{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:56:55Z","timestamp":1773295015579,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01CA233085"],"award-info":[{"award-number":["U01CA233085"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aberrant angiogenesis in ovarian cancer (OC), driven by excessive vascular endothelial growth factor (VEGF) and other proangiogenic mediators, gives rise to structurally and functionally abnormal tumor vasculature that hinders effective T-cell infiltration. To overcome these barriers, we investigated how modulation of the perivascular niche influences antitumor T-cell trafficking and function in OC. T cells expressing a rearranged TCR transgene specific for SV40 T antigen (TAG) were adoptively transferred into TAG+ MOVCAR 5009 ovarian tumor\u2013bearing SCID mice or syngeneic TgMISIIR-TAg-Low transgenic mice, which express TAG as a self-antigen in the fallopian tube epithelium. Transfers were performed either alone or following treatment with an oncolytic vaccinia virus expressing a CXCR4 antagonist (OV-CXCR4-A) or a control virus (OV-Fc). Compared with OV-Fc, OV-CXCR4-A treatment remodeled the tumor vasculature, inhibited recruitment of VEGF-producing myeloid-derived suppressor cells, and disrupted the proangiogenic microenvironment. These changes enhanced infiltration of adoptively transferred TCRTAG T cells within the perivascular niche, correlating with improved antitumor activity and survival. Collectively, our findings demonstrate that CXCR4 blockade\u2013mediated reprogramming of the perivascular tumor microenvironment promotes effective T-cell trafficking and function, providing a mechanistic rationale for combining oncolytic virotherapy with adoptive cell transfer in OC.<\/jats:p>","DOI":"10.1093\/immhor\/vlaf084","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T23:15:19Z","timestamp":1770938119000},"source":"Crossref","is-referenced-by-count":1,"title":["Consequences of the perivascular niche remodeling for tumoricidal T-cell trafficking into metastasis of ovarian cancer"],"prefix":"10.1093","volume":"10","author":[{"given":"Marta","family":"Winkler","sequence":"first","affiliation":[{"name":"Department of Immunology, Roswell Park Comprehensive Cancer Center , Buffalo, NY,","place":["United 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Buffalo, NY,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Gambotto","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Pittsburgh , Pittsburgh, PA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott I","family":"Abrams","sequence":"additional","affiliation":[{"name":"Department of Immunology, Roswell Park Comprehensive Cancer Center , Buffalo, NY,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashant K","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center , Buffalo, NY,","place":["United 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