{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T07:14:24Z","timestamp":1774768464809,"version":"3.50.1"},"reference-count":215,"publisher":"Oxford University Press (OUP)","issue":"2-3","license":[{"start":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T00:00:00Z","timestamp":1615075200000},"content-version":"vor","delay-in-days":431,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007408","name":"University of Pittsburgh Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","award":["19H05759"],"award-info":[{"award-number":["19H05759"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MIND","award":["JP20dm0207065"],"award-info":[{"award-number":["JP20dm0207065"]}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genetic modification of nonhuman primate (NHP) zygotes is a useful method for the development of NHP models of human diseases. This review summarizes the recent advances in the development of assisted reproductive and genetic manipulation techniques in NHP, providing the basis for the generation of genetically modified NHP disease models. In this study, we review assisted reproductive techniques, including ovarian stimulation, in vitro maturation of oocytes, in vitro fertilization, embryo culture, embryo transfer, and intracytoplasmic sperm injection protocols in marmosets. Furthermore, we review genetic manipulation techniques, including transgenic strategies, target gene knock-out and knock-in using gene editing protocols, and newly developed gene-editing approaches that may potentially impact the production of genetically manipulated NHP models. We further discuss the progress of assisted reproductive and genetic manipulation techniques in NHP; future prospects on genetically modified NHP models for biomedical research are also highlighted.<\/jats:p>","DOI":"10.1093\/ilar\/ilab002","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T12:59:42Z","timestamp":1610542782000},"page":"286-303","source":"Crossref","is-referenced-by-count":20,"title":["Assisted Reproductive Techniques and Genetic Manipulation in the Common Marmoset"],"prefix":"10.1093","volume":"61","author":[{"given":"Jung Eun","family":"Park","sequence":"first","affiliation":[{"name":"Department of Neurobiology, University of Pittsburgh, School of Medicine in Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Marmoset Biology and Medicine, Central Institute for Experimental Animals in Kawasaki, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"issue":"4","key":"2022031316002312700_ref1","first-page":"383","article-title":"Marmoset models commonly used in biomedical research","volume":"53","author":"Mansfield","year":"2003","journal-title":"Comp Med"},{"issue":"1","key":"2022031316002312700_ref2","first-page":"15","article-title":"Development of genetically modified nonhuman primates toward models for translational research","volume":"1","author":"Sasaki","year":"2019","journal-title":"Transl Reg Scie"},{"issue":"4","key":"2022031316002312700_ref3","first-page":"339","article-title":"Aspects of common marmoset basic biology and life history important for biomedical research","volume":"53","author":"Abbott","year":"2003","journal-title":"Comp Med"},{"issue":"3","key":"2022031316002312700_ref4","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/dneu.22464","article-title":"Marmoset vocal communication: behavior and neurobiology","volume":"77","author":"Eliades","year":"2017","journal-title":"Dev Neurobiol"},{"issue":"11\u201312","key":"2022031316002312700_ref5","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1387\/ijdb.103196ms","article-title":"Cloning of non-human primates: the road \"less traveled by.\"","volume":"54","author":"Sparman","year":"2010","journal-title":"Int J Dev Biol"},{"issue":"4","key":"2022031316002312700_ref6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.5625\/lar.2015.31.4.155","article-title":"Modeling Parkinson's disease in the common marmoset (Callithrix jacchus): overview of models, methods, and animal care","volume":"31","author":"Yun","year":"2015","journal-title":"Lab Anim Res"},{"issue":"1","key":"2022031316002312700_ref7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40478-017-0413-0","article-title":"Propagation of pathological alpha-synuclein in marmoset brain","volume":"5","author":"Shimozawa","year":"2017","journal-title":"Acta Neuropathol Commun"},{"issue":"2","key":"2022031316002312700_ref8","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/jnr.20436","article-title":"Transplantation of human neural stem cells for spinal cord injury in primates","volume":"80","author":"Iwanami","year":"2005","journal-title":"J Neurosci Res"},{"issue":"2","key":"2022031316002312700_ref9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/jnr.20435","article-title":"Establishment of graded spinal cord injury model in a nonhuman primate: the common marmoset","volume":"80","author":"Iwanami","year":"2005","journal-title":"J Neurosci Res"},{"issue":"12","key":"2022031316002312700_ref10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052787","article-title":"Pre-evaluated safe human iPSC-derived neural stem cells promote functional recovery after spinal cord injury in common marmoset without tumorigenicity","volume":"7","author":"Kobayashi","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"2022031316002312700_ref11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1538\/expanim.17-0156","article-title":"Thioacetamide-induced hepatic fibrosis in the common marmoset","volume":"67","author":"Inoue","year":"2018","journal-title":"Exp Anim"},{"issue":"1","key":"2022031316002312700_ref12","doi-asserted-by":"crossref","first-page":"14546","DOI":"10.1038\/s41598-019-51199-5","article-title":"Establishment of a diabetes mellitus type 1 model in the common marmoset","volume":"9","author":"Yuan","year":"2019","journal-title":"Sci Rep"},{"issue":"1","key":"2022031316002312700_ref13","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/ilar.52.1.54","article-title":"The marmoset as a model of aging and age-related diseases","volume":"52","author":"Tardif","year":"2011","journal-title":"ILAR J"},{"issue":"9","key":"2022031316002312700_ref14","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s00702-017-1742-7","article-title":"Twenty years since the discovery of the parkin gene","volume":"124","author":"Hattori","year":"2017","journal-title":"J Neural Transm (Vienna)"},{"issue":"5","key":"2022031316002312700_ref15","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.neuron.2019.11.010","article-title":"A large panel of isogenic APP and PSEN1 mutant human iPSC neurons reveals shared endosomal abnormalities mediated by APP beta-CTFs","volume":"104","author":"Kwart","year":"2019","journal-title":"Not Abeta Neuron"},{"issue":"6","key":"2022031316002312700_ref16","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1086\/522590","article-title":"Contribution of SHANK3 mutations to autism spectrum disorder","volume":"81","author":"Moessner","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"1","key":"2022031316002312700_ref17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000165342","article-title":"Rett syndrome: from the gene to the disease","volume":"61","author":"Matijevic","year":"2009","journal-title":"Eur Neurol"},{"issue":"2","key":"2022031316002312700_ref18","doi-asserted-by":"crossref","DOI":"10.1002\/ajp.22931","article-title":"Generation of genetically engineered non-human primate models of brain function and neurological disorders","volume":"81","author":"Park","year":"2019","journal-title":"Am J Primatol"},{"key":"2022031316002312700_ref19","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1471-2164-13-98","article-title":"Quantitative molecular assessment of chimerism across tissues in marmosets and tamarins","volume":"13","author":"Sweeney","year":"2012","journal-title":"BMC Genomics"},{"issue":"15","key":"2022031316002312700_ref20","doi-asserted-by":"crossref","first-page":"6278","DOI":"10.1073\/pnas.0607426104","article-title":"Germ-line chimerism and paternal care in marmosets (Callithrix kuhlii)","volume":"104","author":"Ross","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2022031316002312700_ref21","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.stem.2016.06.003","article-title":"Generation of a nonhuman primate model of severe combined immunodeficiency using highly efficient genome editing","volume":"19","author":"Sato","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"4","key":"2022031316002312700_ref22","first-page":"364","article-title":"Reproduction in captive common marmosets (Callithrix jacchus)","volume":"53","author":"Tardif","year":"2003","journal-title":"Comp Med"},{"issue":"2","key":"2022031316002312700_ref23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1469-7998.1983.tb04276.x","article-title":"The relationship between plasma progesterone and the timing of ovulation and early embryonic development in the marmoset monkey (Callithrix jacchus)","volume":"201","author":"Harlow","year":"1983","journal-title":"J Zool"},{"issue":"1","key":"2022031316002312700_ref24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000460023","article-title":"Plasma progesterone levels throughout the ovarian cycle of the common marmoset (Callithrix jacchus)","volume":"11","author":"Harding","year":"1982","journal-title":"J Med Primatol"},{"issue":"1","key":"2022031316002312700_ref25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1530\/jrf.0.0730133","article-title":"Cloprostenol-induced luteolysis in the marmoset monkey (Callithrix jacchus)","volume":"73","author":"Summers","year":"1985","journal-title":"J Reprod Fertil"},{"issue":"2","key":"2022031316002312700_ref26","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1677\/joe.0.1140231","article-title":"Regulation of the corpus luteum of early pregnancy in the marmoset monkey: local interactions of luteotrophic and luteolytic hormones in vivo and their effects on the secretion of progesterone","volume":"114","author":"Hearn","year":"1987","journal-title":"J Endocrinol"},{"issue":"2","key":"2022031316002312700_ref27","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0015-0282(16)59360-1","article-title":"Controlled ovulation in the marmoset monkey (Callithrix jacchus) with human chorionic gonadotropin following prostaglandin-induced luteal regression","volume":"48","author":"Hodges","year":"1987","journal-title":"Fertil Steril"},{"issue":"3","key":"2022031316002312700_ref28","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0015-0282(16)60141-3","article-title":"Births following the transfer of cultured embryos obtained by in vitro and in vivo fertilization in the marmoset monkey (Callithrix jacchus)","volume":"50","author":"Lopata","year":"1988","journal-title":"Fertil Steril"},{"issue":"2","key":"2022031316002312700_ref29","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1530\/jrf.0.0970481","article-title":"In vitro fertilization and embryo development in the marmoset monkey (Callithrix jacchus)","volume":"97","author":"Wilton","year":"1993","journal-title":"J Reprod Fertil"},{"issue":"6","key":"2022031316002312700_ref30","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1095\/biolreprod59.6.1491","article-title":"Parthenogenetic activation of marmoset (Callithrix jacchus) oocytes and the development of marmoset parthenogenones in vitro and in vivo","volume":"59","author":"Marshall","year":"1998","journal-title":"Biol Reprod"},{"issue":"6","key":"2022031316002312700_ref31","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1095\/biolreprod52.6.1234","article-title":"Meiotic competence of marmoset monkey oocytes is related to follicle size and oocyte-somatic cell associations","volume":"52","author":"Gilchrist","year":"1995","journal-title":"Biol Reprod"},{"issue":"1","key":"2022031316002312700_ref32","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/humrep\/dei283","article-title":"Meiotic abnormalities in in vitro-matured marmoset monkey (Callithrix jacchus) oocytes: development of a non-human primate model to investigate causal factors","volume":"21","author":"Delimitreva","year":"2006","journal-title":"Hum Reprod"},{"issue":"8","key":"2022031316002312700_ref33","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1093\/humrep\/deq148","article-title":"Epidermal growth factor effects on marmoset monkey (Callithrix jacchus) oocyte in vitro maturation, IVF and embryo development are altered by gonadotrophin concentration during oocyte maturation","volume":"25","author":"Tkachenko","year":"2010","journal-title":"Hum Reprod"},{"issue":"1","key":"2022031316002312700_ref34","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1095\/biolreprod56.1.238","article-title":"Maturation, fertilization, and development of marmoset monkey oocytes in vitro","volume":"56","author":"Gilchrist","year":"1997","journal-title":"Biol Reprod"},{"issue":"1","key":"2022031316002312700_ref35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1034\/j.1600-0684.2003.00003.x","article-title":"Ovarian stimulation of marmoset monkeys (Callithrix jacchus) using recombinant human follicle stimulating hormone","volume":"32","author":"Marshall","year":"2003","journal-title":"J Med Primatol"},{"issue":"6","key":"2022031316002312700_ref36","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.theriogenology.2007.07.009","article-title":"Effects of ovarian stimulation, with and without human chorionic gonadotrophin, on oocyte meiotic and developmental competence in the marmoset monkey (Callithrix jacchus)","volume":"68","author":"Grupen","year":"2007","journal-title":"Theriogenology"},{"issue":"4","key":"2022031316002312700_ref37","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1089\/clo.2009.0005","article-title":"Preimplantation development of somatic cell cloned embryos in the common marmoset (Callithrix jacchus)","volume":"11","author":"Sotomaru","year":"2009","journal-title":"Cloning Stem Cells"},{"issue":"7246","key":"2022031316002312700_ref38","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature08090","article-title":"Generation of transgenic non-human primates with germline transmission","volume":"459","author":"Sasaki","year":"2009","journal-title":"Nature"},{"issue":"4","key":"2022031316002312700_ref39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095560","article-title":"Birth of healthy offspring following ICSI in in vitro-matured common marmoset (Callithrix jacchus) oocytes","volume":"9","author":"Takahashi","year":"2014","journal-title":"PLoS One"},{"key":"2022031316002312700_ref40","doi-asserted-by":"crossref","first-page":"34931","DOI":"10.1038\/srep34931","article-title":"Generation of transgenic marmosets expressing genetically encoded calcium indicators","volume":"6","author":"Park","year":"2016","journal-title":"Sci Rep"},{"key":"2022031316002312700_ref41","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.theriogenology.2017.10.023","article-title":"Quality of common marmoset (Callithrix jacchus) oocytes collected after ovarian stimulation","volume":"106","author":"Kanda","year":"2018","journal-title":"Theriogenology"},{"issue":"8","key":"2022031316002312700_ref42","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.theriogenology.2015.01.012","article-title":"Critical estradiol dose optimization for oocyte in vitro maturation in the common marmoset","volume":"83","author":"Tkachenko","year":"2015","journal-title":"Theriogenology"},{"issue":"7","key":"2022031316002312700_ref43","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.theriogenology.2012.06.024","article-title":"Birth of common marmoset (Callithrix jacchus) offspring derived from in vitro-matured oocytes in chemically defined medium","volume":"78","author":"Tomioka","year":"2012","journal-title":"Theriogenology"},{"issue":"2","key":"2022031316002312700_ref44","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/humupd\/1.2.91","article-title":"Culture of preimplantation embryos: facts and artifacts","volume":"1","author":"Bavister","year":"1995","journal-title":"Hum Reprod Update"},{"issue":"9","key":"2022031316002312700_ref45","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s10815-015-0552-9","article-title":"Ultrastructural markers of quality are impaired in human metaphase II aged oocytes: a comparison between reproductive and in vitro aging","volume":"32","author":"Bianchi","year":"2015","journal-title":"J Assist Reprod Genet"},{"issue":"2","key":"2022031316002312700_ref46","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1093\/humrep\/13.2.394","article-title":"Post-ovulatory ageing of the human oocyte and embryo failure","volume":"13","author":"Wilcox","year":"1998","journal-title":"Hum Reprod"},{"issue":"2","key":"2022031316002312700_ref47","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/j.1939-4640.1996.tb01766.x","article-title":"Influence of semen collection method on ejaculate characteristics in the common marmoset, Callithrix jacchus","volume":"17","author":"Morrell","year":"1996","journal-title":"J Androl"},{"issue":"3","key":"2022031316002312700_ref48","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1258\/002367796780684845","article-title":"Collection of semen from marmoset monkeys (Callithrix jacchus) for experimental use by vaginal washing","volume":"30","author":"Kuederling","year":"1996","journal-title":"Lab Anim"},{"issue":"3","key":"2022031316002312700_ref49","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/j.1939-4640.1991.tb00253.x","article-title":"Collection and analysis of semen from the common marmoset (Callithrix jacchus)","volume":"12","author":"Cui","year":"1991","journal-title":"J Androl"},{"issue":"3","key":"2022031316002312700_ref50","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/1098-2345(200011)52:3<149::AID-AJP4>3.0.CO;2-B","article-title":"Non-invasive collection of ejaculates from the common marmoset (Callithrix jacchus) using penile vibrostimulation","volume":"52","author":"Kuederling","year":"2000","journal-title":"Am J Primatol"},{"issue":"2","key":"2022031316002312700_ref51","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1600-0684.2004.00058.x","article-title":"Penile vibratory stimulation in the marmoset monkey: a practical alternative to electro-ejaculation, yielding ejaculates of enhanced quality","volume":"33","author":"Schneiders","year":"2004","journal-title":"J Med Primatol"},{"key":"2022031316002312700_ref52","first-page":"309","article-title":"In vitro culture of embryos from the common marmoset (Callithrix jacchus)","volume":"2019","author":"Schmidt","year":"2006","journal-title":"Methods Mol Biol"},{"issue":"2","key":"2022031316002312700_ref53","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1600-0684.2005.00095.x","article-title":"Comparison of the effects of Percoll and PureSperm on the common marmoset (Callithrix jacchus) semen","volume":"34","author":"Hernandez-Lopez","year":"2005","journal-title":"J Med Primatol"},{"issue":"S1","key":"2022031316002312700_ref54","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/zoo.1430080505","article-title":"In vitro fertilization and embryo transfer technology as an aid to the conservation of endangered primates","volume":"8","author":"Bavister","year":"1989","journal-title":"Zoo Biology"},{"issue":"2","key":"2022031316002312700_ref55","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1530\/jrf.0.0710357","article-title":"Stimulation of rhesus monkey sperm capacitation by cyclic nucleotide mediators","volume":"71","author":"Boatman","year":"1984","journal-title":"J Reprod Fertil"},{"issue":"7","key":"2022031316002312700_ref56","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1242\/dev.00353","article-title":"Bicarbonate actions on flagellar and Ca2+ \u2212channel responses: initial events in sperm activation","volume":"130","author":"Wennemuth","year":"2003","journal-title":"Development"},{"key":"2022031316002312700_ref57","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1477-7827-7-119","article-title":"The BSA-induced Ca2+ influx during sperm capacitation is CATSPER channel-dependent","volume":"7","author":"Xia","year":"2009","journal-title":"Reprod Biol Endocrinol"},{"key":"2022031316002312700_ref58","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0378-4320(00)00096-8","article-title":"In vitro culture and embryo metabolism of cattle and sheep embryos - a decade of achievement","volume":"60-61","author":"Thompson","year":"2000","journal-title":"Anim Reprod Sci"},{"issue":"1","key":"2022031316002312700_ref59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1274\/032.034.0103","article-title":"Practical reproductive techniques for the common marmoset","volume":"34","author":"Kurotaki","year":"2017","journal-title":"J Mammal Ova Res"},{"issue":"1","key":"2022031316002312700_ref60","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1530\/jrf.0.0790241","article-title":"The effects of cryopreservation and transfer on embryonic development in the common marmoset monkey, Callithrix jacchus","volume":"79","author":"Summers","year":"1987","journal-title":"J Reprod Fertil"},{"issue":"5","key":"2022031316002312700_ref61","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-0684.1997.tb00218.x","article-title":"Nonsurgical embryo transfer in the common marmoset monkey","volume":"26","author":"Marshall","year":"1997","journal-title":"J Med Primatol"},{"issue":"5","key":"2022031316002312700_ref62","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1095\/biolreprod.113.109165","article-title":"Efficient embryo transfer in the common marmoset monkey (Callithrix jacchus) with a reduced transfer volume: a non-surgical approach with cryopreserved late-stage embryos","volume":"88","author":"Ishibashi","year":"2013","journal-title":"Biol Reprod"},{"issue":"3","key":"2022031316002312700_ref63","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/BF01730575","article-title":"Comparative anatomy and histology of the cervix uteri in non-human primates","volume":"13","author":"Hafez","year":"1972","journal-title":"Primates"},{"issue":"Pt 3","key":"2022031316002312700_ref64","first-page":"481","article-title":"Anatomy of adult female common marmoset (Callithrix jacchus) reproductive system","volume":"185","author":"Cui","year":"1994","journal-title":"J Anat"},{"issue":"4526","key":"2022031316002312700_ref65","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1126\/science.6272397","article-title":"Integration and stable germ line transmission of genes injected into mouse pronuclei","volume":"214","author":"Gordon","year":"1981","journal-title":"Science"},{"issue":"5556","key":"2022031316002312700_ref66","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1126\/science.1067081","article-title":"Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors","volume":"295","author":"Lois","year":"2002","journal-title":"Science"},{"key":"2022031316002312700_ref67","first-page":"23","article-title":"Inducible transgene expression in mouse stem cells","volume":"105","author":"Ting","year":"2005","journal-title":"Methods Mol Med"},{"issue":"6087","key":"2022031316002312700_ref68","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/323445a0","article-title":"Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector","volume":"323","author":"Robertson","year":"1986","journal-title":"Nature"},{"issue":"7","key":"2022031316002312700_ref69","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nmeth.1225","article-title":"Transgenesis via permanent integration of genes in repopulating spermatogonial cells in vivo","volume":"5","author":"Dhup","year":"2008","journal-title":"Nat Methods"},{"issue":"1","key":"2022031316002312700_ref70","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1095\/biolreprod.104.035659","article-title":"Genetic selection of mouse male germline stem cells in vitro: offspring from single stem cells","volume":"72","author":"Kanatsu-Shinohara","year":"2005","journal-title":"Biol Reprod"},{"issue":"5576","key":"2022031316002312700_ref71","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1126\/science.1071607","article-title":"Germline stem cell transplantation and transgenesis","volume":"296","author":"Brinster","year":"2002","journal-title":"Science"},{"key":"2022031316002312700_ref72","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-1-4939-1215-5_7","article-title":"Intracytoplasmic sperm injection (ICSI)-mediated transgenesis in mice","volume":"1194","author":"Moreira","year":"2014","journal-title":"Methods Mol Biol"},{"issue":"5417","key":"2022031316002312700_ref73","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1126\/science.284.5417.1180","article-title":"Mammalian transgenesis by intracytoplasmic sperm injection","volume":"284","author":"Perry","year":"1999","journal-title":"Science"},{"issue":"6790","key":"2022031316002312700_ref74","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/35016604","article-title":"Production of gene-targeted sheep by nuclear transfer from cultured somatic cells","volume":"405","author":"McCreath","year":"2000","journal-title":"Nature"},{"issue":"2","key":"2022031316002312700_ref75","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1081\/ABIO-100108344","article-title":"Production of nuclear transfer-derived swine that express the enhanced green fluorescent protein","volume":"12","author":"Park","year":"2001","journal-title":"Anim Biotechnol"},{"issue":"5367","key":"2022031316002312700_ref76","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1126\/science.280.5367.1256","article-title":"Cloned transgenic calves produced from nonquiescent fetal fibroblasts","volume":"280","author":"Cibelli","year":"1998","journal-title":"Science"},{"issue":"12","key":"2022031316002312700_ref77","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkr218","article-title":"Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting","volume":"39","author":"Cermak","year":"2011","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"2022031316002312700_ref78","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1534\/genetics.111.131433","article-title":"Genome engineering with zinc-finger nucleases","volume":"188","author":"Carroll","year":"2011","journal-title":"Genetics"},{"issue":"6121","key":"2022031316002312700_ref79","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex genome engineering using CRISPR\/Cas systems","volume":"339","author":"Cong","year":"2013","journal-title":"Science"},{"issue":"9","key":"2022031316002312700_ref80","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/nbt.2675","article-title":"CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering","volume":"31","author":"Mali","year":"2013","journal-title":"Nat Biotechnol"},{"issue":"6018","key":"2022031316002312700_ref81","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/315413a0","article-title":"Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth","volume":"315","author":"Hammer","year":"1985","journal-title":"Nature"},{"issue":"6021","key":"2022031316002312700_ref82","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/315680a0","article-title":"Production of transgenic rabbits, sheep and pigs by microinjection","volume":"315","author":"Hammer","year":"1985","journal-title":"Nature"},{"issue":"2","key":"2022031316002312700_ref83","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1023\/A:1008918913249","article-title":"Size matters: use of YACs, BACs and PACs in transgenic animals","volume":"10","author":"Giraldo","year":"2001","journal-title":"Transgenic Res"},{"issue":"4","key":"2022031316002312700_ref84","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1089\/15362300152725936","article-title":"Pronuclear microinjection","volume":"3","author":"Wall","year":"2001","journal-title":"Cloning Stem Cells"},{"issue":"2","key":"2022031316002312700_ref85","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1095\/biolreprod.116.146514","article-title":"Assisted reproductive technologies in the common marmoset: an integral species for developing nonhuman primate models of human diseases","volume":"96","author":"Kropp","year":"2017","journal-title":"Biol Reprod"},{"issue":"10","key":"2022031316002312700_ref86","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.1073\/pnas.72.10.4008","article-title":"Infection of preimplantation mouse embryos and of newborn mice with leukemia virus: tissue distribution of viral DNA and RNA and leukemogenesis in the adult animal","volume":"72","author":"Jaenisch","year":"1975","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"2022031316002312700_ref87","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1073\/pnas.73.4.1260","article-title":"Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus","volume":"73","author":"Jaenisch","year":"1976","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"2022031316002312700_ref88","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/j.1460-2075.1987.tb04766.x","article-title":"Expression of retroviral vectors in transgenic mice obtained by embryo infection","volume":"6","author":"Stewart","year":"1987","journal-title":"EMBO J"},{"issue":"4782","key":"2022031316002312700_ref89","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1126\/science.3024318","article-title":"Tissue-specific and ectopic expression of genes introduced into transgenic mice by retroviruses","volume":"234","author":"Soriano","year":"1986","journal-title":"Science"},{"issue":"2","key":"2022031316002312700_ref90","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1073\/pnas.83.2.366","article-title":"Introduction of genes into preimplantation mouse embryos by use of a defective recombinant retrovirus","volume":"83","author":"Rubenstein","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"18","key":"2022031316002312700_ref91","doi-asserted-by":"crossref","first-page":"6148","DOI":"10.1073\/pnas.82.18.6148","article-title":"Efficient insertion of genes into the mouse germ line via retroviral vectors","volume":"82","author":"van der Putten","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"2022031316002312700_ref92","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nm0395-275","article-title":"Pseudotyped retroviral vectors for studies of human gene therapy","volume":"1","author":"Friedmann","year":"1995","journal-title":"Nat Med"},{"issue":"11","key":"2022031316002312700_ref93","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/sj.embor.7400007","article-title":"Efficient transgenesis in farm animals by lentiviral vectors","volume":"4","author":"Hofmann","year":"2003","journal-title":"EMBO Rep"},{"issue":"2","key":"2022031316002312700_ref94","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1095\/biolreprod.104.028472","article-title":"Generation of transgenic cattle by lentiviral gene transfer into oocytes","volume":"71","author":"Hofmann","year":"2004","journal-title":"Biol Reprod"},{"issue":"4","key":"2022031316002312700_ref95","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s11248-009-9333-5","article-title":"Germ-line transmission of lentiviral PGK-EGFP integrants in transgenic cattle: new perspectives for experimental embryology","volume":"19","author":"Reichenbach","year":"2010","journal-title":"Transgenic Res"},{"issue":"1","key":"2022031316002312700_ref96","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054614","article-title":"Highly efficient generation of transgenic sheep by lentivirus accompanying the alteration of methylation status","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"2022031316002312700_ref97","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.anireprosci.2016.05.009","article-title":"Production of germline transgenic pigs co-expressing double fluorescent proteins by lentiviral vector","volume":"174","author":"Chen","year":"2016","journal-title":"Anim Reprod Sci"},{"issue":"3","key":"2022031316002312700_ref98","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/mrd.1080400316","article-title":"Efficient production of transgenic cattle by retroviral infection of early embryos","volume":"40","author":"Haskell","year":"1995","journal-title":"Mol Reprod Dev"},{"issue":"24","key":"2022031316002312700_ref99","doi-asserted-by":"crossref","first-page":"14028","DOI":"10.1073\/pnas.95.24.14028","article-title":"Transgenic cattle produced by reverse-transcribed gene transfer in oocytes","volume":"95","author":"Chan","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5502","key":"2022031316002312700_ref100","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.291.5502.309","article-title":"Transgenic monkeys produced by retroviral gene transfer into mature oocytes","volume":"291","author":"Chan","year":"2001","journal-title":"Science"},{"issue":"19","key":"2022031316002312700_ref101","doi-asserted-by":"crossref","first-page":"10728","DOI":"10.1073\/pnas.181336098","article-title":"Rhesus monkey placental transgene expression after lentiviral gene transfer into preimplantation embryos","volume":"98","author":"Wolfgang","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"41","key":"2022031316002312700_ref102","doi-asserted-by":"crossref","first-page":"17663","DOI":"10.1073\/pnas.1006563107","article-title":"Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector","volume":"107","author":"Niu","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"2022031316002312700_ref103","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nbt1280","article-title":"Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer","volume":"25","author":"Okada","year":"2007","journal-title":"Nat Biotechnol"},{"issue":"7","key":"2022031316002312700_ref104","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/dvg.20313","article-title":"Lentivirus as a tool for lineage-specific gene manipulations","volume":"45","author":"Malashicheva","year":"2007","journal-title":"Genesis"},{"key":"2022031316002312700_ref105","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jbiotec.2017.07.037","article-title":"Placenta-specific gene manipulation in rabbits","volume":"259","author":"Skoda","year":"2017","journal-title":"J Biotechnol"},{"key":"2022031316002312700_ref106","doi-asserted-by":"crossref","first-page":"24868","DOI":"10.1038\/srep24868","article-title":"Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body","volume":"6","author":"Seita","year":"2016","journal-title":"Sci Rep"},{"issue":"15","key":"2022031316002312700_ref107","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1089\/104303401753153947","article-title":"Systematic determination of the packaging limit of lentiviral vectors","volume":"12","author":"Kumar","year":"2001","journal-title":"Hum Gene Ther"},{"issue":"5","key":"2022031316002312700_ref108","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/0092-8674(89)90787-3","article-title":"Sperm cells as vectors for introducing foreign DNA into eggs: genetic transformation of mice","volume":"57","author":"Lavitrano","year":"1989","journal-title":"Cell"},{"issue":"2","key":"2022031316002312700_ref109","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0092-8674(89)90282-1","article-title":"No simple solution for making transgenic mice","volume":"59","author":"Brinster","year":"1989","journal-title":"Cell"},{"issue":"1\u20132","key":"2022031316002312700_ref110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10495399909525917","article-title":"Sperm cell mediated transgenesis: a review","volume":"10","author":"Smith","year":"1999","journal-title":"Anim Biotechnol"},{"issue":"5","key":"2022031316002312700_ref111","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/bies.20211","article-title":"Sperm-mediated gene transfer: applications and implications","volume":"27","author":"Smith","year":"2005","journal-title":"BioEssays"},{"key":"2022031316002312700_ref112","first-page":"151","article-title":"Generation of yeast artificial chromosome transgenic mice by intracytoplasmic sperm injection","volume":"349","author":"Moreira","year":"2006","journal-title":"Methods Mol Biol"},{"issue":"1","key":"2022031316002312700_ref113","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.theriogenology.2006.09.034","article-title":"Transgenic animal production and animal biotechnology","volume":"67","author":"Robl","year":"2007","journal-title":"Theriogenology"},{"issue":"5","key":"2022031316002312700_ref114","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1095\/biolreprod.107.063040","article-title":"Genomic DNA damage in mouse transgenesis","volume":"77","author":"Yamauchi","year":"2007","journal-title":"Biol Reprod"},{"issue":"6","key":"2022031316002312700_ref115","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1095\/biolreprod.104.032904","article-title":"Efficient generation of transgenic mice with intact yeast artificial chromosomes by intracytoplasmic sperm injection","volume":"71","author":"Moreira","year":"2004","journal-title":"Biol Reprod"},{"issue":"1","key":"2022031316002312700_ref116","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/molehr\/6.1.26","article-title":"Foreign DNA transmission by ICSI: injection of spermatozoa bound with exogenous DNA results in embryonic GFP expression and live rhesus monkey births","volume":"6","author":"Chan","year":"2000","journal-title":"Mol Hum Reprod"},{"issue":"1","key":"2022031316002312700_ref117","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/humrep\/16.1.130","article-title":"Developmental competence of oocytes after ICSI in the rhesus monkey","volume":"16","author":"Nusser","year":"2001","journal-title":"Hum Reprod"},{"issue":"S2","key":"2022031316002312700_ref118","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/(SICI)1098-2795(200006)56:2+<325::AID-MRD25>3.0.CO;2-N","article-title":"TransgenICSI reviewed: foreign DNA transmission by intracytoplasmic sperm injection in rhesus monkey","volume":"56","author":"Chan","year":"2000","journal-title":"Mol Reprod Dev"},{"issue":"5965","key":"2022031316002312700_ref119","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/309255a0","article-title":"Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines","volume":"309","author":"Bradley","year":"1984","journal-title":"Nature"},{"issue":"7151","key":"2022031316002312700_ref120","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nature05944","article-title":"In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state","volume":"448","author":"Wernig","year":"2007","journal-title":"Nature"},{"issue":"7151","key":"2022031316002312700_ref121","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature05934","article-title":"Generation of germline-competent induced pluripotent stem cells","volume":"448","author":"Okita","year":"2007","journal-title":"Nature"},{"issue":"1","key":"2022031316002312700_ref122","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.stem.2007.05.014","article-title":"Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution","volume":"1","author":"Maherali","year":"2007","journal-title":"Cell Stem Cell"},{"issue":"18","key":"2022031316002312700_ref123","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1242\/dev.116061","article-title":"The pluripotent state in mouse and human","volume":"142","author":"Davidson","year":"2015","journal-title":"Development"},{"issue":"5819","key":"2022031316002312700_ref124","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/292154a0","article-title":"Establishment in culture of pluripotential cells from mouse embryos","volume":"292","author":"Evans","year":"1981","journal-title":"Nature"},{"issue":"12","key":"2022031316002312700_ref125","doi-asserted-by":"crossref","first-page":"7634","DOI":"10.1073\/pnas.78.12.7634","article-title":"Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells","volume":"78","author":"Martin","year":"1981","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"2022031316002312700_ref126","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/humrep\/dep012","article-title":"A novel embryonic stem cell line derived from the common marmoset monkey (Callithrix jacchus) exhibiting germ cell-like characteristics","volume":"24","author":"Muller","year":"2009","journal-title":"Hum Reprod"},{"issue":"9","key":"2022031316002312700_ref127","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1634\/stemcells.2004-0366","article-title":"Establishment of novel embryonic stem cell lines derived from the common marmoset (Callithrix jacchus)","volume":"23","author":"Sasaki","year":"2005","journal-title":"Stem Cells"},{"issue":"9","key":"2022031316002312700_ref128","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/j.1365-2443.2010.01437.x","article-title":"Generating induced pluripotent stem cells from common marmoset (Callithrix jacchus) fetal liver cells using defined factors, including Lin28","volume":"15","author":"Tomioka","year":"2010","journal-title":"Genes Cells"},{"issue":"6","key":"2022031316002312700_ref129","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1089\/cell.2012.0036","article-title":"Induced pluripotent stem cells generated from adult bone marrow-derived cells of the nonhuman primate (Callithrix jacchus) using a novel quad-cistronic and excisable lentiviral vector","volume":"14","author":"Wiedemann","year":"2012","journal-title":"Cell Reprogram"},{"issue":"7","key":"2022031316002312700_ref130","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/gtc.12702","article-title":"Highly efficient induction of primate iPS cells by combining RNA transfection and chemical compounds","volume":"24","author":"Watanabe","year":"2019","journal-title":"Genes Cells"},{"issue":"6","key":"2022031316002312700_ref131","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/ncb2965","article-title":"The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification","volume":"16","author":"Boroviak","year":"2014","journal-title":"Nat Cell Biol"},{"issue":"7194","key":"2022031316002312700_ref132","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature06968","article-title":"The ground state of embryonic stem cell self-renewal","volume":"453","author":"Ying","year":"2008","journal-title":"Nature"},{"issue":"7","key":"2022031316002312700_ref133","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.cell.2008.12.006","article-title":"Germline competent embryonic stem cells derived from rat blastocysts","volume":"135","author":"Li","year":"2008","journal-title":"Cell"},{"issue":"7","key":"2022031316002312700_ref134","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.cell.2008.12.007","article-title":"Capture of authentic embryonic stem cells from rat blastocysts","volume":"135","author":"Buehr","year":"2008","journal-title":"Cell"},{"issue":"4","key":"2022031316002312700_ref135","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.stem.2014.07.002","article-title":"Systematic identification of culture conditions for induction and maintenance of naive human pluripotency","volume":"15","author":"Theunissen","year":"2014","journal-title":"Cell Stem Cell"},{"issue":"6","key":"2022031316002312700_ref136","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.cell.2014.08.029","article-title":"Resetting transcription factor control circuitry toward ground-state pluripotency in human","volume":"158","author":"Takashima","year":"2014","journal-title":"Cell"},{"issue":"20","key":"2022031316002312700_ref137","doi-asserted-by":"crossref","first-page":"9222","DOI":"10.1073\/pnas.1004584107","article-title":"Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs","volume":"107","author":"Hanna","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022031316002312700_ref138","doi-asserted-by":"crossref","first-page":"45285","DOI":"10.1038\/srep45285","article-title":"Discrimination of stem cell status after subjecting Cynomolgus monkey pluripotent stem cells to naive conversion","volume":"7","author":"Honda","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"2022031316002312700_ref139","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.stem.2015.06.004","article-title":"Generation of Cynomolgus monkey chimeric Fetuses using embryonic stem cells","volume":"17","author":"Chen","year":"2015","journal-title":"Cell Stem Cell"},{"issue":"1\u20132","key":"2022031316002312700_ref140","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2011.12.007","article-title":"Generation of chimeric rhesus monkeys","volume":"148","author":"Tachibana","year":"2012","journal-title":"Cell"},{"issue":"7260","key":"2022031316002312700_ref141","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/nature08267","article-title":"iPS cells produce viable mice through tetraploid complementation","volume":"461","author":"Zhao","year":"2009","journal-title":"Nature"},{"issue":"4","key":"2022031316002312700_ref142","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.cell.2008.01.015","article-title":"Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming","volume":"132","author":"Jaenisch","year":"2008","journal-title":"Cell"},{"issue":"3","key":"2022031316002312700_ref143","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1242\/dev.110.3.815","article-title":"Embryonic stem cells alone are able to support fetal development in the mouse","volume":"110","author":"Nagy","year":"1990","journal-title":"Development"},{"issue":"2","key":"2022031316002312700_ref144","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0027-5107(93)90159-D","article-title":"A quantitative study of spermatogonial multiplication and stem cell renewal in the C3H\/101 F1 hybrid mouse","volume":"290","author":"Tegelenbosch","year":"1993","journal-title":"Mutat Res"},{"key":"2022031316002312700_ref145","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.scr.2018.04.009","article-title":"Spermatogonial stem cells and spermatogenesis in mice, monkeys and men","volume":"29","author":"Fayomi","year":"2018","journal-title":"Stem Cell Res"},{"issue":"24","key":"2022031316002312700_ref146","doi-asserted-by":"crossref","first-page":"11298","DOI":"10.1073\/pnas.91.24.11298","article-title":"Spermatogenesis following male germ-cell transplantation","volume":"91","author":"Brinster","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"2022031316002312700_ref147","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1095\/biolreprod.103.017012","article-title":"Long-term proliferation in culture and germline transmission of mouse male germline stem cells","volume":"69","author":"Kanatsu-Shinohara","year":"2003","journal-title":"Biol Reprod"},{"issue":"21","key":"2022031316002312700_ref148","doi-asserted-by":"crossref","first-page":"8018","DOI":"10.1073\/pnas.0601139103","article-title":"Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells","volume":"103","author":"Kanatsu-Shinohara","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7088","key":"2022031316002312700_ref149","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/nature04697","article-title":"Pluripotency of spermatogonial stem cells from adult mouse testis","volume":"440","author":"Guan","year":"2006","journal-title":"Nature"},{"issue":"6","key":"2022031316002312700_ref150","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nbt0606-663","article-title":"The germ of pluripotency","volume":"24","author":"Kanatsu-Shinohara","year":"2006","journal-title":"Nat Biotechnol"},{"issue":"7","key":"2022031316002312700_ref151","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cell.2004.11.011","article-title":"Generation of pluripotent stem cells from neonatal mouse testis","volume":"119","author":"Kanatsu-Shinohara","year":"2004","journal-title":"Cell"},{"issue":"2","key":"2022031316002312700_ref152","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00441-020-03212-x","article-title":"The study and manipulation of spermatogonial stem cells using animal models","volume":"380","author":"Ibtisham","year":"2020","journal-title":"Cell Tissue Res"},{"issue":"1","key":"2022031316002312700_ref153","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1095\/biolreprod.111.090837","article-title":"Homologous recombination in rat germline stem cells","volume":"85","author":"Kanatsu-Shinohara","year":"2011","journal-title":"Biol Reprod"},{"issue":"4","key":"2022031316002312700_ref154","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1095\/biolreprod.103.018788","article-title":"Fertility and germline transmission of donor haplotype following germ cell transplantation in immunocompetent goats","volume":"69","author":"Honaramooz","year":"2003","journal-title":"Biol Reprod"},{"issue":"5","key":"2022031316002312700_ref155","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1095\/biolreprod.109.078279","article-title":"Irradiation enhances the efficiency of testicular germ cell transplantation in sheep","volume":"81","author":"Herrid","year":"2009","journal-title":"Biol Reprod"},{"issue":"6619","key":"2022031316002312700_ref156","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/385810a0","article-title":"Viable offspring derived from fetal and adult mammalian cells","volume":"385","author":"Wilmut","year":"1997","journal-title":"Nature"},{"issue":"6691","key":"2022031316002312700_ref157","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/28615","article-title":"Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei","volume":"394","author":"Wakayama","year":"1998","journal-title":"Nature"},{"issue":"5","key":"2022031316002312700_ref158","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/8632","article-title":"Production of goats by somatic cell nuclear transfer","volume":"17","author":"Baguisi","year":"1999","journal-title":"Nat Biotechnol"},{"issue":"5636","key":"2022031316002312700_ref159","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1126\/science.1086743","article-title":"A mule cloned from fetal cells by nuclear transfer","volume":"301","author":"Woods","year":"2003","journal-title":"Science"},{"issue":"6949","key":"2022031316002312700_ref160","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/424635a","article-title":"Pregnancy: a cloned horse born to its dam twin","volume":"424","author":"Galli","year":"2003","journal-title":"Nature"},{"issue":"5648","key":"2022031316002312700_ref161","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1126\/science.1088313","article-title":"Generation of fertile cloned rats by regulating oocyte activation","volume":"302","author":"Zhou","year":"2003","journal-title":"Science"},{"issue":"5396","key":"2022031316002312700_ref162","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1126\/science.282.5396.2095","article-title":"Eight calves cloned from somatic cells of a single adult","volume":"282","author":"Kato","year":"1998","journal-title":"Science"},{"issue":"4","key":"2022031316002312700_ref163","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1095\/biolreprod60.4.996","article-title":"Production of cloned calves following nuclear transfer with cultured adult mural granulosa cells","volume":"60","author":"Wells","year":"1999","journal-title":"Biol Reprod"},{"issue":"5503","key":"2022031316002312700_ref164","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.291.5503.409A","article-title":"Endangered species. Cloned gaur a short-lived success","volume":"291","author":"Vogel","year":"2001","journal-title":"Science"},{"issue":"6874","key":"2022031316002312700_ref165","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nature723","article-title":"A cat cloned by nuclear transplantation","volume":"415","author":"Shin","year":"2002","journal-title":"Nature"},{"issue":"5482","key":"2022031316002312700_ref166","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1126\/science.289.5482.1188","article-title":"Pig cloning by microinjection of fetal fibroblast nuclei","volume":"289","author":"Onishi","year":"2000","journal-title":"Science"},{"issue":"6800","key":"2022031316002312700_ref167","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35024082","article-title":"Cloned pigs produced by nuclear transfer from adult somatic cells","volume":"407","author":"Polejaeva","year":"2000","journal-title":"Nature"},{"issue":"7051","key":"2022031316002312700_ref168","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/436641a","article-title":"Dogs cloned from adult somatic cells","volume":"436","author":"Lee","year":"2005","journal-title":"Nature"},{"issue":"2","key":"2022031316002312700_ref169","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1095\/biolreprod57.2.454","article-title":"Rhesus monkeys produced by nuclear transfer","volume":"57","author":"Meng","year":"1997","journal-title":"Biol Reprod"},{"issue":"5","key":"2022031316002312700_ref170","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1095\/biolreprod66.5.1367","article-title":"Rhesus monkey embryos produced by nuclear transfer from embryonic blastomeres or somatic cells","volume":"66","author":"Mitalipov","year":"2002","journal-title":"Biol Reprod"},{"issue":"8","key":"2022031316002312700_ref171","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1093\/humrep\/dem136","article-title":"Reprogramming following somatic cell nuclear transfer in primates is dependent upon nuclear remodeling","volume":"22","author":"Mitalipov","year":"2007","journal-title":"Hum Reprod"},{"issue":"10","key":"2022031316002312700_ref172","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1242\/dev.01118","article-title":"The first cell cycle after transfer of somatic cell nuclei in a non-human primate","volume":"131","author":"Ng","year":"2004","journal-title":"Development"},{"issue":"5617","key":"2022031316002312700_ref173","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1126\/science.1082091","article-title":"Molecular correlates of primate nuclear transfer failures","volume":"300","author":"Simerly","year":"2003","journal-title":"Science"},{"issue":"2","key":"2022031316002312700_ref174","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ydbio.2004.10.006","article-title":"Embryogenesis and blastocyst development after somatic cell nuclear transfer in nonhuman primates: overcoming defects caused by meiotic spindle extraction","volume":"276","author":"Simerly","year":"2004","journal-title":"Dev Biol"},{"issue":"7169","key":"2022031316002312700_ref175","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature06357","article-title":"Producing primate embryonic stem cells by somatic cell nuclear transfer","volume":"450","author":"Byrne","year":"2007","journal-title":"Nature"},{"issue":"3","key":"2022031316002312700_ref176","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1095\/biolreprod.109.077016","article-title":"Significant improvement in cloning efficiency of an inbred miniature pig by histone deacetylase inhibitor treatment after somatic cell nuclear transfer","volume":"81","author":"Zhao","year":"2009","journal-title":"Biol Reprod"},{"issue":"1","key":"2022031316002312700_ref177","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bbrc.2005.11.164","article-title":"Significant improvement of mouse cloning technique by treatment with trichostatin a after somatic nuclear transfer","volume":"340","author":"Kishigami","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"2022031316002312700_ref178","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1262\/jrd.10-058A","article-title":"Treatment with a histone deacetylase inhibitor after nuclear transfer improves the preimplantation development of cloned bovine embryos","volume":"57","author":"Akagi","year":"2011","journal-title":"J Reprod Dev"},{"issue":"6","key":"2022031316002312700_ref179","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.cell.2013.05.006","article-title":"Human embryonic stem cells derived by somatic cell nuclear transfer","volume":"153","author":"Tachibana","year":"2013","journal-title":"Cell"},{"issue":"4","key":"2022031316002312700_ref180","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.cell.2014.09.055","article-title":"Embryonic development following somatic cell nuclear transfer impeded by persisting histone methylation","volume":"159","author":"Matoba","year":"2014","journal-title":"Cell"},{"key":"2022031316002312700_ref181","doi-asserted-by":"crossref","first-page":"16010","DOI":"10.1038\/celldisc.2016.10","article-title":"Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing","volume":"2","author":"Liu","year":"2016","journal-title":"Cell Discov"},{"issue":"6","key":"2022031316002312700_ref182","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.stem.2015.10.001","article-title":"Histone demethylase expression enhances human somatic cell nuclear transfer efficiency and promotes derivation of pluripotent stem cells","volume":"17","author":"Chung","year":"2015","journal-title":"Cell Stem Cell"},{"issue":"5","key":"2022031316002312700_ref183","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1128\/MCB.01014-12","article-title":"Transient JMJD2B-mediated reduction of H3K9me3 levels improves reprogramming of embryonic stem cells into cloned embryos","volume":"33","author":"Antony","year":"2013","journal-title":"Mol Cell Biol"},{"issue":"1","key":"2022031316002312700_ref184","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.cell.2018.01.036","article-title":"Cloning of macaque monkeys by somatic cell nuclear transfer","volume":"174","author":"Liu","year":"2018","journal-title":"Cell"},{"issue":"1","key":"2022031316002312700_ref185","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/nsr\/nwz003","article-title":"Cloning of a gene-edited macaque monkey by somatic cell nuclear transfer","volume":"6","author":"Liu","year":"2019","journal-title":"Natl Sci Rev"},{"issue":"4","key":"2022031316002312700_ref186","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.cell.2014.01.027","article-title":"Generation of gene-modified cynomolgus monkey via Cas9\/RNA-mediated gene targeting in one-cell embryos","volume":"156","author":"Niu","year":"2014","journal-title":"Cell"},{"issue":"3","key":"2022031316002312700_ref187","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.stem.2014.01.018","article-title":"TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys","volume":"14","author":"Liu","year":"2014","journal-title":"Cell Stem Cell"},{"issue":"1","key":"2022031316002312700_ref188","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11033-013-2853-3","article-title":"Targeted disruption of the sheep MSTN gene by engineered zinc-finger nucleases","volume":"41","author":"Zhang","year":"2014","journal-title":"Mol Biol Rep"},{"key":"2022031316002312700_ref189","article-title":"Production of apolipoprotein C-III knockout rabbits using zinc finger nucleases","volume":"81","author":"Yang","year":"2013","journal-title":"J Vis Exp"},{"key":"2022031316002312700_ref190","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1038\/srep02847","article-title":"Live pigs produced from genome edited zygotes","volume":"3","author":"Lillico","year":"2013","journal-title":"Sci Rep"},{"key":"2022031316002312700_ref191","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1038\/srep01981","article-title":"Production of biallelic CMP-Neu5Ac hydroxylase knock-out pigs","volume":"3","author":"Kwon","year":"2013","journal-title":"Sci Rep"},{"key":"2022031316002312700_ref192","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13059-015-0653-x","article-title":"Cloning-free CRISPR\/Cas system facilitates functional cassette knock-in in mice","volume":"16","author":"Aida","year":"2015","journal-title":"Genome Biol"},{"issue":"1","key":"2022031316002312700_ref193","doi-asserted-by":"crossref","first-page":"12719","DOI":"10.1038\/s41598-019-49110-3","article-title":"Efficient generation of knock-in\/knock-out marmoset embryo via CRISPR\/Cas9 gene editing","volume":"9","author":"Kumita","year":"2019","journal-title":"Sci Rep"},{"issue":"6","key":"2022031316002312700_ref194","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.cell.2013.08.022","article-title":"One-step generation of mice carrying reporter and conditional alleles by CRISPR\/Cas-mediated genome engineering","volume":"154","author":"Yang","year":"2013","journal-title":"Cell"},{"issue":"1","key":"2022031316002312700_ref195","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nprot.2015.140","article-title":"MMEJ-assisted gene knock-in using TALENs and CRISPR-Cas9 with the PITCh systems","volume":"11","author":"Sakuma","year":"2016","journal-title":"Nat Protoc"},{"issue":"1","key":"2022031316002312700_ref196","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/s12864-018-4713-y","article-title":"CLICK: one-step generation of conditional knockout mice","volume":"19","author":"Miyasaka","year":"2018","journal-title":"BMC Genomics"},{"issue":"17","key":"2022031316002312700_ref197","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1111\/febs.12935","article-title":"Generation of eGFP and Cre knockin rats by CRISPR\/Cas9","volume":"281","author":"Ma","year":"2014","journal-title":"FEBS J"},{"issue":"8","key":"2022031316002312700_ref198","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nrm.2017.48","article-title":"Non-homologous DNA end joining and alternative pathways to double-strand break repair","volume":"18","author":"Chang","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"2022031316002312700_ref199","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/cr.2018.10","article-title":"Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR\/Cas9-assisted homologous recombination","volume":"28","author":"Cui","year":"2018","journal-title":"Cell Res"},{"issue":"3","key":"2022031316002312700_ref200","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/cr.2018.9","article-title":"Generation of knock-in cynomolgus monkey via CRISPR\/Cas9 editing","volume":"28","author":"Yao","year":"2018","journal-title":"Cell Res"},{"issue":"13","key":"2022031316002312700_ref201","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1016\/j.celrep.2019.05.103","article-title":"CRISPR-READI: efficient generation of Knockin mice by CRISPR RNP electroporation and AAV donor infection","volume":"27","author":"Chen","year":"2019","journal-title":"Cell Rep"},{"key":"2022031316002312700_ref202","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.isci.2018.10.030","article-title":"Intra-embryo gene cassette Knockin by CRISPR\/Cas9-mediated genome editing with adeno-associated viral vector","volume":"9","author":"Mizuno","year":"2018","journal-title":"iScience"},{"issue":"6305","key":"2022031316002312700_ref203","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf8729","article-title":"Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems","volume":"353","author":"Nishida","year":"2016","journal-title":"Science"},{"issue":"7603","key":"2022031316002312700_ref204","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nature17946","article-title":"Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage","volume":"533","author":"Komor","year":"2016","journal-title":"Nature"},{"issue":"7681","key":"2022031316002312700_ref205","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nature24644","article-title":"Programmable base editing of a*T to G*C in genomic DNA without DNA cleavage","volume":"551","author":"Gaudelli","year":"2017","journal-title":"Nature"},{"issue":"1","key":"2022031316002312700_ref206","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1038\/s41467-020-16173-0","article-title":"Multiplex precise base editing in cynomolgus monkeys","volume":"11","author":"Zhang","year":"2020","journal-title":"Nat Commun"},{"key":"2022031316002312700_ref207","article-title":"Protein cell: generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing","author":"Wang","year":"2020"},{"issue":"2","key":"2022031316002312700_ref208","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0378-4320(97)00092-4","article-title":"Artificial insemination in Callithrix jacchus using fresh or cryopreserved sperm","volume":"52","author":"Morrell","year":"1998","journal-title":"Anim Reprod Sci"},{"key":"2022031316002312700_ref209","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neuroscience.2017.09.021","article-title":"Developmental trajectories of macroanatomical structures in common marmoset brain","volume":"364","author":"Seki","year":"2017","journal-title":"Neuroscience"},{"issue":"4","key":"2022031316002312700_ref210","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1016\/j.neuroimage.2010.10.061","article-title":"Population-averaged standard template brain atlas for the common marmoset (Callithrix jacchus)","volume":"54","author":"Hikishima","year":"2011","journal-title":"NeuroImage"},{"key":"2022031316002312700_ref211","first-page":"102","volume-title":"Atlas of the developing brain of the marmoset monkey constructed using magnetic resonance histology","author":"Hikishima","year":"2013"},{"key":"2022031316002312700_ref212","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.neuroimage.2017.12.004","article-title":"A digital 3D atlas of the marmoset brain based on multi-modal MRI","volume":"169","author":"Liu","year":"2018","journal-title":"NeuroImage"},{"key":"2022031316002312700_ref213","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fnbeh.2020.00034","article-title":"Avoidant coping style to high imminence threat is linked to higher anxiety-like behavior","volume":"14","author":"Quah","year":"2020","journal-title":"Front Behav Neurosci"},{"issue":"3","key":"2022031316002312700_ref214","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3174\/ajnr.A1390","article-title":"Voxel-based morphometry in individual patients: a pilot study in early Huntington disease","volume":"30","author":"Muhlau","year":"2009","journal-title":"AJNR Am J Neuroradiol"},{"key":"2022031316002312700_ref215","article-title":"Transgenic Monkey Model of the Polyglutamine Diseases Recapitulating Progressive Neurological Symptoms","volume":"28","author":"","year":"2017","journal-title":"eNeuro"}],"container-title":["ILAR Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ilarjournal\/article-pdf\/61\/2-3\/286\/42828837\/ilab002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ilarjournal\/article-pdf\/61\/2-3\/286\/42828837\/ilab002.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T05:18:40Z","timestamp":1698556720000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ilarjournal\/article\/61\/2-3\/286\/6159788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":215,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2021,3,8]]},"published-print":{"date-parts":[[2020,12,31]]}},"URL":"https:\/\/doi.org\/10.1093\/ilar\/ilab002","relation":{},"ISSN":["1084-2020","1930-6180"],"issn-type":[{"value":"1084-2020","type":"print"},{"value":"1930-6180","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020]]},"published":{"date-parts":[[2020]]}}}