{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:06:39Z","timestamp":1785521199033,"version":"3.56.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":32,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["25K18836"],"award-info":[{"award-number":["25K18836"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The generation and function of effector and memory CD8+ T cells are crucial for effective immune responses and long-term immunity. Using gene expression analysis, we found that doublesex- and mab-3-related transcription factor like family A1 (Dmrta1), a member of the DMRT family of transcription factors, is highly expressed in activated and memory CD8+ T cells. In this study, we investigated the role of Dmrta1 in the activation and differentiation of CD8+ T cells. The Dmrta1-deficient (Dmrta1-KO) mice showed an equivalent number of thymic and splenic T cells compared with wild-type mice. Dmrta1 deficiency in T cells resulted in impaired early activation of CD8+ but not CD4+ T cells and reduced expression of granzyme B in CD8+ T cells following influenza virus infection. Although virus-specific CD8+ T cell numbers and cytotoxicity in the lung were comparable between wild-type and Dmrta1-deficient mice during primary infection, Dmrta1-KO mice exhibited a transient accumulation of virus-specific CD8+ T cells in the spleen with reduced cytotoxic activity. Upon secondary challenge, memory CD8+ T cells from Dmrta1-KO mice showed persistent defects in granzyme B expression and cytotoxic function. These findings demonstrate that Dmrta1 modulates the early activation of na\u00efve CD8+ T cells and supports the cytotoxic functionality of both effector and memory CD8+ T cells, particularly in secondary lymphoid organs, with significant implications for antiviral immunity.<\/jats:p>","DOI":"10.1093\/immhor\/vlaf054","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T04:52:17Z","timestamp":1762750337000},"source":"Crossref","is-referenced-by-count":1,"title":["Loss of\n                    <i>Dmrta1<\/i>\n                    alters CD8+ T cell activation and resistance to influenza virus infection"],"prefix":"10.1093","volume":"9","author":[{"given":"Hiroyuki","family":"Kondo","sequence":"first","affiliation":[{"name":"Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University , Tokushima 770-8503,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University , Tokushima 770-8503,","place":["Japan"]},{"name":"Department of Interdisciplinary Research on Medicine and Photonics, Institute of Post-LED Photonics, Tokushima University , Tokushima 770-8503,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University , Tokushima 770-8503,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Arimochi","sequence":"additional","affiliation":[{"name":"Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University , Tokushima 770-8503,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichi","family":"Tsukumo","sequence":"additional","affiliation":[{"name":"Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University , Tokushima 770-8503,","place":["Japan"]},{"name":"Department of Interdisciplinary Research on Medicine and Photonics, Institute of Post-LED Photonics, Tokushima University , Tokushima 770-8503,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Yasutomo","sequence":"additional","affiliation":[{"name":"Department of Immunology and Parasitology, Graduate School of Medicine, Tokushima University , Tokushima 770-8503,","place":["Japan"]},{"name":"Department of Interdisciplinary Research on Medicine and Photonics, Institute of Post-LED Photonics, Tokushima University , Tokushima 770-8503,","place":["Japan"]},{"name":"Laboratory of Immunology, Institute of Photonics and Human Health 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