{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:05:43Z","timestamp":1792785943147,"version":"4.5.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2018,5,12]],"date-time":"2018-05-12T00:00:00Z","timestamp":1526083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Association of Specialization and Scientific Guidance (Lebanon). O.H."},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,1]]},"DOI":"10.1093\/ijnp\/pyy043","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T07:37:58Z","timestamp":1525851478000},"page":"871-882","source":"Crossref","is-referenced-by-count":92,"title":["Motor Impairments Correlate with Social Deficits and Restricted Neuronal Loss in an Environmental Model of Autism"],"prefix":"10.1093","volume":"21","author":[{"given":"Tareq","family":"Al Sagheer","sequence":"first","affiliation":[{"name":"INSERM U-1084, Experimental and Clinical Neurosciences Laboratory, University of Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obelia","family":"Haida","sequence":"additional","affiliation":[{"name":"INSERM U-1084, Experimental and Clinical Neurosciences Laboratory, University of Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anais","family":"Balbous","sequence":"additional","affiliation":[{"name":"INSERM U-1084, Experimental and Clinical Neurosciences Laboratory, University of Poitiers, Poitiers, France"},{"name":"CHU Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Francheteau","sequence":"additional","affiliation":[{"name":"INSERM U-1084, Experimental and Clinical Neurosciences Laboratory, University of Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Matas","sequence":"additional","affiliation":[{"name":"INSERM U-1084, Experimental and Clinical Neurosciences Laboratory, University of Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Olivier","family":"Fernagut","sequence":"additional","affiliation":[{"name":"INSERM U-1084, Experimental and Clinical Neurosciences Laboratory, University of Poitiers, Poitiers, France"},{"name":"Universit\u00e9 de Bordeaux, Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, UMR, Bordeaux, France"},{"name":"CNRS, Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, UMR, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Jaber","sequence":"additional","affiliation":[{"name":"INSERM U-1084, Experimental and Clinical Neurosciences Laboratory, University of Poitiers, Poitiers, France"},{"name":"CHU Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,5,12]]},"reference":[{"key":"key\n\t\t\t\t20180901065402_CIT0001","volume-title":"Diagnostic and statistical manual of mental disorders","author":"APA","year":"2013","edition":"5th ed"},{"key":"key\n\t\t\t\t20180901065402_CIT0002","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ijdevneu.2004.11.001","article-title":"The teratology of autism","volume":"23","author":"Arndt","year":"2005","journal-title":"Int J Dev Neurosci"},{"key":"key\n\t\t\t\t20180901065402_CIT0003","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/BF01837709","article-title":"Die autistisehen psychopathen im kindesalter","volume":"117","author":"Asperger","year":"1944","journal-title":"Arch Psychiatr Nurs"},{"key":"key\n\t\t\t\t20180901065402_CIT0004","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/brain\/121.5.889","article-title":"A clinicopathological study of autism","volume":"121","author":"Bailey","year":"1998","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180901065402_CIT0005","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.infbeh.2012.07.019","article-title":"Relation between early motor delay and later communication delay in infants at risk for autism","volume":"35","author":"Bhat","year":"2012","journal-title":"Infant Behav Dev"},{"key":"key\n\t\t\t\t20180901065402_CIT0006","doi-asserted-by":"crossref","first-page":"8452","DOI":"10.1073\/pnas.1000496107","article-title":"The basal ganglia communicate with the cerebellum","volume":"107","author":"Bostan","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20180901065402_CIT0007","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/1028415X.2015.1133029","article-title":"The effect of ketogenic diet in an animal model of autism induced by prenatal exposure to valproic acid","volume":"20","author":"Castro","year":"2017","journal-title":"Nutr Neurosci"},{"key":"key\n\t\t\t\t20180901065402_CIT0008","volume-title":"Health, United States, 2014: with special feature on adults aged 55\u201364","author":"CDC","year":"2014"},{"key":"key\n\t\t\t\t20180901065402_CIT0009","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1469-8749.1994.tb11858.x","article-title":"Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs","volume":"36","author":"Christianson","year":"1994","journal-title":"Dev Med Child Neurol"},{"key":"key\n\t\t\t\t20180901065402_CIT0010","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2214\/ajr.162.1.8273650","article-title":"Abnormality of cerebellar vermian lobules VI and VII in patients with infantile autism: identification of hypoplastic and hyperplastic subgroups with MR imaging","volume":"162","author":"Courchesne","year":"1994","journal-title":"AJR Am J Roentgenol"},{"key":"key\n\t\t\t\t20180901065402_CIT0011","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.braindev.2008.04.005","article-title":"An exploration of symmetry in early autism spectrum disorders: analysis of lying","volume":"31","author":"Esposito","year":"2009","journal-title":"Brain Dev"},{"key":"key\n\t\t\t\t20180901065402_CIT0012","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s12311-012-0355-9","article-title":"Consensus paper: pathological role of the cerebellum in autism","volume":"11","author":"Fatemi","year":"2012","journal-title":"Cerebellum"},{"key":"key\n\t\t\t\t20180901065402_CIT0013","doi-asserted-by":"crossref","first-page":"9434","DOI":"10.1523\/JNEUROSCI.3080-04.2004","article-title":"Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein","volume":"24","author":"Fleming","year":"2004","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180901065402_CIT0014","doi-asserted-by":"crossref","DOI":"10.3791\/50303","article-title":"Assessment of sensorimotor function in mouse models of Parkinson\u2019s disease","author":"Fleming","year":"2013","journal-title":"J Vis Exp"},{"key":"key\n\t\t\t\t20180901065402_CIT0015","volume-title":"The mouse brain in stereotaxic coordinates","author":"Franklin","year":"2008"},{"key":"key\n\t\t\t\t20180901065402_CIT0016","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.biopsych.2010.09.031","article-title":"Validating \u03b3 oscillations and delayed auditory responses as translational biomarkers of autism","volume":"68","author":"Gandal","year":"2010","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20180901065402_CIT0017","doi-asserted-by":"crossref","first-page":"27400","DOI":"10.1038\/srep27400","article-title":"Distinct defects in synaptic differentiation of neocortical neurons in response to prenatal valproate exposure","volume":"6","author":"Iijima","year":"2016","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20180901065402_CIT0018","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrn.2015.8","article-title":"Neurobiology of rodent self-grooming and its value for translational neuroscience","volume":"17","author":"Kalueff","year":"2016","journal-title":"Nat Rev Neurosci"},{"key":"key\n\t\t\t\t20180901065402_CIT0019","first-page":"217","article-title":"Autistic disturbances of affective contact","volume":"2","author":"Kanner","year":"1943","journal-title":"Nerv Child"},{"key":"key\n\t\t\t\t20180901065402_CIT0020","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1542\/peds.2009-2680","article-title":"Early medical and behavioral characteristics of NICU infants later classified with ASD","volume":"126","author":"Karmel","year":"2010","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t20180901065402_CIT0021","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1017\/S1461145711001714","article-title":"Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid","volume":"16","author":"Kataoka","year":"2013","journal-title":"Int J Neuropsychopharmacol"},{"key":"key\n\t\t\t\t20180901065402_CIT0022","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ridd.2017.10.025","article-title":"Comparing motor performance, praxis, coordination, and interpersonal synchrony between children with and without autism spectrum disorder (ASD)","volume":"72","author":"Kaur","year":"2018","journal-title":"Res Dev Disabil"},{"key":"key\n\t\t\t\t20180901065402_CIT0023","doi-asserted-by":"crossref","first-page":"8432","DOI":"10.1523\/JNEUROSCI.23-23-08432.2003","article-title":"Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate","volume":"23","author":"Kelly","year":"2003","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180901065402_CIT0024","doi-asserted-by":"crossref","first-page":"e104927","DOI":"10.1371\/journal.pone.0104927","article-title":"Subchronic treatment of donepezil rescues impaired social, hyperactive, and stereotypic behavior in valproic acid-induced animal model of autism","volume":"9","author":"Kim","year":"2014","journal-title":"Plos One"},{"key":"key\n\t\t\t\t20180901065402_CIT0025","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s12035-013-8535-2","article-title":"Pax6-dependent cortical glutamatergic neuronal differentiation regulates autism-like behavior in prenatally valproic acid-exposed rat offspring","volume":"49","author":"Kim","year":"2014","journal-title":"Mol Neurobiol"},{"key":"key\n\t\t\t\t20180901065402_CIT0026","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1467-8624.2012.01870.x","article-title":"Developmental trajectories in children with and without autism spectrum disorders: the first 3 years","volume":"84","author":"Landa","year":"2013","journal-title":"Child Dev"},{"key":"key\n\t\t\t\t20180901065402_CIT0027","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jaac.2017.03.013","article-title":"What is the male-to-female ratio in autism spectrum disorder? A systematic review and meta-analysis","volume":"56","author":"Loomes","year":"2017","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"key\n\t\t\t\t20180901065402_CIT0028","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuroscience.2016.10.052","article-title":"Repeated prenatal exposure to valproic acid results in cerebellar hypoplasia and ataxia","volume":"340","author":"Main","year":"2017","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20180901065402_CIT0029","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/brain\/awu394","article-title":"Behavioural and neural basis of anomalous motor learning in children with autism","volume":"138","author":"Marko","year":"2015","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180901065402_CIT0030","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.braindev.2007.03.002","article-title":"Prevalence of motor impairment in autism spectrum disorders","volume":"29","author":"Ming","year":"2007","journal-title":"Brain Dev"},{"key":"key\n\t\t\t\t20180901065402_CIT0031","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1136\/jmg.37.7.489","article-title":"A clinical study of 57 children with fetal anticonvulsant syndromes","volume":"37","author":"Moore","year":"2000","journal-title":"J Med Genet"},{"key":"key\n\t\t\t\t20180901065402_CIT0032","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0940-9602(11)80209-8","article-title":"Mammalian neural crest and neural crest derivatives","volume":"175","author":"Morriss-Kay","year":"1993","journal-title":"Ann Anat"},{"key":"key\n\t\t\t\t20180901065402_CIT0033","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1601-1848.2004.00076.x","article-title":"Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice","volume":"3","author":"Moy","year":"2004","journal-title":"Genes Brain Behav"},{"key":"key\n\t\t\t\t20180901065402_CIT0034","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.biopsych.2015.08.029","article-title":"Intrinsic visual-motor synchrony correlates with social deficits in autism","volume":"79","author":"Nebel","year":"2016","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20180901065402_CIT0035","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.expneurol.2017.04.017","article-title":"The valproic acid-induced rodent model of autism","volume":"299","author":"Nicolini","year":"2018","journal-title":"Exp Neurol"},{"key":"key\n\t\t\t\t20180901065402_CIT0036","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s10803-007-0430-0","article-title":"Gross motor development, movement abnormalities, and early identification of autism","volume":"38","author":"Ozonoff","year":"2008","journal-title":"J Autism Dev Disord"},{"key":"key\n\t\t\t\t20180901065402_CIT0037","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0006-3223(00)01008-8","article-title":"Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autism","volume":"49","author":"Pierce","year":"2001","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20180901065402_CIT0038","doi-asserted-by":"crossref","first-page":"5586","DOI":"10.1038\/ncomms6586","article-title":"Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism","volume":"5","author":"Piochon","year":"2014","journal-title":"Nat Commun"},{"key":"key\n\t\t\t\t20180901065402_CIT0039","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1017\/S0012162205001076","article-title":"Characteristics of fetal anticonvulsant syndrome associated autistic disorder","volume":"47","author":"Rasalam","year":"2005","journal-title":"Dev Med Child Neurol"},{"key":"key\n\t\t\t\t20180901065402_CIT0040","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/(SICI)1096-9861(19960624)370:2<247::AID-CNE8>3.0.CO;2-2","article-title":"Embryological origin for autism: developmental anomalies of the cranial nerve motor nuclei","volume":"370","author":"Rodier","year":"1996","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180901065402_CIT0041","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s003359900551","article-title":"Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment","volume":"8","author":"Rogers","year":"1997","journal-title":"Mamm Genome"},{"key":"key\n\t\t\t\t20180901065402_CIT0042","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.neuroscience.2010.06.069","article-title":"Behavioral and molecular changes in the mouse in response to prenatal exposure to the anti-epileptic drug valproic acid","volume":"170","author":"Roullet","year":"2010","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20180901065402_CIT0043","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/sj.npp.1300518","article-title":"Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism","volume":"30","author":"Schneider","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"key\n\t\t\t\t20180901065402_CIT0044","doi-asserted-by":"crossref","first-page":"e81255","DOI":"10.1371\/journal.pone.0081255","article-title":"Regional alterations in purkinje cell density in patients with autism","volume":"9","author":"Skefos","year":"2014","journal-title":"Plos One"},{"key":"key\n\t\t\t\t20180901065402_CIT0045","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/dev.20337","article-title":"Altered morphology of motor cortex neurons in the VPA rat model of autism","volume":"50","author":"Snow","year":"2008","journal-title":"Dev Psychobiol"},{"key":"key\n\t\t\t\t20180901065402_CIT0046","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/j.neuroimage.2011.08.065","article-title":"Functional topography of the cerebellum for motor and cognitive tasks: an fmri study","volume":"59","author":"Stoodley","year":"2012","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20180901065402_CIT0047","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1038\/s41593-017-0004-1","article-title":"Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice","volume":"20","author":"Stoodley","year":"2017","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20180901065402_CIT0048","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.rasd.2015.11.013","article-title":"Looking behind the mask: social coping strategies of girls on the autistic spectrum","volume":"23","author":"Tierney","year":"2016","journal-title":"Res Autism Spectr Disord"},{"key":"key\n\t\t\t\t20180901065402_CIT0049","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nature11310","article-title":"Autistic-like behaviour and cerebellar dysfunction in purkinje cell tsc1 mutant mice","volume":"488","author":"Tsai","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180901065402_CIT0050","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s10803-006-0117-y","article-title":"A new neurobehavioral model of autism in mice: pre- and postnatal exposure to sodium valproate","volume":"36","author":"Wagner","year":"2006","journal-title":"J Autism Dev Disord"},{"key":"key\n\t\t\t\t20180901065402_CIT0051","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s40478-014-0141-7","article-title":"Stereological study of the neuronal number and volume of 38 brain subdivisions of subjects diagnosed with autism reveals significant alterations restricted to the striatum, amygdala and cerebellum","volume":"2","author":"Wegiel","year":"2014","journal-title":"Acta Neuropathol Commun"},{"key":"key\n\t\t\t\t20180901065402_CIT0052","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.neuroscience.2006.03.070","article-title":"Stereological estimation of purkinje neuron number in C57BL\/6 mice and its relation to associative learning","volume":"141","author":"Woodruff-Pak","year":"2006","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20180901065402_CIT0053","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbr.2017.06.035","article-title":"Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice","volume":"333","author":"Yamaguchi","year":"2017","journal-title":"Behav Brain Res"},{"key":"key\n\t\t\t\t20180901065402_CIT0054","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1469-7610.2010.02214.x","article-title":"The prodrome of autism: early behavioral and biological signs, regression, peri- and post-natal development and genetics","volume":"51","author":"Yirmiya","year":"2010","journal-title":"J Child Psychol Psychiatry"}],"container-title":["International Journal of Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ijnp\/article-pdf\/21\/9\/871\/25645775\/pyy043.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T15:54:14Z","timestamp":1571327654000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijnp\/article\/21\/9\/871\/4995459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,12]]},"references-count":54,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,5,12]]},"published-print":{"date-parts":[[2018,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ijnp\/pyy043","relation":{},"ISSN":["1461-1457","1469-5111"],"issn-type":[{"value":"1461-1457","type":"print"},{"value":"1469-5111","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,9]]},"published":{"date-parts":[[2018,5,12]]}}}