{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:47:02Z","timestamp":1786117622019,"version":"build-2736575974"},"reference-count":34,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Understanding patient preferences is vital for promoting person-centred care, treatment adherence, and better health outcomes. Preferences across pharmacological and non-pharmacological therapies may be influenced by a range of personal and contextual factors, but they are seldom explicitly described and considered in treatment recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To review the factors influencing patient preferences for various treatment options across a range of chronic health conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. Literature was searched across Google Scholar, PubMed, EMBASE, CINAHL, and Medline (inception to April 2025), including English-language studies examining patient preferences for pharmacological and non-pharmacological treatment options in chronic health conditions. Studies were screened against predefined criteria and synthesized narratively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventeen studies were identified, involving persons diagnosed with osteoporosis, stroke, depression, early cancer, acute myeloid leukemia or advanced myelodysplastic syndrome, multiple chronic diseases, and people in aged care. Factors influencing preferences included sex\/gender, age, beliefs (e.g. health conditions, treatment), ethnicity and culture, economic concerns, prior treatment experiences, perceptions of treatment safety and effectiveness, accessibility, interaction with healthcare providers, and family and social support. Among these, age was the most common influencer, with older adults more likely to prefer non-pharmacological strategies. Sex\/gender also shaped preferences; females\/women were more inclined toward non-pharmacological strategies. Ethnocultural beliefs were linked to increased use of complementary and alternative medicines. Furthermore, patients tended to prefer treatments they perceived as having fewer side-effects and greater long-term efficacy. Alignment with patients\u2019 preferred treatments was associated with greater satisfaction and improved clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review underscores the multifactorial nature of patient preferences, shaped by demographics, culture, and perceptions. These findings highlight the importance of considering patient preferences in clinical trials and when developing treatment guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ijpp\/riag104","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:33:00Z","timestamp":1784633580000},"source":"Crossref","is-referenced-by-count":0,"title":["Factors influencing patient preferences for pharmacological and non-pharmacological treatment options in chronic health conditions: a systematic review"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4566-0865","authenticated-orcid":false,"given":"Yuanchen","family":"Liang","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy, University of Newcastle , Newcastle, New South Wales 2308 ,","place":["Australia"]},{"name":"Heart and Stroke Program, Hunter Medical Research Institute , Newcastle, New South Wales 2308 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9474-796X","authenticated-orcid":false,"given":"Christopher","family":"Levi","sequence":"additional","affiliation":[{"name":"Heart and Stroke Program, Hunter Medical Research Institute , Newcastle, New South Wales 2308 ,","place":["Australia"]},{"name":"School of Medicine and Public Health, University of Newcastle , Newcastle, New South Wales 2308 ,","place":["Australia"]},{"name":"Hunter New England Local Health District , Newcastle, New South Wales 2300 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2532-7187","authenticated-orcid":false,"given":"Beata","family":"Bajorek","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy, University of Newcastle , Newcastle, New South Wales 2308 ,","place":["Australia"]},{"name":"Heart and Stroke Program, Hunter Medical Research Institute , Newcastle, New South Wales 2308 ,","place":["Australia"]},{"name":"Hunter New England Local Health District , Newcastle, New South Wales 2300 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"2026080610141864400_ref1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3109\/09638237.2014.954695","article-title":"Factors influencing patients' preferences and perceived involvement in shared decision-making in mental health care","volume":"24","author":"Eliacin","year":"2015","journal-title":"J Ment Health"},{"key":"2026080610141864400_ref2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/00005650-200003000-00010","article-title":"Patient preferences for medical decision making: who really wants to participate?","volume":"38","author":"Arora","year":"2000","journal-title":"Med Care"},{"key":"2026080610141864400_ref3","first-page":"19","article-title":"Best clinical practice: guidelines for managing major depression in primary medical care","volume":"60","author":"Schulberg","year":"1999","journal-title":"J Clin Psychiatry"},{"key":"2026080610141864400_ref4","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1080\/03007995.2016.1202817","article-title":"Phase IV randomized preference study in patients eligible for calcium and vitamin D supplementation","volume":"32","author":"Thomasius","year":"2016","journal-title":"Curr Med Res Opin"},{"key":"2026080610141864400_ref5","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s00198-011-1780-1","article-title":"Final results of the DAPS (denosumab adherence preference satisfaction) study: a 24-month, randomized, crossover comparison with alendronate in postmenopausal women","volume":"23","author":"Freemantle","year":"2012","journal-title":"Osteoporos Int"},{"key":"2026080610141864400_ref6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10865-007-9147-y","article-title":"The impact of medication regimen factors on adherence to chronic treatment: a review of literature","volume":"31","author":"Ingersoll","year":"2008","journal-title":"J Behav Med"},{"key":"2026080610141864400_ref7","doi-asserted-by":"crossref","DOI":"10.3390\/jcm14176034","article-title":"Understanding treatment adherence in chronic diseases: challenges, consequences, and strategies for improvement","volume":"14","author":"Patel","year":"2025","journal-title":"J Clin Med"},{"key":"2026080610141864400_ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejim.2023.07.008","article-title":"The role of adherence in patients with chronic diseases","volume":"119","author":"Burnier","year":"2024","journal-title":"Eur J Intern Med"},{"key":"2026080610141864400_ref9","doi-asserted-by":"publisher","volume-title":"Medicina (Kaunas)","DOI":"10.3390\/medicina61010153"},{"key":"2026080610141864400_ref10","doi-asserted-by":"publisher","first-page":"e067268","DOI":"10.1136\/bmjopen-2022-067268","article-title":"Integrating patient values and preferences in healthcare: a systematic review of qualitative evidence","volume":"12","author":"Tringale","year":"2022","journal-title":"BMJ Open"},{"key":"2026080610141864400_ref11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1136\/jamia.1998.0050257","article-title":"Improving health care by understanding patient preferences: the role of computer technology","volume":"5","author":"Brennan","year":"1998","journal-title":"J Am Med Inform Assoc"},{"key":"2026080610141864400_ref12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0021-9681(81)90053-9","article-title":"Impact of patient preferences on the selection of therapy","volume":"34","author":"Pauker","year":"1981","journal-title":"J Chronic Dis"},{"key":"2026080610141864400_ref13","doi-asserted-by":"publisher","volume":"23","DOI":"10.1177\/2515690X18765945"},{"key":"2026080610141864400_ref14","first-page":"905","article-title":"Treating depression in general practice: factors affecting patients' treatment preferences","volume":"50","author":"Churchill","year":"2000","journal-title":"Br J Gen Pract"},{"key":"2026080610141864400_ref15","doi-asserted-by":"publisher","first-page":"866","DOI":"10.15537\/smj.2020.8.25192","article-title":"Factors influencing patients' preferences for their treating physician","volume":"41","author":"Alraddadi","year":"2020","journal-title":"Saudi Med J"},{"key":"2026080610141864400_ref16","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1207\/s15324796abm3002_9","article-title":"The influence of patient preference on depression treatment in primary care","volume":"30","author":"Lin","year":"2005","journal-title":"Ann Behav Med"},{"key":"2026080610141864400_ref17","doi-asserted-by":"publisher","first-page":"354","DOI":"10.2340\/16501977-0678","article-title":"Early rehabilitation management after stroke: what do stroke patients prefer?","volume":"43","author":"Laver","year":"2011","journal-title":"J Rehabil Med"},{"key":"2026080610141864400_ref18","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3389\/fstro.2024.1386300","article-title":"Exploring unmet needs and preferences of young adult stroke patients for post-stroke care through PROMs and gender differences. Frontiers","volume":"3","author":"Ibrahim","year":"2024","journal-title":"Stroke"},{"key":"2026080610141864400_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.106993","article-title":"Stroke survivors\u2019 preferences for post-stroke self-management programs: a discrete choice experiment","volume":"32","author":"Doshi","year":"2023","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2026080610141864400_ref20","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ctcp.2014.03.001","article-title":"Hypertensive patients' preferences for complementary and alternative medicine and the influence of these preferences on the adherence to prescribed medication","volume":"20","author":"Lee","year":"2014","journal-title":"Complement Ther Clin Pract"},{"key":"2026080610141864400_ref21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3944\/AOTT.2015.14.0082","article-title":"Compliance, persistence, and preference outcomes of postmenopausal osteoporotic women receiving a flexible or fixed regimen of daily risedronate: a multicenter, prospective, parallel group study","volume":"49","author":"Oral","year":"2015","journal-title":"Acta Orthop Traumatol Turc"},{"key":"2026080610141864400_ref22","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1310\/tsr1705-394","article-title":"Patient preferences for stroke rehabilitation","volume":"17","author":"Gregory","year":"2010","journal-title":"Top Stroke Rehabil"},{"key":"2026080610141864400_ref23","doi-asserted-by":"publisher","first-page":"e720","DOI":"10.1002\/osp4.720","article-title":"Patient perspectives about treatment preferences for obesity with complications","volume":"10","author":"Craig","year":"2024","journal-title":"Obes Sci Pract"},{"key":"2026080610141864400_ref24","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s41366-024-01524-4","article-title":"Factors that determine patients considering medication for the disease of obesity: an IMI2 SOPHIA study","volume":"49","author":"Craig","year":"2025","journal-title":"Int J Obes"},{"key":"2026080610141864400_ref25","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1046\/j.1523-5394.2000.83004.x","article-title":"Patient age and cancer treatment decisions","volume":"8","author":"Kutner","year":"2000","journal-title":"Patient Physician Views Cancer Pract"},{"key":"2026080610141864400_ref26","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1056\/NEJMsa012528","article-title":"Understanding the treatment preferences of seriously ill patients","volume":"346","author":"Fried","year":"2002","journal-title":"N Engl J Med"},{"key":"2026080610141864400_ref27","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3928\/00989134-20061101-05","article-title":"Assessing the stability of values and health care preferences of older adults: a long-term comparison","volume":"32","author":"Martin","year":"2006","journal-title":"J Gerontol Nurs"},{"key":"2026080610141864400_ref28","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1038\/sj.leu.2403289","article-title":"Decision-making and quality of life in older adults with acute myeloid leukemia or advanced myelodysplastic syndrome","volume":"18","author":"Sekeres","year":"2004","journal-title":"Leukemia"},{"key":"2026080610141864400_ref29","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1093\/fampra\/cmh613","article-title":"Complementary and alternative medicine use in patients with chronic diseases in primary care is associated with perceived quality of care and cultural beliefs","volume":"21","author":"Lee","year":"2004","journal-title":"Fam Pract"},{"key":"2026080610141864400_ref30","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0140-6736(96)91271-4","article-title":"Prevalence and cost of alternative medicine in Australia","volume":"347","author":"MacLennan","year":"1996","journal-title":"Lancet"},{"key":"2026080610141864400_ref31","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1186\/s12905-022-02097-y","article-title":"Conservative non-pharmacological interventions in women with pelvic floor dysfunction: a systematic review of qualitative studies","volume":"22","author":"Fernandes","year":"2022","journal-title":"BMC Womens Health"},{"key":"2026080610141864400_ref32","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1369-7625.2004.00298.x","article-title":"Patients\u2019 perceptions of cultural factors affecting the quality of their medical encounters","volume":"8","author":"N\u00e1poles-Springer","year":"2005","journal-title":"Health Expect"},{"key":"2026080610141864400_ref33","volume-title":"Measuring and Interpreting Health Care Quality across Culturally-Diverse Populations: A Focus on Consumer-Reported Indicators of Health Care Quality","author":"Bethell","year":"2003"},{"key":"2026080610141864400_ref34","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1046\/j.1369-6513.2003.00221.x","article-title":"Patient characteristics as predictors of primary health care preferences: a systematic literature analysis","volume":"6","author":"Jung","year":"2003","journal-title":"Health Expect"}],"container-title":["International Journal of Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ijpp\/advance-article-pdf\/doi\/10.1093\/ijpp\/riag104\/70507814\/riag104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ijpp\/advance-article-pdf\/doi\/10.1093\/ijpp\/riag104\/70507814\/riag104.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:14:57Z","timestamp":1786025697000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijpp\/advance-article\/doi\/10.1093\/ijpp\/riag104\/8753234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":34,"URL":"https:\/\/doi.org\/10.1093\/ijpp\/riag104","relation":{},"ISSN":["2042-7174"],"issn-type":[{"value":"2042-7174","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]},"article-number":"riag104"}}