{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T21:49:33Z","timestamp":1782769773198,"version":"3.54.5"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1136849"],"award-info":[{"award-number":["1136849"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To describe the variation in the use of potentially inappropriate antipsychotic and benzodiazepine medications in residents who have received a medication review and to evaluate the extent to which this variation is associated with aged care home (ACH) and resident characteristics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This cross-sectional, retrospective study used pharmacist-extracted data from 15,442 residents across 342 Australian ACHs who had a medication review during 2019. The proportion of residents receiving \u22651 potentially inappropriate antipsychotic and benzodiazepine medication according to Beers criteria were classified into quintiles by facility usage (Q1\u2013Q5). Quintile characteristics were compared using descriptive analysis of facility and resident data. Logistic regression was used to compare individual usage between residents in each quintile adjusting for facility and resident characteristics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>The cohort had mean age 85 years (SD \u00b19), with less than 14% of residents in Q1 (n = 68), and &amp;gt;31% of residents in Q5 (n = 68) using an antipsychotic. For benzodiazepines, these proportions were &amp;lt;19% in Q1 (n = 68) and &amp;gt;45% in Q5 (n = 67). Facilities in major cities were significantly more likely to report antipsychotic (Q1:74% vs Q5:88%, P = .03) and benzodiazepine use (Q1:69% vs Q5:87%, P = .015). Residents in Q5 were seven times more likely to be prescribed an antipsychotic (aOR:7.22, 95% CI:5.93\u20138.79) than residents in Q1, and eight times more likely to be prescribed a benzodiazepine (aOR:8.57, 95% CI 7.33\u201310.01, P &amp;lt; .001) than residents in Q1.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Significant variation exists in potentially inappropriate antipsychotic and benzodiazepine use among ACH residents receiving a medication review highlighting the need for further research to reduce prescribing of these high-risk medications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ijpp\/riaf028","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T13:47:54Z","timestamp":1744120074000},"page":"332-339","source":"Crossref","is-referenced-by-count":1,"title":["Variation in the potentially inappropriate use of antipsychotic and benzodiazepine medications among individuals receiving residential medication management reviews"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0565-3524","authenticated-orcid":false,"given":"Mouna J","family":"Sawan","sequence":"first","affiliation":[{"name":"Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney , Camperdown, NSW ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9140-8412","authenticated-orcid":false,"given":"Alexander J","family":"Clough","sequence":"additional","affiliation":[{"name":"Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney , Camperdown, NSW ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie","family":"Hillen","sequence":"additional","affiliation":[{"name":"Clinical and Health Sciences, University of South Australia , Adelaide, SA ,","place":["Australia"]},{"name":"Ward Medication Management , Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1673-4570","authenticated-orcid":false,"given":"Andrew R","family":"Zullo","sequence":"additional","affiliation":[{"name":"Department of Health Services, Policy, and Practice, Brown University School of Public Health , Providence, RI ,","place":["United States"]},{"name":"Center for Gerontology and Healthcare Research, Brown University School of Public Health , Providence, RI ,","place":["United States"]},{"name":"Department of Epidemiology, Brown University School of Public Health , Providence, RI ,","place":["United States"]},{"name":"Center of Innovation in Long-Term Services and Supports, Providence Veterans Affairs Medical Center , Providence, RI ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela C","family":"Moga","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky , Lexington, KY ,","place":["United States"]},{"name":"Department of Epidemiology, College of Public Health, University of Kentucky , Lexington, KY ,","place":["United States"]},{"name":"Sanders-Brown Center on Aging, University of Kentucky , Lexington, KY ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Soulsby","sequence":"additional","affiliation":[{"name":"Ward Medication Management , Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danijela","family":"Gnjidic","sequence":"additional","affiliation":[{"name":"Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney , Camperdown, NSW 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