{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:17:32Z","timestamp":1785237452443,"version":"3.55.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T00:00:00Z","timestamp":1648944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior - Brasil","doi-asserted-by":"crossref","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We propose a mathematical model to study the antibody-dependent enhancement (ADE) phenomenon. Here, we explore the interaction between macrophages, dengue virus and plasma cells, especially the effect of a limitation on plasma cell proliferation, which occurs due to immunological memory. The model has up to three equilibrium points: one virus-free equilibrium and two virus-presence equilibrium, depending on the value of two thresholds. We determine the existence regions for the model equilibrium points and their stability, a sensitivity analysis was performed in the model thresholds. Numerical simulations illustrate that ADE can occur even when the basic reproduction number is less than one.<\/jats:p>","DOI":"10.1093\/imammb\/dqab021","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T20:11:12Z","timestamp":1639771872000},"page":"169-196","source":"Crossref","is-referenced-by-count":6,"title":["A mathematical model to describe antibody-dependent enhancement and assess the effect of limiting cloning for plasma cells in heterologous secondary dengue infection"],"prefix":"10.1093","volume":"39","author":[{"given":"Felipe","family":"Alves Rubio","sequence":"first","affiliation":[{"name":"Institute of Collective Health , Federal University of Bahia, Bas\u00edlio da Gama, s\/n\u00b0 Campus Universit\u00e1rio Canela, CEP 40110-040, Salvador, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Mo Yang","sequence":"additional","affiliation":[{"name":"Institute of Mathematics , Statistics and Scientific Computing, University of Campinas, S\u00e9rgio Buarque de Holanda 651, CEP 13083-859, Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,3]]},"reference":[{"key":"2022061112552283500_ref1","volume-title":"Imunologia Celular e Molecular","author":"Abbas","year":"2015"},{"key":"2022061112552283500_ref2","volume-title":"Molecular Biology of the Cell","author":"Alberts","year":"2002"},{"key":"2022061112552283500_ref3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2307\/1403510","article-title":"Sensitivity and uncertainty analysis of complex models of disease transmission: an HIV model, as an example","volume":"62","author":"Blower","year":"1994","journal-title":"Int. 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