{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:39:28Z","timestamp":1792143568765,"version":"4.4.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["SFB-TRR-58"],"award-info":[{"award-number":["SFB-TRR-58"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"German Ministry of Research and Education","award":["01EE1402F"],"award-info":[{"award-number":["01EE1402F"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,1]]},"DOI":"10.1093\/ijnp\/pyy050","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T07:19:05Z","timestamp":1527664745000},"page":"822-827","source":"Crossref","is-referenced-by-count":45,"title":["Plasticity of Functional MAOA Gene Methylation in Acrophobia"],"prefix":"10.1093","volume":"21","author":[{"given":"Miriam A","family":"Schiele","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical Center \u2013 University of Freiburg, Faculty of Medicine, University of Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical Center \u2013 University of Freiburg, Faculty of Medicine, University of Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Kollert","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychosomatics and Psychotherapy, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Katzorke","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychosomatics and Psychotherapy, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schartner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychosomatics and Psychotherapy, University of W\u00fcrzburg, W\u00fcrzburg, Germany"},{"name":"Department of Physiology, University of California, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Busch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychosomatics and Psychotherapy, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gromer","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Clinical Psychology and Psychotherapy, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Reif","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe-University, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Pauli","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Clinical Psychology and Psychotherapy, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Deckert","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychosomatics and Psychotherapy, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychosomatics and Psychotherapy, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Domschke","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical Center \u2013 University of Freiburg, Faculty of Medicine, University of Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,5,31]]},"reference":[{"key":"key\n\t\t\t\t20180901065355_CIT0001","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/0005-7967(89)90091-0","article-title":"Cardiac and neuroendocrine responses to exposure therapy in height phobics: Desynchrony within the \u201cphysiological response system.\u201d","volume":"27","author":"Abelson","year":"1989","journal-title":"Behav Res Ther"},{"key":"key\n\t\t\t\t20180901065355_CIT0002","doi-asserted-by":"crossref","first-page":"e14524","DOI":"10.1371\/journal.pone.0014524","article-title":"DNA methylation of the first exon is tightly linked to transcriptional silencing","volume":"6","author":"Brenet","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180901065355_CIT0003","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1192\/bjp.bp.114.144964","article-title":"Monoamine oxidase A gene promoter methylation and transcriptional downregulation in an offender population with antisocial personality disorder","volume":"206","author":"Checknita","year":"2015","journal-title":"Br J Psychiatry"},{"key":"key\n\t\t\t\t20180901065355_CIT0004","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0005-7894(77)80116-0","article-title":"Comparison of self-report and overt-behavioral procedures for assessing acrophobia","volume":"8","author":"Cohen","year":"1977","journal-title":"Behav Therapy"},{"key":"key\n\t\t\t\t20180901065355_CIT0005","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1017\/S146114571200020X","article-title":"Monoamine oxidase A gene DNA hypomethylation - a risk factor for panic disorder","volume":"15","author":"Domschke","year":"2012","journal-title":"Int J Neuropsychopharmacol"},{"key":"key\n\t\t\t\t20180901065355_CIT0006","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.pnpbp.2013.07.014","article-title":"Epigenetic signature of panic disorder: a role of glutamate decarboxylase 1 (GAD1) DNA hypomethylation","volume":"46","author":"Domschke","year":"2013","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"key\n\t\t\t\t20180901065355_CIT0007","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1017\/S146114571400039X","article-title":"Serotonin transporter gene hypomethylation predicts impaired antidepressant treatment response","volume":"17","author":"Domschke","year":"2014","journal-title":"Int J Neuropsychopharmacol"},{"key":"key\n\t\t\t\t20180901065355_CIT0008","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00702-014-1227-x","article-title":"Pharmacoepigenetics of depression: no major influence of MAO-A DNA methylation on treatment response","volume":"122","author":"Domschke","year":"2015","journal-title":"J Neural Transm"},{"key":"key\n\t\t\t\t20180901065355_CIT0009","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11055-006-0022-z","article-title":"Acquisition and extinction of a conditioned passive avoidance reflex in mice with genetic knockout of monoamine oxidase A","volume":"36","author":"Dubrovina","year":"2006","journal-title":"Neurosci Behav Physiol"},{"key":"key\n\t\t\t\t20180901065355_CIT0010","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.brs.2016.11.007","article-title":"Medial prefrontal cortex stimulation accelerates therapy response of exposure therapy in acrophobia","volume":"10","author":"Herrmann","year":"2016","journal-title":"Brain Stimul"},{"key":"key\n\t\t\t\t20180901065355_CIT0011","first-page":"383","article-title":"Human monoamine oxidase A gene determines levels of enzyme activity","volume":"49","author":"Hotamisligil","year":"1991","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t20180901065355_CIT0012","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nn.3302","article-title":"Epigenetics and persistent memory: implications for reconsolidation and silent extinction beyond the zero","volume":"16","author":"Lattal","year":"2013","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20180901065355_CIT0013","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1093\/bioinformatics\/bth346","article-title":"Quantitative DNA methylation analysis based on four-dye trace data from direct sequencing of PCR amplificates","volume":"20","author":"Lewin","year":"2004","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20180901065355_CIT0014","first-page":"1","article-title":"Influence of information and instructions on human behavior in tunnel accidents: a virtual reality study","volume":"12","author":"M\u00fchlberger","year":"2015","journal-title":"JVRB"},{"key":"key\n\t\t\t\t20180901065355_CIT0015","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/ajmg.b.32085","article-title":"Meta-analysis argues for a female-specific role of MAOA-uVNTR in panic disorder in four European populations","volume":"159B","author":"Reif","year":"2012","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"key\n\t\t\t\t20180901065355_CIT0016","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/tp.2014.83","article-title":"Serotonin transporter [corrected] methylation and response to cognitive behaviour therapy in children with anxiety disorders","volume":"4","author":"Roberts","year":"2014","journal-title":"Transl Psychiatry"},{"key":"key\n\t\t\t\t20180901065355_CIT0017","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/da.22430","article-title":"HPA axis related genes and response to psychological therapies: genetics and epigenetics","volume":"32","author":"Roberts","year":"2015","journal-title":"Depress Anxiety"},{"key":"key\n\t\t\t\t20180901065355_CIT0018","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.psychres.2004.05.012","article-title":"Association studies of MAO-A, COMT, and 5-HTT genes polymorphisms in patients with anxiety disorders of the phobic spectrum","volume":"128","author":"Samochowiec","year":"2004","journal-title":"Psychiatry Res"},{"key":"key\n\t\t\t\t20180901065355_CIT0019","doi-asserted-by":"crossref","DOI":"10.1111\/gbb.12423","article-title":"Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders","author":"Schiele","year":"2018","journal-title":"Genes Brain Behav"},{"key":"key\n\t\t\t\t20180901065355_CIT0020","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4161\/epi.21976","article-title":"Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men","volume":"7","author":"Shumay","year":"2012","journal-title":"Epigenetics"},{"key":"key\n\t\t\t\t20180901065355_CIT0021","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.nlm.2011.04.012","article-title":"Is an epigenetic switch the key to persistent extinction","volume":"96","author":"Stafford","year":"2011","journal-title":"Neurobiol Learn Mem"},{"key":"key\n\t\t\t\t20180901065355_CIT0022","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/mp.2013.58","article-title":"Methylation of the promoter of brain-derived neurotrophic factor exon IV and antidepressant response in major depression","volume":"19","author":"Tadi\u0107","year":"2014","journal-title":"Mol Psychiatry"},{"key":"key\n\t\t\t\t20180901065355_CIT0023","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1042\/BST20130233","article-title":"HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: where do we stand","volume":"42","author":"Whittle","year":"2014","journal-title":"Biochem Soc T"},{"key":"key\n\t\t\t\t20180901065355_CIT0024","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/npp.2015.2","article-title":"Oxytocin receptor gene methylation: converging multilevel evidence for a role in social anxiety","volume":"40","author":"Ziegler","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"key\n\t\t\t\t20180901065355_CIT0025","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.41","article-title":"MAOA gene hypomethylation in panic disorder-reversibility of an epigenetic risk pattern by psychotherapy","volume":"6","author":"Ziegler","year":"2016","journal-title":"Transl Psychiatry"},{"key":"key\n\t\t\t\t20180901065355_CIT0026","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyx111","article-title":"Monoamine oxidase A gene methylation and its role in posttraumatic stress disorder - first evidence from the South Eastern Europe (SEE)-PTSD study","author":"Ziegler","year":"2018","journal-title":"Int J Neuropsychopharmacol"}],"container-title":["International Journal of Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ijnp\/article-pdf\/21\/9\/822\/25645720\/pyy050.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T16:40:50Z","timestamp":1571416850000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijnp\/article\/21\/9\/822\/5026103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,31]]},"references-count":26,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,5,31]]},"published-print":{"date-parts":[[2018,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ijnp\/pyy050","relation":{},"ISSN":["1461-1457","1469-5111"],"issn-type":[{"value":"1461-1457","type":"print"},{"value":"1469-5111","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,9]]},"published":{"date-parts":[[2018,5,31]]}}}