{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:45:04Z","timestamp":1782733504700,"version":"3.54.5"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Public Health Service grants from the National Institutes of Health","award":["R01 AI129241"],"award-info":[{"award-number":["R01 AI129241"]}]},{"name":"Public Health Service grants from the National Institutes of Health","award":["R01 AI180518"],"award-info":[{"award-number":["R01 AI180518"]}]},{"name":"Veterans Health Administration","award":["BX006631"],"award-info":[{"award-number":["BX006631"]}]},{"name":"NIH T32 Training","award":["HL007910"],"award-info":[{"award-number":["HL007910"]}]},{"name":"NIH T32 training","award":["AI060519"],"award-info":[{"award-number":["AI060519"]}]},{"name":"The Indiana University Simon Comprehensive Cancer Center Flow Cytometry Core is funded in part by NIH"},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA082709"],"award-info":[{"award-number":["P30 CA082709"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U54 DK106846"],"award-info":[{"award-number":["U54 DK106846"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH instrumentation","award":["1S10D012270"],"award-info":[{"award-number":["1S10D012270"]}]},{"name":"Herman B. Wells Center for Pediatric Research"},{"name":"Riley Children\u2019s Foundation"},{"name":"Brown Center for Immunotherapy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Systemic lupus erythematosus (SLE) is a progressive antibody-mediated autoimmune disease characterized by systemic immune complex deposition. A subset of SLE patients has elevated CD4+IL-9+ T cells as well as increased levels of secreted interleukin (IL)-9 and IL9 messenger RNA compared with healthy control subjects. However, because IL-9 can have both pro- and anti-inflammatory effects in autoimmune disease, its function in SLE is unclear. We use the MRL\/lpr murine model of SLE to demonstrate that IL-9 exhibits protective activity in the early stages of disease. Treatment of these mice with an IL-9 neutralizing antibody from 6 to 12\u2009wk of age results in an expansion of immune cells, leading to exacerbation of disease. In contrast, treatment with anti-IL-9 from 6 to 18\u2009wk of age does not significantly alter disease course compared with isotype control. Anti-IL-9 antibody treatment of these mice results in reduced systemic IL-2 levels, IL-9+ type 2 innate lymphoid cells, and regulatory T cells in the kidney, suggesting an IL-9\u2013dependent suppressive cellular circuit similar to that observed in rheumatoid arthritis. Importantly, supplementation of IL-2 during IL-9 blockade recovers regulatory T cell numbers and limits disease. Together, these data demonstrate an IL-9\u2013dependent suppressive circuit that is evident early in the development of SLE which may be amenable to manipulation to achieve a therapeutic benefit.<\/jats:p>","DOI":"10.1093\/immhor\/vlag024","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:02:28Z","timestamp":1781712148000},"source":"Crossref","is-referenced-by-count":0,"title":["An early protective effect of IL-9 in murine systemic lupus erythematosus"],"prefix":"10.1093","volume":"10","author":[{"given":"Maya S","family":"Krishnan","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine , Indianapolis, IN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine , Indianapolis, IN,","place":["United States"]},{"name":"Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine , Indianapolis, IN,","place":["United States"]},{"name":"Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine , Indianapolis, IN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongming","family":"Yang","sequence":"additional","affiliation":[{"name":"Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine , Indianapolis, IN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao I","family":"Goncalves","sequence":"additional","affiliation":[{"name":"Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine , Indianapolis, IN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn G","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine , Indianapolis, IN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria R","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine , Indianapolis, IN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine , Indianapolis, IN,","place":["United States"]},{"name":"Department of Dermatology, Indiana University School of Medicine , Indianapolis, IN,","place":["United States"]},{"name":"Richard L. Roudebush VA Medical Center , Indianapolis, IN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2923-8245","authenticated-orcid":false,"given":"Mark H","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine , Indianapolis, IN,","place":["United States"]},{"name":"Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine , Indianapolis, IN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"2026062906564756000_vlag024-B1","doi-asserted-by":"publisher","first-page":"e30330","DOI":"10.7759\/cureus.30330","article-title":"An overview of systemic lupus erythematosus (SLE) pathogenesis, classification, and management","volume":"14","author":"Ameer","year":"2022","journal-title":"Cureus"},{"key":"2026062906564756000_vlag024-B2","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/s41581-023-00720-1","article-title":"Pathogenesis of autoimmune disease","volume":"19","author":"Pisetsky","year":"2023","journal-title":"Nat Rev Nephrol"},{"key":"2026062906564756000_vlag024-B3","doi-asserted-by":"publisher","first-page":"102861","DOI":"10.1016\/j.jaut.2022.102861","article-title":"Autoantibodies in systemic lupus erythematosus: from immunopathology to therapeutic target","volume":"132","author":"Lou","year":"2022","journal-title":"J Autoimmun"},{"key":"2026062906564756000_vlag024-B4","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1016\/S0140-6736(23)00457-9","article-title":"Incidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population-based cohort study of 22 million individuals in the UK","volume":"401","author":"Conrad","year":"2023","journal-title":"Lancet"},{"key":"2026062906564756000_vlag024-B5","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.yfrne.2014.04.004","article-title":"Gender differences in autoimmune disease","volume":"35","author":"Ngo","year":"2014","journal-title":"Front Neuroendocrinol"},{"key":"2026062906564756000_vlag024-B6","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1097\/BOR.0000000000000480","article-title":"Epidemiology of systemic lupus erythematosus: an update","volume":"30","author":"Stojan","year":"2018","journal-title":"Curr Opin Rheumatol"},{"key":"2026062906564756000_vlag024-B7","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3390\/biomedicines10020287","article-title":"CAR-T Regulatory (CAR-Treg) cells: engineering and applications","volume":"10","author":"Arjomandnejad","year":"2022","journal-title":"Biomedicines"},{"key":"2026062906564756000_vlag024-B8","doi-asserted-by":"publisher","first-page":"108587","DOI":"10.1016\/j.intimp.2022.108587","article-title":"Novel insights in CAR-NK cells beyond CAR-T cell technology; promising advantages","volume":"106","author":"Ebrahimiyan","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"2026062906564756000_vlag024-B9","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1056\/NEJMoa2308917","article-title":"CD19 CAR T-cell therapy in autoimmune disease\u2013a case series with follow-up","volume":"390","author":"M\u00fcller","year":"2024","journal-title":"N Engl J Med"},{"key":"2026062906564756000_vlag024-B10","doi-asserted-by":"publisher","first-page":"4835","DOI":"10.1182\/blood-2023-186669","article-title":"CD19\/BCMA CAR-T cell therapy for refractory systemic lupus erythematosus - safety and preliminary efficacy data from a Phase I clinical study","volume":"142","author":"Feng","year":"2023","journal-title":"Blood"},{"key":"2026062906564756000_vlag024-B11","doi-asserted-by":"publisher","first-page":"eabi9768","DOI":"10.1126\/sciimmunol.abi9768","article-title":"An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment","volume":"7","author":"Fu","year":"2022","journal-title":"Sci Immunol"},{"key":"2026062906564756000_vlag024-B12","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.mucimm.2023.05.002","article-title":"Interleukin-9 promotes mast cell progenitor proliferation and CCR2-dependent mast cell migration in allergic airway inflammation","volume":"16","author":"Pajulas","year":"2023","journal-title":"Mucosal Immunol"},{"key":"2026062906564756000_vlag024-B13","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00281-016-0604-y","article-title":"Th9 cells in the pathogenesis of EAE and multiple sclerosis","volume":"39","author":"Elyaman","year":"2017","journal-title":"Semin Immunopathol"},{"key":"2026062906564756000_vlag024-B14","doi-asserted-by":"publisher","first-page":"BSR20181521","DOI":"10.1042\/BSR20181521","article-title":"IL-9 promotes the pathogenesis of ulcerative colitis through STAT3\/SOCS3 signaling","volume":"38","author":"Tian","year":"2018","journal-title":"Biosci Rep"},{"key":"2026062906564756000_vlag024-B15","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1038\/nm.4373","article-title":"Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells","volume":"23","author":"Rauber","year":"2017","journal-title":"Nat Med"},{"key":"2026062906564756000_vlag024-B16","doi-asserted-by":"publisher","first-page":"eabo5407","DOI":"10.1126\/sciimmunol.abo5407","article-title":"FOXP3 exon 2 controls Treg stability and autoimmunity","volume":"7","author":"Du","year":"2022","journal-title":"Sci Immunol"},{"key":"2026062906564756000_vlag024-B17","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/s41423-018-0004-4","article-title":"When worlds collide: Th17 and Treg cells in cancer and autoimmunity","volume":"15","author":"Knochelmann","year":"2018","journal-title":"Cell Mol Immunol"},{"key":"2026062906564756000_vlag024-B18","first-page":"28","article-title":"Potential roles of IL-9 in the pathogenesis of systemic lupus erythematosus","volume":"1","author":"Leng","year":"2012","journal-title":"Am J Clin Exp Immunol"},{"key":"2026062906564756000_vlag024-B19","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.3892\/mmr.2013.1258","article-title":"Increased interleukin\u20119 and CD4+IL-9+ T cells in patients with systemic lupus erythematosus","volume":"7","author":"Ouyang","year":"2013","journal-title":"Mol Med Rep"},{"key":"2026062906564756000_vlag024-B20","doi-asserted-by":"publisher","first-page":"916011","DOI":"10.3389\/fmed.2022.916011","article-title":"The genetic landscape of cutaneous lupus erythematosus","volume":"9","author":"Chen","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"2026062906564756000_vlag024-B21","doi-asserted-by":"publisher","first-page":"1615611","DOI":"10.3389\/fimmu.2025.1615611","article-title":"Targeting Th9 cells in autoimmune diseases: a narrative review","volume":"16","author":"Xu","year":"2025","journal-title":"Front Immunol"},{"key":"2026062906564756000_vlag024-B22","doi-asserted-by":"publisher","DOI":"10.1038\/356314a0"},{"key":"2026062906564756000_vlag024-B23","doi-asserted-by":"publisher","first-page":"364","DOI":"10.2119\/molmed.2014.00237","article-title":"Interleukin-9 is associated with elevated anti\u2013double-stranded DNA antibodies in lupus-prone mice","volume":"21","author":"Yang","year":"2015","journal-title":"Mol Med"},{"key":"2026062906564756000_vlag024-B24","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.bbrc.2021.03.025","article-title":"New inducible mast cell-deficient mouse model (Mcpt5\/Cma1DTR)","volume":"551","author":"Sasaki","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"2026062906564756000_vlag024-B25","doi-asserted-by":"publisher","first-page":"622","DOI":"10.3390\/cells11040622","article-title":"Fc\u03b5RI: a master regulator of mast cell functions","volume":"11","author":"Nagata","year":"2022","journal-title":"Cells"},{"key":"2026062906564756000_vlag024-B26","doi-asserted-by":"crossref","first-page":"599","DOI":"10.4049\/jimmunol.149.2.599","article-title":"The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils","volume":"149","author":"Columbo","year":"1992","journal-title":"J Immunol"},{"key":"2026062906564756000_vlag024-B27","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1084\/jem.174.1.125","article-title":"The rat c-kit ligand, stem cell factor, induces the development of connective tissue-type and mucosal mast cells in vivo. Analysis by anatomical distribution, histochemistry, and protease phenotype","volume":"174","author":"Tsai","year":"1991","journal-title":"J Exp Med"},{"key":"2026062906564756000_vlag024-B28","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1182\/blood-2006-02-004747","article-title":"IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo","volume":"108","author":"Zorn","year":"2006","journal-title":"Blood"},{"key":"2026062906564756000_vlag024-B29","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.kint.2016.09.022","article-title":"2\/anti-IL-2 complexes ameliorate lupus nephritis by expansion of CD4+CD25+Foxp3+ regulatory T cells","volume":"91","author":"Yan","year":"2017","journal-title":"Kidney Int"},{"key":"2026062906564756000_vlag024-B30","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1073\/pnas.0903158107","article-title":"Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus","volume":"107","author":"Humrich","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026062906564756000_vlag024-B31","doi-asserted-by":"publisher","first-page":"dxaf062","DOI":"10.1093\/intimm\/dxaf062","article-title":"Functional diversity and tissue-specific regulation of Group 2 innate lymphoid cells in barrier immunity","volume":"38","author":"Ito","year":"2026","journal-title":"Int Immunol"},{"key":"2026062906564756000_vlag024-B32","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1073\/pnas.0909384107","article-title":"IL-2\/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor \u03b1 subunit CD25","volume":"107","author":"L\u00e9tourneau","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026062906564756000_vlag024-B33","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.immuni.2012.02.012","article-title":"Interleukin-2 inhibits germinal center formation by limiting T follicular helper differentiation","volume":"36","author":"Ballesteros-Tato","year":"2012","journal-title":"Immunity"},{"key":"2026062906564756000_vlag024-B34","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/ni.2133","article-title":"Interleukin 9 fate reporter reveals induction of innate IL-9 response in lung inflammation","volume":"12","author":"Wilhelm","year":"2011","journal-title":"Nat Immunol"},{"key":"2026062906564756000_vlag024-B35","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1177\/0961203321992434","article-title":"Bioinformatic analysis of key biomarkers and immune filtration of skin biopsy in discoid lupus erythematosus","volume":"30","author":"Xiang","year":"2021","journal-title":"Lupus"},{"key":"2026062906564756000_vlag024-B36","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.4049\/jimmunol.1901520","article-title":"Treg cells maintain selective access to IL-2 and immune homeostasis despite substantially reduced CD25 function","volume":"205","author":"Hayes","year":"2020","journal-title":"J Immunol"},{"key":"2026062906564756000_vlag024-B37","doi-asserted-by":"publisher","first-page":"25","DOI":"10.4103\/ijt.ijt_43_16","article-title":"Presence of mast cells and mast cell degranulation in scalp biopsies of telogen effluvium","volume":"9","author":"Grace","year":"2017","journal-title":"Int J Trichol"},{"key":"2026062906564756000_vlag024-B38","doi-asserted-by":"publisher","first-page":"e1962","DOI":"10.31661\/gmj.v9i0.1962","article-title":"Infiltration of mast cells in scalp biopsies of patients with Alopcia areata or androgenic alopecia versus healthy individuals: a case control study","volume":"9","author":"Nasiri","year":"2020","journal-title":"Galen Med J"},{"key":"2026062906564756000_vlag024-B39","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1002\/eji.201747303","article-title":"T cell-derived IFN-\u03b3 downregulates protective group 2 innate lymphoid cells in murine lupus erythematosus","volume":"48","author":"D\u00fcster","year":"2018","journal-title":"Eur J Immunol"},{"key":"2026062906564756000_vlag024-B40","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/ni.3309","article-title":"Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses","volume":"17","author":"Moro","year":"2016","journal-title":"Nat Immunol"},{"key":"2026062906564756000_vlag024-B41","doi-asserted-by":"publisher","first-page":"1425847","DOI":"10.3389\/fimmu.2024.1425847","article-title":"Imbalance of Th17 cells, Treg cells and associated cytokines in patients with systemic lupus erythematosus: a meta-analysis","volume":"15","author":"Huang","year":"2024","journal-title":"Front Immunol"},{"key":"2026062906564756000_vlag024-B42","doi-asserted-by":"publisher","first-page":"14017","DOI":"10.1038\/ncomms14017","article-title":"A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis","volume":"8","author":"Moretti","year":"2017","journal-title":"Nat Commun"},{"key":"2026062906564756000_vlag024-B43","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1002\/eji.1830200632","article-title":"Mast cell growth-enhancing activity (MEA) is structurally related and functionally identical to the novel mouse T cell growth factor P40\/TCGFIII (interleukin 9)","volume":"20","author":"H\u00fcltner","year":"1990","journal-title":"Eur J Immunol"},{"key":"2026062906564756000_vlag024-B44","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1007\/s10753-013-9802-0","article-title":"IL-33 Neutralization suppresses lupus disease in lupus-prone mice","volume":"37","author":"Li","year":"2014","journal-title":"Inflammation"},{"key":"2026062906564756000_vlag024-B45","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1126\/science.aac9593","article-title":"Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs","volume":"350","author":"Gasteiger","year":"2015","journal-title":"Science"},{"key":"2026062906564756000_vlag024-B46","doi-asserted-by":"publisher","first-page":"802","DOI":"10.3389\/fimmu.2020.00802","article-title":"Unique phenotypes of heart resident type 2 innate lymphoid cells","volume":"11","author":"Deng","year":"2020","journal-title":"Front Immunol"},{"key":"2026062906564756000_vlag024-B47","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.immuni.2018.06.002","article-title":"Why ILCs?","volume":"48","author":"Kotas","year":"2018","journal-title":"Immunity"},{"key":"2026062906564756000_vlag024-B48","doi-asserted-by":"publisher","first-page":"1254176","DOI":"10.3389\/fimmu.2023.1254176","article-title":"Regulatory T cells inhibit autoantigen-specific CD4+ T cell responses in lupus-prone NZB\/W F1 mice","volume":"14","author":"Rosenberger","year":"2023","journal-title":"Front Immunol"},{"key":"2026062906564756000_vlag024-B49","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1681\/ASN.2004100837","article-title":"CD4+CD25+ regulatory T cells inhibit experimental anti-glomerular basement membrane glomerulonephritis in mice","volume":"16","author":"Wolf","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"2026062906564756000_vlag024-B50","doi-asserted-by":"publisher","first-page":"34","DOI":"10.4049\/jimmunol.2100078","article-title":"Mouse IL-2\/CD25 fusion protein induces regulatory T cell expansion and immune suppression in preclinical models of systemic lupus erythematosus","volume":"207","author":"Xie","year":"2021","journal-title":"J Immunol"}],"container-title":["ImmunoHorizons"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/immunohorizons\/article-pdf\/10\/6\/vlag024\/68540668\/vlag024.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/immunohorizons\/article-pdf\/10\/6\/vlag024\/68540668\/vlag024.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:56:54Z","timestamp":1782730614000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/immunohorizons\/article\/doi\/10.1093\/immhor\/vlag024\/8709685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,16]]}},"URL":"https:\/\/doi.org\/10.1093\/immhor\/vlag024","relation":{},"ISSN":["2573-7732"],"issn-type":[{"value":"2573-7732","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,6]]},"article-number":"vlag024"}}