{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T05:50:42Z","timestamp":1772949042871,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T00:00:00Z","timestamp":1584576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R01AI099727"],"award-info":[{"award-number":["1R01AI099727"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5R01AI139265-02"],"award-info":[{"award-number":["5R01AI139265-02"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["P30MH058107"],"award-info":[{"award-number":["P30MH058107"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To investigate the role of serum cytokine assays to distinguish between active from treated syphilis among serofast patients, we recruited individuals into a prospective cohort study. Participants underwent routine syphilis screening. We selected specimens from a majority cohort of serofast participants with treated and active syphilis. We analyzed specimens with a 62-cytokine multiplex bead-based enzyme-linked immunosorbent assay. Cytokines, brain-derived neurotrophic factor and tumor necrosis factor \u03b2, were most predictive. We built a decision tree that was 82.4% accurate, 100% (95% confidence interval, 82%\u2013100%) sensitive, and 45% (18%\u201375%) specific. Our decision tree differentiated between serum specimens from serofast participants with treated syphilis versus active syphilis.<\/jats:p>","DOI":"10.1093\/infdis\/jiaa127","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T12:16:59Z","timestamp":1584447419000},"page":"690-694","source":"Crossref","is-referenced-by-count":5,"title":["The Application of Cytokine Expression Assays to Differentiate Active From Previously Treated Syphilis"],"prefix":"10.1093","volume":"222","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3667-9719","authenticated-orcid":false,"given":"Noah","family":"Kojima","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California Los Angeles, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet C","family":"Siebert","sequence":"additional","affiliation":[{"name":"CytoAnalytics, Denver, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holden","family":"Maecker","sequence":"additional","affiliation":[{"name":"Human Immune Monitoring Center, Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael","family":"Rosenberg-Hasson","sequence":"additional","affiliation":[{"name":"Human Immune Monitoring Center, Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Segundo R","family":"Leon","sequence":"additional","affiliation":[{"name":"School of Medical Technology, Universidad Privada San Juan Bautista, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silver K","family":"Vargas","sequence":"additional","affiliation":[{"name":"Laboratory of Sexual Health and Unit of Health, Sexuality and Human Development, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelika A","family":"Konda","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California Los Angeles, Los Angeles, California, USA"},{"name":"Laboratory of Sexual Health and Unit of Health, Sexuality and Human Development, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos F","family":"Caceres","sequence":"additional","affiliation":[{"name":"Laboratory of Sexual Health and Unit of Health, Sexuality and Human Development, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey 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