{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:44:00Z","timestamp":1773679440492,"version":"3.50.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301099"],"award-info":[{"award-number":["81301099"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773698"],"award-info":[{"award-number":["81773698"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872735"],"award-info":[{"award-number":["81872735"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundation for Science and Technology Program","award":["2016A020217008"],"award-info":[{"award-number":["2016A020217008"]}]},{"name":"Science and Technology Program of Guangzhou","award":["201604020112"],"award-info":[{"award-number":["201604020112"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["S2013040014202"],"award-info":[{"award-number":["S2013040014202"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A030313046"],"award-info":[{"award-number":["2018A030313046"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,1]]},"DOI":"10.1093\/ijnp\/pyy092","type":"journal-article","created":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T12:08:40Z","timestamp":1541246920000},"page":"143-156","source":"Crossref","is-referenced-by-count":25,"title":["Inhibition of Phosphodiesterase 4 by FCPR03 Alleviates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors and Prevents Dendritic Spine Loss in Mice Hippocampi"],"prefix":"10.1093","volume":"22","author":[{"given":"Hui","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Neuropharmacology and Drug DiscoverySouthern Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahong","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology and Drug DiscoverySouthern Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology and Drug DiscoverySouthern Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuping","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology and Drug DiscoverySouthern Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology and Drug DiscoverySouthern Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinfeng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology and Drug DiscoverySouthern Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manna","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology and Drug DiscoverySouthern Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongzhen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology and Drug DiscoverySouthern Medical University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of New Drug ScreeningSouthern Medical University, Guangzhou, China"},{"name":"School of Pharmaceutical Sciences, and Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology and Drug DiscoverySouthern Medical University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of New Drug ScreeningSouthern Medical University, Guangzhou, China"},{"name":"School of Pharmaceutical Sciences, and Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology and Drug DiscoverySouthern Medical University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of New Drug ScreeningSouthern Medical University, Guangzhou, China"},{"name":"School of Pharmaceutical Sciences, and Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"key\n\t\t\t\t2019021603400139500_CIT0001","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1667\/RR14103.1","article-title":"(56)fe irradiation alters spine density and dendritic complexity in the mouse hippocampus","volume":"184","author":"Allen","year":"2015","journal-title":"Radiat Res"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0002","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/978-3-319-58811-7_4","article-title":"The PDE4 camp-specific phosphodiesterases: targets for drugs with antidepressant and memory-enhancing action","volume":"17","author":"Bolger","year":"2017","journal-title":"Adv Neurobiol"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0003","first-page":"121","article-title":"PDE4 inhibitors as potential therapeutic agents in the treatment of COPD-focus on roflumilast","volume":"2","author":"Boswell-Smith","year":"2007","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0058","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0006-3223(00)01114-8","article-title":"Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect","volume":"49","author":"Chen","year":"2001","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0004","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jad.2015.06.040","article-title":"The GSK3B gene confers risk for both major depressive disorder and schizophrenia in the han chinese population","volume":"185","author":"Chen","year":"2015","journal-title":"J Affect Disord"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0005","first-page":"CD002309","article-title":"Phosphodiesterase 4 inhibitors for chronic obstructive pulmonary disease","volume":"9","author":"Chong","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0006","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.jaac.2017.07.783","article-title":"Suicide attempts in juvenile bipolar versus major depressive disorders: systematic review and meta-analysis","volume":"56","author":"De Crescenzo","year":"2017","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0007","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1093\/brain\/awu280","article-title":"Immunotherapy alleviates amyloid-associated synaptic pathology in an alzheimer\u2019s disease mouse model","volume":"137","author":"Dorostkar","year":"2014","journal-title":"Brain"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0008","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1016\/S0140-6736(05)79827-5","article-title":"Increased temporal cortex CREB concentrations and antidepressant treatment in major depression","volume":"352","author":"Dowlatshahi","year":"1998","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0009","doi-asserted-by":"crossref","first-page":"28587","DOI":"10.1074\/jbc.M110.125740","article-title":"Regulation of dendritic development by BDNF requires activation of CRTC1 by glutamate","volume":"285","author":"Finsterwald","year":"2010","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0010","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/mp.2016.171","article-title":"Camp signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor","volume":"22","author":"Fujita","year":"2017","journal-title":"Mol Psychiatry"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0011","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1111\/bph.13924","article-title":"Neuroadaptations of presynaptic and postsynaptic GABAB receptor function in the paraventricular nucleus in response to chronic unpredictable stress","volume":"174","author":"Gao","year":"2017","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0012","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1007\/s00213-017-4697-3","article-title":"Attenuation of ethanol abstinence-induced anxiety- and depressive-like behavior by the phosphodiesterase-4 inhibitor rolipram in rodents","volume":"234","author":"Gong","year":"2017","journal-title":"Psychopharmacology (Berl)"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0013","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.neuropharm.2017.01.004","article-title":"FFPM, a PDE4 inhibitor, reverses learning and memory deficits in APP\/PS1 transgenic mice via camp\/PKA\/CREB signaling and anti-inflammatory effects","volume":"116","author":"Guo","year":"2017","journal-title":"Neuropharmacology"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0014","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3389\/fpsyt.2017.00275","article-title":"Methodological flaws, conflicts of interest, and scientific fallacies: implications for the evaluation of antidepressants\u2019 efficacy and harm","volume":"8","author":"Hengartner","year":"2017","journal-title":"Front Psychiatry"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0015","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1038\/mp.2017.147","article-title":"Efficacy of selective serotonin reuptake inhibitors in the absence of side effects: a mega-analysis of citalopram and paroxetine in adult depression","volume":"23","author":"Hieronymus","year":"2018","journal-title":"Mol Psychiatry"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0016","first-page":"1","article-title":"Fluoxetine regulates neurogenesis in vitro through modulation of GSK-3beta\/beta-catenin signaling","volume":"18","author":"Hui","year":"2014","journal-title":"Int J Neuropsychopharmacol"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0017","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pbb.2013.01.020","article-title":"Etazolate, a phosphodiesterase 4 inhibitor reverses chronic unpredictable mild stress-induced depression-like behavior and brain oxidative damage","volume":"105","author":"Jindal","year":"2013","journal-title":"Pharmacol Biochem Behav"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0018","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00213-014-3705-0","article-title":"Etazolate, a phosphodiesterase-4 enzyme inhibitor produces antidepressant-like effects by blocking the behavioral, biochemical, neurobiological deficits and histological abnormalities in hippocampus region caused by olfactory bulbectomy","volume":"232","author":"Jindal","year":"2015","journal-title":"Psychopharmacology (Berl)"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0019","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1093\/hmg\/ddw312","article-title":"Reduced dynamin-related protein 1 protects against phosphorylated tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer\u2019s disease","volume":"25","author":"Kandimalla","year":"2016","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0020","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3389\/fpsyt.2017.00308","article-title":"Brain-derived neurotrophic factor and major depressive disorder: evidence from meta-analyses","volume":"8","author":"Kishi","year":"2017","journal-title":"Front Psychiatry"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0021","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000209350","article-title":"Changes in CREB phosphorylation and BDNF plasma levels during psychotherapy of depression","volume":"78","author":"Koch","year":"2009","journal-title":"Psychother Psychosom"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0022","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/bs.vh.2016.11.006","article-title":"BDNF propeptide: a novel modulator of synaptic plasticity","volume":"104","author":"Kojima","year":"2017","journal-title":"Vitam Horm"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0023","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.neubiorev.2017.03.007","article-title":"Serotonin and neuroplasticity - links between molecular, functional and structural pathophysiology in depression","volume":"77","author":"Kraus","year":"2017","journal-title":"Neurosci Biobehav Rev"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0024","doi-asserted-by":"crossref","first-page":"704103","DOI":"10.1155\/2012\/704103","article-title":"Examining form and function of dendritic spines","volume":"2012","author":"Lee","year":"2012","journal-title":"Neural Plast"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0025","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1038\/npp.2009.66","article-title":"Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus","volume":"34","author":"Li","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0026","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3109\/13880209.2014.922586","article-title":"Involvement of norepinephrine and serotonin system in antidepressant-like effects of hederagenin in the rat model of unpredictable chronic mild stress-induced depression","volume":"53","author":"Liang","year":"2015","journal-title":"Pharm Biol"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0027","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuroscience.2012.09.057","article-title":"Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression","volume":"251","author":"Licznerski","year":"2013","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0028","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.neuropharm.2011.02.020","article-title":"Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice","volume":"62","author":"Lipina","year":"2012","journal-title":"Neuropharmacology"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0029","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/ijnp\/pyx009","article-title":"Z-guggulsterone produces antidepressant-like effects in mice through activation of the BDNF signaling pathway","volume":"20","author":"Liu","year":"2017","journal-title":"Int J Neuropsychopharmacol"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0030","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/hipo.20744","article-title":"Effect of brain-derived neurotrophic factor haploinsufficiency on stress-induced remodeling of hippocampal neurons","volume":"21","author":"Magari\u00f1os","year":"2011","journal-title":"Hippocampus"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0031","doi-asserted-by":"crossref","first-page":"9104","DOI":"10.1523\/JNEUROSCI.20-24-09104.2000","article-title":"Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus","volume":"20","author":"Malberg","year":"2000","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0032","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0896-6273(00)80239-1","article-title":"Neurotrophin regulation of cortical dendritic growth requires activity","volume":"17","author":"McAllister","year":"1996","journal-title":"Neuron"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0033","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1083\/jcb.201110101","article-title":"Dynamic remodeling of scaffold interactions in dendritic spines controls synaptic excitability","volume":"198","author":"Moutin","year":"2012","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0034","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1172\/JCI24381","article-title":"Deficits in amygdaloid camp-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholism","volume":"115","author":"Pandey","year":"2005","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0035","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0036","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF00280065","article-title":"In-patient major depression: is rolipram as effective as amitriptyline","volume":"40","author":"Scott","year":"1991","journal-title":"Eur J Clin Pharmacol"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0037","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.eurpsy.2017.06.009","article-title":"Brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) levels in post-mortem brain tissue from patients with depression compared to healthy individuals - a proof of concept study","volume":"46","author":"Sheldrick","year":"2017","journal-title":"Eur Psychiatry"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0038","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jad.2018.02.014","article-title":"Cognitive complaints and predictors of perceived cognitive dysfunction in adults with major depressive disorder: findings from the cognitive dysfunction in asians with depression (cogdad) study","volume":"232","author":"Srisurapanont","year":"2018","journal-title":"J Affect Disord"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0039","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1017\/S0033291712001742","article-title":"Does early-onset chronic or recurrent major depression impact outcomes with antidepressant medications? A CO-MED trial report","volume":"43","author":"Sung","year":"2013","journal-title":"Psychol Med"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0040","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S2215-0366(15)00505-2","article-title":"Estimating the true global burden of mental illness","volume":"3","author":"Vigo","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0041","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.psychres.2017.07.081","article-title":"Schisandrin rescues depressive-like behaviors induced by chronic unpredictable mild stress via GDNF\/ERK1\/2\/ROS and PI3K\/AKT\/NOX signaling pathways in mice","volume":"257","author":"Wan","year":"2017","journal-title":"Psychiatry Res"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0042","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s11011-014-9533-4","article-title":"Antidepressant-like effects of the phosphodiesterase-4 inhibitor etazolate and phosphodiesterase-5 inhibitor sildenafil via cyclic AMP or cyclic GMP signaling in mice","volume":"29","author":"Wang","year":"2014","journal-title":"Metab Brain Dis"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0043","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1097\/WNR.0b013e32836384db","article-title":"Systematic correlation between spine plasticity and the anxiety\/depression-like phenotype induced by corticosterone in mice","volume":"24","author":"Wang","year":"2013","journal-title":"Neuroreport"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0044","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.neuropharm.2015.08.020","article-title":"Forkhead box O transcription factors as possible mediators in the development of major depression","volume":"99","author":"Wang","year":"2015","journal-title":"Neuropharmacology"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0045","doi-asserted-by":"crossref","first-page":"11332","DOI":"10.1038\/srep11332","article-title":"Phosphodiesterase-4D knock-down in the prefrontal cortex alleviates chronic unpredictable stress-induced depressive-like behaviors and memory deficits in mice","volume":"5","author":"Wang","year":"2015","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0046","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1111\/j.1476-5381.2012.02225.x","article-title":"RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects","volume":"168","author":"Wang","year":"2013","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0047","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19020513","article-title":"Inhibition of phosphodiesterase 4 by FCPR03 alleviates lipopolysaccharide-induced depressive-like behaviors in mice: involvement of p38 and JNK signaling pathways","volume":"19","author":"Yu","year":"2018","journal-title":"Int J Mol Sci"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0048","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1055\/s-2007-1017435","article-title":"Results of a phase II study of the antidepressant effect of rolipram","volume":"17","author":"Zeller","year":"1984","journal-title":"Pharmacopsychiatry"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0049","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s12031-016-0779-7","article-title":"Involvement of PI3K\/akt\/foxo3a and PKA\/CREB signaling pathways in the protective effect of fluoxetine against corticosterone-induced cytotoxicity in PC12 cells","volume":"59","author":"Zeng","year":"2016","journal-title":"J Mol Neurosci"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0050","doi-asserted-by":"crossref","first-page":"40115","DOI":"10.1038\/srep40115","article-title":"Comparison of the pharmacological profiles of selective PDE4B and PDE4D inhibitors in the central nervous system","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0051","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1017\/S1461145713001661","article-title":"Effects of curcumin on chronic, unpredictable, mild, stress-induced depressive-like behaviour and structural plasticity in the lateral amygdala of rats","volume":"17","author":"Zhang","year":"2014","journal-title":"Int J Neuropsychopharmacol"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0052","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.brainres.2012.06.032","article-title":"The possible role of the Akt signaling pathway in schizophrenia","volume":"1470","author":"Zheng","year":"2012","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0053","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.redox.2018.02.008","article-title":"Inhibition of phosphodiesterase 4 by FCPR16 protects SH-SY5Y cells against MPP+-induced decline of mitochondrial membrane potential and oxidative stress","volume":"16","author":"Zhong","year":"2018","journal-title":"Redox Biol"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0054","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.pbb.2009.11.003","article-title":"Antidepressant effect of the extracts from Fructus Akebiae","volume":"94","author":"Zhou","year":"2010","journal-title":"Pharmacol Biochem Behav"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0055","doi-asserted-by":"crossref","first-page":"e881","DOI":"10.1038\/tp.2016.129","article-title":"Anxiety and depression with neurogenesis defects in exchange protein directly activated by camp 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, prozac","volume":"6","author":"Zhou","year":"2016","journal-title":"Transl Psychiatry"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0056","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1021\/acschemneuro.6b00271","article-title":"Discovery of N-alkyl catecholamides as selective phosphodiesterase-4 inhibitors with anti-neuroinflammation potential exhibiting antidepressant-like effects at non-emetic doses","volume":"8","author":"Zhou","year":"2016","journal-title":"ACS Chem Neurosci"},{"key":"key\n\t\t\t\t2019021603400139500_CIT0057","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1124\/jpet.116.239608","article-title":"Novel phosphodiesterase 4 inhibitor FCPR03 alleviates lipopolysaccharide-induced neuroinflammation by regulation of the camp\/PKA\/CREB signaling pathway and NF-\u03bab inhibition","volume":"362","author":"Zou","year":"2017","journal-title":"J Pharmacol Exp Ther"}],"container-title":["International Journal of Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ijnp\/article-pdf\/22\/2\/143\/27789930\/pyy092.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T19:00:43Z","timestamp":1694026843000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijnp\/article\/22\/2\/143\/5165105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,8]]},"references-count":58,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,11,8]]},"published-print":{"date-parts":[[2019,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ijnp\/pyy092","relation":{},"ISSN":["1461-1457","1469-5111"],"issn-type":[{"value":"1461-1457","type":"print"},{"value":"1469-5111","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,2]]},"published":{"date-parts":[[2018,11,8]]}}}