{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:10:55Z","timestamp":1790151055186,"version":"4.0.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160279"],"award-info":[{"award-number":["82160279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guizhou Provincial Hundred level Talent Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The clonal selection theory of \u201cone lymphocyte expresses one type of antigen receptor\u201d has been challenged and complemented by the concept of dual receptor lymphocytes. However, the proportion, source, and characterization of dual TCR \u03b3\u03b4 T cells have not been determined. Using single-cell RNA plus single-cell TCR sequencing, we discovered a high proportion of dual \u03b3\u03b4 T cells datasets of the human thymus and mouse spleens. We observed differences in the proportion of single and dual TCR from \u03b3\u03b4 T cells, the types of \u03b4 and \u03b3 pairings, the frequency of TRDV and TRGV genes, and the expression of mRNA molecules across various \u03b3\u03b4 T-cell subgroups. Additionally, we investigated the likely genesis of dual TCR mRNA based on its compositional properties. This work provides a new perspective and scheme for the study of \u03b3\u03b4 T cells.<\/jats:p>","DOI":"10.1093\/immhor\/vlag044","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:56:06Z","timestamp":1790121366000},"source":"Crossref","is-referenced-by-count":0,"title":["Integrative scRNA-seq and scTCR-seq analyses decode dual TCR \u03b3\u03b4 T-cell characteristics in human and mouse"],"prefix":"10.1093","volume":"10","author":[{"given":"Huifang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Immunology, Center of Immuno-molecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University , Zunyi,","place":["China"]},{"name":"The Second Affiliated Hospital of Luohe Medical College , Blood Transfusion Department , 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