{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T16:54:35Z","timestamp":1794070475238,"version":"4.8.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study aimed to better understand the importance of CD8 T cell responses in protective immunity to chlamydia. In women evaluated for reinfection at a 3-month follow-up visit after treatment for chlamydia, the presence or magnitude of Chlamydia trachomatis-specific CD8 interferon-gamma (IFN-\u03b3) responses to Momp and Pgp3 peptide pools was not associated with reinfection status, despite having an increased frequency of responses compared to C. trachomatis CD4-specific T cells. However, reinfected women with detectable interferon-gamma (IFN-\u03b3)-producing CD8 T cells had lower C. trachomatis bacterial load compared to women without these CD8 T cell responses. Moreover, the frequency of IFN-\u03b3-producing CD8 T cells was inversely associated with C. trachomatis bacterial load. We further determined that C. trachomatis-specific IFN-\u03b3-producing CD8 T cells were predominately late differentiated effector memory T cells that re-expressed CD45RA (Temra; CCR7-CD45RA+) or effector memory T cells (Tem; CCR7-CD45RA-). Together, these data support the concept that CD8 T cells may contribute to protective immunity against chlamydia in women.<\/jats:p>","DOI":"10.1093\/immhor\/vlaf004","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T07:16:32Z","timestamp":1743491792000},"source":"Crossref","is-referenced-by-count":6,"title":["<i>Chlamydia trachomatis<\/i>-specific interferon-\u03b3-producing CD8 T-cells are associated with lower chlamydia bacterial load in reinfected women"],"prefix":"10.1093","volume":"9","author":[{"given":"William M","family":"Geisler","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Alabama at Birmingham , Birmingham, AL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shara B","family":"Legg","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Alabama at Birmingham , Birmingham, AL,","place":["United 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