{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:15:11Z","timestamp":1788308111914,"version":"build-2803163510"},"reference-count":30,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health\u2014Ricerca Corrente\u2014IRCCS MultiMedica"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Optimizing drug treatments in older adults is essential for improving health outcomes and reducing drug-related issues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to develop an updated and comprehensive explicit indicator of potentially inappropriate medications in older adults, and to evaluate its association with all-cause hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Administrative healthcare data from Local Health Units (LHUs) in Lombardy, Italy (2015\u20132018) were used to identify individuals aged \u226565\u00a0years who were exposed to potentially inappropriate medications (PIMs), identified through an explicit criteria-based list. Risk-set matching was used to select unexposed controls, and logistic regression models adjusted for high-dimensional propensity scores were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for all-cause hospitalization within 90\u00a0days after the first exposure date.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Among 641\u2009230 older patients, between 52.8% and 56.3% were exposed to at least one PIM. After matching (128\u2009063 pairs) hospitalization rates were higher among the exposed (8.3%\u201310.2%) compared with the not exposed (5.1%\u20136.0%) across the LHUs. Pooled estimates showed an increased risk of hospitalization for those exposed (ORs 1.55, 95% CIs 1.48\u20131.62), with the highest risk observed in adults aged 65\u201374\u00a0years (1.67, 1.59\u20131.76) and in women (1.62, 1.55\u20131.70).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Over half of older individuals were exposed to at least one PIM, with a 55% increase in short-term hospitalization risk. These findings highlight the urgent need for improved prescribing practices tailored to older populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ijpp\/riag112","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:34:51Z","timestamp":1787052891000},"source":"Crossref","is-referenced-by-count":0,"title":["The clinical burden of potentially inappropriate medications on hospitalization risk in an Italian older adult cohort: a large-scale real-world study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6475-2418","authenticated-orcid":false,"given":"Andrea","family":"Rossi","sequence":"first","affiliation":[{"name":"Epidemiology and Preventive Pharmacology Service (SEFAP), Department of Pharmacological and Biomolecular Sciences, University of Milan , Milan 20133 ,","place":["Italy"]},{"name":"IRCCS MultiMedica , Sesto S. Giovanni, Milan 20099 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7107-243X","authenticated-orcid":false,"given":"Elena","family":"Olmastroni","sequence":"additional","affiliation":[{"name":"Epidemiology and Preventive Pharmacology Service (SEFAP), Department of Pharmacological and Biomolecular Sciences, University of Milan , Milan 20133 ,","place":["Italy"]},{"name":"IRCCS MultiMedica , Sesto S. Giovanni, Milan 20099 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9305-3852","authenticated-orcid":false,"given":"Gerard","family":"Ompad","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, University of Copenhagen , Copenhagen \u00d8 2100 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-5361","authenticated-orcid":false,"given":"Manuela","family":"Casula","sequence":"additional","affiliation":[{"name":"Epidemiology and Preventive Pharmacology Service (SEFAP), Department of Pharmacological and Biomolecular Sciences, University of Milan , Milan 20133 ,","place":["Italy"]},{"name":"IRCCS MultiMedica , Sesto S. Giovanni, Milan 20099 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0874-4744","authenticated-orcid":false,"given":"Maurizio","family":"Sessa","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, University of Copenhagen , Copenhagen \u00d8 2100 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"2026090119372094900_ref1","volume-title":"WHO EDM PAR 2004.5","author":"WHO","year":"2004"},{"key":"2026090119372094900_ref2","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1001\/jama.293.11.1348","article-title":"Potentially inappropriate medication use among elderly home care patients in 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