{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:07:05Z","timestamp":1773202025343,"version":"3.50.1"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Kawasaki Medical School and a Grant-in-Aid for Scientific Research","award":["JP26460499"],"award-info":[{"award-number":["JP26460499"]}]},{"name":"Kawasaki Medical School and a Grant-in-Aid for Scientific Research","award":["JP17K08798"],"award-info":[{"award-number":["JP17K08798"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Bone marrow stromal cell antigen-1 (BST-1)\/CD157 and CD38 are ectoenzymes belonging to the mammalian ADP-ribosyl cyclase family. Previous analyses of BST-1\u2013deficient mice (Bst1KO) in a 129\u00d7C57BL\/6J(B6) mixed background revealed that BST-1 is a positive regulator of humoral immunity. Murine BST-1 has recently been known to be an enteroneuroimmune regulator. To further clarify the functions of the ADP-ribosyl cyclase family in vivo, in this study, we generated CD38 and BST-1 double knockout mice (Cd38Bst1DKO) and compared them with Cd38KO, Bst1KO, and wild-type (WT) mice in B6 backgrounds. Flow cytometry analyses of the spleen revealed a decrease in B cells in Cd38KO mice, an increase in marginal zone (MZ) B cells of Bst1KO, and a decrease in neutrophils in Cd38Bst1DKO mice. Compared with WT mice, Cd38Bst1DKO mice showed decreased basal serum immunoglobulins and antigen-specific antibodies in memory responses to a thymus-dependent antigen. Because BST-1 is selectively expressed on WT MZ B cells responsive to lipopolysaccharide, enhanced antibody production in Bst1KO and increased growth responses of Bst1KO B cells to lipopolysaccharide stimulation suggest a suppressive role for BST-1 in Toll-like receptor 4 signaling in MZ B cells. Additionally, aged Cd38Bst1DKO mice displayed enlarged mesenteric lymph nodes and elongated small intestine; these phenotypes appeared only in Cd38Bst1DKO and not in Cd38KO or Bst1KO mice, indicating a cooperative role of CD38 and BST-1 in intestinal homeostasis regulation. Overall, these findings indicate the involvement of ADP-ribosyl cyclases CD38 and BST-1 in regulating humoral immune responses and small intestine homeostasis.<\/jats:p>","DOI":"10.1093\/immhor\/vlaf029","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T06:51:07Z","timestamp":1752907867000},"source":"Crossref","is-referenced-by-count":3,"title":["Aberrant humoral immune responses and intestinal homeostasis in <i>Cd38 Bst1<\/i> double knockout mice"],"prefix":"10.1093","volume":"9","author":[{"given":"Ayano","family":"Yahagi","sequence":"first","affiliation":[{"name":"Department of Immunology and Molecular Genetics, Kawasaki Medical School , Kurashiki,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Iseki","sequence":"additional","affiliation":[{"name":"Department of Immunology and Molecular Genetics, Kawasaki Medical School , Kurashiki,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2420-4265","authenticated-orcid":false,"given":"Keisuke","family":"Yaku","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama , Toyama,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5539-7605","authenticated-orcid":false,"given":"Takashi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama , Toyama,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoyuki","family":"Itoh","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Graduate School of Pharmaceutical Sciences, Chiba University ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0103-1621","authenticated-orcid":false,"given":"Tomoyuki","family":"Mukai","sequence":"additional","affiliation":[{"name":"Department of Immunology and Molecular Genetics, Kawasaki Medical School , Kurashiki,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2826-5188","authenticated-orcid":false,"given":"Katsuhiko","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Immunology and Molecular Genetics, Kawasaki Medical School , Kurashiki,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"2025071902510216100_vlaf029-B1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000058772","article-title":"BST-1\/CD157 regulates the humoral immune responses in 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