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While its role in cancer is established, the involvement of PDLIM2 in viral infection remains unclear. Here we analyzed public gene expression data of blood leukocytes, bronchoalveolar lavage cells, and lung tissues from uninfected healthy humans and those infected with the respiratory virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or influenza. We found that PDLIM2 expression was repressed by viral infection, and notably, this repression correlated with the severity of infectious diseases. Consistently, the expression level of PDLIM2 was negatively associated with NF-\u03baB and STAT3 activity across a diverse range of cell types, such as macrophages, monocytes, neutrophils, T cells, alveolar type 1 and 2 epithelial cells, airway epithelial cells, and fibroblasts. Accordingly, cells with low PDLIM2 expression exhibited aberrant activation of signaling pathways essential for cellular functions and immune responses. These findings highlight PDLIM2 repression as a common mechanism underlying human viral infectious diseases and suggest PDLIM2 as a potential biomarker and therapeutic target for disease prognosis, prevention, and treatment.<\/jats:p>","DOI":"10.1093\/immhor\/vlag010","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T12:35:57Z","timestamp":1774787757000},"source":"Crossref","is-referenced-by-count":1,"title":["PDLIM2 repression: a common mechanism in viral lung infection"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8764-1107","authenticated-orcid":false,"given":"Feng","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Immunology and Immune Therapeutics, Hastings Center for Pulmonary Research, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine , Los Angeles, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzheng W","family":"Chen","sequence":"additional","affiliation":[{"name":"Bridge Undergraduate Science (BUGS) Jr. Program, University of Southern California , Los Angeles, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Southern California Keck School of Medicine , Los Angeles, 90033, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gutian","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Immunology and Immune Therapeutics, Hastings Center for Pulmonary Research, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine , Los Angeles, CA,","place":["United 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