{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:49:01Z","timestamp":1792612141873,"version":"4.5.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The present in-silico study incorporates a stochastic framework for GLUT4 recruitment to examine the coupled dynamics of glucose transport and myocardial contractile function. In their previous study, Das et al. (2020) developed a glucose\u2013insulin interaction model incorporating a transportation delay associated with GLUT4-mediated glucose uptake. However, prior evidence suggests that GLUT4 recruitment exhibits stochastic behavior. Accordingly, the present study extends the model by introducing stochastic perturbations into GLUT4-mediated glucose transport. The results indicate that stochasticity constrains parameter recalibration under diabetic conditions. Moreover, in the absence of delay, although the deterministic system attains a steady state, the stochastic counterpart exhibits persistent temporal fluctuations, inducing transient dynamics at the molecular level.<\/jats:p>","DOI":"10.1093\/imammb\/dqag014","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:45:03Z","timestamp":1792496703000},"source":"Crossref","is-referenced-by-count":0,"title":["Effect of randomness and delay in extracellular glucose transportation into cardiac contractility under diabetic conditions"],"prefix":"10.1093","author":[{"given":"Phonindra Nath","family":"Das","sequence":"first","affiliation":[{"name":"Department of Mathematics, Ramakrishna Mission Vivekananda Centenary College , Rahara, Kolkata-700118, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaibhab","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Ramakrishna Mission Vivekananda Centenary College , Rahara, Kolkata-700118, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,21]]},"container-title":["Mathematical Medicine and Biology: A Journal of the IMA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/imammb\/advance-article-pdf\/doi\/10.1093\/imammb\/dqag014\/72258140\/dqag014.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/imammb\/advance-article-pdf\/doi\/10.1093\/imammb\/dqag014\/72258140\/dqag014.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:27:47Z","timestamp":1792610867000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/imammb\/advance-article\/doi\/10.1093\/imammb\/dqag014\/8965294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/imammb\/dqag014","relation":{},"ISSN":["1477-8599","1477-8602"],"issn-type":[{"value":"1477-8599","type":"print"},{"value":"1477-8602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,21]]},"article-number":"dqag014"}}