{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T12:50:29Z","timestamp":1774788629672,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-162254"],"award-info":[{"award-number":["PJT-162254"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Type 2 airway inflammation is one of the main characteristics of allergen-induced asthma. Evidence from animal studies supports a model in which inhalation of allergens triggers epithelial cell release of alarmin cytokines, including IL-33, which activate a number of innate cells in the lung, including group 2 innate lymphoid cells (ILC2s), which produce large amounts of IL-13 and IL-5, to amplify allergic inflammation. Amongst other activities, ILC2-derived IL-13 promotes DC migration to the lung draining mediastinal lymph nodes (MLNs). Our published data indicate that topical administration of an immunomodulatory peptide, STAT6-IP, at the time of antigen priming inhibits T helper 2 adaptive immunity in murine models of asthma, at least in part, through inhibition of dendritic cells (DCs). In this study, we sought to clarify inhibitory activity of STAT6-IP toward DC responses in the lung and the lung draining MLNs induced by IL-33 and ovalbumin (OVA). Our data show that STAT6-IP reduced expansion of total and IL-13\u2013producing ILC2s in OVA\/IL-33\u2013treated mice. STAT6-IP also inhibited OVA\/IL-33\u2013induced recruitment to and activation of lung DCs, which in turn reduced DC migration and CD4+ Th2 differentiation in the lung MLNs. When challenged several weeks later with OVA, allergic inflammatory responses, including airway hyperresponsiveness, were reduced in STAT6-IP\u2013treated mice. STAT6-IP retained inhibitory activity whether delivered before or after OVA\/IL-33 and activity coincided with expansion of IL-13\u2013producing ILC2s. Altogether, our findings provide insight into mechanisms by which STAT6-IP interacts with innate immune cells of the lung to reduce maladaptive type 2 innate and T helper 2 adaptive immunity.<\/jats:p>","DOI":"10.1093\/immhor\/vlag012","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T12:35:58Z","timestamp":1774787758000},"source":"Crossref","is-referenced-by-count":0,"title":["STAT6-IP\u2013dependent inhibition of type 2 innate and Th2 adaptive immunity in the murine lung"],"prefix":"10.1093","volume":"10","author":[{"given":"Haya","family":"Aldossary","sequence":"first","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of McGill University Health Centre , Montr\u00e9al, QC,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami","family":"Karkout","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of McGill University Health Centre , Montr\u00e9al, QC,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Gaudreault","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of McGill University Health Centre , Montr\u00e9al, QC,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia","family":"Labrie","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of McGill University Health Centre , Montr\u00e9al, QC,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jichuan","family":"Shan","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of McGill University Health Centre , Montr\u00e9al, QC,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6177-8794","authenticated-orcid":false,"given":"Elizabeth D","family":"Fixman","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Research Institute of McGill University Health Centre , Montr\u00e9al, QC,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,3,29]]},"reference":[{"key":"2026032908355274600_vlag012-B1","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.immuni.2019.03.018","article-title":"The cytokines of asthma","volume":"50","author":"Lambrecht","year":"2019","journal-title":"Immunity"},{"key":"2026032908355274600_vlag012-B2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/all.15609","article-title":"Sounding the alarmins-the role of alarmin cytokines in asthma","volume":"78","author":"Gauvreau","year":"2023","journal-title":"Allergy"},{"key":"2026032908355274600_vlag012-B3","doi-asserted-by":"crossref","first-page":"155891","DOI":"10.1016\/j.cyto.2022.155891","article-title":"Interleukin-33 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