{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:25:17Z","timestamp":1776705917579,"version":"3.51.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nova Laboratories Limited"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the accuracy of tablet splitting for paediatric dosing by assessing mass and content uniformity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Whole, half, and quarter tablets of mercaptopurine, azathioprine, and spironolactone were prepared using a manual tablet splitter. Fragment mass and quarter-tablet drug content were assessed against European Pharmacopoeia criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Split fragments showed high variability (coefficient of variation 8.6%\u201323.3%). Most failed European Pharmacopoeia mass uniformity criteria. Content analysis revealed only 50%\u201370% of quarters complied with acceptance limits, with ranges of 52%\u2013133% of claim.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tablet splitting introduces substantial dose variability undetectable by weighing alone. Where possible, low-strength tablets or alternative formulations should be preferred.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ijpp\/riag055","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:21:52Z","timestamp":1774869712000},"source":"Crossref","is-referenced-by-count":0,"title":["Accuracy of tablet splitting for paediatric dosing: mass and content uniformity"],"prefix":"10.1093","author":[{"given":"Claire","family":"Hodkinson","sequence":"first","affiliation":[{"name":"Product Development, Nova Laboratories Limited , Leicester LE18 4YL ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Edge","sequence":"additional","affiliation":[{"name":"Product Development, Nova Laboratories Limited , Leicester LE18 4YL ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant","family":"Kelly","sequence":"additional","affiliation":[{"name":"Product Development, Nova Laboratories Limited , Leicester LE18 4YL ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"White","sequence":"additional","affiliation":[{"name":"Product Development, Nova Laboratories Limited , Leicester LE18 4YL ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3171-691X","authenticated-orcid":false,"given":"Hussain","family":"Mulla","sequence":"additional","affiliation":[{"name":"Product Development, Nova Laboratories Limited , Leicester LE18 4YL ,","place":["United Kingdom"]},{"name":"Department of Pharmacy, University Hospitals of Leicester , Leicester LE3 9QP ,","place":["United Kingdom"]},{"name":"College of Life Sciences, School of Healthcare, University of Leicester ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"2026042012342485800_ref1","doi-asserted-by":"crossref","DOI":"10.1136\/archdischild-2019-317512","article-title":"The KidzMed project: teaching children to swallow tablet medication","volume":"105","author":"Tse","year":"2020","journal-title":"Arch Dis Child"},{"key":"2026042012342485800_ref2","article-title":"Formulations for children: problems and solutions","volume":"79","year":"2015","journal-title":"Br J Clin Pharmacol"},{"key":"2026042012342485800_ref3","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2016.12.032","article-title":"Systematic review of dosage form manipulation in paediatric practice","volume":"518","author":"Richey","year":"2017","journal-title":"Int J Pharm"},{"key":"2026042012342485800_ref4","doi-asserted-by":"crossref","DOI":"10.1097\/00007691-200202000-00001","article-title":"Therapeutic drug monitoring in paediatrics","volume":"24","author":"Soldin","year":"2002","journal-title":"Ther Drug Monit"},{"key":"2026042012342485800_ref5","article-title":"Challenges of paediatric pharmacotherapy","volume":"80","author":"Watanabe","year":"2024","journal-title":"Eur J Clin Pharmacol"},{"key":"2026042012342485800_ref6","article-title":"Tablet splitting: is it worthwhile?","volume":"21","author":"Helmy","year":"2015","journal-title":"J Manag Care Spec Pharm"},{"key":"2026042012342485800_ref7","article-title":"Does splitting a tablet obtain an accurate dose?","volume":"52","year":"2022","journal-title":"J Pharm Pract Res"},{"key":"2026042012342485800_ref8","author":"European Pharmacopoeia Commission"},{"key":"2026042012342485800_ref9","author":"European Pharmacopoeia Commission"},{"key":"2026042012342485800_ref10","author":"EMA","year":"2015"}],"container-title":["International Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ijpp\/advance-article-pdf\/doi\/10.1093\/ijpp\/riag055\/68116537\/riag055.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ijpp\/advance-article-pdf\/doi\/10.1093\/ijpp\/riag055\/68116537\/riag055.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:34:26Z","timestamp":1776702866000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijpp\/advance-article\/doi\/10.1093\/ijpp\/riag055\/8659344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":10,"URL":"https:\/\/doi.org\/10.1093\/ijpp\/riag055","relation":{},"ISSN":["0961-7671","2042-7174"],"issn-type":[{"value":"0961-7671","type":"print"},{"value":"2042-7174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]},"article-number":"riag055"}}