{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T07:21:50Z","timestamp":1772176910830,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T00:00:00Z","timestamp":1585353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","award":["IP.2007.31080.003"],"award-info":[{"award-number":["IP.2007.31080.003"]}],"id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Malaria in Pregnancy Consortium"},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["46099"],"award-info":[{"award-number":["46099"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CDC Division of Parasitic Diseases and Malaria"},{"name":"Malaria Epidemiology Unit of the Liverpool School of Tropical Medicine","award":["U01CK000146"],"award-info":[{"award-number":["U01CK000146"]}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K08AI100924"],"award-info":[{"award-number":["K08AI100924"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institutes of Health, National Center for Advancing Translational Sciences","award":["UL1TR001117"],"award-info":[{"award-number":["UL1TR001117"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Sulfadoxine-pyrimethamine (SP) is used as intermittent preventive therapy in pregnancy (IPTp) for malaria in sub-Saharan Africa. The resistance marker dhps A581G has been associated with reduced IPTp-SP efficacy and enhanced morbidity in SP recipients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We measured SP-resistance allele frequencies in Malawian women participating in a trial comparing IPTp with SP against intermittent screening by rapid diagnostic tests (ISTp). We genotyped polymerase chain reaction-detected parasites using deep sequencing of SP-resistance alleles.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 125 placental infections, A581G-bearing parasites were associated with reduced birth weight (mean difference [MD], 252 g; 95% confidence interval [CI], 46\u2013457; P = .017). Relative to ISTp, IPTp-SP was associated with higher birth weights in women with wild-type parasites (MD, 116 g; 95% CI, \u221240 to 272; P = .142) and lower birth weights in women with A581G-bearing parasites (MD, 192 g; 95% CI, \u2212264 to 648; P = .385) (Pinteraction = .033). Similar associations were noted on gestational age (Pinteraction = .075). Amongst only IPTp-SP recipients, relative to women who last received SP &amp;gt; 4 weeks before delivery, recent SP receipt was associated with lower birth weight in women with wild-type parasites (MD, 118 g; 95% CI, \u2212376 to 139; P = .361) and higher birth weight in women with A581G-bearing parasites (MD, 783 g; 95% CI, \u221220 to 1586; P = .054) (Pinteraction = .005).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The effectiveness in birth weight of IPTp-SP is compromised by A581G-bearing parasites, but there was no evidence that the adverse effects of these parasites are exacerbated by antenatal SP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>ISRCTN Registry<\/jats:title>\n                  <jats:p>www.isrctn.com\/ISRCTN69800930.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiaa145","type":"journal-article","created":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T20:09:29Z","timestamp":1585166969000},"page":"661-669","source":"Crossref","is-referenced-by-count":13,"title":["Interactions Between Antenatal Sulfadoxine-Pyrimethamine, Drug-Resistant Plasmodium falciparum Parasites, and Delivery Outcomes in Malawi"],"prefix":"10.1093","volume":"222","author":[{"given":"Steve M","family":"Taylor","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA"},{"name":"Duke Global Health Institute, Durham, North Carolina, USA"},{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandt","family":"Levitt","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betsy","family":"Freedman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mwayiwawo","family":"Madanitsa","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Public Health and Family Medicine, College of Medicine, Blantyre, Malawi"},{"name":"Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyaw-Lay","family":"Thwai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Kalilani-Phiri","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Public Health and Family Medicine, College of Medicine, Blantyre, Malawi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Khairallah","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Mwapasa","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Public Health and Family Medicine, College of Medicine, Blantyre, Malawi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiko O","family":"ter Kuile","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R","family":"Meshnick","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,3,28]]},"reference":[{"key":"2020072311065801300_CIT0001","first-page":"CD000169","article-title":"Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no treatment","volume":"10)","author":"Radeva-Petrova","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"2020072311065801300_CIT0002","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/cid\/civ881","article-title":"Impact of sulfadoxine-pyrimethamine resistance on effectiveness of intermittent preventive therapy for malaria in pregnancy at clearing infections and preventing 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