{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:13:39Z","timestamp":1779297219179,"version":"3.51.4"},"reference-count":10,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n The purpose of this study was to quantify and compare potential drug\u2013drug interactions between hepatitis C medications and comedications across six online drug\u2013drug interaction databases.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Investigators assessed drug\u2013drug interactions between prescription and non-prescription medications with ribavirin and five hepatitis C virus direct-acting antiviral regimens, across online drug\u2013drug interaction databases. The primary outcome was the number of drug pairs that resulted in potential interactions.<\/jats:p>\n <\/jats:sec>\n \n Key findings<\/jats:title>\n A total of 1488 medication pairs were evaluated for each database and varying potential interactions were identified. Variability also existed among identification of potentially contraindicated drug pairs, and only 2 of 41 (4.9%) of these pairs were identified as contraindicated by all 6 databases.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Due to institutional differences and inconsistencies in the identification of potential drug\u2013drug interactions, clinical judgment is imperative, and cross-referencing multiple databases can offer additional insight.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/ijpp\/riag065","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:37:45Z","timestamp":1777376265000},"source":"Crossref","is-referenced-by-count":0,"title":["Hepatitis C virus drug\u2013drug interactions: a comparison of online drug interaction databases"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4039-867X","authenticated-orcid":false,"given":"Emily N","family":"Drwiega","sequence":"first","affiliation":[{"name":"University of Illinois Chicago, Retzky College of Pharmacy, University of Illinois Hospital and Health Sciences System , Chicago, IL 60612, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle T","family":"Martin","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago, Retzky College of Pharmacy, University of Illinois Hospital and Health Sciences System , Chicago, IL 60612, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7564-0131","authenticated-orcid":false,"given":"Melissa E","family":"Badowski","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago, Retzky College of Pharmacy, University of Illinois Hospital and Health Sciences System , Chicago, IL 60612, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"2026052012495195800_ref1","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1111\/jcpt.13750","article-title":"Antiretroviral drug-drug interactions: a comparison of online drug interaction databases","volume":"47","author":"Drwiega","year":"2022","journal-title":"J Clin Pharm Ther"},{"key":"2026052012495195800_ref2","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s11096-022-01385-9","article-title":"Potential drug-drug interactions of immunosuppressants in kidney transplant recipients: comparison of drug interaction resources","volume":"44","author":"Pehlivanli","year":"2022","journal-title":"Int J Clin Pharm"},{"key":"2026052012495195800_ref3","volume-title":"2020\/2021 Top 100 Nonprescription Drug Cards","author":"Kolesar"},{"key":"2026052012495195800_ref4","volume-title":"Top 200 Drugs of 2019","author":"ClinCalc DrugStats Database"},{"key":"2026052012495195800_ref5","author":"Drug Interaction Report - Clinical Pharmacology"},{"key":"2026052012495195800_ref6","author":"Epocrates Web MultiCheck"},{"key":"2026052012495195800_ref7","author":"Lexicomp\u00ae Drug Interactions - UpToDate"},{"key":"2026052012495195800_ref8","author":"Drug Interactions search - MICROMEDEX"},{"key":"2026052012495195800_ref9","author":"Liverpool HEP Interactions"},{"key":"2026052012495195800_ref10","author":"Drug Interaction Checker \u2013 Check for Interactions Between Prescription Medications"}],"container-title":["International Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ijpp\/advance-article-pdf\/doi\/10.1093\/ijpp\/riag065\/68346719\/riag065.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ijpp\/advance-article-pdf\/doi\/10.1093\/ijpp\/riag065\/68346719\/riag065.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T16:49:58Z","timestamp":1779295798000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijpp\/advance-article\/doi\/10.1093\/ijpp\/riag065\/8688260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":10,"URL":"https:\/\/doi.org\/10.1093\/ijpp\/riag065","relation":{},"ISSN":["2042-7174"],"issn-type":[{"value":"2042-7174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]},"article-number":"riag065"}}