{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:58:11Z","timestamp":1788235091593,"version":"build-2803163510"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,2,8]],"date-time":"2020-02-08T00:00:00Z","timestamp":1581120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Grant-in-Aid for Emerging and Reemerging Infectious Diseases"},{"name":"Ministry of Health, Labor and Welfare","award":["10110400"],"award-info":[{"award-number":["10110400"]}]},{"name":"JSPS KAKENHI","award":["18K10036"],"award-info":[{"award-number":["18K10036"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>During the 2018\u20132019 influenza seasons, we detected reduced baloxavir marboxil (baloxavir) susceptible variants with I38S or I38T amino acid substitutions on the PA subunit of influenza virus ribonucleic acid polymerase in 7 of 18 baloxavi-treated children and found that virus titer rebounded in some of these children with variants. We also found fever durations to be similar between patients with or without the variants, but the patients with variants shed the virus 3 days longer and took longer to improve clinical symptoms than those without variants.<\/jats:p>\n                  <jats:p>The emergence of these variants should be monitored during future influenza seasons.<\/jats:p>","DOI":"10.1093\/infdis\/jiaa061","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T07:09:12Z","timestamp":1580972952000},"page":"121-125","source":"Crossref","is-referenced-by-count":41,"title":["Detection of Variants With Reduced Baloxavir Marboxil Susceptibility After Treatment of Children With Influenza A During the 2018\u20132019 Influenza Season"],"prefix":"10.1093","volume":"222","author":[{"given":"Masatoki","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Takashita","sequence":"first","affiliation":[{"name":"Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Katayose","sequence":"first","affiliation":[{"name":"Nanohana Kids Clinic, Soma, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Nemoto","sequence":"first","affiliation":[{"name":"Nemoto Kids Clinic, Shirakawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuko","family":"Sakai","sequence":"first","affiliation":[{"name":"Jin Kids Clinic, Koriyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuaki","family":"Hosoya","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Fukushima Medical University, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,2,8]]},"reference":[{"key":"2020061607133334900_CIT0001","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.antiviral.2018.10.008","article-title":"In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit","volume":"160","author":"Noshi","year":"2018","journal-title":"Antiviral Res"},{"key":"2020061607133334900_CIT0002","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1056\/NEJMoa1716197","article-title":"Baloxavir marboxil for uncomplicated influenza in adults and adolescents","volume":"379","author":"Hayden","year":"2018","journal-title":"N Engl J 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