{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T08:55:32Z","timestamp":1742806532749},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Research Training Group in Modeling and Simulation","award":["RTG\/DMS-1646339"],"award-info":[{"award-number":["RTG\/DMS-1646339"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This paper describes computer models of three interventions used for treating refractory pulmonary hypertension (RPH). These procedures create either an atrial septal defect, a ventricular septal defect or, in the case of a Potts shunt, a patent ductus arteriosus. The aim in all three cases is to generate a right-to-left shunt, allowing for either pressure or volume unloading of the right side of the heart in the setting of right ventricular failure, while maintaining cardiac output. These shunts are created, however, at the expense of introducing de-oxygenated blood into the systemic circulation, thereby lowering the systemic arterial oxygen saturation. The models developed in this paper are based on compartmental descriptions of human hemodynamics and oxygen transport. An important parameter included in our models is the cross-sectional area of the surgically created defect. Numerical simulations are performed to compare different interventions and various shunt sizes and to assess their impact on hemodynamic variables and oxygen saturations. We also create a model for exercise and use it to study exercise tolerance in simulated pre-intervention and post-intervention RPH patients.<\/jats:p>","DOI":"10.1093\/imammb\/dqac011","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T17:28:18Z","timestamp":1660930098000},"page":"1-23","source":"Crossref","is-referenced-by-count":1,"title":["Computer simulation of surgical interventions for the treatment of refractory pulmonary hypertension"],"prefix":"10.1093","volume":"40","author":[{"given":"Seong Woo","family":"Han","sequence":"first","affiliation":[{"name":"Courant Institute of Mathematical Sciences , New York University"},{"name":"Department of Computer and Information Science , University of Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Puelz","sequence":"additional","affiliation":[{"name":"Courant Institute of Mathematical Sciences , New York University"},{"name":"Department of Pediatrics, Division of Cardiology , Baylor College of Medicine and Texas Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig G","family":"Rusin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology , Baylor College of Medicine and Texas Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J","family":"Penny","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology , Baylor College of Medicine and Texas Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Coleman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Critical Care Medicine , Baylor College of Medicine and Texas Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles S","family":"Peskin","sequence":"additional","affiliation":[{"name":"Courant Institute of Mathematical Sciences , New York University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"2023031311360294900_","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1007\/s10237-017-0940-4","article-title":"Cardiovascular mechanics in the early stages of pulmonary hypertension: a computational study","volume":"16","author":"Acosta","year":"2017","journal-title":"Biomech. 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