{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T21:26:15Z","timestamp":1786397175664,"version":"build-2736575974"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1510743"],"award-info":[{"award-number":["1510743"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIHR Manchester Biomedical Research Centre (\u201cInflammatory Hair Diseases\u201d Programme)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,11]]},"DOI":"10.1093\/imammb\/dqx009","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T15:11:20Z","timestamp":1498662680000},"page":"387-407","source":"Crossref","is-referenced-by-count":10,"title":["Analysing the dynamics of a model for alopecia areata as an autoimmune disorder of hair follicle cycling"],"prefix":"10.1093","volume":"35","author":[{"given":"Atanaska","family":"Dobreva","sequence":"first","affiliation":[{"name":"Department of Mathematics, Florida State University, Tallahassee, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Paus","sequence":"additional","affiliation":[{"name":"Centre for Dermatology Research, University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N G","family":"Cogan","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Florida State University, Tallahassee, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,8,7]]},"reference":[{"key":"key\n\t\t\t\t20180911023317_B1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4049\/jimmunol.1100657","article-title":"A mouse model of clonal CD8$+$ T lymphocyte-mediated alopecia areata progressing to alopecia universalis.","volume":"188","author":"Alli","year":"2012","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20180911023317_B2","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1600-0625.2010.01114.x","article-title":"The cycling hair follicle as an ideal systems biology research model,","volume":"19","author":"Al-Nuaimi","year":"2010","journal-title":"Exp. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jtbi.2012.05.027","article-title":"A prototypic mathematical model of the human hair cycle,","volume":"310","author":"Al-Nuaimi","year":"2012","journal-title":"J. Theor. Biol."},{"key":"key\n\t\t\t\t20180911023317_B4","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/exd.12785","article-title":"MicroRNAs (miRNAs) in the control of HF development and cycling: the next frontiers in hair research,","volume":"24","author":"Andl","year":"2015","journal-title":"Exp. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B5","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.gde.2012.11.007","article-title":"Understanding hair follicle cycling: a systems approach,","volume":"22","author":"Baker","year":"2012","journal-title":"Curr. Opin. Genet. Dev."},{"key":"key\n\t\t\t\t20180911023317_B6","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1600-0625.2012.01457.x","article-title":"The human hair follicle, a bistable organ?","volume":"21","author":"Bernard","year":"2012","journal-title":"Exp. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B7","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/bjd.14645","article-title":"Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse,","volume":"175","author":"Bertolini","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B8","doi-asserted-by":"crossref","first-page":"e94260","DOI":"10.1371\/journal.pone.0094260","article-title":"Abnormal interactions between perifollicular mast cells and CD8$^{+}$ T-cells may contribute to the pathogenesis of alopecia areata,","volume":"9","author":"Bertolini","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180911023317_B9","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1046\/j.1523-1747.2003.12171.x","article-title":"Molecular control of epithelial-mesenchymal interactions during hair follicle cycling,","volume":"8","author":"Botchkarev","year":"2003","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"key\n\t\t\t\t20180911023317_B10","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jtbi.2015.05.033","article-title":"Mathematical model for alopecia areata,","volume":"380","author":"Dobreva","year":"2015","journal-title":"J. Theor. Biol."},{"key":"key\n\t\t\t\t20180911023317_B11","first-page":"25","article-title":"Alopecia Areata: news on diagnosis, pathogenesis and treatment,","volume":"149","author":"D\u2019Ovidio","year":"2014","journal-title":"G. Ital. Dermatol. Venereol."},{"key":"key\n\t\t\t\t20180911023317_B12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/bs.ctdb.2015.11.033","article-title":"Epithelial skin biology: three decades of developmental biology, a hundred questions answered and a thousand new ones to address,","volume":"116","author":"Fuchs","year":"2016","journal-title":"Curr. Top. Dev. Biol."},{"key":"key\n\t\t\t\t20180911023317_B13","doi-asserted-by":"crossref","first-page":"11758","DOI":"10.1073\/pnas.1209592109","article-title":"Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis,","volume":"109","author":"Geyfman","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180911023317_B14","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/brv.12151","article-title":"Resting no more: re-defining telogen, the maintenance stage of the hair growth cycle,","volume":"90","author":"Geyfman","year":"2014","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"key\n\t\t\t\t20180911023317_B15","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1056\/NEJMra1103442","article-title":"Medical progress: alopecia areata,","volume":"366","author":"Gilhar","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20180911023317_B16","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/jid.2012.365","article-title":"Autoimmune disease induction in a healthy human organ: a humanized mouse model of alopecia areata,","volume":"133","author":"Gilhar","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B17","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1172\/JCI31942","article-title":"Lymphocytes, neuropeptides, and genes involved in alopecia areata,","volume":"117","author":"Gilhar","year":"2007","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20180911023317_B18","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.autrev.2016.03.008","article-title":"Alopecia areata: animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies,","volume":"15","author":"Gilhar","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"key\n\t\t\t\t20180911023317_B19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1172\/JCI551","article-title":"Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice,","volume":"101","author":"Gilhar","year":"1998","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20180911023317_B20","first-page":"1335","article-title":"The role of lymphocytes in the development and treatment of alopecia areata,","volume":"11","author":"Guo","year":"2015","journal-title":"Autoimmun. Rev."},{"key":"key\n\t\t\t\t20180911023317_B21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.immuni.2016.01.010","article-title":"In vivo killing capacity of cytotoxic T cells is limited and involves dynamic interactions and T cell cooperativity,","volume":"44","author":"Halle","year":"2016","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20180911023317_B22","doi-asserted-by":"crossref","first-page":"8328","DOI":"10.1073\/pnas.97.15.8328","article-title":"Modeling the dynamics of human hair cycles by a follicular automaton,","volume":"97","author":"Halloy","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180911023317_B23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1006\/jtbi.2001.2474","article-title":"The follicular automaton model: effect of stochasticity and of synchronization of hair cycles,","volume":"214","author":"Halloy","year":"2002","journal-title":"J. Theor. Biol."},{"key":"key\n\t\t\t\t20180911023317_B24","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/jid.2014.442","article-title":"The peripheral clock regulates human pigmentation,","volume":"135","author":"Hardman","year":"2015","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B25","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1517\/14656566.2015.1084501","article-title":"Treatments options for alopecia,","volume":"16","author":"Iorizzo","year":"2015","journal-title":"Expert. Opin. Pharmacother."},{"key":"key\n\t\t\t\t20180911023317_B26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.autrev.2014.10.014","article-title":"The autoimmune basis of alopecia areata: A comprehensive review,","volume":"14","author":"Islam","year":"2015","journal-title":"Autoimmun. Rev."},{"key":"key\n\t\t\t\t20180911023317_B27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/348546","article-title":"Recent advances in the pathogenesis of autoimmune hair loss disease alopecia areata,","volume":"2013","author":"Ito","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"key\n\t\t\t\t20180911023317_B28","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0002-9440(10)63151-3","article-title":"Collapse and restoration of MHC Class-I-dependent immune privilege,","volume":"164","author":"Ito","year":"2004","journal-title":"Am. J. Pathol."},{"key":"key\n\t\t\t\t20180911023317_B29","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1365-2133.2005.06453.x","article-title":"Interferon-gamma is a potent inducer of catagen-like changes in cultured human anagen hair follicles,","volume":"152","author":"Ito","year":"2005","journal-title":"Br. J. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B30","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/sj.jid.5701183","article-title":"Maintenance of hair follicle immune privilege is linked to prevention of NK cell attack,","volume":"128","author":"Ito","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B31","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/exd.12489","article-title":"The role of cytokines and chemokines in the T-cell-mediated autoimmune process in alopecia areata,","volume":"23","author":"Ito","year":"2014","journal-title":"Exp. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B32","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ebiom.2015.02.015","article-title":"Reversal of alopecia areata following treatment with the JAK1\/2 inhibitor baricitinib,","volume":"2","author":"Jabbari","year":"2015","journal-title":"EBioMedicine"},{"key":"key\n\t\t\t\t20180911023317_B33","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/exd.13060","article-title":"Treatment of an alopecia areata patient with tofacitinib results in regrowth of hair and changes in serum and skin biomarkers","volume":"25","author":"Jabbari","year":"2016","journal-title":"Exp. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B34","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1600-0625.2011.01432.x","article-title":"Calcitonin gene-related peptide (CGRP) may award relative protection from interferon-\u00ce\u00b3induced collapse of human hair follicle immune privilege,","volume":"21","author":"Kinori","year":"2012","journal-title":"Exp. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B35","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1038\/jid.2014.82","article-title":"NF-$\\kappa$B activity is required for anagen maintenance in human hair follicles in vitro","volume":"134","author":"Kloepper","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B36","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/exd.12836","article-title":"Human hair follicle organ culture: theory, application and perspectives,","volume":"24","author":"Langan","year":"2015","journal-title":"Exp. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7696(05)43001-6","article-title":"Keratins of the human hair follicle,","volume":"243","author":"Langbein","year":"2005","journal-title":"Int. Rev. Cytol."},{"key":"key\n\t\t\t\t20180911023317_B38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/ncb2903","article-title":"In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators,","volume":"16","author":"Lien","year":"2014","journal-title":"Nat. Cell. Biol."},{"key":"key\n\t\t\t\t20180911023317_B39","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jtbi.2008.04.011","article-title":"A methodology for performing global uncertainty and sensitivity analysis in systems biology,","volume":"254","author":"Marino","year":"2008","journal-title":"J. Theoret. Biol."},{"key":"key\n\t\t\t\t20180911023317_B40","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0738-081X(00)00134-6","article-title":"Alopecia areata,","volume":"19","author":"McDonagh","year":"2001","journal-title":"Clin. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B41","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/exd.12209","article-title":"What causes alopecia areata?","volume":"22","author":"McElwee","year":"2013","journal-title":"Exp. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B42","doi-asserted-by":"crossref","first-page":"a015180","DOI":"10.1101\/cshperspect.a015180","article-title":"The dermal papilla: an instructive niche for epithelial stem and progenitor cells in development and regeneration of the hair follicle,","volume":"4","author":"Morgan","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"key\n\t\t\t\t20180911023317_B43","doi-asserted-by":"crossref","first-page":"e1002804","DOI":"10.1371\/journal.pcbi.1002804","article-title":"Modelling hair follicle growth dynamics as an excitable medium,","volume":"8","author":"Murray","year":"2012","journal-title":"PLoS Comput. Biol."},{"key":"key\n\t\t\t\t20180911023317_B44","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/JID.2015.354","article-title":"A guide to studying human hair follicle cycling in vivo,","volume":"136","author":"Oh","year":"2016","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B45","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1600-0625.2009.00935.x","article-title":"The mesenchymal component of hair follicle neogenesis: background, methods and molecular characterization,","volume":"19","author":"Ohyama","year":"2010","journal-title":"Exp. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B46","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.stem.2011.11.005","article-title":"Paracrine TGF-$\\beta$ signaling counterbalances BMP-mediated repression in hair follicle stem cell activation,","volume":"10","author":"Oshimori","year":"2012","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t20180911023317_B47","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mce.2008.02.023","article-title":"(Neuro-)endocrinology of epithelial hair follicle stem cells,","volume":"288","author":"Paus","year":"2008","journal-title":"Mol. Cell. Endocrinol."},{"key":"key\n\t\t\t\t20180911023317_B48","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1432-0436.2004.07209004.x","article-title":"In search of the \u201chair cycle clock\u201d: a guided tour,","volume":"72","author":"Paus","year":"2004","journal-title":"Differentiation"},{"key":"key\n\t\t\t\t20180911023317_B49","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.it.2004.09.014","article-title":"A \u2018hairy\u2019 privilege,","volume":"26","author":"Paus","year":"2005","journal-title":"Trends Immunol."},{"key":"key\n\t\t\t\t20180911023317_B50","first-page":"541","article-title":"Is alopecia areata an autoimmune-response against melanogenesis-related proteins, exposed by abnormal MHC class I expression in the anagen hair bulb?","volume":"66","author":"Paus","year":"1993","journal-title":"Yale J. Biol. Med."},{"key":"key\n\t\t\t\t20180911023317_B51","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature09114","article-title":"Genome-wide association study in alopecia areata implicates both innate and adaptive immunity,","volume":"466","author":"Petukhova","year":"2010","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180911023317_B52","doi-asserted-by":"crossref","DOI":"10.7551\/mitpress\/2022.001.0001","volume-title":"Computational Molecular Biology \u2014 An Algorithmic Approach","author":"Pevzner","year":"2000"},{"key":"key\n\t\t\t\t20180911023317_B53","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/jid.2012.38","article-title":"New activators and inhibitors in the hair cycle clock: targeting stem cells\u2019 state of competence,","volume":"132","author":"Plikus","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B54","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1126\/science.1201647","article-title":"Self-organizing and stochastic behaviors during the regeneration of hair stem cells,","volume":"332","author":"Plikus","year":"2011","journal-title":"Science"},{"key":"key\n\t\t\t\t20180911023317_B55","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nature06457","article-title":"Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration,","volume":"451","author":"Plikus","year":"2008","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180911023317_B56","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/exd.13046","article-title":"A primer for studying cell cycle dynamics of the human hair follicle,","volume":"25","author":"Purba","year":"2016","journal-title":"Exp. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B57","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1080\/14712598.2016.1188076","article-title":"A novel therapeutic paradigm for patients with extensive alopecia areata,","volume":"16","author":"Renert-Yuval","year":"2016","journal-title":"Expert. Opin. Biol. Ther."},{"key":"key\n\t\t\t\t20180911023317_B58","volume-title":"The Autoimmune Diseases","author":"Rose","year":"2013","edition":"5th edn"},{"key":"key\n\t\t\t\t20180911023317_B59","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/00401706.1999.10485594","article-title":"A quantitative model-independent method for global sensitivity analysis of model output,","volume":"41","author":"Saltelli","year":"1999","journal-title":"Technometrics"},{"key":"key\n\t\t\t\t20180911023317_B60","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1214\/ss\/1009213004","article-title":"Sensitivity analysis as an ingredient of modeling,","volume":"15","author":"Saltelli","year":"2000","journal-title":"Stat. Sci."},{"key":"key\n\t\t\t\t20180911023317_B61","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.ress.2005.11.014","article-title":"Sensitivity analysis practices: Strategies for model-based inference,","volume":"91","author":"Saltelli","year":"2006","journal-title":"Reliab. Eng. Syst. Safe."},{"key":"key\n\t\t\t\t20180911023317_B62","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.semcdb.2012.08.011","article-title":"Mesenchymal-epithelial interactions during hair follicle morphogenesis and cycling,","volume":"23","author":"Sennett","year":"2012","journal-title":"Semin. Cell Dev. Biol"},{"key":"key\n\t\t\t\t20180911023317_B63","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.devcel.2015.06.023","article-title":"An integrated transcriptome atlas of embryonic hair follicle progenitors, their niche, and the developing skin,","volume":"34","author":"Sennett","year":"2015","journal-title":"Dev. Cell"},{"key":"key\n\t\t\t\t20180911023317_B64","doi-asserted-by":"crossref","first-page":"R132","DOI":"10.1016\/j.cub.2008.12.005","article-title":"The hair follicle as a dynamic miniorgan,","volume":"19","author":"Schneider","year":"2009","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t20180911023317_B65","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1152\/physrev.2001.81.1.449","article-title":"Controls of hair follicle cycling,","volume":"81","author":"Stenn","year":"2001","journal-title":"Physiol. Rev."},{"key":"key\n\t\t\t\t20180911023317_B66","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/sji.12469","article-title":"Complex interaction between diphenylcyclopropenone and immune responses in alopecia areata,","volume":"84","author":"Tavakolpour","year":"2016","journal-title":"Scand. J. Immunol."},{"key":"key\n\t\t\t\t20180911023317_B67","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1365-2133.2005.06521.x","article-title":"Human hair shape is programmed from the bulb,","volume":"152","author":"Thibaut","year":"2005","journal-title":"Br. J. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B68","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/jid.1958.121","article-title":"Geometric relationships between the matrix of the hair bulb and its dermal papilla in normal and alopecic scalp,","volume":"31","author":"Van Scott","year":"1958","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20180911023317_B69","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4899-6846-3","volume-title":"Introduction to Computational Biology: Maps, Sequences, Genomes","author":"Waterman","year":"1995","edition":"1st edn"},{"key":"key\n\t\t\t\t20180911023317_B70","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-3-540-31339-7_3","article-title":"Systems biology: new paradigms for cell biology and drug design,","volume":"61","author":"Westerhoff","year":"2007","journal-title":"Ernst Schering Res. Found. Workshop"},{"key":"key\n\t\t\t\t20180911023317_B71","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1016\/j.febslet.2009.11.018","article-title":"Systems biology: the elements and principles of life,","volume":"583","author":"Westerhoff","year":"2007","journal-title":"FEBS Lett."},{"key":"key\n\t\t\t\t20180911023317_B72","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ddtec.2015.06.006","article-title":"Systems pharmacology: an opinion on how to turn the impossible into grand challenges,","volume":"15","author":"Westerhoff","year":"2015","journal-title":"Drug Discov. Today Technol."},{"key":"key\n\t\t\t\t20180911023317_B73","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.gde.2016.07.001","article-title":"Quorum sensing and other collective regenerative behavior in organ populations,","volume":"40","author":"Widelitz","year":"2016","journal-title":"Curr. Opin. Genet. Dev."},{"key":"key\n\t\t\t\t20180911023317_B74","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nm.3645","article-title":"Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition,","volume":"20","author":"Xing","year":"2014","journal-title":"Nat. Med."}],"container-title":["Mathematical Medicine and Biology: A Journal of the IMA"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/imammb\/article-pdf\/35\/3\/387\/25692995\/dqx009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T09:19:29Z","timestamp":1569575969000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/imammb\/article\/35\/3\/387\/4071274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,7]]},"references-count":74,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,8,7]]},"published-print":{"date-parts":[[2018,9,11]]}},"URL":"https:\/\/doi.org\/10.1093\/imammb\/dqx009","relation":{},"ISSN":["1477-8599","1477-8602"],"issn-type":[{"value":"1477-8599","type":"print"},{"value":"1477-8602","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,9]]},"published":{"date-parts":[[2017,8,7]]}}}