{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:37:27Z","timestamp":1740141447670,"version":"3.37.3"},"reference-count":57,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Australian Postgraduate Award"},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP1092619","FT0991634"],"award-info":[{"award-number":["DP1092619","FT0991634"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1093\/imammb\/dqz003","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T12:15:32Z","timestamp":1549282532000},"source":"Crossref","is-referenced-by-count":2,"title":["Optimal control with MANF treatment of photoreceptor degeneration"],"prefix":"10.1093","author":[{"given":"Erika T","family":"Camacho","sequence":"first","affiliation":[{"name":"School of Mathematical & Natural Sciences, Arizona State University, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Lenhart","sequence":"additional","affiliation":[{"name":"Department of Mathematics, University of Tennessee, Knoxville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A","family":"Melara","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Shippensburg University, Shippensburg, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Cristina","family":"Villalobos","sequence":"additional","affiliation":[{"name":"School of Mathematical and Statistical Sciences, The University of Texas Rio Grande Valley, Edinburg, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Wirkus","sequence":"additional","affiliation":[{"name":"School of Mathematical & Natural Sciences, Arizona State University, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"key\n\t\t\t\t2019022705303300000_ref1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.cell.2015.03.023","article-title":"Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis","volume":"161","author":"A\u00eft-Ali","year":"2015","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019022705303300000_ref2","first-page":"1659","article-title":"Retinitis pigmentosa. The Friedenwald Lecture. Retinal photorecptor-pigment epithelium interactions: Friedenwald lecture","volume":"34","author":"Berson","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"volume-title":"The Retina and Its Disorders","year":"2011","author":"Besharse","key":"key\n\t\t\t\t2019022705303300000_ref3"},{"key":"key\n\t\t\t\t2019022705303300000_ref4","first-page":"1659","article-title":"Retinal photorecptor-pigment epithelium interactions: Friedenwald lecture","volume":"26","author":"Bok","year":"1985","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t2019022705303300000_ref5","doi-asserted-by":"crossref","first-page":"e888","DOI":"10.1016\/S2214-109X(17)30293-0","article-title":"Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis","volume":"5","author":"Bourne","year":"2017","journal-title":"Lancet Glob. Health"},{"key":"key\n\t\t\t\t2019022705303300000_ref6","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1126\/science.1190897","article-title":"Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa","volume":"329","author":"Busskamp","year":"2010","journal-title":"Science"},{"key":"key\n\t\t\t\t2019022705303300000_ref7","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.jtbi.2010.09.006","article-title":"A mathematical model for photoreceptor interactions","volume":"21","author":"Camacho","year":"2010","journal-title":"J. Theor. Biol."},{"key":"key\n\t\t\t\t2019022705303300000_ref8","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1007\/s11538-016-0185-x","article-title":"Mathematical model of the role of rdcvf in the coexistence of rods and cones in a healthy eye","volume":"78","author":"Camacho","year":"2016","journal-title":"Bull. Math. Biol."},{"key":"key\n\t\t\t\t2019022705303300000_ref9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jtbi.2016.08.001","article-title":"Quantifying the metabolic contribution to photoreceptor death in retinitis pigmentosa via a mathematical model","volume":"408","author":"Camacho","year":"2016","journal-title":"J. Theor. Biol."},{"key":"key\n\t\t\t\t2019022705303300000_ref10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cnsns.2016.02.030","article-title":"Bifurcation analysis of a photoreceptor interaction model for retinitis pigmentosa","volume":"38","author":"Camacho","year":"2016","journal-title":"Commun. Nonlinear Sci. Numer. Simul."},{"key":"key\n\t\t\t\t2019022705303300000_ref11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jtbi.2012.09.034","article-title":"Tracing the progression of retinitis pigmentosa via photoreceptor interactions","volume":"317","author":"Camacho","year":"2013","journal-title":"J. Theor. Biol."},{"key":"key\n\t\t\t\t2019022705303300000_ref12","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s11538-013-9919-1","article-title":"Optimal control in the treatment of retinitis pigmentosa","volume":"76","author":"Camacho","year":"2014","journal-title":"Bull. Math. Biol."},{"key":"key\n\t\t\t\t2019022705303300000_ref13","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1471-2199-8-74","article-title":"Rod-derived cone viability factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential","volume":"8","author":"Chalmel","year":"2007","journal-title":"BMC Mol. Biol."},{"key":"key\n\t\t\t\t2019022705303300000_ref14","first-page":"844","article-title":"Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd\/rd mouse","volume":"40","author":"Frasson","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t2019022705303300000_ref15","first-page":"175","article-title":"Recovery of photoreceptor outer segment length and analysis of membrane assembly rates in regenerating primate photoreceptor outer segments","volume":"34","author":"Gu\u00e9rin","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t2019022705303300000_ref16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1750-1172-1-40","article-title":"Retinitis pigmentosa","volume":"1","author":"Hamel","year":"2006","journal-title":"Orphanet J. Rare Dis."},{"key":"key\n\t\t\t\t2019022705303300000_ref17","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/S0140-6736(06)69740-7","article-title":"Retinitis pigmentosa","volume":"368","author":"Hartong","year":"2006","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019022705303300000_ref18","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.exer.2008.07.016","article-title":"Rod photoreceptor differentiation in fetal and infant human retina","volume":"87","author":"Hendrickson","year":"2008","journal-title":"Exp. Eye. Res."},{"key":"key\n\t\t\t\t2019022705303300000_ref19","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.1364\/OE.18.005257","article-title":"Imaging outer segment renewal in living human cone photoreceptors","volume":"18","author":"Jonnal","year":"2010","journal-title":"Opt. Express"},{"volume-title":"Mathematical Physiology II: Systems Physiology","year":"2008","author":"Keener","key":"key\n\t\t\t\t2019022705303300000_ref20"},{"key":"key\n\t\t\t\t2019022705303300000_ref21","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-59745-186-4_16","article-title":"On the suppression of photoreceptor cell death in retinitis pigmentosa","volume-title":"Ophthalmology Research: Retinal Degenerations: Biology, Diagnostics, and Therapeutics","author":"Kernan","year":"2007"},{"key":"key\n\t\t\t\t2019022705303300000_ref22","first-page":"592","article-title":"Protection of mouse photoreceptors by survival factors in retinal degenerations","volume":"39","author":"LaVail","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t2019022705303300000_ref23","article-title":"Chapman & Hall\/CRC Mathematical and Computational Biology Series","volume-title":"Optimal Control Applied to Biological Models","author":"Lenhart","year":"2007"},{"key":"key\n\t\t\t\t2019022705303300000_ref24","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/ng1386","article-title":"Identification and characterization of rod-derived cone viability factor","volume":"36","author":"L\u00e9veillard","year":"2004","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t2019022705303300000_ref25","doi-asserted-by":"crossref","first-page":"26ps16","DOI":"10.1126\/scitranslmed.3000866","article-title":"Rod-derived cone viability factor for treating blinding diseases: from clinic to redox signaling","volume":"2","author":"L\u00e9veillard","year":"2010","journal-title":"Science translational medicine"},{"key":"key\n\t\t\t\t2019022705303300000_ref26","first-page":"1","article-title":"Cntf induces regeneration of cone outer segments in a rat model of retinal degeneration","volume":"5","author":"Li","year":"2010","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t2019022705303300000_ref27","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/dneu.20760","article-title":"Novel cdnf\/manf family of neurotrophic factors","volume":"70","author":"Lindholm","year":"2010","journal-title":"Dev. Neurobiol."},{"key":"key\n\t\t\t\t2019022705303300000_ref28","doi-asserted-by":"crossref","first-page":"18728","DOI":"10.1073\/pnas.0902593106","article-title":"Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors","volume":"3","author":"Longbottom","year":"2009","journal-title":"Proc. Natl Acad. Sci. U. S. A."},{"key":"key\n\t\t\t\t2019022705303300000_ref29","first-page":"1","article-title":"Chapter 1 rhodopsin-mediated retinitis pigmentosa","volume-title":"Progress in Molecular Biology and Translational Science","author":"Malanson","year":"2009"},{"key":"key\n\t\t\t\t2019022705303300000_ref30","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jtbi.2008.04.011","article-title":"A methodology for performing global uncertainty and sensitivity analysis in systems biology","volume":"254","author":"Marino","year":"2008","journal-title":"J. Theor. Biol."},{"key":"key\n\t\t\t\t2019022705303300000_ref31","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1167\/iovs.14-14238","article-title":"Strain difference in photoreceptor cell death after retinal detachment in mice","volume":"55","author":"Matsumoto","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t2019022705303300000_ref32","doi-asserted-by":"crossref","first-page":"8357","DOI":"10.1073\/pnas.95.14.8357","article-title":"Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse","volume":"95","author":"Mohand-Sa\u00efd","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"key\n\t\t\t\t2019022705303300000_ref33","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1001\/archopht.118.6.807","article-title":"Selective transplantation of rods delays cone loss in a retinitis pigmentosa model","volume":"118","author":"Mohand-Said","year":"2000","journal-title":"Arch. Ophthalmol."},{"key":"key\n\t\t\t\t2019022705303300000_ref34","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S1350-9462(01)00006-4","article-title":"Rod-cone interactions: developmental and clinical significance","volume":"20","author":"Mohand-Said","year":"2001","journal-title":"Prog. Retin. Eye Res."},{"key":"key\n\t\t\t\t2019022705303300000_ref35","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.2353\/ajpath.2008.080466","article-title":"Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of the neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration","volume":"173","author":"Murakami","year":"2008","journal-title":"Am. J. Pathol."},{"key":"key\n\t\t\t\t2019022705303300000_ref36","doi-asserted-by":"crossref","first-page":"14598","DOI":"10.1073\/pnas.1206937109","article-title":"Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration","volume":"109","author":"Murakami","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"key\n\t\t\t\t2019022705303300000_ref37","doi-asserted-by":"crossref","first-page":"aaf3646","DOI":"10.1126\/science.aaf3646","article-title":"Immune modulation by manf promotes tissue repair and regenerative success in the retina","volume":"353","author":"Neves","year":"2016","journal-title":"Science"},{"volume-title":"The Human Eye: Structure and Function","year":"1999","author":"Oyster","key":"key\n\t\t\t\t2019022705303300000_ref38"},{"key":"key\n\t\t\t\t2019022705303300000_ref39","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.1167\/iovs.03-0094","article-title":"The reflectance of single cones in the living human eye","volume":"44","author":"Pallikaris","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t2019022705303300000_ref40","first-page":"1300","article-title":"The birth and death of photoreceptors: the friedenwald lecture","volume":"43","author":"Papermaster","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t2019022705303300000_ref41","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0079-6123(03)46012-3","article-title":"Discovering novel phenotype-selective neurotrophic factors to treat neurodegenerative diseases","volume":"146","author":"Petrova","year":"2004","journal-title":"Prog. Brain Res."},{"key":"key\n\t\t\t\t2019022705303300000_ref42","first-page":"116","article-title":"A brief review of retinitis pigmentosa and the identified retinitis pigmentosa genes","volume":"6","author":"Phelan","year":"2000","journal-title":"Mol. Vis."},{"key":"key\n\t\t\t\t2019022705303300000_ref43","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1001\/archopht.122.4.615","article-title":"Vision 2020: The right to sight: a global initiative to eliminate avoidable blindness","volume":"122","author":"Pizzarello","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"key\n\t\t\t\t2019022705303300000_ref44","doi-asserted-by":"crossref","DOI":"10.1201\/9780203749319","volume-title":"Mathematical Theory of Optimal Processes","author":"Pontryagin","year":"2018"},{"key":"key\n\t\t\t\t2019022705303300000_ref45","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nn.2234","article-title":"Stimulation of the insulin\/mtor pathway delays cone death in a mouse model of retinitis pigmentosa","volume":"12","author":"Punzo","year":"2009","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t2019022705303300000_ref46","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1074\/jbc.R111.304428","article-title":"Loss of daylight vision in retinal degeneration: are oxidative stress and metabolic dysregulation to blame","volume":"287","author":"Punzo","year":"2012","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t2019022705303300000_ref47","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1097\/00006982-200512001-00015","volume":"25","author":"Sahel","year":"2005","journal-title":"Retina"},{"key":"key\n\t\t\t\t2019022705303300000_ref48","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/jcp.20346","article-title":"Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa","volume":"203","author":"Shen","year":"2005","journal-title":"J. Cell. Physiol."},{"key":"key\n\t\t\t\t2019022705303300000_ref49","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.optm.2008.01.026","article-title":"Review and update: current treatment trends for patients with retinitis pigmentosa","volume":"80","author":"Shintani","year":"2009","journal-title":"Optometry"},{"key":"key\n\t\t\t\t2019022705303300000_ref50","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1152\/physrev.00021.2004","article-title":"The retinal pigment epithelium in visual function","volume":"85","author":"Strauss","year":"2005","journal-title":"Physiol. Rev."},{"key":"key\n\t\t\t\t2019022705303300000_ref51","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.preteyeres.2004.08.002","article-title":"Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration","volume":"24","author":"Wenzel","year":"2005","journal-title":"Prog. Retin. Eye Res."},{"key":"key\n\t\t\t\t2019022705303300000_ref52","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1523\/JNEUROSCI.21-01-00053.2001","article-title":"The rpe65 leu450met variation increases retinal resistance against light-induced degeneration by slowing rhodopsin regeneration","volume":"21","author":"Wenzel","year":"2001","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t2019022705303300000_ref53","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S1350-9462(96)00032-8","article-title":"Investigating retinitis pigmentosa: a laboratory scientist\u2019s perspective","volume":"16","author":"Wong","year":"1997","journal-title":"Prog. Retin. Eye Res."},{"article-title":"Vision Impairment and Blindness","year":"2017","author":"World Health Organization Vision Impairment and Blindness","key":"key\n\t\t\t\t2019022705303300000_ref54"},{"article-title":"Blindness: Vision 2020\u2014the global initiative for the elimination of avoidable blindness.","year":"2018","author":"World Health Organization Vision Media Center","key":"key\n\t\t\t\t2019022705303300000_ref55"},{"key":"key\n\t\t\t\t2019022705303300000_ref56","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/mt.2009.28","article-title":"Functional cone rescue by RdCVF protein in a dominant model of retinitis pigmentosas","volume":"17","author":"Yang","year":"2009","journal-title":"Mol. Ther."},{"key":"key\n\t\t\t\t2019022705303300000_ref57","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1083\/jcb.49.2.303","article-title":"The renewal of rod and cone outer segments in the rhesus monkey","volume":"49","author":"Young","year":"1971","journal-title":"J. Cell Biol."}],"container-title":["Mathematical Medicine and Biology: A Journal of the IMA"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/imammb\/advance-article-pdf\/doi\/10.1093\/imammb\/dqz003\/27987345\/dqz003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T11:17:19Z","timestamp":1694603839000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/imammb\/advance-article\/doi\/10.1093\/imammb\/dqz003\/5363832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,27]]},"references-count":57,"URL":"https:\/\/doi.org\/10.1093\/imammb\/dqz003","relation":{},"ISSN":["1477-8599","1477-8602"],"issn-type":[{"type":"print","value":"1477-8599"},{"type":"electronic","value":"1477-8602"}],"subject":[],"published":{"date-parts":[[2019,2,27]]}}}