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To address this question, a review of clinical observational studies and autopsy data in English and Chinese languages was conducted with a search of registered clinical trials. Peripheral lymphopenia affecting CD4 and CD8 T cells was a striking feature of severe COVID-19 compared with non-severe disease. Autopsy data demonstrated infiltration of T cells into organs, particularly the lung. Seventy-four clinical trials are on-going that could target T cell-related pathogenesis, particularly IL-6 pathways. SARS-CoV-2 infection interrupts T cell circulation in patients with severe COVID-19. This could be due to redistribution of T cells into infected organs, activation induced exhaustion, apoptosis, or pyroptosis. Measuring T cell dynamics during COVID-19 will inform clinical risk-stratification of hospitalised patients and could identify those who would benefit most from treatments that target T cells.<\/jats:p>","DOI":"10.1093\/immadv\/ltab015","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T02:43:35Z","timestamp":1625193815000},"source":"Crossref","is-referenced-by-count":45,"title":["Peripheral T cell lymphopenia in COVID-19: potential mechanisms and impact"],"prefix":"10.1093","volume":"1","author":[{"given":"Sifan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Infectious Disease, Imperial College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Becca","family":"Asquith","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Imperial College London , London , 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