{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:20:30Z","timestamp":1783466430300,"version":"3.55.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH-P01AI34533"],"award-info":[{"award-number":["NIH-P01AI34533"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006753","name":"U.S. Army Materiel Command","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006753","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Major histocompatibility complex class I chain\u2013related (MIC) A and B (MICA and MICB) are polymorphic stress molecules recognized by natural killer cells. This study was performed to analyze MIC gene profiles in hospitalized Thai children with acute dengue illness.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>MIC allele profiles were determined in a discovery cohort of patients with dengue fever or dengue hemorrhagic fever (DHF) (n\u2005=\u2005166) and controls (n\u2005=\u2005149). A replication cohort of patients with dengue (n\u2005=\u2005222) was used to confirm specific MICB associations with disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>MICA*045 and MICB*004 associated with susceptibility to DHF in secondary dengue virus (DENV) infections (odds ratio [OR],\u20053.22; [95% confidence interval (CI), 1.18\u20138.84] and 1.99 [1.07\u20132.13], respectively), and MICB*002 with protection from DHF in secondary DENV infections (OR,\u20050.41; 95% CI, .21\u2013.68). The protective effect of MICB*002 against secondary DHF was confirmed in the replication cohort (OR,\u20050.43; 95% CI, .22\u2013.82) and was stronger when MICB*002 is present in individuals also carrying HLA-B*18, B*40, and B*44 alleles which form the B44 supertype of functionally related alleles (0.29, 95% CI, .14\u2013.60).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Given that MICB*002 is a low expresser of soluble proteins, these data indicate that surface expression of MICB*002 with B44 supertype alleles on DENV-infected cells confer a protective advantage in controlling DENV infection using natural killer cells.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiaa134","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T11:14:29Z","timestamp":1596194069000},"page":"840-846","source":"Crossref","is-referenced-by-count":10,"title":["Major Histocompatibility Complex Class I Chain\u2013Related A and B (MICA and MICB) Gene, Allele, and Haplotype Associations With Dengue Infections in Ethnic Thais"],"prefix":"10.1093","volume":"222","author":[{"given":"Panpimon","family":"Luangtrakool","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasijit","family":"Vejbaesya","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, 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Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis R","family":"Macareo","sequence":"additional","affiliation":[{"name":"Department of Virology, Armed Forces Research Institute of Medical Science, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Virology, Armed Forces Research Institute of Medical Science, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G","family":"Jarman","sequence":"additional","affiliation":[{"name":"Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W M","family":"Collins","sequence":"additional","affiliation":[{"name":"Clinical Science Laboratory, Guy\u2019s Hospital, London, United 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