{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:58:01Z","timestamp":1772773081272,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008982","name":"National Science Foundation","doi-asserted-by":"publisher","award":["award CBET-2042834"],"award-info":[{"award-number":["award CBET-2042834"]}],"id":[{"id":"10.13039\/501100008982","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH\/National Institute of Mental Health Ruth L. Kirchstein NRSA","award":["F30 MH122076-01"],"award-info":[{"award-number":["F30 MH122076-01"]}]},{"DOI":"10.13039\/100006063","name":"Paul and Daisy Soros Fellowship for New Americans","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006063","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This paper reports a minimal model simulating the growth of a Lewy body (LB). To the best of our knowledge, this is the first model simulating LB growth. The LB is assumed to consist of a central spherical core, which is composed of membrane fragments and various dysfunctional intracellular organelles, and a halo, which is composed of alpha-synuclein (\u03b1-syn) fibrils. Membrane fragments and \u03b1-syn monomers are assumed to be produced in the soma at constant rates. The growth of the core and the halo are simulated by the Finke\u2013Watzky model. Analytical (closed-form) solutions describing the growth of the core and the halo are obtained. A sensitivity analysis in terms of model parameters is performed.<\/jats:p>","DOI":"10.1093\/imammb\/dqac006","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T15:09:45Z","timestamp":1651676985000},"page":"299-312","source":"Crossref","is-referenced-by-count":10,"title":["An analytical solution simulating growth of Lewy bodies"],"prefix":"10.1093","volume":"39","author":[{"given":"Ivan A","family":"Kuznetsov","sequence":"first","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine, , Philadelphia, PA 19104, USA"},{"name":"University of Pennsylvania Department of Bioengineering, , Philadelphia, PA 19104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey V","family":"Kuznetsov","sequence":"additional","affiliation":[{"name":"North Carolina State University, Raleigh Department of Mechanical and Aerospace Engineering, , NC 27695-7910, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,6,2]]},"reference":[{"key":"2022091304342385600_ref1","volume-title":"Parameter Estimation in Science and Engineering","author":"Beck","year":"1977"},{"key":"2022091304342385600_ref2","doi-asserted-by":"crossref","first-page":"5302","DOI":"10.1021\/acs.jpcc.6b12021","article-title":"Sigmoidal nucleation and growth curves across nature fit by the Finke\u2013Watzky model of slow continuous nucleation and autocatalytic growth: explicit formulas for the lag and growth times plus other key insights","volume":"121","author":"Bentea","year":"2017","journal-title":"J. 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