{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:26:06Z","timestamp":1793733966508,"version":"4.6.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Regulatory CD4+ T cells (Tregs), as defined by expression of the transcription factor Foxp3, strongly depend on the cytokine interleukin 2 (IL-2) for their survival and function and are often identified by the combination of high IL-2R\u03b1 (CD25) and low IL-7R\u03b1 (CD127) expression. Nevertheless, subsets expressing higher levels of IL-7R\u03b1 have been described, and IL-7 signaling does play a role in Treg function in some specific biologic contexts and tissues. The precise role of IL-7R\u03b1-expressing Tregs in autoimmunity remains poorly defined though, potentially hampering current efforts to develop IL-7R\u03b1 blockade for the treatment of various autoimmune diseases. To ask whether cell-intrinsic IL-7R\u03b1 expression in Tregs was required for their function during type 1 diabetes (T1D) development, we generated non-obese diabetic (NOD) mice in which IL-7R\u03b1 is exclusively deleted in Foxp3-expressing Tregs. In young NOD mice, IL-7R\u03b1 deficiency did not alter Treg numbers and phenotype. However, 100% of NOD mice with IL-7R\u03b1-deficient Tregs became diabetic, while the T1D incidence is typically around 50\u201360% in our colony. This increased susceptibility for T1D indicates that IL-7R\u03b1 expression in Tregs is required to protect a subset of NOD mice against islet autoimmunity. At the time of T1D onset, CD4+ and CD8+ T cells from NOD mice with IL-7R\u03b1-deficient Tregs showed increased IFN-\u03b3 and IL-2 cytokine production. Our data demonstrate that cell-intrinsic IL-7R signaling in Foxp3+ Tregs is required to suppress effector T cell responses and to prevent full penetrance of T1D in NOD mice.<\/jats:p>","DOI":"10.1093\/immhor\/vlag034","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:40:53Z","timestamp":1785818453000},"source":"Crossref","is-referenced-by-count":0,"title":["Cell-intrinsic IL-7R\u03b1 deficiency in Foxp3+ Tregs increases type 1 diabetes incidence in NOD mice"],"prefix":"10.1093","volume":"10","author":[{"given":"Albert R","family":"Jones IV","sequence":"first","affiliation":[{"name":"Arthritis and Autoimmune Diseases Center, Rheumatology Section, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine , Boston, MA,","place":["United States"]},{"name":"Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyton S","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Immunology and Genomic Medicine, National Jewish Health , Denver, CO,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7964-0876","authenticated-orcid":false,"given":"Hans","family":"Dooms","sequence":"additional","affiliation":[{"name":"Arthritis and Autoimmune Diseases Center, Rheumatology Section, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine , Boston, MA,","place":["United States"]},{"name":"Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine , Boston, MA,","place":["United States"]},{"name":"Department of Immunology and Genomic Medicine, National Jewish Health , Denver, CO,","place":["United States"]},{"name":"Department of Immunology and Microbiology, 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