{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:51:14Z","timestamp":1790293874607,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1093\/ijnp\/pyu070","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T17:16:04Z","timestamp":1432660564000},"source":"Crossref","is-referenced-by-count":31,"title":["Paliperidone Prevents Brain Toll-Like Receptor 4 Pathway Activation and Neuroinflammation in Rat Models of Acute and Chronic Restraint Stress"],"prefix":"10.1093","volume":"18","author":[{"given":"KS","family":"MacDowell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JR","family":"Caso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Mart\u00edn-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JL","family":"Madrigal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JC","family":"Leza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Garc\u00eda-Bueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,1,24]]},"reference":[{"key":"key\n\t\t\t\t20170523185508_CIT0001","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.schres.2011.11.002","article-title":"SNP-based analysis of neuroactive ligand-receptor interaction pathways implicates PGE2 as a novel mediator of antipsychotic treatment response: data from the CATIE study","volume":"135","author":"Adkins","year":"(2012)","journal-title":"Schizophr Res"},{"key":"key\n\t\t\t\t20170523185508_CIT0002","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"(2006)","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170523185508_CIT0003","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0952-3278(96)90153-2","article-title":"Heat stress lipids and schizophrenia","volume":"55","author":"Bates","year":"(1996)","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"key\n\t\t\t\t20170523185508_CIT0004","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1176\/appi.ajp.2011.11030516","article-title":"Autoimmune diseases and severe infections as risk factors for schizophrenia: a 30-year population-based register study","volume":"168","author":"Benros","year":"(2011)","journal-title":"Am J Psych"},{"key":"key\n\t\t\t\t20170523185508_CIT0005","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.lfs.2014.02.006","article-title":"HSP70 polymorphisms in first psychotic episode drug-na\u00efve schizophrenic patients","volume":"100","author":"Bozidis","year":"(2014)","journal-title":"Life Sci"},{"key":"key\n\t\t\t\t20170523185508_CIT0006","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/1359786810385491","article-title":"A systematic review of hypothalamic-pituitary-adrenal axis function in schizophrenia: implications for mortality","volume":"24","author":"Bradley","year":"(2010)","journal-title":"J Psychopharmacol"},{"key":"key\n\t\t\t\t20170523185508_CIT0007","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1176\/appi.ajp.2009.09030361","article-title":"Prenatal infection and schizophrenia: a review of epidemiologic and translational studies","volume":"167","author":"Brown","year":"(2010)","journal-title":"Am J Psych"},{"key":"key\n\t\t\t\t20170523185508_CIT0008","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1471-4159.2011.07410.x","article-title":"Chronic olanzapine treatment decreases arachidonic acid turnover and prostaglandin E(2) concentration in rat brain","volume":"119","author":"Cheon","year":"(2011)","journal-title":"J Neurochem"},{"key":"key\n\t\t\t\t20170523185508_CIT0009","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.brainres.2008.07.021","article-title":"Paliperidone as a mood stabilizer: a pre-frontal cortex synaptoneurosomal proteomics comparison with lithium and valproic acid after chronic treatment reveals similarities in protein expression","volume":"1233","author":"Corena-McLeod Mdel","year":"(2008)","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20170523185508_CIT0010","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.biopsych.2012.09.030","article-title":"High mobility group box 1\/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence","volume":"73","author":"Crews","year":"(2013)","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20170523185508_CIT0500"},{"key":"key\n\t\t\t\t20170523185508_CIT0011","doi-asserted-by":"crossref","first-page":"e309","DOI":"10.1038\/tp.2013.83","article-title":"Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat","volume":"3","author":"Davey","year":"(2013)","journal-title":"Transl Psychiatry"},{"key":"key\n\t\t\t\t20170523185508_CIT0012","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.biopsych.2010.03.021","article-title":"Markers of gluten sensitivity and celiac disease in recent-onset psychosis and multi-episode schizophrenia","volume":"68","author":"Dickerson","year":"(2010)","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20170523185508_CIT0013","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s12035-012-8264-y","article-title":"HMGB1 in development and diseases of the central nervous system","volume":"45","author":"Fang","year":"(2012)","journal-title":"Mol Neurobiol"},{"key":"key\n\t\t\t\t20170523185508_CIT0014","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1196\/annals.1443.012","article-title":"Toll-like receptors in autoimmunity","volume":"1143","author":"Fischer","year":"(2008)","journal-title":"Ann NY Acad Sci"},{"key":"key\n\t\t\t\t20170523185508_CIT0015","doi-asserted-by":"crossref","DOI":"10.1186\/1742-2094-8-151","article-title":"Origin and consequences of brain toll-like receptor 4 pathway stimulation in an experimental model of depression","volume":"8","author":"G\u00e1rate","year":"(2011)","journal-title":"J Neuroinflammation"},{"key":"key\n\t\t\t\t20170523185508_CIT0016","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.biopsych.2012.07.005","article-title":"Stress-induced neuroinflammation: role of the Toll-like receptor-4 pathway","volume":"73","author":"G\u00e1rate","year":"(2013)","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20170523185508_CIT0017","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.neubiorev.2008.04.001","article-title":"Stress as a neuroinflammatory condition in brain: damaging and protective mechanisms","volume":"32","author":"Garc\u00eda-Bueno","year":"(2008)","journal-title":"Neurosci Biobehav Rev"},{"key":"key\n\t\t\t\t20170523185508_CIT0018","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.neuroscience.2009.08.053","article-title":"Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery","volume":"164","author":"Goldwater","year":"(2009)","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20170523185508_CIT0019","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3109\/13651501.2013.859708","article-title":"The adapter proteins of TLRs, TRIF and MYD88, are upregulated in depressed individuals","volume":"18","author":"Hajebrahimi","year":"(2014)","journal-title":"Int J Psychiatry Clin Pract"},{"key":"key\n\t\t\t\t20170523185508_CIT0020","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1042\/CS20110164","article-title":"Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential","volume":"121","author":"Hanke","year":"(2011)","journal-title":"Clin Sci"},{"key":"key\n\t\t\t\t20170523185508_CIT0021","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1600-0447.2005.00687.x","article-title":"The gluten connection: the association between schizophrenia and celiac disease","volume":"113","author":"Kalaydjian","year":"(2006)","journal-title":"Acta Psychiatr Scand"},{"key":"key\n\t\t\t\t20170523185508_CIT0022","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0920-9964(00)00091-8","article-title":"Identification of antibodies to heat shock proteins 90kDa and 70kDa in patients with schizophrenia","volume":"52","author":"Kim","year":"(2001)","journal-title":"Schizophr Res"},{"key":"key\n\t\t\t\t20170523185508_CIT0023","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00406-007-0791-6","article-title":"Association analysis of heat shock protein 70 gene polymorphisms in schizophrenia","volume":"258","author":"Kim","year":"(2008)","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"key\n\t\t\t\t20170523185508_CIT0024","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1093\/schbul\/sbt141","article-title":"Inflammation and schizophrenia","volume":"39","author":"Kirkpatrick","year":"(2013)","journal-title":"Schizophr Bull"},{"key":"key\n\t\t\t\t20170523185508_CIT0025","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.neuron.2013.04.005","article-title":"Innate immunity in the CNS: redefining the relationship between the CNS and Its environment","volume":"78","author":"Lampron","year":"(2013)","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170523185508_CIT0026","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/S0022-3565(24)37736-5","article-title":"The effects of stress on homeostasis in JCR-LA-cp rats: the role of nitric oxide","volume":"286","author":"Leza","year":"(1998)","journal-title":"J Pharm Exp Ther"},{"key":"key\n\t\t\t\t20170523185508_CIT0027","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s12192-012-0327-5","article-title":"The HSP co-inducer BGP-15 can prevent the metabolic side effects of the atypical antipsychotics","volume":"17","author":"Liter\u00e1ti-Nagy","year":"(2012)","journal-title":"Cell Stress Chaperones"},{"key":"key\n\t\t\t\t20170523185508_CIT0028","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1017\/S1461145711001775","article-title":"Risperidone normalizes increased inflammatory parameters and restores anti-inflammatory pathways in a model of neuroinflammation","volume":"16","author":"MacDowell","year":"(2013)","journal-title":"Int J Neuropsychop"},{"key":"key\n\t\t\t\t20170523185508_CIT0029","doi-asserted-by":"crossref","first-page":"561","DOI":"10.2174\/187152706778559327","article-title":"Stress-induced oxidative changes in brain","volume":"5","author":"Madrigal","year":"(2006)","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"key\n\t\t\t\t20170523185508_CIT0030","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1038\/tp.2011.37","article-title":"Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype","volume":"1","author":"McKernan","year":"(2011)","journal-title":"Transl Psychiatry"},{"key":"key\n\t\t\t\t20170523185508_CIT0031","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1359-6101(00)00006-X","article-title":"The biology of toll-like receptors","volume":"11","author":"Means","year":"(2000)","journal-title":"Cytokine Growth Factor Rev"},{"key":"key\n\t\t\t\t20170523185508_CIT0032","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/35100529","article-title":"Toll-like receptors and innate immunity","volume":"1","author":"Medzhitov","year":"(2001)","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170523185508_CIT0033","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pnpbp.2011.11.003","article-title":"Developmental neuroinflammation and schizophrenia","volume":"42","author":"Meyer","year":"(2013)","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"key\n\t\t\t\t20170523185508_CIT0034","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pharmthera.2011.06.003","article-title":"Inflammatory processes in schizophrenia: a promising neuroimmunological target for the treatment of negative\/cognitive symptoms and beyond","volume":"132","author":"Meyer","year":"(2011)","journal-title":"Pharmacol Ther"},{"key":"key\n\t\t\t\t20170523185508_CIT0035","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.psychres.2011.12.049","article-title":"Impaired monocyte activation in schizophrenia","volume":"198","author":"M\u00fcller","year":"(2012)","journal-title":"Psychiatry Res"},{"key":"key\n\t\t\t\t20170523185508_CIT0036","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000218075","article-title":"The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients","volume":"59","author":"Pae","year":"(2009)","journal-title":"Neuropsychobiology"},{"key":"key\n\t\t\t\t20170523185508_CIT0037","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/672395","article-title":"DAMPening inflammation by modulating TLR signaling","author":"Piccinini","year":"(2010)","journal-title":"Mediators Inflamm"},{"key":"key\n\t\t\t\t20170523185508_CIT0038","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/j.pnpbp.2008.07.018","article-title":"Effects of haloperidol and risperidone on the expression of heat shock protein 70 in MK-801-treated rat C6 glioma cells","volume":"32","author":"Roh","year":"(2008)","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"key\n\t\t\t\t20170523185508_CIT0501"},{"key":"key\n\t\t\t\t20170523185508_CIT0040","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.schres.2013.05.018","article-title":"Discordant patterns of bacterial translocation markers and implications for innate immune imbalances in schizophrenia","volume":"148","author":"Severance","year":"(2013)","journal-title":"Schizophr Res"},{"key":"key\n\t\t\t\t20170523185508_CIT0041","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1084\/jem.189.11.1777","article-title":"MD-2, a molecule that confers lipopolysaccharide responsiveness on toll like receptor 4","volume":"189","author":"Shimazu","year":"(1999)","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20170523185508_CIT0042","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/schbul\/sbt139","article-title":"Efficacy of anti-inflammatory agents to improve symptoms in patients with schizophrenia: an update","volume":"40","author":"Sommer","year":"(2013)","journal-title":"Schizophr Bull"},{"key":"key\n\t\t\t\t20170523185508_CIT0043","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.pnpbp.2008.12.006","article-title":"Atypical antipsychotics suppress production of proinflammatory cytokines and up-regulate interleukin-10 in lipopolysaccharide-treated mice","volume":"33","author":"Sugino","year":"(2009)","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"key\n\t\t\t\t20170523185508_CIT0044","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/npp.2010.29","article-title":"Psychiatric stress testing: novel strategy for translational psychopharmacology","volume":"35","author":"Stahl","year":"(2010)","journal-title":"Neuropsychopharmacology"},{"key":"key\n\t\t\t\t20170523185508_CIT0045","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/18715265112129990032","article-title":"Inflammation theories in psychotic disorders: a critical review","volume":"13","author":"Suvisaari","year":"(2013)","journal-title":"Infect Disord Drug Targets"},{"key":"key\n\t\t\t\t20170523185508_CIT0046","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1567-5769(01)00010-8","article-title":"Toll-like receptors: their physiological role and signal transduction system","volume":"1","author":"Takeuchi","year":"(2001)","journal-title":"Int Immunopharmacol"},{"key":"key\n\t\t\t\t20170523185508_CIT0047","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0968-0004(01)01801-1","article-title":"HMG1 and 2, and related \u2018architectural\u2019 DNA-binding proteins","volume":"26","author":"Thomas","year":"(2001)","journal-title":"Trends Biochem Sci"},{"key":"key\n\t\t\t\t20170523185508_CIT0048","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.pnpbp.2013.04.001","article-title":"The TRIPS (toll-like receptors in immuno-inflammatory pathogenesis) hypothesis: a novel postulate to understand schizophrenia","volume":"44","author":"Venkatasubramanian","year":"(2013)","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"key\n\t\t\t\t20170523185508_CIT0049","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.mehy.2004.08.011","article-title":"Gene, gut and schizophrenia: the meeting point for the gene-environment interaction in developing schizophrenia","volume":"64","author":"Wei","year":"(2005)","journal-title":"Med Hypotheses"},{"key":"key\n\t\t\t\t20170523185508_CIT0050","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.2741\/s119","article-title":"Targeting HMGB1\/TLR4 signaling as a novel approach to treatment of cerebral ischemia","volume":"2","author":"Yang","year":"(2010)","journal-title":"Front Biosci (Schol Ed)"}],"container-title":["International Journal of Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ijnp\/article-pdf\/18\/3\/pyu070\/17487247\/pyu070.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T03:20:30Z","timestamp":1748402430000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijnp\/article-lookup\/doi\/10.1093\/ijnp\/pyu070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,24]]},"references-count":51,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,1,24]]},"published-print":{"date-parts":[[2015,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ijnp\/pyu070","relation":{},"ISSN":["1469-5111","1461-1457"],"issn-type":[{"value":"1469-5111","type":"electronic"},{"value":"1461-1457","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1,24]]}}}