{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T05:34:53Z","timestamp":1731648893525,"version":"3.28.0"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The symptomatic management of Parkinson\u2019s disease (PD) relies heavily on medications, which increase in complexity as the disease progresses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To describe (i) the extent, range, and nature of research describing the experience and challenges people with PD and their carers have with their medicines for symptomatic treatment, and (ii) any interventions that have been reported in a community setting that address medicine-related challenges experienced by people with PD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The scoping review searched electronic databases (EMBASE, PubMed, and CINAHL). The studies included were full-text articles in English only, including conference abstracts that focussed on patients with PD or their carers and discussed medicines in the primary care setting, even where this was not the primary focus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Thirty-nine papers were taken forward for data extraction. Twenty described patient experience and challenges. Although none were explicitly focussed on medications, they did highlight challenges including the work of taking multiple medications and a desire for non-oral formulations. Nineteen described or tested interventions to support people with PD with their medication including community pharmacist-led reviews, medication compliance aids, and the use of text message reminders. These were all small-scale feasibility and pilot studies, and none were grounded in a methodological framework. Positive outcomes were reported against various scales, but no evidence of scaling up any of the interventions was found.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>There is very little published research surrounding the challenges people with PD have with their medicines. The published research that does exist alludes to challenges with medicines taking in people with PD but identifies a gap in the detail and understanding. Further work is required to improve our understanding and allow the development of sustainable interventions that support people with PD and their carers.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ijpp\/riae051","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T18:58:39Z","timestamp":1726599519000},"page":"431-445","source":"Crossref","is-referenced-by-count":0,"title":["What is known about the challenges people with Parkinson\u2019s disease experience with their medicines and what solutions have been explored to overcome them? A scoping review"],"prefix":"10.1093","volume":"32","author":[{"given":"Shelley","family":"Jones","sequence":"first","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London , 16 De Crespigny Park, London, SE5 8AB ,","place":["United Kingdom"]},{"name":"Department of Haematological Medicine, King\u2019s College Hospital NHS Foundation Trust , Denmark Hill, London, SE5 9RS ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jignesh P","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Haematological Medicine, King\u2019s College Hospital NHS Foundation Trust , Denmark Hill, London, SE5 9RS ,","place":["United Kingdom"]},{"name":"Institute of Pharmaceutical Science, King\u2019s College London , Franklin-Wilkins Building, 150 Stamford St, London, SE1 9NH ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J","family":"Twigg","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of East Anglia , Norwich Research Park, Norwich, NR4 7TJ ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kallol Ray","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London , 16 De Crespigny Park, London, SE5 8AB ,","place":["United Kingdom"]},{"name":"Department of Haematological Medicine, King\u2019s College Hospital NHS Foundation Trust , Denmark Hill, London, SE5 9RS ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"2024111413413974200_CIT0001","doi-asserted-by":"crossref","DOI":"10.1159\/isbn.978-1-910797-22-8","volume-title":"Fast Facts: Parkinson\u2019s Disease","author":"Chaudhuri","year":"2016","edition":"4"},{"key":"2024111413413974200_CIT0002","doi-asserted-by":"publisher","first-page":"e551","DOI":"10.1016\/S2468-2667(20)30190-0","article-title":"The burden of neurological diseases in Europe: an analysis for the Global Burden of Disease Study 2017","volume":"5","author":"Deuschl","year":"2020","journal-title":"The Lancet Public Health"},{"key":"2024111413413974200_CIT0003","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41531-020-0117-1","article-title":"Current and projected future economic burden of Parkinson\u2019s disease in the U.S","volume":"6","author":"Yang","year":"2020","journal-title":"NPJ Parkinsons Dis"},{"key":"2024111413413974200_CIT0004","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1345\/aph.1K348","article-title":"Role of the pharmacist in the effective management of wearing-off in Parkinson\u2019s disease","volume":"41","author":"Simonson","year":"2007","journal-title":"Ann Pharmacother"},{"key":"2024111413413974200_CIT0005","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1212\/wnl.58.1.11","article-title":"Practice parameter: initiation of treatment for Parkinson\u2019s disease: an evidence-based review: report of the Quality Standards Subcommittee of the American Academy of Neurology","volume":"58","author":"MIYASAKI","year":"2002","journal-title":"Neurology"},{"year":"2017","author":"Parkinson\u2019s Disease in Adults. 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