{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:51:57Z","timestamp":1778161917065,"version":"3.51.4"},"reference-count":60,"publisher":"Oxford University Press (OUP)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJNPPY"],"DOI":"10.1093\/ijnp\/pyw108","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T15:06:36Z","timestamp":1479913596000},"page":"pyw108","source":"Crossref","is-referenced-by-count":13,"title":["The ROCK Inhibitor Fasudil Prevents Chronic Restraint Stress-Induced Depressive-Like Behaviors and Dendritic Spine Loss in Rat Hippocampus"],"prefix":"10.1093","author":[{"given":"Gonzalo","family":"Garc\u00eda-Rojo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crist\u00f3bal","family":"Fresno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Vilches","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"D\u00edaz-V\u00e9liz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Mora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Aguayo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An\u00edbal","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00e1s","family":"Parra-Fiedler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio S.","family":"Parra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina S.","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Macarena","family":"Tejos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Aliaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny L.","family":"Fiedler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,12,7]]},"reference":[{"key":"2017010518102159000_pyw108v2.1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.34.20246"},{"key":"2017010518102159000_pyw108v2.2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.178.3.200"},{"key":"2017010518102159000_pyw108v2.3","doi-asserted-by":"publisher","DOI":"10.1037\/a0029699"},{"key":"2017010518102159000_pyw108v2.4","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.119"},{"key":"2017010518102159000_pyw108v2.5","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.physbeh.2013.05.012","article-title":"Factors influencing behavior in the forced swim test","volume":"118","author":"Bogdanova","year":"2013","journal-title":"Physiol Behav"},{"key":"2017010518102159000_pyw108v2.6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301410"},{"key":"2017010518102159000_pyw108v2.7","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e32832c70d9"},{"key":"2017010518102159000_pyw108v2.8","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00042.2005"},{"key":"2017010518102159000_pyw108v2.9","first-page":"417","article-title":"The role of the hippocampus in the pathophysiology of major depression","volume":"29","author":"Campbell","year":"2004","journal-title":"J Psychiatry Neurosci"},{"key":"2017010518102159000_pyw108v2.10","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1038\/mp.2015.176","article-title":"Activation of a ventral hippocampus-medial prefrontal cortex pathway is both necessary and sufficient for an antidepressant response to ketamine","volume":"21","author":"Carreno","year":"2016","journal-title":"Mol Psychiatry"},{"key":"2017010518102159000_pyw108v2.11","doi-asserted-by":"crossref","first-page":"Spc1","DOI":"10.1002\/jnr.23635","article-title":"Association of N-cadherin levels and downstream effectors of Rho GTPases with dendritic spine loss induced by chronic stress in rat hippocampal neurons","volume":"93","author":"Castaneda","year":"2015","journal-title":"J Neurosci Res"},{"key":"2017010518102159000_pyw108v2.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.03.008"},{"key":"2017010518102159000_pyw108v2.13","doi-asserted-by":"publisher","DOI":"10.1038\/nature03012"},{"key":"2017010518102159000_pyw108v2.14","doi-asserted-by":"crossref","first-page":"6503162","DOI":"10.1155\/2016\/6503162","article-title":"Coping with the Forced Swim Stressor: Towards Understanding an Adaptive Mechanism","volume":"2016","author":"de Kloet","year":"2016","journal-title":"Neural Plast"},{"key":"2017010518102159000_pyw108v2.15","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245592"},{"key":"2017010518102159000_pyw108v2.16","doi-asserted-by":"publisher","DOI":"10.1037\/1064-1297.5.2.107"},{"key":"2017010518102159000_pyw108v2.17","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-008-0189-x"},{"key":"2017010518102159000_pyw108v2.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.05.018"},{"key":"2017010518102159000_pyw108v2.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.03.053"},{"key":"2017010518102159000_pyw108v2.20","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1312592"},{"key":"2017010518102159000_pyw108v2.21","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1256405"},{"key":"2017010518102159000_pyw108v2.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2011.01.018"},{"key":"2017010518102159000_pyw108v2.23","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005385302064"},{"key":"2017010518102159000_pyw108v2.24","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1409"},{"key":"2017010518102159000_pyw108v2.25","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.141.7.1625"},{"key":"2017010518102159000_pyw108v2.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.10.030"},{"key":"2017010518102159000_pyw108v2.27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2015.04.004","article-title":"Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice","volume":"288","author":"Huang","year":"2015","journal-title":"Behav Brain Res"},{"key":"2017010518102159000_pyw108v2.28","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pnpbp.2014.10.008","article-title":"Infralimbic cortex Rho-kinase inhibition causes antidepressant-like activity in rats","volume":"57","author":"Inan","year":"2015","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2017010518102159000_pyw108v2.29","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.6.837"},{"key":"2017010518102159000_pyw108v2.30","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5272.245"},{"key":"2017010518102159000_pyw108v2.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.09.057"},{"key":"2017010518102159000_pyw108v2.32","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-060909-153204"},{"key":"2017010518102159000_pyw108v2.33","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-199711000-00010"},{"key":"2017010518102159000_pyw108v2.34","doi-asserted-by":"publisher","DOI":"10.1038\/35044547"},{"key":"2017010518102159000_pyw108v2.35","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.18.031802.150501"},{"key":"2017010518102159000_pyw108v2.36","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5429.895"},{"key":"2017010518102159000_pyw108v2.37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05331.x"},{"key":"2017010518102159000_pyw108v2.38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08103.x"},{"key":"2017010518102159000_pyw108v2.39","doi-asserted-by":"crossref","first-page":"5329","DOI":"10.1523\/JNEUROSCI.20-14-05329.2000","article-title":"Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons","volume":"20","author":"Nakayama","year":"2000","journal-title":"J Neurosci"},{"key":"2017010518102159000_pyw108v2.40","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1063(2000)10:5<582::AID-HIPO8>3.0.CO;2-K"},{"key":"2017010518102159000_pyw108v2.41","unstructured":"Paxinos G Watson CW . 1982. The rat brain in stereotaxic coordinates. Waltham, MA: Academic Press."},{"key":"2017010518102159000_pyw108v2.42","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-2048-7"},{"key":"2017010518102159000_pyw108v2.43","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301574"},{"key":"2017010518102159000_pyw108v2.44","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(79)90366-2"},{"key":"2017010518102159000_pyw108v2.45","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.104"},{"key":"2017010518102159000_pyw108v2.46","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600406"},{"key":"2017010518102159000_pyw108v2.47","doi-asserted-by":"publisher","DOI":"10.1037\/a0035302"},{"key":"2017010518102159000_pyw108v2.48","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2343"},{"key":"2017010518102159000_pyw108v2.49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-2-00177.x"},{"key":"2017010518102159000_pyw108v2.50","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12116"},{"key":"2017010518102159000_pyw108v2.51","doi-asserted-by":"crossref","first-page":"e1133266","DOI":"10.1080\/21592799.2015.1133266","article-title":"ROCK1 and ROCK2 inhibition alters dendritic spine morphology in hippocampal neurons","volume":"5","author":"Swanger","year":"2015","journal-title":"Cell Logist"},{"key":"2017010518102159000_pyw108v2.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.04.001"},{"key":"2017010518102159000_pyw108v2.53","doi-asserted-by":"publisher","DOI":"10.1038\/nature11740"},{"key":"2017010518102159000_pyw108v2.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2010.08.001"},{"key":"2017010518102159000_pyw108v2.55"},{"key":"2017010518102159000_pyw108v2.56","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature11617","article-title":"A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge","volume":"492","author":"Warden","year":"2012","journal-title":"Nature"},{"key":"2017010518102159000_pyw108v2.57","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s12013-014-9931-6","article-title":"Fasudil hydrochloride protects neurons in rat hippocampal CA1 region through inhibiting GluR6-MLK3-JNKs signal pathway","volume":"70","author":"Wei","year":"2014","journal-title":"Cell Biochem Biophys"},{"key":"2017010518102159000_pyw108v2.58","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-012-9845-z"},{"key":"2017010518102159000_pyw108v2.59","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.167924"},{"key":"2017010518102159000_pyw108v2.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.07.031"}],"container-title":["International Journal of Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ijnp\/article-pdf\/20\/4\/336\/14042040\/pyw108.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T18:29:32Z","timestamp":1568572172000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijnp\/article-lookup\/doi\/10.1093\/ijnp\/pyw108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,7]]},"references-count":60,"alternative-id":["10.1093\/ijnp\/pyw108"],"URL":"https:\/\/doi.org\/10.1093\/ijnp\/pyw108","relation":{},"ISSN":["1461-1457","1469-5111"],"issn-type":[{"value":"1461-1457","type":"print"},{"value":"1469-5111","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,7]]}}}