{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:35:41Z","timestamp":1792046141738,"version":"4.4.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K09819"],"award-info":[{"award-number":["15K09819"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K18883"],"award-info":[{"award-number":["16K18883"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K19796"],"award-info":[{"award-number":["16K19796"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"DOI":"10.1093\/ijnp\/pyx086","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T16:28:49Z","timestamp":1505406529000},"page":"236-241","source":"Crossref","is-referenced-by-count":20,"title":["Possible Association between Serum Matrix Metalloproteinase-9 (MMP-9) Levels and Relapse in Depressed Patients following Electroconvulsive Therapy (ECT)"],"prefix":"10.1093","volume":"21","author":[{"given":"Chiyo","family":"Shibasaki","sequence":"first","affiliation":[{"name":"Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Kure, Japan"},{"name":"Department of Psychiatry and Neurosciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Itagaki","sequence":"additional","affiliation":[{"name":"Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Kure, Japan"},{"name":"Department of Psychiatry, NHO Kure Medical Center and Chugoku Cancer Center, Kure, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Kure, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Kajitani","sequence":"additional","affiliation":[{"name":"Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Kure, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Okada-Tsuchioka","sequence":"additional","affiliation":[{"name":"Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Kure, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Takebayashi","sequence":"additional","affiliation":[{"name":"Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Kure, Japan"},{"name":"Department of Psychiatry, NHO Kure Medical Center and Chugoku Cancer Center, Kure, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,9,16]]},"reference":[{"key":"key\n\t\t\t\t20180305091446_CIT0001","volume-title":"The practice of electroconvulsive therapy: recommendations for treatment, training, and privileging: a task force report of the American Psychiatric Association","author":"American Psychiatric Association","year":"2001"},{"key":"key\n\t\t\t\t20180305091446_CIT0002","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jad.2016.03.068","article-title":"Role of MMP-2, MMP-7, MMP-9 and TIMP-2 in the development of recurrent depressive disorder","volume":"205","author":"Bobi\u0144ska","year":"2016","journal-title":"J Affect Disord"},{"key":"key\n\t\t\t\t20180305091446_CIT0003","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.12659\/MSM.895978","article-title":"Expression and Activity of metalloproteinases in depression","volume":"22","author":"Bobi\u0144ska","year":"2016","journal-title":"Med Sci Monit"},{"key":"key\n\t\t\t\t20180305091446_CIT0004","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.psyneuen.2015.12.012","article-title":"Association of peripheral inflammation with body mass index and depressive relapse in bipolar disorder","volume":"65","author":"Bond","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"key\n\t\t\t\t20180305091446_CIT0005","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00124509-200003000-00003","article-title":"Relapse of depression after ECT: a review","volume":"16","author":"Bourgon","year":"2000","journal-title":"J ECT"},{"key":"key\n\t\t\t\t20180305091446_CIT0006","doi-asserted-by":"crossref","first-page":"e9166","DOI":"10.1371\/journal.pone.0009166","article-title":"Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections","volume":"5","author":"Domenici","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180305091446_CIT0007","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/ajmg.a.36023","article-title":"High MMP-9 activity levels in fragile X syndrome are lowered by minocycline","volume":"161","author":"Dziembowska","year":"2013","journal-title":"Am J Med Genet Part A"},{"key":"key\n\t\t\t\t20180305091446_CIT0008","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neuroscience.2013.04.060","article-title":"Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications","volume":"246","author":"Felger","year":"2013","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20180305091446_CIT0009","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/PSY.0b013e3181960e7f","article-title":"Plasma levels of matrix metalloproteinase-9 are independently associated with psychosocial factors in a middle-aged normal population","volume":"71","author":"Garvin","year":"2009","journal-title":"Psychosom Med"},{"key":"key\n\t\t\t\t20180305091446_CIT0010","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1017\/S1461145710000891","article-title":"Characterization of electroconvulsive seizure-induced TIMP-1 and MMP-9 in hippocampal vasculature","volume":"14","author":"Girgenti","year":"2011","journal-title":"Int J Neuropsychopharmacol"},{"key":"key\n\t\t\t\t20180305091446_CIT0011","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/00019442-199400210-00007","article-title":"Sleep electroencephalographic studies after ECT","volume":"2","author":"Grunhaus","year":"1994","journal-title":"Am J Geriatr Psychiatry"},{"key":"key\n\t\t\t\t20180305091446_CIT0012","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/JCP.0b013e3181ee0f5f","article-title":"Antidepressant pharmacotherapy failure and response to subsequent electroconvulsive therapy","volume":"30","author":"Heijnen","year":"2010","journal-title":"J Clin Psychopharmacol"},{"key":"key\n\t\t\t\t20180305091446_CIT0013","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00124509-200312000-00002","article-title":"Raised plasma levels of tumor necrosis factor alpha in patients with depression: normalization during electroconvulsive therapy","volume":"19","author":"Hestad","year":"2003","journal-title":"J ECT"},{"key":"key\n\t\t\t\t20180305091446_CIT0014","first-page":"966","article-title":"Matrix metalloproteinases in peripheral blood and cerebrospinal fluid in patients with Alzheimer\u2019s disease","volume":"226","author":"Horstmann","year":"2017","journal-title":"Int Psychogeriatrics C Int Psychogeriatr Assoc"},{"key":"key\n\t\t\t\t20180305091446_CIT0015","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jad.2016.08.047","article-title":"Factors associated with relapse after a response to electroconvulsive therapy in unipolar versus bipolar depression","volume":"208","author":"Itagaki","year":"2017","journal-title":"J Affect Disord"},{"key":"key\n\t\t\t\t20180305091446_CIT0016","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1038\/npp.2013.149","article-title":"Relapse following successful electroconvulsive therapy for major depression: a meta-analysis","volume":"38","author":"Jelovac","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"key\n\t\t\t\t20180305091446_CIT0017","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1001\/archpsyc.63.12.1337","article-title":"Continuation electroconvulsive therapy vs pharmacotherapy for relapse prevention in major depression","volume":"63","author":"Kellner","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"key\n\t\t\t\t20180305091446_CIT0018","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4062\/biomolther.2012.20.2.133","article-title":"Matrix metalloproteinases, new insights into the understanding of neurodegenerative disorders","volume":"20","author":"Kim Y-","year":"2012","journal-title":"Biomol Ther"},{"key":"key\n\t\t\t\t20180305091446_CIT0019","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.pnpbp.2011.09.006","article-title":"Activation of cell-mediated immunity in depression: association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression","volume":"36","author":"Maes","year":"2012","journal-title":"Prog Neuro-Psychopharmacology Biol Psychiatry"},{"key":"key\n\t\t\t\t20180305091446_CIT0020","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/YCT.0b013e3182887b7a","article-title":"Long-term naturalistic follow-up of patients with bipolar depression and mixed state treated with electroconvulsive therapy","volume":"29","author":"Medda","year":"2013","journal-title":"J ECT"},{"key":"key\n\t\t\t\t20180305091446_CIT0021","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1468-1331.2009.02775.x","article-title":"Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis","volume":"17","author":"Niebroj-Dobosz","year":"2010","journal-title":"Eur J Neurol"},{"key":"key\n\t\t\t\t20180305091446_CIT0022","first-page":"470985","article-title":"Predictors of time to relapse\/recurrence after electroconvulsive therapy in patients with major depressive disorder: a population-based cohort study","author":"Nordenskj\u00f6ld","year":"2011","journal-title":"Depress Res Treat"},{"key":"key\n\t\t\t\t20180305091446_CIT0023","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pnpbp.2014.01.013","article-title":"Inflamed moods: a review of the interactions between inflammation and mood disorders","volume":"53","author":"Rosenblat","year":"2014","journal-title":"Prog Neuro-Psychopharmacology Biol Psychiatry"},{"key":"key\n\t\t\t\t20180305091446_CIT0024","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/YCT.0b013e3182843942","article-title":"Changes of cytokine profiles during electroconvulsive therapy in patients with major depression","volume":"29","author":"Rotter","year":"2013","journal-title":"J ECT"},{"key":"key\n\t\t\t\t20180305091446_CIT0025","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jad.2012.07.019","article-title":"Increased serum matrix metalloproteinase-9 (MMP-9) levels in young patients during bipolar depression","volume":"146","author":"Rybakowski","year":"2013","journal-title":"J Affect Disord"},{"key":"key\n\t\t\t\t20180305091446_CIT0026","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.mam.2011.10.015","article-title":"Human matrix metalloproteinases: an ubiquitarian class of enzymes involved in several pathological processes","volume":"33","author":"Sbardella","year":"2012","journal-title":"Mol Aspects Med"},{"key":"key\n\t\t\t\t20180305091446_CIT0030","author":"Shibasaki"},{"key":"key\n\t\t\t\t20180305091446_CIT0027","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyw019","article-title":"Altered serum levels of matrix metalloproteinase-2, -9 in response to electroconvulsive therapy for mood disorders","volume":"19","author":"Shibasaki","year":"2016","journal-title":"Int J Neuropsychopharmacol"},{"key":"key\n\t\t\t\t20180305091446_CIT0028","doi-asserted-by":"crossref","first-page":"9867","DOI":"10.1523\/JNEUROSCI.1162-14.2014","article-title":"Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile X syndrome in a mouse model","volume":"34","author":"Sidhu","year":"2014","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180305091446_CIT0029","doi-asserted-by":"crossref","first-page":"e42676","DOI":"10.1371\/journal.pone.0042676","article-title":"Decreased Serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder","volume":"7","author":"Yoshida","year":"2012","journal-title":"PLoS One"}],"container-title":["International Journal of Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ijnp\/article-pdf\/21\/3\/236\/24250354\/pyx086.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T09:15:00Z","timestamp":1520241300000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijnp\/article\/21\/3\/236\/4159412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,16]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,9,16]]},"published-print":{"date-parts":[[2018,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ijnp\/pyx086","relation":{},"ISSN":["1461-1457","1469-5111"],"issn-type":[{"value":"1461-1457","type":"print"},{"value":"1469-5111","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,3]]},"published":{"date-parts":[[2017,9,16]]}}}