{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T08:00:46Z","timestamp":1774771246806,"version":"3.50.1"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI163333"],"award-info":[{"award-number":["AI163333"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neonates have increased vulnerability to life-threatening infections due to the distinct immune landscape. Interleukin (IL)-27 is a key component of this immune profile that we have previously shown to be elevated in both newborn humans and mice. IL-27 continues to increase in the serum and tissues consistent with poor outcomes during gram-negative neonatal bacterial sepsis. Presently, we dissected the IL-27 producer profile at a single-cell level using IL-27p28eGFP reporter mice in our previously established model of neonatal sepsis with luciferase-expressing K1-encapsulated Escherichia coli. Whole animal imaging regionally highlighted the spleen, liver, and lungs as key infection sites by bacterial luminescence. Flow cytometry showed that IL-27 producers increased significantly in the liver with infection and were predominantly F4\/80+ and CD11b+ with subpopulations that emerged expressing additional markers. This information paired with single-cell RNA sequencing further identified the most robust populations as monocytes, monocyte-derived cells, and Kupffer cells followed by smaller populations of dendritic cells and neutrophils. The transcriptome demonstrated a diverse range of functionality amongst populations that included differential expression of genes implicated in bactericidal, metabolic, and inflammatory changes. Collectively, the transcriptome of IL-27 producers from the livers of infected animals suggests an uncoordinated mix of inflammatory and suppressive activity that may contribute to immune dysregulation characteristic of sepsis. Together, this work provides previously undescribed insight into the details of IL-27 producers during early-life infection. This further provides essential information needed to support IL-27 as a therapeutic target for neonatal bacterial sepsis.<\/jats:p>","DOI":"10.1093\/immhor\/vlaf026","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T06:50:09Z","timestamp":1752907809000},"source":"Crossref","is-referenced-by-count":1,"title":["Interleukin-27\u2013producing cells in gram-negative neonatal sepsis display diverse phenotypes and functions in the liver"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6167-4848","authenticated-orcid":false,"given":"Jordan K","family":"Vance","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine , Morgantown, WV,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Lailler","sequence":"additional","affiliation":[{"name":"Rancho Biosciences , San Diego, CA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley M","family":"Divens","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine , Morgantown, WV,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica M","family":"Povroznik","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine , Morgantown, WV,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhavi","family":"Annamanedi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine , Morgantown, WV,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M","family":"Brundage","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine , Morgantown, WV,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2122-2046","authenticated-orcid":false,"given":"Cory M","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine , Morgantown, WV,","place":["United States"]},{"name":"Vaccine Development Center, West Virginia University Health Sciences Center , Morgantown, WV,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"2025071902495987100_vlaf026-B1","author":"Hug","year":"2019"},{"key":"2025071902495987100_vlaf026-B2","author":"Hug","year":"2022"},{"key":"2025071902495987100_vlaf026-B3","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/s2213-2600(18)30063-8","article-title":"The global burden of paediatric and neonatal sepsis: a systematic review","volume":"6","author":"Fleischmann-Struzek","year":"2018","journal-title":"Lancet Respir Med"},{"key":"2025071902495987100_vlaf026-B4","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1136\/archdischild-2020-320217","article-title":"Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis","volume":"106","author":"Fleischmann","year":"2021","journal-title":"Arch Dis Child"},{"key":"2025071902495987100_vlaf026-B5","doi-asserted-by":"publisher","first-page":"7150","DOI":"10.4049\/jimmunol.0901481","article-title":"Neonatal innate TLR-mediated responses are distinct from those of adults","volume":"183","author":"Kollmann","year":"2009","journal-title":"J Immunol"},{"key":"2025071902495987100_vlaf026-B6","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1159\/000255165","article-title":"Multiplex analysis of toll-like receptor-stimulated neonatal cytokine response","volume":"97","author":"Caron","year":"2010","journal-title":"Neonatology"},{"key":"2025071902495987100_vlaf026-B7","doi-asserted-by":"publisher","first-page":"6583","DOI":"10.1128\/iai.70.12.6583-6588.2002","article-title":"Development of interleukin-12-producing capacity throughout childhood","volume":"70","author":"Upham","year":"2002","journal-title":"Infect Immun"},{"key":"2025071902495987100_vlaf026-B8","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1172\/jci19523","article-title":"The enigma of sepsis","volume":"112","author":"Riedemann","year":"2003","journal-title":"J Clin Invest"},{"key":"2025071902495987100_vlaf026-B9","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1097\/INF.0b013e318223bad2","article-title":"The burden of invasive early-onset neonatal sepsis in the United States, 2005-2008","volume":"30","author":"Weston","year":"2011","journal-title":"Pediatr Infect Dis J"},{"issue":"Suppl 2","key":"2025071902495987100_vlaf026-B10","doi-asserted-by":"publisher","first-page":"S69","DOI":"10.1016\/s0378-3782(12)70019-1","article-title":"Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units","volume":"88","author":"Hornik","year":"2012","journal-title":"Early Hum Dev."},{"key":"2025071902495987100_vlaf026-B11","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/imcb.12224","article-title":"Murine myeloid-derived suppressor cells are a source of elevated levels of interleukin-27 in early life and compromise control of bacterial infection","volume":"97","author":"Gleave Parson","year":"2019","journal-title":"Immunol Cell Biol"},{"key":"2025071902495987100_vlaf026-B12","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/imm.12625","article-title":"Elevated interleukin-27 levels in human neonatal macrophages regulate indoleamine dioxygenase in a STAT-1 and STAT-3-dependent manner","volume":"149","author":"Jung","year":"2016","journal-title":"Immunology"},{"key":"2025071902495987100_vlaf026-B13","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1111\/imm.12095","article-title":"Neonatal macrophages express elevated levels of interleukin-27 that oppose immune responses","volume":"139","author":"Kraft","year":"2013","journal-title":"Immunology"},{"key":"2025071902495987100_vlaf026-B14","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.imlet.2008.01.011","article-title":"Advances in understanding the anti-inflammatory properties of IL-27","volume":"117","author":"Stumhofer","year":"2008","journal-title":"Immunol Lett"},{"key":"2025071902495987100_vlaf026-B15","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1074-7613(02)00324-2","article-title":"IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells","volume":"16","author":"Pflanz","year":"2002","journal-title":"Immunity"},{"key":"2025071902495987100_vlaf026-B16","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.4049\/jimmunol.172.4.2225","article-title":"WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27","volume":"172","author":"Pflanz","year":"2004","journal-title":"J Immunol"},{"key":"2025071902495987100_vlaf026-B17","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1038\/ni1008-1091","article-title":"The Immunological Genome Project: networks of gene expression in immune cells","volume":"9","author":"Heng","year":"2008","journal-title":"Nat Immunol"},{"key":"2025071902495987100_vlaf026-B18","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1002\/eji.201445346","article-title":"Liver sinusoidal endothelial cells induce immunosuppressive IL-10-producing Th1 cells via the Notch pathway","volume":"45","author":"Neumann","year":"2015","journal-title":"Eur J Immunol"},{"key":"2025071902495987100_vlaf026-B19","doi-asserted-by":"publisher","first-page":"5377","DOI":"10.4049\/jimmunol.177.8.5377","article-title":"Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism1","volume":"177","author":"Yoshimura","year":"2006","journal-title":"J Immunol"},{"key":"2025071902495987100_vlaf026-B20","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1189\/jlb.0609445","article-title":"Interleukin 27: a double-edged sword for offense and defense","volume":"86","author":"Yoshida","year":"2009","journal-title":"J Leukoc Biol"},{"key":"2025071902495987100_vlaf026-B21","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1146\/annurev-immunol-032414-112134","article-title":"The immunobiology of interleukin-27","volume":"33","author":"Yoshida","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"2025071902495987100_vlaf026-B22","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1038\/ni1537","article-title":"Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10","volume":"8","author":"Stumhofer","year":"2007","journal-title":"Nat Immunol"},{"key":"2025071902495987100_vlaf026-B23","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1038\/ni1541","article-title":"A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells","volume":"8","author":"Awasthi","year":"2007","journal-title":"Nat Immunol"},{"key":"2025071902495987100_vlaf026-B24","doi-asserted-by":"publisher","first-page":"FSO588","DOI":"10.2144\/fsoa-2020-0032","article-title":"IL-27 regulation of innate immunity and control of microbial growth","volume":"6","author":"Povroznik","year":"2020","journal-title":"Future Sci OA"},{"key":"2025071902495987100_vlaf026-B25","doi-asserted-by":"publisher","first-page":"e00828-19","DOI":"10.1128\/iai.00828-19","article-title":"Elevated levels of interleukin-27 in early life compromise protective immunity in a mouse model of gram-negative neonatal sepsis","volume":"88","author":"Seman","year":"2020","journal-title":"Infect Immun"},{"key":"2025071902495987100_vlaf026-B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4049\/immunohorizons.1700054","article-title":"IL-27p28 production by XCR1(+) dendritic cells and monocytes effectively predicts adjuvant-elicited CD8(+) T cell responses","volume":"2","author":"Kilgore","year":"2018","journal-title":"Immunohorizons"},{"key":"2025071902495987100_vlaf026-B27","doi-asserted-by":"publisher","DOI":"10.3791\/61609","article-title":"A neonatal imaging model of gram-negative bacterial sepsis","volume":"162","author":"Seman","year":"2020","journal-title":"J Vis Exp"},{"key":"2025071902495987100_vlaf026-B28","doi-asserted-by":"publisher","first-page":"e0008324","DOI":"10.1128\/mbio.00083-24","article-title":"Endogenous IL-27 during toxoplasmosis limits early monocyte responses and their inflammatory activation by pathological T cells","volume":"15","author":"Aldridge","year":"2024","journal-title":"mBio"},{"key":"2025071902495987100_vlaf026-B29","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/laban0109-35","article-title":"A method for gender determination in newborn dark pigmented mice","volume":"38","author":"Wolterink-Donselaar","year":"2009","journal-title":"Lab Animal"},{"key":"2025071902495987100_vlaf026-B30","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/nbt.4314","article-title":"Dimensionality reduction for visualizing single-cell data using UMAP","volume":"37","author":"Becht","year":"2018","journal-title":"Nature Biotechnology"},{"key":"2025071902495987100_vlaf026-B31","doi-asserted-by":"publisher","author":"McInnes","DOI":"10.48550\/arXiv.1802.03426"},{"key":"2025071902495987100_vlaf026-B32","doi-asserted-by":"publisher","first-page":"5876","DOI":"10.1016\/j.cell.2023.11.026","article-title":"Automatic cell-type harmonization and integration across Human Cell Atlas datasets","volume":"186","author":"Xu","year":"2023","journal-title":"Cell"},{"key":"2025071902495987100_vlaf026-B33","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.cell.2021.12.018","article-title":"Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches","volume":"185","author":"Guilliams","year":"2022","journal-title":"Cell"},{"key":"2025071902495987100_vlaf026-B34","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat Commun"},{"key":"2025071902495987100_vlaf026-B35","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/ni1376","article-title":"Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system","volume":"7","author":"Stumhofer","year":"2006","journal-title":"Nat Immunol"},{"key":"2025071902495987100_vlaf026-B36","doi-asserted-by":"publisher","first-page":"1124140","DOI":"10.3389\/fimmu.2023.1124140","article-title":"Interleukin-27-dependent transcriptome signatures during neonatal sepsis","volume":"14","author":"Povroznik","year":"2023","journal-title":"Front Immunol"},{"key":"2025071902495987100_vlaf026-B37","doi-asserted-by":"publisher","first-page":"E297","DOI":"10.1152\/ajpendo.00243.2024","article-title":"The influence of interleukin-27 on metabolic fitness in a murine neonatal model of bacterial sepsis","volume":"328","author":"Povroznik","year":"2025","journal-title":"Am J Physiol-Endocrinol Metabol"},{"key":"2025071902495987100_vlaf026-B38","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1165\/rcmb.2012-0366MA","article-title":"Identification of myeloid cell subsets in murine lungs using flow cytometry","volume":"49","author":"Zaynagetdinov","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2025071902495987100_vlaf026-B39","doi-asserted-by":"publisher","first-page":"100029","DOI":"10.1016\/j.xpro.2020.100029","article-title":"Analysis of myeloid cells in mouse tissues with flow cytometry","volume":"1","author":"Liu","year":"2020","journal-title":"STAR Protoc"},{"key":"2025071902495987100_vlaf026-B40","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1038\/ni.2419","article-title":"Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages","volume":"13","author":"Gautier","year":"2012","journal-title":"Nat Immunol"},{"key":"2025071902495987100_vlaf026-B41","doi-asserted-by":"publisher","first-page":"100791","DOI":"10.1016\/j.bbrep.2020.100791","article-title":"CD204-positive monocytes and macrophages ameliorate septic shock by suppressing proinflammatory cytokine production in mice","volume":"23","author":"Uchida","year":"2020","journal-title":"Biochem Biophys Rep"},{"key":"2025071902495987100_vlaf026-B42","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.bbrc.2011.06.161","article-title":"Suppression of TLR4-mediated inflammatory response by macrophage class A scavenger receptor (CD204)","volume":"411","author":"Ohnishi","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"2025071902495987100_vlaf026-B43","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1056\/NEJM199902113400607","article-title":"Acute-phase proteins and other systemic responses to inflammation","volume":"340","author":"Gabay","year":"1999","journal-title":"N Engl J Med"},{"key":"2025071902495987100_vlaf026-B44","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1111\/jvim.16550","article-title":"Serum amyloid A as a marker to detect sepsis and predict outcome in hospitalized neonatal foals","volume":"36","author":"Hoeberg","year":"2022","journal-title":"J Vet Intern Med"},{"key":"2025071902495987100_vlaf026-B45","doi-asserted-by":"publisher","first-page":"S28","DOI":"10.1093\/jpids\/piad067","article-title":"Association between hypoglycemia and the occurrence of early onset sepsis in premature infants","volume":"12","author":"Kumar","year":"2023","journal-title":"J Pediatric Infect Dis Soc."},{"key":"2025071902495987100_vlaf026-B46","doi-asserted-by":"publisher","first-page":"e000544","DOI":"10.1136\/bmjmed-2023-000544","article-title":"Neonatal hypoglycaemia","volume":"3","author":"Harding","year":"2024","journal-title":"BMJ Med"},{"key":"2025071902495987100_vlaf026-B47","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s10020-022-00510-8","article-title":"The liver in sepsis: molecular mechanism of liver failure and their potential for clinical translation","volume":"28","author":"Beyer","year":"2022","journal-title":"Mol Med"},{"key":"2025071902495987100_vlaf026-B48","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.3389\/fimmu.2018.01918","article-title":"Energy demands of early life drive a disease tolerant phenotype and dictate outcome in neonatal bacterial sepsis","volume":"9","author":"Harbeson","year":"2018","journal-title":"Front Immunol"},{"key":"2025071902495987100_vlaf026-B49","doi-asserted-by":"publisher","first-page":"3733","DOI":"10.1242\/dev.02568","article-title":"The journey of developing hematopoietic stem cells","volume":"133","author":"Mikkola","year":"2006","journal-title":"Development"},{"key":"2025071902495987100_vlaf026-B50","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.jhep.2018.08.018","article-title":"Immune and metabolic shifts during neonatal development reprogram liver identity and function","volume":"69","author":"Nakagaki","year":"2018","journal-title":"J Hepatol"},{"key":"2025071902495987100_vlaf026-B51","doi-asserted-by":"publisher","first-page":"eadq9704","DOI":"10.1126\/sciimmunol.adq9704","article-title":"Kupffer cell reverse migration into the liver sinusoids mitigates neonatal sepsis and meningitis","volume":"9","author":"Araujo David","year":"2024","journal-title":"Sci Immunol"},{"key":"2025071902495987100_vlaf026-B52","doi-asserted-by":"publisher","first-page":"9868","DOI":"10.3390\/ijms23179868","article-title":"An eye on Kupffer cells: development, phenotype and the macrophage niche","volume":"23","author":"Elchaninov","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2025071902495987100_vlaf026-B53","doi-asserted-by":"publisher","first-page":"8459193","DOI":"10.1155\/2018\/8459193","article-title":"Tumor-associated CD204-positive macrophage is a prognostic marker in clinical stage I lung adenocarcinoma","volume":"2018","author":"Sun","year":"2018","journal-title":"Biomed Res Int"},{"key":"2025071902495987100_vlaf026-B54","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1111\/cas.13287","article-title":"High density of CD204-positive macrophages predicts worse clinical prognosis in patients with breast cancer","volume":"108","author":"Miyasato","year":"2017","journal-title":"Cancer Sci"},{"key":"2025071902495987100_vlaf026-B55","doi-asserted-by":"publisher","first-page":"e211","DOI":"10.1016\/j.jss.2009.05.026","article-title":"Significance of M2-polarized tumor-associated macrophage in pancreatic cancer","volume":"167","author":"Kurahara","year":"2011","journal-title":"J Surg Res"},{"key":"2025071902495987100_vlaf026-B56","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1097\/JTO.0b013e3181eba692","article-title":"Stromal macrophage expressing CD204 is associated with tumor aggressiveness in lung adenocarcinoma","volume":"5","author":"Ohtaki","year":"2010","journal-title":"J Thorac Oncol"},{"key":"2025071902495987100_vlaf026-B57","doi-asserted-by":"publisher","first-page":"e0150606","DOI":"10.1371\/journal.pone.0150606","article-title":"A protocol for the comprehensive flow cytometric analysis of immune cells in normal and inflamed murine non-lymphoid tissues","volume":"11","author":"Yu","year":"2016","journal-title":"PLoS One"},{"key":"2025071902495987100_vlaf026-B58","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1165\/rcmb.2013-0086MA","article-title":"Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung","volume":"49","author":"Misharin","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2025071902495987100_vlaf026-B59","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1097\/shk.0000000000000425","article-title":"Endoplasmic reticulum stress in sepsis","volume":"44","author":"Khan","year":"2015","journal-title":"Shock"},{"key":"2025071902495987100_vlaf026-B60","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1038\/ni1518","article-title":"Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow","volume":"8","author":"Onai","year":"2007","journal-title":"Nat Immunol"},{"key":"2025071902495987100_vlaf026-B61","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1084\/jem.20170277","article-title":"CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes","volume":"216","author":"Rapp","year":"2019","journal-title":"J Exp Med"},{"key":"2025071902495987100_vlaf026-B62","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1097\/hep.0000000000000757","article-title":"C-C chemokine receptor type 7 (CCR7) regulates hepatic CD8 + T cell homeostasis and response to acute liver injury","volume":"80","author":"Niemietz","year":"2024","journal-title":"Hepatology"},{"key":"2025071902495987100_vlaf026-B63","doi-asserted-by":"publisher","first-page":"e0133227","DOI":"10.1371\/journal.pone.0133227","article-title":"CCR4 controls the suppressive effects of regulatory T cells on early and late events during severe sepsis","volume":"10","author":"Molinaro","year":"2015","journal-title":"PLoS One"}],"container-title":["ImmunoHorizons"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/immunohorizons\/article-pdf\/9\/8\/vlaf026\/63798167\/vlaf026.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/immunohorizons\/article-pdf\/9\/8\/vlaf026\/63798167\/vlaf026.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T06:50:10Z","timestamp":1752907810000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/immunohorizons\/article\/doi\/10.1093\/immhor\/vlaf026\/8206941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":63,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,7,14]]}},"URL":"https:\/\/doi.org\/10.1093\/immhor\/vlaf026","relation":{},"ISSN":["2573-7732"],"issn-type":[{"value":"2573-7732","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,7,14]]},"article-number":"vlaf026"}}