{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T22:48:06Z","timestamp":1792363686079,"version":"4.4.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-136833"],"award-info":[{"award-number":["MOP-136833"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec-Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Experimental studies provide evidence of the harmful effect of human papillomavirus (HPV) infection on pregnancy, but observational studies are inconclusive. We systematically assessed the association between HPV and adverse pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched electronic databases up to December 1, 2019. We included observational studies on the association between HPV and adverse pregnancy outcomes. We conducted a random-effect meta-analysis for each outcome and assessed heterogeneity between studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 3034 citations, we included 38 studies and quantitatively synthesized 36 studies. Human papillomavirus was significantly associated with preterm birth (age-adjusted odds ratio [aOR], 1.50; 95% confidence interval [CI], 1.19\u20131.88), preterm premature rupture of membranes (aOR, 1.96; 95% CI, 1.11\u20133.45), premature rupture of membranes (aOR, 1.42; 95% CI, 1.08\u20131.86), intrauterine growth restriction (aOR, 1.17; 95% CI, 1.01\u20131.37), low birth weight (aOR, 1.91; 95% CI, 1.33\u20132.76), and fetal death (aOR, 2.23; 95% CI, 1.14\u20134.37). No significant association was found for spontaneous abortion (aOR, 1.14; 95% CI, 0.40\u20133.22) and pregnancy-induced hypertensive disorders (aOR, 1.24; 95% CI, 0.80\u20131.92). Most of the studies were of moderate or low quality, and substantial between-studies heterogeneity remained unexplained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found a consistent and significant association between HPV and preterm birth and preterm premature rupture of membranes. Human papillomavirus may also be associated with intrauterine growth restriction, low birth weight, and fetal death, but findings are limited by suboptimal control of biases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiaa054","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T15:08:48Z","timestamp":1580828928000},"page":"1925-1937","source":"Crossref","is-referenced-by-count":70,"title":["Association Between Maternal Human Papillomavirus Infection and Adverse Pregnancy Outcomes: Systematic Review and Meta-Analysis"],"prefix":"10.1093","volume":"221","author":[{"given":"Joseph","family":"Niyibizi","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al, School of Public Health, Department of Social and Preventive Medicine, Montreal, Quebec, Canada"},{"name":"Centre de recherche du Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, CRCHUM, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nad\u00e8ge","family":"Zanr\u00e9","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al, Faculty of Medicine, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Mayrand","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al, School of Public Health, Department of Social and Preventive Medicine, Montreal, Quebec, Canada"},{"name":"Research Centre of University of Montreal Hospital Centre, CRCHUM, Montreal, Quebec, Canada"},{"name":"Universit\u00e9 de Montr\u00e9al, Department of Obstetrics and Gynecology, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Trottier","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al, School of Public Health, Department of Social and Preventive Medicine, Montreal, Quebec, Canada"},{"name":"Centre de recherche du Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, CRCHUM, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,2,5]]},"reference":[{"key":"2020061115545787400_CIT0001","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.siny.2015.12.008","article-title":"Infection and preterm birth","volume":"21","author":"Nadeau","year":"2016","journal-title":"Semin Fetal Neonatal Med"},{"key":"2020061115545787400_CIT0002","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s10815-006-9030-8","article-title":"Human papilloma virus DNA exposure and embryo survival is stage-specific","volume":"23","author":"Henneberg","year":"2006","journal-title":"J Assist Reprod Genet"},{"key":"2020061115545787400_CIT0003","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s00404-013-2711-5","article-title":"HPV-16 exposed mouse embryos: a potential model for pregnancy wastage","volume":"287","author":"Hong","year":"2013","journal-title":"Arch Gynecol Obstet"},{"key":"2020061115545787400_CIT0004","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/humrep\/dem404","article-title":"Placental infection with human papillomavirus is associated with spontaneous preterm delivery","volume":"23","author":"Gomez","year":"2008","journal-title":"Hum Reprod"},{"key":"2020061115545787400_CIT0005","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1023\/A:1007975005433","article-title":"Human papillomavirus is more prevalent in first trimester spontaneously aborted products of conception compared to elective specimens","volume":"14","author":"Hermonat","year":"1997","journal-title":"Virus Genes"},{"key":"2020061115545787400_CIT0006","doi-asserted-by":"crossref","first-page":"138 e1","DOI":"10.1016\/j.ajog.2013.09.040","article-title":"High risk human papillomavirus at entry to prenatal care and risk of preeclampsia","volume":"210","author":"McDonnold","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"2020061115545787400_CIT0007","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1586\/14760584.2014.944164","article-title":"The potential role of HPV vaccination in the prevention of infectious complications of pregnancy","volume":"13","author":"Bonde","year":"2014","journal-title":"Expert Rev Vaccines"},{"key":"2020061115545787400_CIT0008","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jcv.2014.09.002","article-title":"Can HPV vaccine have other health benefits more than cancer prevention? 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