026090913171633100_ref17","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.brainres.2018.04.031","article-title":"Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity","volume":"1694","author":"Weina","year":"2018","journal-title":"Brain Res"},{"key":"2026090913171633100_ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28803-1","article-title":"Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference associated with heightened anxiety","volume":"8","author":"Higashida","year":"2018","journal-title":"Sci Rep"},{"key":"2026090913171633100_ref19","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.jphs.2024.02.010","article-title":"Chronic stress alters lipid mediator profiles associated with immune-related gene expressions and cell compositions in mouse bone marrow and spleen","volume":"154","author":"Horikawa","year":"2024","journal-title":"J Pharmacol Sci"},{"key":"2026090913171633100_ref20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76717-8","article-title":"Stress-induced sleep-like inactivity modulates stress susceptibility in mice","volume":"10","author":"Nagai","year":"2020","journal-title":"Sci Rep"},{"key":"2026090913171633100_ref21","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1038\/nprot.2013.155","article-title":"Object recognition test in mice","volume":"8","author":"Leger","year":"2013","journal-title":"Nat Protoc"},{"key":"2026090913171633100_ref22","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.jphs.2025.01.002","article-title":"C57BL\/6J and C57BL\/6N mice show distinct aging-associated behavioral alterations","volume":"157","author":"Yamada","year":"2025","journal-title":"J Pharmacol Sci"},{"key":"2026090913171633100_ref23","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.1093\/hmg\/ddl402","article-title":"Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior","volume":"15","author":"Nishijima","year":"2006","journal-title":"Hum Mol Genet"},{"key":"2026090913171633100_ref24","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1038\/s41593-017-0010-3","article-title":"Social stress induces neurovascular pathology promoting depression","volume":"20","author":"Menard","year":"2017","journal-title":"Nat Neurosci"},{"key":"2026090913171633100_ref25","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1172\/JCI25495","article-title":"ATP-sensitive potassium channelopathies: focus on insulin secretion","volume":"115","author":"Ashcroft","year":"2005","journal-title":"J Clin Invest"},{"key":"2026090913171633100_ref26","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1124\/pr.115.011395","article-title":"Glucagon-like peptide-1 and its class B G protein-coupled receptors: a long march to therapeutic successes","volume":"68","author":"Graaf","year":"2016","journal-title":"Pharmacol Rev"},{"key":"2026090913171633100_ref27","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1038\/s41586-025-09420-1","article-title":"Amygdala-liver signalling orchestrates glycaemic responses to stress","volume":"646","author":"Carty","year":"2025","journal-title":"Nature"},{"key":"2026090913171633100_ref28","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1016\/j.neuron.2024.05.001","article-title":"Neurobiological basis of stress resilience","volume":"112","author":"Nestler","year":"2024","journal-title":"Neuron"},{"key":"2026090913171633100_ref29","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1007\/s00429-014-0954-y","article-title":"Afferent projections to the different medial amygdala subdivisions: a retrograde tracing study in the mouse","volume":"221","author":"C\u00e1diz-Moretti","year":"2016","journal-title":"Brain Struct Funct"},{"key":"2026090913171633100_ref30","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/0006-8993(83)91029-6","article-title":"Dopaminergic and non-dopaminergic projections to amygdala from substantia nigra and ventral tegmental area","volume":"262","author":"Loughlin","year":"1983","journal-title":"Brain Res"},{"key":"2026090913171633100_ref31","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.bbr.2010.04.038","article-title":"Restraint stress-induced brain activation patterns in two strains of mice differing in their anxiety behaviour","volume":"213","author":"O'Mahony","year":"2010","journal-title":"Behav Brain Res"},{"key":"2026090913171633100_ref32","doi-asserted-by":"publisher","first-page":"4809","DOI":"10.1074\/jbc.RA119.012349","article-title":"Regulation of gene expression during the fasting-feeding cycle of the liver displays mouse strain specificity","volume":"295","author":"Chi","year":"2020","journal-title":"J Biol Chem"},{"key":"2026090913171633100_ref33","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1007\/s00125-013-2846-8","article-title":"Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding","volume":"56","author":"Montgomery","year":"2013","journal-title":"Diabetologia"},{"key":"2026090913171633100_ref34","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.bbr.2010.07.014","article-title":"Different susceptibility to social defeat stress of BalbC and C57BL6\/J mice","volume":"216","author":"Razzoli","year":"2011","journal-title":"Behav Brain Res"},{"key":"2026090913171633100_ref35","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.neuron.2018.06.035","article-title":"The innate immune receptors TLR2\/4 mediate repeated social defeat stress-induced social avoidance through prefrontal microglial activation","volume":"99","author":"Nie","year":"2018","journal-title":"Neuron"},{"key":"2026090913171633100_ref36","doi-asserted-by":"publisher","first-page":"3034","DOI":"10.1038\/s41467-024-47266-9","article-title":"Stress increases hepatic release of lipocalin 2 which contributes to anxiety-like behavior in mice","volume":"15","author":"Yan","year":"2024","journal-title":"Nat Commun"},{"key":"2026090913171633100_ref37","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1001\/archpsyc.58.7.631","article-title":"Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings","volume":"58","author":"Brody","year":"2001","journal-title":"Arch Gen Psychiatry"},{"key":"2026090913171633100_ref38","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1017\/s1092852900013754","article-title":"The subgenual anterior cingulate cortex in mood disorders","volume":"13","author":"Drevets","year":"2008","journal-title":"CNS Spectr"},{"key":"2026090913171633100_ref39","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1093\/jmicro\/dfae036","article-title":"Deciphering prefrontal circuits underlying stress and depression: exploring the potential of volume electron microscopy","volume":"73","author":"Nagai","year":"2024","journal-title":"Microscopy (Oxf)"},{"key":"2026090913171633100_ref40","doi-asserted-by":"publisher","first-page":"3463","DOI":"10.1073\/pnas.1500877112","article-title":"Insulin resistance in brain alters dopamine turnover and causes behavioral disorders","volume":"112","author":"Kleinridders","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026090913171633100_ref41","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.neuropharm.2017.12.001","article-title":"Insulin-mediated synaptic plasticity in the CNS: anatomical, functional and temporal contexts","volume":"136","author":"Ferrario","year":"2018","journal-title":"Neuropharmacology"},{"key":"2026090913171633100_ref42","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1007\/s43440-021-00274-8","article-title":"Insights into a possible role of glucagon-like peptide-1 receptor agonists in the treatment of depression","volume":"73","author":"Detka","year":"2021","journal-title":"Pharmacol Rep"},{"key":"2026090913171633100_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.108036","article-title":"Psychotropic effects of GLP-1R agonists","volume":"222","author":"Bucciarelli","year":"2025","journal-title":"Pharmacol Res"},{"key":"2026090913171633100_ref44","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1093\/cid\/ciq192","article-title":"Glyburide is anti-inflammatory and associated with reduced mortality in melioidosis","volume":"52","author":"Koh","year":"2011","journal-title":"Clin Infect Dis"}],"container-title":["International Journal of Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ijnp\/advance-article-pdf\/doi\/10.1093\/ijnp\/pyag046\/70765650\/pyag046.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ijnp\/article-pdf\/29\/9\/pyag046\/70765650\/pyag046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ijnp\/article-pdf\/29\/9\/pyag046\/70765650\/pyag046.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:17:24Z","timestamp":1788974244000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijnp\/article\/doi\/10.1093\/ijnp\/pyag046\/8768894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,23]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ijnp\/pyag046","relation":{},"ISSN":["1461-1457","1469-5111"],"issn-type":[{"value":"1461-1457","type":"print"},{"value":"1469-5111","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,8,23]]},"article-number":"pyag046"}}