{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:58:27Z","timestamp":1767927507028,"version":"3.49.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20-GM103625"],"award-info":[{"award-number":["P20-GM103625"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R21 AI133103"],"award-info":[{"award-number":["1R21 AI133103"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Early after inhalation, Yersinia pestis replicates to high numbers in the airways in the absence of disease symptoms or notable inflammatory responses to cause primary pneumonic plague. The plasminogen activator protease (Pla) is a critical Y. pestis virulence factor that is important for early bacterial growth in the lung via an unknown mechanism. In this article, we define a dual role for Pla in the initial stages of pulmonary infection. We show that Pla functions as an adhesin independent of its proteolytic function to suppress early neutrophil influx into the lungs, and that Pla enzymatic activity contributes to bacterial resistance to neutrophil-mediated bacterial killing. Our results suggest that the fate of Y. pestis infection of the lung is decided extremely early during infection and that Pla plays a dual role to tilt the balance in favor of the pathogen.<\/jats:p>","DOI":"10.1093\/infdis\/jiaa094","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T20:13:55Z","timestamp":1582834435000},"page":"407-416","source":"Crossref","is-referenced-by-count":15,"title":["A Dual Role for the Plasminogen Activator Protease During the Preinflammatory Phase of Primary Pneumonic Plague"],"prefix":"10.1093","volume":"222","author":[{"given":"Srijon K","family":"Banerjee","sequence":"first","affiliation":[{"name":"University of Arkansas for Medical Sciences, Department of Microbiology and Immunology, Little Rock, Arkansas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha D","family":"Crane","sequence":"first","affiliation":[{"name":"University of Arkansas for Medical Sciences, Department of Microbiology and Immunology, Little Rock, Arkansas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5434-4744","authenticated-orcid":false,"given":"Roger D","family":"Pechous","sequence":"first","affiliation":[{"name":"University of Arkansas for Medical Sciences, Department of Microbiology and Immunology, Little Rock, Arkansas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"key":"2020070607241542300_CIT0001","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.tim.2015.11.008","article-title":"Pneumonic plague: the darker side of Yersinia pestis","volume":"24","author":"Pechous","year":"2016","journal-title":"Trends Microbiol"},{"key":"2020070607241542300_CIT0002","doi-asserted-by":"crossref","first-page":"17786","DOI":"10.1073\/pnas.0506840102","article-title":"Progression of primary pneumonic plague: a mouse model of infection, pathology, and 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