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Given the central role that B cells play in SLE pathogenesis, we aimed to characterize genetic variation within the B cell compartment of African ancestry (AFR) women with SLE who are disproportionately and more severely affected by SLE. Here, we analyzed RNA-seq data from a previously published study of high disease activity AFR SLE individuals and healthy controls (HC) to identify coding variants in B cells with potential functional consequence that may underpin disease. In this cohort, we identified 575 missense variants associated with 158 unique genes. While many variant-containing genes did not exhibit large transcriptional changes between cohorts, a subset occurred within genes involved in B cell signaling, activation, and differentiation. However, genes enriched in AFR SLE were consistently upregulated across multiple B cell subtypes, suggesting that variant-associated transcriptional changes occur broadly across the B cell compartment and not within a single subset. Among these, the TNFAIP3 variant rs2230926 was enriched in AFR SLE individuals and occurs at a substantially higher allele frequency in AFR populations. This study provides insights into genetic variation found within the B cell compartment that may contribute to immune dysregulation and disease pathogenesis in SLE in AFR populations.<\/jats:p>","DOI":"10.1093\/immhor\/vlag029","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T16:17:37Z","timestamp":1784650657000},"source":"Crossref","is-referenced-by-count":0,"title":["Identification of genetic variants in B cell expressed genes associated with systemic lupus erythematosus in African American females"],"prefix":"10.1093","volume":"10","author":[{"given":"Rachel","family":"Kidwell","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, Emory University , Atlanta, GA,","place":["United States"]},{"name":"Division of Rheumatology, Department of Medicine, School of Medicine, Emory University , Atlanta, GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5475-3838","authenticated-orcid":false,"given":"Mansi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, Emory University , Atlanta, GA,","place":["United States"]},{"name":"Division of Rheumatology, Department of Medicine, School of Medicine, Emory University , Atlanta, GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Department of Biology, Emory University , Atlanta, GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Sanz","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, School of Medicine, Emory University , Atlanta, GA,","place":["United States"]},{"name":"Lowance Center for 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