{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T04:24:14Z","timestamp":1767673454664,"version":"3.48.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Academic Science Education and Research Training Program","award":["K12 GM088021"],"award-info":[{"award-number":["K12 GM088021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Na\u00efve T cells are highly metabolically active, maintaining homeostatic function as well as continuously moving and surveying lymph nodes for dendritic cells (DCs) presenting cognate antigen. T-cell metabolism is thought to change throughout development: Na\u00efve T cells have been found to predominantly utilize catabolism for na\u00efve T-cell homeostasis while T-cell activation leads effector T cells to become glycolytic. There is still relatively less known about how individual and combinations of molecular signals drive specific metabolic programs in na\u00efve T cells. Na\u00efve T cells primarily depend on IL-7 signaling to IL-7R for homeostasis and are driven by the chemokine receptor CCR7 responding to CCL21 for rapid motility in lymph nodes, leading to T-cell surveillance. We identify specific roles for IL-7R and CCR7 in driving differential metabolic programs in na\u00efve CD8+ and CD4+ T cells. We find that while IL-7 treatment increases glycolysis in both na\u00efve CD4+ and CD8+ T cells, CCL21 treatment does not affect glycolysis. Instead, CCR7 signaling decreases respiratory capacity and mitochondrial intensity and area. While IL-7 treatment does not impact overall oxidative phosphorylation, IL-7 also alters mitochondrial dynamics. Interestingly, a combination of IL-7R and CCR7 signaling using IL-7 with CCL21 differentially affects CD4+ versus CD8+ T-cell metabolism. Our results demonstrate that multiple molecular signals can differentially regulate na\u00efve CD4+ and CD8+ T-cell metabolism, leading to changes in both glycolysis and oxidative phosphorylation in na\u00efve T cells.<\/jats:p>","DOI":"10.1093\/immhor\/vlaf071","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T04:21:03Z","timestamp":1767673263000},"source":"Crossref","is-referenced-by-count":0,"title":["Interleukin-7R and chemokine receptor type 7 differentially regulate metabolism in CD4+ and CD8+ T cells"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3035-2985","authenticated-orcid":false,"given":"Kimberly A","family":"Morrissey","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Valenzuela-Cardenas","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebekah","family":"Gridley","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Gabaldon-Parish","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Languit","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy L","family":"Cannon","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM,","place":["United States"]},{"name":"Department of Pathology, University of New Mexico Health Sciences Center , Albuquerque, NM,","place":["United States"]},{"name":"Autophagy, Inflammation, and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM,","place":["United 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